SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKT6_LEIBR

TriTrypDb:

LbrM.32.3190 , LBRM2903_320039800

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.467
CLV_C14_Caspase3-7	476	480	PF00656	0.542
CLV_C14_Caspase3-7	485	489	PF00656	0.533
CLV_NRD_NRD_1	129	131	PF00675	0.604
CLV_NRD_NRD_1	398	400	PF00675	0.412
CLV_NRD_NRD_1	568	570	PF00675	0.641
CLV_NRD_NRD_1	75	77	PF00675	0.470
CLV_PCSK_KEX2_1	210	212	PF00082	0.315
CLV_PCSK_KEX2_1	25	27	PF00082	0.480
CLV_PCSK_KEX2_1	385	387	PF00082	0.478
CLV_PCSK_KEX2_1	397	399	PF00082	0.459
CLV_PCSK_KEX2_1	537	539	PF00082	0.467
CLV_PCSK_KEX2_1	570	572	PF00082	0.674
CLV_PCSK_KEX2_1	75	77	PF00082	0.494
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.315
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.480
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.496
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.467
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.674
CLV_PCSK_SKI1_1	110	114	PF00082	0.558
CLV_PCSK_SKI1_1	152	156	PF00082	0.475
CLV_PCSK_SKI1_1	16	20	PF00082	0.616
CLV_PCSK_SKI1_1	522	526	PF00082	0.475
DEG_APCC_DBOX_1	25	33	PF00400	0.530
DEG_APCC_DBOX_1	375	383	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.606
DOC_CYCLIN_RxL_1	195	208	PF00134	0.361
DOC_CYCLIN_RxL_1	238	246	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.323
DOC_MAPK_DCC_7	10	20	PF00069	0.728
DOC_MAPK_gen_1	170	176	PF00069	0.423
DOC_MAPK_gen_1	441	450	PF00069	0.315
DOC_MAPK_gen_1	467	473	PF00069	0.402
DOC_MAPK_gen_1	537	544	PF00069	0.421
DOC_MAPK_gen_1	75	83	PF00069	0.489
DOC_MAPK_JIP1_4	599	605	PF00069	0.683
DOC_MAPK_MEF2A_6	152	160	PF00069	0.390
DOC_MAPK_MEF2A_6	537	546	PF00069	0.416
DOC_MAPK_MEF2A_6	87	95	PF00069	0.543
DOC_PP1_RVXF_1	509	516	PF00149	0.493
DOC_PP1_SILK_1	223	228	PF00149	0.391
DOC_PP2B_LxvP_1	411	414	PF13499	0.397
DOC_PP4_FxxP_1	14	17	PF00568	0.492
DOC_PP4_FxxP_1	496	499	PF00568	0.447
DOC_SPAK_OSR1_1	66	70	PF12202	0.538
DOC_USP7_MATH_1	306	310	PF00917	0.598
DOC_USP7_MATH_1	363	367	PF00917	0.716
DOC_USP7_MATH_1	507	511	PF00917	0.524
DOC_USP7_MATH_2	499	505	PF00917	0.476
DOC_USP7_UBL2_3	102	106	PF12436	0.485
DOC_USP7_UBL2_3	508	512	PF12436	0.629
DOC_USP7_UBL2_3	573	577	PF12436	0.414
DOC_WW_Pin1_4	228	233	PF00397	0.315
DOC_WW_Pin1_4	361	366	PF00397	0.583
DOC_WW_Pin1_4	443	448	PF00397	0.315
LIG_14-3-3_CanoR_1	177	183	PF00244	0.426
LIG_14-3-3_CanoR_1	227	232	PF00244	0.334
LIG_14-3-3_CanoR_1	248	256	PF00244	0.329
LIG_14-3-3_CanoR_1	26	35	PF00244	0.455
LIG_14-3-3_CanoR_1	557	563	PF00244	0.567
LIG_14-3-3_CanoR_1	66	72	PF00244	0.413
LIG_14-3-3_CanoR_1	75	83	PF00244	0.460
LIG_APCC_ABBA_1	91	96	PF00400	0.438
LIG_BIR_III_2	479	483	PF00653	0.661
LIG_BIR_III_4	289	293	PF00653	0.461
LIG_BRCT_BRCA1_1	63	67	PF00533	0.552
LIG_FHA_1	22	28	PF00498	0.640
LIG_FHA_1	260	266	PF00498	0.315
LIG_FHA_1	293	299	PF00498	0.432
LIG_FHA_1	435	441	PF00498	0.476
LIG_FHA_1	583	589	PF00498	0.422
LIG_FHA_2	29	35	PF00498	0.393
LIG_LIR_Apic_2	495	499	PF02991	0.439
LIG_LIR_Apic_2	594	600	PF02991	0.515
LIG_LIR_Gen_1	407	418	PF02991	0.564
LIG_LIR_Gen_1	469	478	PF02991	0.460
LIG_LIR_Nem_3	294	299	PF02991	0.409
LIG_LIR_Nem_3	469	473	PF02991	0.333
LIG_LIR_Nem_3	488	493	PF02991	0.396
LIG_LIR_Nem_3	518	524	PF02991	0.439
LIG_NRBOX	140	146	PF00104	0.435
LIG_Pex14_1	449	453	PF04695	0.223
LIG_Pex14_2	387	391	PF04695	0.531
LIG_PTB_Apo_2	40	47	PF02174	0.434
LIG_PTB_Apo_2	577	584	PF02174	0.311
LIG_PTB_Phospho_1	577	583	PF10480	0.316
LIG_SH2_CRK	229	233	PF00017	0.334
LIG_SH2_CRK	341	345	PF00017	0.529
LIG_SH2_CRK	597	601	PF00017	0.538
LIG_SH2_GRB2like	242	245	PF00017	0.435
LIG_SH2_GRB2like	400	403	PF00017	0.360
LIG_SH2_NCK_1	597	601	PF00017	0.538
LIG_SH2_PTP2	470	473	PF00017	0.435
LIG_SH2_STAP1	341	345	PF00017	0.484
LIG_SH2_STAP1	63	67	PF00017	0.527
LIG_SH2_STAT3	579	582	PF00017	0.418
LIG_SH2_STAT5	229	232	PF00017	0.315
LIG_SH2_STAT5	242	245	PF00017	0.315
LIG_SH2_STAT5	410	413	PF00017	0.538
LIG_SH2_STAT5	470	473	PF00017	0.435
LIG_SH2_STAT5	532	535	PF00017	0.522
LIG_SH2_STAT5	583	586	PF00017	0.461
LIG_SH2_STAT5	597	600	PF00017	0.512
LIG_SH3_3	253	259	PF00018	0.315
LIG_SH3_3	66	72	PF00018	0.414
LIG_SH3_3	78	84	PF00018	0.424
LIG_SUMO_SIM_anti_2	377	383	PF11976	0.387
LIG_SUMO_SIM_par_1	172	178	PF11976	0.558
LIG_TRAF2_1	147	150	PF00917	0.570
LIG_TRAF2_1	482	485	PF00917	0.600
LIG_UBA3_1	279	285	PF00899	0.510
LIG_UBA3_1	379	385	PF00899	0.380
LIG_UBA3_1	502	508	PF00899	0.498
LIG_UBA3_1	90	97	PF00899	0.379
LIG_WRC_WIRS_1	435	440	PF05994	0.391
MOD_CK1_1	178	184	PF00069	0.445
MOD_CK1_1	343	349	PF00069	0.591
MOD_CK1_1	39	45	PF00069	0.486
MOD_CK1_1	564	570	PF00069	0.565
MOD_CK1_1	581	587	PF00069	0.290
MOD_CK1_1	595	601	PF00069	0.530
MOD_CK1_1	74	80	PF00069	0.442
MOD_CK2_1	248	254	PF00069	0.223
MOD_CK2_1	355	361	PF00069	0.667
MOD_CK2_1	542	548	PF00069	0.391
MOD_CK2_1	549	555	PF00069	0.453
MOD_Cter_Amidation	208	211	PF01082	0.315
MOD_Cter_Amidation	383	386	PF01082	0.584
MOD_GlcNHglycan	121	124	PF01048	0.434
MOD_GlcNHglycan	177	180	PF01048	0.514
MOD_GlcNHglycan	256	259	PF01048	0.334
MOD_GlcNHglycan	357	360	PF01048	0.689
MOD_GlcNHglycan	475	478	PF01048	0.514
MOD_GlcNHglycan	551	554	PF01048	0.452
MOD_GSK3_1	33	40	PF00069	0.450
MOD_GSK3_1	339	346	PF00069	0.577
MOD_GSK3_1	363	370	PF00069	0.745
MOD_GSK3_1	557	564	PF00069	0.532
MOD_GSK3_1	578	585	PF00069	0.432
MOD_GSK3_1	591	598	PF00069	0.474
MOD_GSK3_1	67	74	PF00069	0.385
MOD_N-GLC_1	259	264	PF02516	0.334
MOD_N-GLC_2	547	549	PF02516	0.436
MOD_NEK2_1	119	124	PF00069	0.447
MOD_NEK2_1	355	360	PF00069	0.641
MOD_NEK2_1	37	42	PF00069	0.486
MOD_NEK2_1	516	521	PF00069	0.429
MOD_NEK2_1	542	547	PF00069	0.407
MOD_NEK2_1	578	583	PF00069	0.427
MOD_NEK2_1	62	67	PF00069	0.537
MOD_NEK2_2	292	297	PF00069	0.461
MOD_NEK2_2	532	537	PF00069	0.530
MOD_NEK2_2	592	597	PF00069	0.482
MOD_PIKK_1	248	254	PF00454	0.412
MOD_PIKK_1	343	349	PF00454	0.593
MOD_PIKK_1	578	584	PF00454	0.413
MOD_PIKK_1	67	73	PF00454	0.523
MOD_PKA_1	442	448	PF00069	0.223
MOD_PKA_2	74	80	PF00069	0.461
MOD_PKB_1	569	577	PF00069	0.646
MOD_Plk_1	33	39	PF00069	0.436
MOD_Plk_4	178	184	PF00069	0.376
MOD_Plk_4	266	272	PF00069	0.487
MOD_Plk_4	292	298	PF00069	0.450
MOD_Plk_4	3	9	PF00069	0.482
MOD_Plk_4	33	39	PF00069	0.413
MOD_Plk_4	340	346	PF00069	0.584
MOD_Plk_4	501	507	PF00069	0.460
MOD_Plk_4	558	564	PF00069	0.571
MOD_Plk_4	592	598	PF00069	0.483
MOD_Plk_4	86	92	PF00069	0.341
MOD_ProDKin_1	228	234	PF00069	0.315
MOD_ProDKin_1	361	367	PF00069	0.588
MOD_ProDKin_1	443	449	PF00069	0.315
MOD_SUMO_for_1	497	500	PF00179	0.577
MOD_SUMO_rev_2	105	112	PF00179	0.546
TRG_DiLeu_BaEn_3	150	156	PF01217	0.514
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.469
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.462
TRG_ENDOCYTIC_2	242	245	PF00928	0.435
TRG_ENDOCYTIC_2	341	344	PF00928	0.536
TRG_ENDOCYTIC_2	410	413	PF00928	0.480
TRG_ENDOCYTIC_2	470	473	PF00928	0.435
TRG_ER_diArg_1	308	311	PF00400	0.478
TRG_ER_diArg_1	397	399	PF00400	0.427
TRG_NLS_MonoExtC_3	283	288	PF00514	0.567
TRG_NLS_MonoExtN_4	130	135	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBK1	Leptomonas seymouri	69%	100%
A0A1X0NRN7	Trypanosomatidae	59%	100%
A0A3R7NSK8	Trypanosoma rangeli	60%	100%
A0A3S7X5W5	Leishmania donovani	88%	100%
A4I8B5	Leishmania infantum	88%	100%
D0AAI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
E9B374	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q9U1E2	Leishmania major	87%	100%
V5DE73	Trypanosoma cruzi	57%	100%