ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKU3_LEIBR

TriTrypDb:

LbrM.32.3260 , LBRM2903_320040400

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.458
CLV_C14_Caspase3-7	431	435	PF00656	0.510
CLV_NRD_NRD_1	272	274	PF00675	0.288
CLV_NRD_NRD_1	350	352	PF00675	0.413
CLV_NRD_NRD_1	375	377	PF00675	0.586
CLV_NRD_NRD_1	487	489	PF00675	0.510
CLV_NRD_NRD_1	682	684	PF00675	0.559
CLV_PCSK_KEX2_1	272	274	PF00082	0.368
CLV_PCSK_KEX2_1	350	352	PF00082	0.413
CLV_PCSK_KEX2_1	375	377	PF00082	0.483
CLV_PCSK_KEX2_1	684	686	PF00082	0.569
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.565
CLV_PCSK_SKI1_1	214	218	PF00082	0.529
CLV_PCSK_SKI1_1	219	223	PF00082	0.574
CLV_PCSK_SKI1_1	313	317	PF00082	0.488
CLV_PCSK_SKI1_1	351	355	PF00082	0.523
CLV_PCSK_SKI1_1	369	373	PF00082	0.281
CLV_PCSK_SKI1_1	436	440	PF00082	0.357
CLV_PCSK_SKI1_1	488	492	PF00082	0.487
CLV_PCSK_SKI1_1	621	625	PF00082	0.498
CLV_PCSK_SKI1_1	678	682	PF00082	0.624
CLV_Separin_Metazoa	294	298	PF03568	0.451
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_ODPH_VHL_1	206	217	PF01847	0.445
DEG_ODPH_VHL_1	394	407	PF01847	0.543
DEG_SPOP_SBC_1	156	160	PF00917	0.321
DEG_SPOP_SBC_1	653	657	PF00917	0.665
DOC_CKS1_1	352	357	PF01111	0.505
DOC_CKS1_1	615	620	PF01111	0.532
DOC_CYCLIN_RxL_1	132	142	PF00134	0.567
DOC_CYCLIN_RxL_1	618	626	PF00134	0.356
DOC_CYCLIN_RxL_1	672	682	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.481
DOC_MAPK_gen_1	245	252	PF00069	0.358
DOC_MAPK_gen_1	272	280	PF00069	0.252
DOC_MAPK_gen_1	417	426	PF00069	0.432
DOC_MAPK_MEF2A_6	245	252	PF00069	0.376
DOC_MAPK_MEF2A_6	272	280	PF00069	0.452
DOC_MAPK_MEF2A_6	44	53	PF00069	0.548
DOC_PP1_RVXF_1	434	441	PF00149	0.354
DOC_PP1_RVXF_1	475	481	PF00149	0.492
DOC_PP1_SILK_1	91	96	PF00149	0.478
DOC_PP2B_LxvP_1	205	208	PF13499	0.337
DOC_PP4_FxxP_1	198	201	PF00568	0.486
DOC_PP4_FxxP_1	352	355	PF00568	0.512
DOC_PP4_FxxP_1	444	447	PF00568	0.445
DOC_PP4_FxxP_1	558	561	PF00568	0.602
DOC_PP4_FxxP_1	742	745	PF00568	0.458
DOC_SPAK_OSR1_1	417	421	PF12202	0.586
DOC_SPAK_OSR1_1	62	66	PF12202	0.459
DOC_USP7_MATH_1	192	196	PF00917	0.559
DOC_USP7_MATH_1	363	367	PF00917	0.467
DOC_USP7_MATH_1	399	403	PF00917	0.566
DOC_USP7_MATH_1	710	714	PF00917	0.540
DOC_WW_Pin1_4	197	202	PF00397	0.472
DOC_WW_Pin1_4	244	249	PF00397	0.322
DOC_WW_Pin1_4	332	337	PF00397	0.575
DOC_WW_Pin1_4	351	356	PF00397	0.531
DOC_WW_Pin1_4	483	488	PF00397	0.546
DOC_WW_Pin1_4	512	517	PF00397	0.559
DOC_WW_Pin1_4	614	619	PF00397	0.530
LIG_14-3-3_CanoR_1	138	142	PF00244	0.673
LIG_14-3-3_CanoR_1	231	238	PF00244	0.588
LIG_14-3-3_CanoR_1	383	390	PF00244	0.496
LIG_14-3-3_CanoR_1	412	417	PF00244	0.474
LIG_14-3-3_CanoR_1	44	53	PF00244	0.500
LIG_14-3-3_CanoR_1	445	451	PF00244	0.333
LIG_14-3-3_CanoR_1	520	524	PF00244	0.466
LIG_14-3-3_CanoR_1	55	61	PF00244	0.300
LIG_Actin_WH2_2	122	140	PF00022	0.672
LIG_Actin_WH2_2	198	216	PF00022	0.436
LIG_APCC_ABBA_1	604	609	PF00400	0.565
LIG_BIR_III_4	191	195	PF00653	0.482
LIG_BRCT_BRCA1_1	127	131	PF00533	0.359
LIG_BRCT_BRCA1_1	194	198	PF00533	0.506
LIG_BRCT_BRCA1_1	414	418	PF00533	0.440
LIG_CtBP_PxDLS_1	583	587	PF00389	0.546
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.529
LIG_EH1_1	80	88	PF00400	0.429
LIG_eIF4E_1	675	681	PF01652	0.650
LIG_FAT_LD_1	267	275	PF03623	0.298
LIG_FHA_1	197	203	PF00498	0.359
LIG_FHA_1	225	231	PF00498	0.322
LIG_FHA_1	245	251	PF00498	0.400
LIG_FHA_1	29	35	PF00498	0.503
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_1	427	433	PF00498	0.519
LIG_FHA_1	45	51	PF00498	0.357
LIG_FHA_1	55	61	PF00498	0.529
LIG_FHA_2	142	148	PF00498	0.419
LIG_FHA_2	429	435	PF00498	0.434
LIG_FHA_2	706	712	PF00498	0.524
LIG_HP1_1	201	205	PF01393	0.405
LIG_LIR_Apic_2	195	201	PF02991	0.463
LIG_LIR_Apic_2	741	745	PF02991	0.496
LIG_LIR_Gen_1	113	121	PF02991	0.608
LIG_LIR_Gen_1	168	178	PF02991	0.447
LIG_LIR_Gen_1	379	388	PF02991	0.397
LIG_LIR_Gen_1	564	572	PF02991	0.566
LIG_LIR_Gen_1	76	87	PF02991	0.294
LIG_LIR_Gen_1	8	16	PF02991	0.594
LIG_LIR_Nem_3	113	117	PF02991	0.487
LIG_LIR_Nem_3	152	156	PF02991	0.382
LIG_LIR_Nem_3	168	173	PF02991	0.442
LIG_LIR_Nem_3	319	325	PF02991	0.609
LIG_LIR_Nem_3	379	384	PF02991	0.377
LIG_LIR_Nem_3	564	569	PF02991	0.622
LIG_LIR_Nem_3	585	591	PF02991	0.467
LIG_LIR_Nem_3	748	753	PF02991	0.468
LIG_LIR_Nem_3	76	82	PF02991	0.256
LIG_LIR_Nem_3	8	13	PF02991	0.589
LIG_LYPXL_yS_3	588	591	PF13949	0.454
LIG_NRBOX	81	87	PF00104	0.449
LIG_NRP_CendR_1	758	759	PF00754	0.441
LIG_Pex14_1	440	444	PF04695	0.463
LIG_REV1ctd_RIR_1	129	139	PF16727	0.527
LIG_SH2_CRK	153	157	PF00017	0.565
LIG_SH2_CRK	364	368	PF00017	0.429
LIG_SH2_CRK	381	385	PF00017	0.299
LIG_SH2_GRB2like	52	55	PF00017	0.295
LIG_SH2_NCK_1	539	543	PF00017	0.596
LIG_SH2_PTP2	10	13	PF00017	0.645
LIG_SH2_SRC	753	756	PF00017	0.284
LIG_SH2_STAP1	225	229	PF00017	0.516
LIG_SH2_STAP1	79	83	PF00017	0.247
LIG_SH2_STAT5	10	13	PF00017	0.645
LIG_SH2_STAT5	364	367	PF00017	0.411
LIG_SH2_STAT5	511	514	PF00017	0.559
LIG_SH2_STAT5	52	55	PF00017	0.405
LIG_SH2_STAT5	566	569	PF00017	0.542
LIG_SH2_STAT5	675	678	PF00017	0.663
LIG_SH2_STAT5	753	756	PF00017	0.362
LIG_SH3_3	205	211	PF00018	0.429
LIG_SH3_3	352	358	PF00018	0.571
LIG_SH3_3	390	396	PF00018	0.506
LIG_SH3_3	658	664	PF00018	0.635
LIG_SUMO_SIM_anti_2	199	206	PF11976	0.359
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.520
LIG_SUMO_SIM_par_1	176	183	PF11976	0.257
LIG_SUMO_SIM_par_1	29	36	PF11976	0.492
LIG_SUMO_SIM_par_1	427	434	PF11976	0.535
LIG_TRAF2_1	290	293	PF00917	0.474
LIG_TRAF2_1	686	689	PF00917	0.490
LIG_TRAF2_1	714	717	PF00917	0.529
LIG_TYR_ITIM	586	591	PF00017	0.471
LIG_UBA3_1	258	266	PF00899	0.299
LIG_UBA3_1	721	729	PF00899	0.529
MOD_CDK_SPK_2	483	488	PF00069	0.546
MOD_CDK_SPxK_1	483	489	PF00069	0.539
MOD_CDK_SPxxK_3	354	361	PF00069	0.531
MOD_CDK_SPxxK_3	614	621	PF00069	0.520
MOD_CK1_1	224	230	PF00069	0.423
MOD_CK1_1	357	363	PF00069	0.500
MOD_CK1_1	514	520	PF00069	0.520
MOD_CK1_1	614	620	PF00069	0.533
MOD_CK1_1	656	662	PF00069	0.585
MOD_CK2_1	231	237	PF00069	0.462
MOD_CK2_1	287	293	PF00069	0.482
MOD_CK2_1	70	76	PF00069	0.379
MOD_CK2_1	705	711	PF00069	0.475
MOD_CK2_1	738	744	PF00069	0.564
MOD_CK2_1	9	15	PF00069	0.677
MOD_Cter_Amidation	735	738	PF01082	0.559
MOD_GlcNHglycan	164	168	PF01048	0.343
MOD_GlcNHglycan	194	197	PF01048	0.576
MOD_GlcNHglycan	5	8	PF01048	0.604
MOD_GlcNHglycan	516	519	PF01048	0.527
MOD_GlcNHglycan	563	566	PF01048	0.695
MOD_GlcNHglycan	625	628	PF01048	0.550
MOD_GlcNHglycan	656	659	PF01048	0.631
MOD_GlcNHglycan	711	715	PF01048	0.551
MOD_GSK3_1	112	119	PF00069	0.473
MOD_GSK3_1	133	140	PF00069	0.539
MOD_GSK3_1	192	199	PF00069	0.462
MOD_GSK3_1	20	27	PF00069	0.602
MOD_GSK3_1	479	486	PF00069	0.401
MOD_GSK3_1	526	533	PF00069	0.628
MOD_GSK3_1	607	614	PF00069	0.565
MOD_GSK3_1	623	630	PF00069	0.372
MOD_GSK3_1	652	659	PF00069	0.571
MOD_GSK3_1	701	708	PF00069	0.583
MOD_N-GLC_1	332	337	PF02516	0.494
MOD_N-GLC_2	471	473	PF02516	0.482
MOD_N-GLC_2	54	56	PF02516	0.499
MOD_N-GLC_2	603	605	PF02516	0.535
MOD_NEK2_1	106	111	PF00069	0.470
MOD_NEK2_1	137	142	PF00069	0.539
MOD_NEK2_1	20	25	PF00069	0.565
MOD_NEK2_1	251	256	PF00069	0.434
MOD_NEK2_1	371	376	PF00069	0.380
MOD_NEK2_1	584	589	PF00069	0.515
MOD_NEK2_1	597	602	PF00069	0.473
MOD_NEK2_1	623	628	PF00069	0.548
MOD_NEK2_1	654	659	PF00069	0.596
MOD_NEK2_1	701	706	PF00069	0.550
MOD_NEK2_1	721	726	PF00069	0.291
MOD_NEK2_1	81	86	PF00069	0.350
MOD_NEK2_2	753	758	PF00069	0.372
MOD_PIKK_1	490	496	PF00454	0.327
MOD_PKA_2	137	143	PF00069	0.678
MOD_PKA_2	382	388	PF00069	0.542
MOD_PKA_2	519	525	PF00069	0.510
MOD_PKA_2	54	60	PF00069	0.334
MOD_Plk_1	112	118	PF00069	0.538
MOD_Plk_1	133	139	PF00069	0.503
MOD_Plk_1	318	324	PF00069	0.494
MOD_Plk_1	405	411	PF00069	0.464
MOD_Plk_1	426	432	PF00069	0.398
MOD_Plk_1	584	590	PF00069	0.531
MOD_Plk_1	710	716	PF00069	0.512
MOD_Plk_2-3	428	434	PF00069	0.526
MOD_Plk_2-3	9	15	PF00069	0.625
MOD_Plk_4	318	324	PF00069	0.538
MOD_Plk_4	405	411	PF00069	0.445
MOD_Plk_4	592	598	PF00069	0.494
MOD_Plk_4	611	617	PF00069	0.360
MOD_Plk_4	628	634	PF00069	0.292
MOD_Plk_4	657	663	PF00069	0.558
MOD_Plk_4	81	87	PF00069	0.348
MOD_Plk_4	89	95	PF00069	0.362
MOD_ProDKin_1	197	203	PF00069	0.465
MOD_ProDKin_1	244	250	PF00069	0.312
MOD_ProDKin_1	332	338	PF00069	0.562
MOD_ProDKin_1	351	357	PF00069	0.523
MOD_ProDKin_1	483	489	PF00069	0.539
MOD_ProDKin_1	512	518	PF00069	0.561
MOD_ProDKin_1	614	620	PF00069	0.532
MOD_SUMO_rev_2	428	438	PF00179	0.394
TRG_DiLeu_BaEn_1	717	722	PF01217	0.516
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.484
TRG_ENDOCYTIC_2	10	13	PF00928	0.590
TRG_ENDOCYTIC_2	153	156	PF00928	0.539
TRG_ENDOCYTIC_2	322	325	PF00928	0.584
TRG_ENDOCYTIC_2	364	367	PF00928	0.408
TRG_ENDOCYTIC_2	381	384	PF00928	0.303
TRG_ENDOCYTIC_2	566	569	PF00928	0.579
TRG_ENDOCYTIC_2	588	591	PF00928	0.468
TRG_ENDOCYTIC_2	79	82	PF00928	0.269
TRG_ER_diArg_1	271	273	PF00400	0.289
TRG_ER_diArg_1	349	351	PF00400	0.403
TRG_ER_diArg_1	683	686	PF00400	0.573
TRG_NES_CRM1_1	104	120	PF08389	0.491
TRG_NLS_MonoCore_2	683	688	PF00514	0.536
TRG_NLS_MonoExtC_3	682	687	PF00514	0.594
TRG_NLS_MonoExtN_4	683	688	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N0	Leptomonas seymouri	54%	89%
A0A1X0NTF1	Trypanosomatidae	31%	88%
A0A3Q8ILH1	Leishmania donovani	84%	100%
A0A422NYN9	Trypanosoma rangeli	31%	88%
A4I8C2	Leishmania infantum	84%	100%
D0AAV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
E9B381	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q4X4	Leishmania major	82%	100%