Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKT5_LEIBR

TriTrypDb:

LbrM.32.3180 , LBRM2903_320039700

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004835	tubulin-tyrosine ligase activity	3	7
GO:0016874	ligase activity	2	10
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016881	acid-amino acid ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.531
CLV_NRD_NRD_1	239	241	PF00675	0.290
CLV_NRD_NRD_1	66	68	PF00675	0.455
CLV_NRD_NRD_1	83	85	PF00675	0.600
CLV_PCSK_KEX2_1	239	241	PF00082	0.308
CLV_PCSK_KEX2_1	485	487	PF00082	0.489
CLV_PCSK_KEX2_1	66	68	PF00082	0.456
CLV_PCSK_KEX2_1	71	73	PF00082	0.518
CLV_PCSK_KEX2_1	82	84	PF00082	0.578
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.361
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.536
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.583
CLV_PCSK_PC7_1	67	73	PF00082	0.588
CLV_PCSK_SKI1_1	120	124	PF00082	0.435
CLV_PCSK_SKI1_1	13	17	PF00082	0.512
CLV_PCSK_SKI1_1	207	211	PF00082	0.349
CLV_PCSK_SKI1_1	233	237	PF00082	0.300
CLV_PCSK_SKI1_1	326	330	PF00082	0.336
CLV_PCSK_SKI1_1	460	464	PF00082	0.340
DEG_APCC_DBOX_1	206	214	PF00400	0.591
DEG_APCC_DBOX_1	311	319	PF00400	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.433
DEG_SPOP_SBC_1	354	358	PF00917	0.411
DEG_SPOP_SBC_1	387	391	PF00917	0.471
DOC_CKS1_1	375	380	PF01111	0.549
DOC_CYCLIN_RxL_1	10	18	PF00134	0.538
DOC_CYCLIN_RxL_1	207	218	PF00134	0.563
DOC_MAPK_gen_1	483	493	PF00069	0.525
DOC_MAPK_MEF2A_6	465	472	PF00069	0.561
DOC_MAPK_MEF2A_6	91	100	PF00069	0.680
DOC_MAPK_NFAT4_5	465	473	PF00069	0.561
DOC_PP1_RVXF_1	109	116	PF00149	0.533
DOC_PP1_RVXF_1	209	216	PF00149	0.561
DOC_PP1_SILK_1	207	212	PF00149	0.591
DOC_PP2B_LxvP_1	98	101	PF13499	0.697
DOC_USP7_MATH_1	101	105	PF00917	0.444
DOC_USP7_MATH_1	155	159	PF00917	0.591
DOC_USP7_MATH_1	354	358	PF00917	0.529
DOC_WW_Pin1_4	278	283	PF00397	0.571
DOC_WW_Pin1_4	333	338	PF00397	0.568
DOC_WW_Pin1_4	361	366	PF00397	0.732
DOC_WW_Pin1_4	374	379	PF00397	0.691
DOC_WW_Pin1_4	92	97	PF00397	0.732
LIG_14-3-3_CanoR_1	120	125	PF00244	0.434
LIG_14-3-3_CanoR_1	20	26	PF00244	0.536
LIG_14-3-3_CanoR_1	266	271	PF00244	0.490
LIG_14-3-3_CanoR_1	91	96	PF00244	0.680
LIG_Actin_WH2_2	109	127	PF00022	0.449
LIG_APCC_ABBA_1	257	262	PF00400	0.531
LIG_CaM_NSCaTE_8	445	452	PF13499	0.531
LIG_eIF4E_1	230	236	PF01652	0.490
LIG_eIF4E_1	258	264	PF01652	0.508
LIG_FHA_1	10	16	PF00498	0.362
LIG_FHA_1	117	123	PF00498	0.451
LIG_FHA_1	128	134	PF00498	0.537
LIG_FHA_1	265	271	PF00498	0.522
LIG_FHA_1	30	36	PF00498	0.587
LIG_FHA_1	426	432	PF00498	0.560
LIG_FHA_1	465	471	PF00498	0.495
LIG_FHA_1	477	483	PF00498	0.529
LIG_FHA_1	63	69	PF00498	0.443
LIG_FHA_2	140	146	PF00498	0.494
LIG_FHA_2	38	44	PF00498	0.614
LIG_LIR_Apic_2	90	96	PF02991	0.629
LIG_LIR_Gen_1	18	26	PF02991	0.462
LIG_LIR_Gen_1	426	437	PF02991	0.508
LIG_LIR_Gen_1	6	16	PF02991	0.447
LIG_LIR_LC3C_4	32	37	PF02991	0.581
LIG_LIR_Nem_3	150	154	PF02991	0.487
LIG_LIR_Nem_3	18	24	PF02991	0.499
LIG_LIR_Nem_3	205	209	PF02991	0.565
LIG_LIR_Nem_3	253	258	PF02991	0.499
LIG_LIR_Nem_3	426	432	PF02991	0.493
LIG_Pex14_2	432	436	PF04695	0.531
LIG_SH2_CRK	206	210	PF00017	0.591
LIG_SH2_CRK	434	438	PF00017	0.476
LIG_SH2_CRK	93	97	PF00017	0.665
LIG_SH2_GRB2like	135	138	PF00017	0.438
LIG_SH2_NCK_1	93	97	PF00017	0.629
LIG_SH2_PTP2	490	493	PF00017	0.462
LIG_SH2_SRC	304	307	PF00017	0.531
LIG_SH2_STAP1	255	259	PF00017	0.490
LIG_SH2_STAP1	434	438	PF00017	0.490
LIG_SH2_STAP1	88	92	PF00017	0.472
LIG_SH2_STAT5	146	149	PF00017	0.508
LIG_SH2_STAT5	230	233	PF00017	0.528
LIG_SH2_STAT5	258	261	PF00017	0.508
LIG_SH2_STAT5	272	275	PF00017	0.508
LIG_SH2_STAT5	475	478	PF00017	0.605
LIG_SH2_STAT5	490	493	PF00017	0.217
LIG_SH2_STAT5	93	96	PF00017	0.628
LIG_SH3_2	453	458	PF14604	0.561
LIG_SH3_3	171	177	PF00018	0.411
LIG_SH3_3	228	234	PF00018	0.561
LIG_SH3_3	372	378	PF00018	0.551
LIG_SH3_3	415	421	PF00018	0.518
LIG_SH3_3	450	456	PF00018	0.558
LIG_TRFH_1	151	155	PF08558	0.561
MOD_CDK_SPxxK_3	278	285	PF00069	0.591
MOD_CDK_SPxxK_3	92	99	PF00069	0.730
MOD_CK1_1	127	133	PF00069	0.487
MOD_CK1_1	22	28	PF00069	0.665
MOD_CK1_1	276	282	PF00069	0.547
MOD_CK1_1	376	382	PF00069	0.762
MOD_CK2_1	156	162	PF00069	0.597
MOD_CK2_1	299	305	PF00069	0.506
MOD_CK2_1	3	9	PF00069	0.488
MOD_GlcNHglycan	103	106	PF01048	0.571
MOD_GlcNHglycan	190	193	PF01048	0.311
MOD_GlcNHglycan	275	278	PF01048	0.310
MOD_GlcNHglycan	383	386	PF01048	0.654
MOD_GlcNHglycan	476	479	PF01048	0.470
MOD_GSK3_1	116	123	PF00069	0.418
MOD_GSK3_1	15	22	PF00069	0.568
MOD_GSK3_1	266	273	PF00069	0.480
MOD_GSK3_1	386	393	PF00069	0.508
MOD_GSK3_1	87	94	PF00069	0.687
MOD_N-GLC_1	373	378	PF02516	0.616
MOD_N-GLC_2	291	293	PF02516	0.290
MOD_NEK2_1	124	129	PF00069	0.484
MOD_NEK2_1	15	20	PF00069	0.516
MOD_NEK2_1	166	171	PF00069	0.508
MOD_NEK2_1	215	220	PF00069	0.535
MOD_NEK2_1	265	270	PF00069	0.507
MOD_NEK2_1	44	49	PF00069	0.646
MOD_NEK2_1	476	481	PF00069	0.344
MOD_NEK2_2	321	326	PF00069	0.571
MOD_PIKK_1	215	221	PF00454	0.531
MOD_PIKK_1	37	43	PF00454	0.632
MOD_PK_1	266	272	PF00069	0.490
MOD_PK_1	27	33	PF00069	0.692
MOD_PKA_2	19	25	PF00069	0.547
MOD_PKA_2	265	271	PF00069	0.490
MOD_PKA_2	273	279	PF00069	0.490
MOD_PKA_2	406	412	PF00069	0.551
MOD_Plk_1	387	393	PF00069	0.569
MOD_Plk_4	124	130	PF00069	0.513
MOD_Plk_4	299	305	PF00069	0.535
MOD_Plk_4	3	9	PF00069	0.498
MOD_Plk_4	406	412	PF00069	0.536
MOD_ProDKin_1	278	284	PF00069	0.571
MOD_ProDKin_1	333	339	PF00069	0.568
MOD_ProDKin_1	361	367	PF00069	0.731
MOD_ProDKin_1	374	380	PF00069	0.691
MOD_ProDKin_1	92	98	PF00069	0.730
MOD_SUMO_for_1	330	333	PF00179	0.571
MOD_SUMO_rev_2	435	444	PF00179	0.487
TRG_DiLeu_BaEn_1	162	167	PF01217	0.531
TRG_DiLeu_BaEn_4	305	311	PF01217	0.508
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.490
TRG_ENDOCYTIC_2	146	149	PF00928	0.520
TRG_ENDOCYTIC_2	206	209	PF00928	0.591
TRG_ENDOCYTIC_2	434	437	PF00928	0.476
TRG_ENDOCYTIC_2	490	493	PF00928	0.431
TRG_ENDOCYTIC_2	8	11	PF00928	0.428
TRG_ER_diArg_1	66	68	PF00400	0.481
TRG_ER_diArg_1	82	84	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M9	Leptomonas seymouri	70%	77%
A0A1X0NRN8	Trypanosomatidae	43%	100%
A0A3Q8IH06	Leishmania donovani	86%	78%
A0A422NE52	Trypanosoma rangeli	29%	100%
A0A422NZN7	Trypanosoma rangeli	41%	96%
A4I8B4	Leishmania infantum	86%	100%
E9B373	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4Y1	Leishmania major	83%	100%