Tubulin-specific chaperone A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor A-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKU0_LEIBR

TriTrypDb:

LbrM.32.3230 , LBRM2903_320040200

Length:

124

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005874	microtubule	6	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HKU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU0

PDB structure(s): 4cqi_A

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0007021	tubulin complex assembly	6	10
GO:0007023	post-chaperonin tubulin folding pathway	3	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0048487	beta-tubulin binding	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.492
CLV_PCSK_KEX2_1	34	36	PF00082	0.262
CLV_PCSK_KEX2_1	44	46	PF00082	0.262
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.262
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.262
CLV_PCSK_SKI1_1	35	39	PF00082	0.283
DOC_MAPK_gen_1	34	42	PF00069	0.519
DOC_PP1_RVXF_1	36	43	PF00149	0.504
DOC_USP7_UBL2_3	34	38	PF12436	0.462
LIG_14-3-3_CanoR_1	113	117	PF00244	0.486
LIG_14-3-3_CanoR_1	27	37	PF00244	0.508
LIG_14-3-3_CanoR_1	64	72	PF00244	0.501
LIG_Actin_WH2_2	21	36	PF00022	0.219
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_EH1_1	80	88	PF00400	0.508
LIG_FHA_1	10	16	PF00498	0.584
LIG_FHA_1	67	73	PF00498	0.508
LIG_FHA_2	113	119	PF00498	0.448
LIG_FHA_2	34	40	PF00498	0.537
LIG_GBD_Chelix_1	89	97	PF00786	0.207
LIG_SH2_STAT5	96	99	PF00017	0.508
LIG_UBA3_1	25	29	PF00899	0.407
LIG_UBA3_1	86	91	PF00899	0.407
MOD_CK1_1	102	108	PF00069	0.508
MOD_CK1_1	2	8	PF00069	0.628
MOD_CK1_1	66	72	PF00069	0.407
MOD_GlcNHglycan	30	33	PF01048	0.345
MOD_GSK3_1	5	12	PF00069	0.594
MOD_GSK3_1	99	106	PF00069	0.407
MOD_NEK2_1	33	38	PF00069	0.524
MOD_NEK2_1	4	9	PF00069	0.568
MOD_PIKK_1	63	69	PF00454	0.407
MOD_PKA_2	112	118	PF00069	0.569
MOD_PKA_2	63	69	PF00069	0.592
MOD_PKA_2	9	15	PF00069	0.485
MOD_SUMO_for_1	43	46	PF00179	0.462
MOD_SUMO_rev_2	73	78	PF00179	0.407
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE53	Leptomonas seymouri	62%	99%
A0A1X0NSC9	Trypanosomatidae	61%	97%
A0A3R7KPE6	Trypanosoma rangeli	43%	98%
A0A3S7X5X5	Leishmania donovani	90%	99%
A4I8B9	Leishmania infantum	90%	99%
D0AAJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9B378	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
O04350	Arabidopsis thaliana	32%	100%
Q75JC8	Dictyostelium discoideum	30%	100%
Q9U1D9	Leishmania major	88%	100%