Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKU2_LEIBR

TriTrypDb:

LbrM.32.3250

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.421
CLV_NRD_NRD_1	130	132	PF00675	0.412
CLV_NRD_NRD_1	80	82	PF00675	0.551
CLV_PCSK_SKI1_1	39	43	PF00082	0.513
DEG_Nend_UBRbox_3	1	3	PF02207	0.660
DOC_CDC14_PxL_1	157	165	PF14671	0.505
DOC_USP7_MATH_1	41	45	PF00917	0.575
LIG_14-3-3_CanoR_1	153	157	PF00244	0.510
LIG_14-3-3_CanoR_1	81	89	PF00244	0.508
LIG_BRCT_BRCA1_1	169	173	PF00533	0.413
LIG_eIF4E_1	46	52	PF01652	0.353
LIG_FHA_1	107	113	PF00498	0.393
LIG_FHA_1	146	152	PF00498	0.479
LIG_FHA_1	181	187	PF00498	0.521
LIG_FHA_1	4	10	PF00498	0.580
LIG_FHA_1	55	61	PF00498	0.438
LIG_LIR_Apic_2	101	107	PF02991	0.488
LIG_LIR_Gen_1	170	177	PF02991	0.395
LIG_LIR_LC3C_4	6	9	PF02991	0.489
LIG_LIR_Nem_3	155	159	PF02991	0.442
LIG_LIR_Nem_3	170	176	PF02991	0.321
LIG_SH2_CRK	171	175	PF00017	0.440
LIG_SH2_CRK	61	65	PF00017	0.425
LIG_SH2_SRC	119	122	PF00017	0.420
LIG_SH2_STAT5	119	122	PF00017	0.481
LIG_SH2_STAT5	125	128	PF00017	0.443
LIG_SH2_STAT5	157	160	PF00017	0.495
LIG_SH2_STAT5	171	174	PF00017	0.362
LIG_SH2_STAT5	84	87	PF00017	0.550
LIG_TRFH_1	157	161	PF08558	0.476
MOD_CK2_1	161	167	PF00069	0.558
MOD_GSK3_1	141	148	PF00069	0.484
MOD_GSK3_1	185	192	PF00069	0.490
MOD_GSK3_1	84	91	PF00069	0.490
MOD_GSK3_1	96	103	PF00069	0.401
MOD_N-GLC_1	52	57	PF02516	0.525
MOD_NEK2_1	145	150	PF00069	0.400
MOD_NEK2_1	152	157	PF00069	0.368
MOD_NEK2_1	3	8	PF00069	0.580
MOD_PIKK_1	88	94	PF00454	0.556
MOD_PKA_2	152	158	PF00069	0.437
MOD_PKB_1	98	106	PF00069	0.474
MOD_Plk_1	23	29	PF00069	0.630
MOD_Plk_2-3	23	29	PF00069	0.630
MOD_Plk_4	141	147	PF00069	0.549
MOD_Plk_4	152	158	PF00069	0.438
MOD_Plk_4	169	175	PF00069	0.279
MOD_SUMO_rev_2	75	83	PF00179	0.518
TRG_ENDOCYTIC_2	156	159	PF00928	0.483
TRG_ENDOCYTIC_2	171	174	PF00928	0.291
TRG_ENDOCYTIC_2	61	64	PF00928	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRP9	Trypanosomatidae	39%	100%
A0A3Q8IFP0	Leishmania donovani	77%	100%
A0A422NZW7	Trypanosoma rangeli	38%	100%
A4I8C1	Leishmania infantum	77%	100%
D0AAJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B380	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q9U1D7	Leishmania major	78%	99%