Nucleoside diphosphate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside diphosphate kinase b

Species:

Leishmania braziliensis

UniProt:

A4HKT8_LEIBR

TriTrypDb:

LbrM.32.3210 , LBRM2903_320039900

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HKT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT8

PDB structure(s): 3ngr_A , 3ngs_A , 3ngs_B , 3ngs_C , 3ngt_A , 3ngt_B , 3ngt_C , 3ngt_D , 3ngt_E , 3ngt_F , 3ngt_G , 3ngt_H , 3ngt_I , 3ngt_J , 3ngt_K , 3ngt_L , 3ngt_M , 3ngt_N , 3ngu_A , 3ngu_B , 4kpc_A , 4kpc_B , 5c7p_A , 5c7p_B , 5c7p_C , 5caa_A , 5caa_B , 5cab_A , 5cab_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	11
GO:0006183	GTP biosynthetic process	8	11
GO:0006220	pyrimidine nucleotide metabolic process	5	11
GO:0006221	pyrimidine nucleotide biosynthetic process	6	11
GO:0006228	UTP biosynthetic process	8	11
GO:0006241	CTP biosynthetic process	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004550	nucleoside diphosphate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.272
CLV_PCSK_SKI1_1	30	34	PF00082	0.286
CLV_PCSK_SKI1_1	57	61	PF00082	0.401
CLV_PCSK_SKI1_1	87	91	PF00082	0.260
DOC_MAPK_gen_1	29	37	PF00069	0.457
DOC_MAPK_MEF2A_6	30	39	PF00069	0.467
DOC_PP1_RVXF_1	125	132	PF00149	0.456
DOC_USP7_MATH_1	95	99	PF00917	0.479
DOC_USP7_UBL2_3	80	84	PF12436	0.488
LIG_BIR_II_1	1	5	PF00653	0.470

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9U6	Leptomonas seymouri	88%	100%
A0A0S4JF35	Bodo saltans	74%	100%
A0A1X0NS53	Trypanosomatidae	83%	99%
A0A3R7RQZ2	Trypanosoma rangeli	82%	99%
A0A3S7X5X3	Leishmania donovani	91%	100%
A0AK41	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	50%	100%
A0KJ40	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	46%	100%
A0KXI2	Shewanella sp. (strain ANA-3)	50%	100%
A0PU19	Mycobacterium ulcerans (strain Agy99)	51%	100%
A0Q4L4	Francisella tularensis subsp. novicida (strain U112)	41%	100%

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