Intergrin alpha chain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKT4_LEIBR

TriTrypDb:

LbrM.32.3170 , LBRM2903_320039600

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HKT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.541
CLV_C14_Caspase3-7	243	247	PF00656	0.380
CLV_NRD_NRD_1	202	204	PF00675	0.541
CLV_NRD_NRD_1	256	258	PF00675	0.669
CLV_NRD_NRD_1	297	299	PF00675	0.649
CLV_NRD_NRD_1	309	311	PF00675	0.597
CLV_NRD_NRD_1	358	360	PF00675	0.573
CLV_NRD_NRD_1	538	540	PF00675	0.528
CLV_NRD_NRD_1	561	563	PF00675	0.768
CLV_NRD_NRD_1	603	605	PF00675	0.657
CLV_NRD_NRD_1	717	719	PF00675	0.463
CLV_NRD_NRD_1	81	83	PF00675	0.620
CLV_PCSK_FUR_1	355	359	PF00082	0.692
CLV_PCSK_KEX2_1	202	204	PF00082	0.541
CLV_PCSK_KEX2_1	297	299	PF00082	0.685
CLV_PCSK_KEX2_1	308	310	PF00082	0.690
CLV_PCSK_KEX2_1	357	359	PF00082	0.609
CLV_PCSK_KEX2_1	421	423	PF00082	0.699
CLV_PCSK_KEX2_1	537	539	PF00082	0.532
CLV_PCSK_KEX2_1	603	605	PF00082	0.636
CLV_PCSK_KEX2_1	723	725	PF00082	0.438
CLV_PCSK_KEX2_1	80	82	PF00082	0.609
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.682
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.683
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.562
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.479
CLV_PCSK_PC7_1	293	299	PF00082	0.724
CLV_PCSK_PC7_1	304	310	PF00082	0.666
CLV_PCSK_SKI1_1	236	240	PF00082	0.702
CLV_PCSK_SKI1_1	309	313	PF00082	0.715
CLV_PCSK_SKI1_1	48	52	PF00082	0.571
CLV_PCSK_SKI1_1	538	542	PF00082	0.616
CLV_PCSK_SKI1_1	60	64	PF00082	0.425
CLV_PCSK_SKI1_1	720	724	PF00082	0.456
DEG_APCC_DBOX_1	356	364	PF00400	0.278
DEG_Nend_UBRbox_1	1	4	PF02207	0.538
DOC_MAPK_gen_1	2	11	PF00069	0.431
DOC_MAPK_gen_1	355	365	PF00069	0.347
DOC_MAPK_gen_1	586	594	PF00069	0.452
DOC_MAPK_gen_1	623	633	PF00069	0.330
DOC_MAPK_MEF2A_6	2	11	PF00069	0.432
DOC_MAPK_MEF2A_6	333	341	PF00069	0.432
DOC_MAPK_MEF2A_6	497	506	PF00069	0.313
DOC_MAPK_RevD_3	681	697	PF00069	0.331
DOC_PP1_RVXF_1	536	543	PF00149	0.317
DOC_PP4_FxxP_1	32	35	PF00568	0.270
DOC_USP7_MATH_1	164	168	PF00917	0.255
DOC_USP7_MATH_1	300	304	PF00917	0.575
DOC_USP7_MATH_1	54	58	PF00917	0.401
DOC_USP7_MATH_1	552	556	PF00917	0.431
DOC_USP7_UBL2_3	295	299	PF12436	0.430
DOC_USP7_UBL2_3	715	719	PF12436	0.656
DOC_WW_Pin1_4	133	138	PF00397	0.358
DOC_WW_Pin1_4	496	501	PF00397	0.306
DOC_WW_Pin1_4	550	555	PF00397	0.411
LIG_14-3-3_CanoR_1	309	314	PF00244	0.490
LIG_14-3-3_CanoR_1	338	342	PF00244	0.545
LIG_14-3-3_CanoR_1	415	419	PF00244	0.349
LIG_14-3-3_CanoR_1	478	484	PF00244	0.471
LIG_14-3-3_CanoR_1	60	70	PF00244	0.307
LIG_14-3-3_CanoR_1	629	634	PF00244	0.438
LIG_14-3-3_CanoR_1	670	679	PF00244	0.397
LIG_14-3-3_CanoR_1	718	723	PF00244	0.743
LIG_14-3-3_CanoR_1	89	99	PF00244	0.300
LIG_14-3-3_CterR_2	724	727	PF00244	0.629
LIG_BRCT_BRCA1_1	24	28	PF00533	0.379
LIG_BRCT_BRCA1_1	360	364	PF00533	0.366
LIG_BRCT_BRCA1_1	415	419	PF00533	0.395
LIG_BRCT_BRCA1_2	415	421	PF00533	0.303
LIG_deltaCOP1_diTrp_1	260	266	PF00928	0.325
LIG_EVH1_1	633	637	PF00568	0.234
LIG_FHA_1	182	188	PF00498	0.321
LIG_FHA_1	377	383	PF00498	0.243
LIG_FHA_1	40	46	PF00498	0.395
LIG_FHA_1	451	457	PF00498	0.391
LIG_FHA_1	480	486	PF00498	0.382
LIG_FHA_1	497	503	PF00498	0.202
LIG_FHA_1	525	531	PF00498	0.319
LIG_FHA_1	605	611	PF00498	0.383
LIG_FHA_1	626	632	PF00498	0.355
LIG_FHA_1	649	655	PF00498	0.384
LIG_FHA_1	705	711	PF00498	0.669
LIG_FHA_2	224	230	PF00498	0.520
LIG_FHA_2	263	269	PF00498	0.358
LIG_FHA_2	322	328	PF00498	0.366
LIG_FHA_2	392	398	PF00498	0.316
LIG_FHA_2	529	535	PF00498	0.292
LIG_FHA_2	551	557	PF00498	0.364
LIG_LIR_Apic_2	704	709	PF02991	0.725
LIG_LIR_Gen_1	123	133	PF02991	0.364
LIG_LIR_Gen_1	260	271	PF02991	0.376
LIG_LIR_Gen_1	394	404	PF02991	0.339
LIG_LIR_Gen_1	425	434	PF02991	0.398
LIG_LIR_Gen_1	518	525	PF02991	0.366
LIG_LIR_Gen_1	658	666	PF02991	0.307
LIG_LIR_Gen_1	67	78	PF02991	0.403
LIG_LIR_Gen_1	84	92	PF02991	0.245
LIG_LIR_Nem_3	123	129	PF02991	0.314
LIG_LIR_Nem_3	260	266	PF02991	0.329
LIG_LIR_Nem_3	394	399	PF02991	0.318
LIG_LIR_Nem_3	425	431	PF02991	0.411
LIG_LIR_Nem_3	518	523	PF02991	0.369
LIG_LIR_Nem_3	600	605	PF02991	0.412
LIG_LIR_Nem_3	614	620	PF02991	0.243
LIG_LIR_Nem_3	658	663	PF02991	0.299
LIG_LIR_Nem_3	67	73	PF02991	0.286
LIG_LIR_Nem_3	84	90	PF02991	0.259
LIG_LYPXL_S_1	286	290	PF13949	0.519
LIG_LYPXL_yS_3	287	290	PF13949	0.322
LIG_NRBOX	678	684	PF00104	0.411
LIG_Pex14_2	28	32	PF04695	0.367
LIG_PTB_Apo_2	72	79	PF02174	0.322
LIG_PTB_Phospho_1	72	78	PF10480	0.320
LIG_SH2_CRK	126	130	PF00017	0.348
LIG_SH2_CRK	428	432	PF00017	0.406
LIG_SH2_CRK	581	585	PF00017	0.255
LIG_SH2_CRK	706	710	PF00017	0.728
LIG_SH2_CRK	99	103	PF00017	0.294
LIG_SH2_GRB2like	70	73	PF00017	0.262
LIG_SH2_NCK_1	396	400	PF00017	0.330
LIG_SH2_SRC	278	281	PF00017	0.345
LIG_SH2_SRC	396	399	PF00017	0.321
LIG_SH2_SRC	70	73	PF00017	0.262
LIG_SH2_SRC	99	102	PF00017	0.216
LIG_SH2_STAP1	278	282	PF00017	0.378
LIG_SH2_STAP1	520	524	PF00017	0.360
LIG_SH2_STAT3	315	318	PF00017	0.431
LIG_SH2_STAT3	74	77	PF00017	0.215
LIG_SH2_STAT5	109	112	PF00017	0.366
LIG_SH2_STAT5	206	209	PF00017	0.316
LIG_SH2_STAT5	253	256	PF00017	0.427
LIG_SH2_STAT5	378	381	PF00017	0.302
LIG_SH2_STAT5	608	611	PF00017	0.276
LIG_SH2_STAT5	70	73	PF00017	0.359
LIG_SH2_STAT5	706	709	PF00017	0.727
LIG_SH3_3	631	637	PF00018	0.308
LIG_SH3_3	95	101	PF00018	0.320
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.276
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.363
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.281
LIG_SUMO_SIM_anti_2	653	658	PF11976	0.273
LIG_SUMO_SIM_par_1	127	132	PF11976	0.308
LIG_SUMO_SIM_par_1	48	53	PF11976	0.280
LIG_SUMO_SIM_par_1	639	645	PF11976	0.310
LIG_SUMO_SIM_par_1	653	658	PF11976	0.259
LIG_TYR_ITIM	426	431	PF00017	0.424
LIG_TYR_ITIM	579	584	PF00017	0.247
LIG_TYR_ITIM	68	73	PF00017	0.304
LIG_TYR_ITSM	392	399	PF00017	0.330
LIG_UBA3_1	33	40	PF00899	0.338
MOD_CK1_1	132	138	PF00069	0.342
MOD_CK1_1	223	229	PF00069	0.492
MOD_CK1_1	407	413	PF00069	0.405
MOD_CK1_1	490	496	PF00069	0.355
MOD_CK1_1	64	70	PF00069	0.371
MOD_CK1_1	669	675	PF00069	0.363
MOD_CK1_1	91	97	PF00069	0.244
MOD_CK2_1	164	170	PF00069	0.439
MOD_CK2_1	182	188	PF00069	0.351
MOD_CK2_1	262	268	PF00069	0.471
MOD_CK2_1	345	351	PF00069	0.469
MOD_CK2_1	438	444	PF00069	0.428
MOD_CK2_1	629	635	PF00069	0.357
MOD_Cter_Amidation	255	258	PF01082	0.609
MOD_GlcNHglycan	183	187	PF01048	0.632
MOD_GlcNHglycan	192	195	PF01048	0.504
MOD_GlcNHglycan	334	337	PF01048	0.741
MOD_GlcNHglycan	440	443	PF01048	0.672
MOD_GlcNHglycan	492	495	PF01048	0.656
MOD_GlcNHglycan	55	59	PF01048	0.615
MOD_GSK3_1	107	114	PF00069	0.363
MOD_GSK3_1	129	136	PF00069	0.350
MOD_GSK3_1	18	25	PF00069	0.509
MOD_GSK3_1	262	269	PF00069	0.381
MOD_GSK3_1	446	453	PF00069	0.306
MOD_GSK3_1	524	531	PF00069	0.264
MOD_GSK3_1	615	622	PF00069	0.318
MOD_GSK3_1	625	632	PF00069	0.361
MOD_GSK3_1	665	672	PF00069	0.316
MOD_GSK3_1	718	725	PF00069	0.677
MOD_N-GLC_1	112	117	PF02516	0.570
MOD_N-GLC_1	351	356	PF02516	0.711
MOD_N-GLC_1	446	451	PF02516	0.494
MOD_NEK2_1	112	117	PF00069	0.348
MOD_NEK2_1	141	146	PF00069	0.322
MOD_NEK2_1	190	195	PF00069	0.401
MOD_NEK2_1	266	271	PF00069	0.379
MOD_NEK2_1	337	342	PF00069	0.440
MOD_NEK2_1	41	46	PF00069	0.373
MOD_NEK2_1	433	438	PF00069	0.291
MOD_NEK2_1	446	451	PF00069	0.293
MOD_NEK2_1	485	490	PF00069	0.384
MOD_NEK2_1	524	529	PF00069	0.288
MOD_NEK2_1	62	67	PF00069	0.277
MOD_NEK2_1	665	670	PF00069	0.353
MOD_NEK2_2	262	267	PF00069	0.447
MOD_NEK2_2	414	419	PF00069	0.293
MOD_PIKK_1	141	147	PF00454	0.420
MOD_PIKK_1	18	24	PF00454	0.509
MOD_PIKK_1	223	229	PF00454	0.465
MOD_PIKK_1	342	348	PF00454	0.515
MOD_PIKK_1	407	413	PF00454	0.319
MOD_PIKK_1	450	456	PF00454	0.418
MOD_PIKK_1	73	79	PF00454	0.225
MOD_PKA_1	309	315	PF00069	0.528
MOD_PKA_1	358	364	PF00069	0.410
MOD_PKA_1	718	724	PF00069	0.735
MOD_PKA_2	266	272	PF00069	0.397
MOD_PKA_2	300	306	PF00069	0.588
MOD_PKA_2	309	315	PF00069	0.511
MOD_PKA_2	337	343	PF00069	0.505
MOD_PKA_2	358	364	PF00069	0.357
MOD_PKA_2	414	420	PF00069	0.299
MOD_PKA_2	587	593	PF00069	0.450
MOD_PKA_2	669	675	PF00069	0.437
MOD_PKA_2	88	94	PF00069	0.295
MOD_Plk_1	112	118	PF00069	0.399
MOD_Plk_1	164	170	PF00069	0.243
MOD_Plk_1	424	430	PF00069	0.352
MOD_Plk_1	446	452	PF00069	0.292
MOD_Plk_1	590	596	PF00069	0.384
MOD_Plk_1	615	621	PF00069	0.379
MOD_Plk_1	704	710	PF00069	0.704
MOD_Plk_4	112	118	PF00069	0.380
MOD_Plk_4	136	142	PF00069	0.352
MOD_Plk_4	266	272	PF00069	0.419
MOD_Plk_4	391	397	PF00069	0.348
MOD_Plk_4	41	47	PF00069	0.231
MOD_Plk_4	414	420	PF00069	0.401
MOD_Plk_4	579	585	PF00069	0.377
MOD_Plk_4	590	596	PF00069	0.416
MOD_Plk_4	604	610	PF00069	0.287
MOD_ProDKin_1	133	139	PF00069	0.356
MOD_ProDKin_1	496	502	PF00069	0.304
MOD_ProDKin_1	550	556	PF00069	0.413
MOD_SUMO_rev_2	193	199	PF00179	0.317
TRG_DiLeu_BaEn_1	124	129	PF01217	0.363
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.500
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.332
TRG_ENDOCYTIC_2	109	112	PF00928	0.329
TRG_ENDOCYTIC_2	126	129	PF00928	0.332
TRG_ENDOCYTIC_2	192	195	PF00928	0.357
TRG_ENDOCYTIC_2	278	281	PF00928	0.325
TRG_ENDOCYTIC_2	287	290	PF00928	0.263
TRG_ENDOCYTIC_2	396	399	PF00928	0.275
TRG_ENDOCYTIC_2	428	431	PF00928	0.368
TRG_ENDOCYTIC_2	520	523	PF00928	0.361
TRG_ENDOCYTIC_2	581	584	PF00928	0.450
TRG_ENDOCYTIC_2	660	663	PF00928	0.302
TRG_ENDOCYTIC_2	70	73	PF00928	0.286
TRG_ENDOCYTIC_2	99	102	PF00928	0.313
TRG_ER_diArg_1	1	4	PF00400	0.538
TRG_ER_diArg_1	202	204	PF00400	0.341
TRG_ER_diArg_1	355	358	PF00400	0.472
TRG_ER_diArg_1	537	539	PF00400	0.342
TRG_ER_diArg_1	602	604	PF00400	0.389
TRG_ER_diArg_1	80	82	PF00400	0.388
TRG_NES_CRM1_1	429	444	PF08389	0.375
TRG_NLS_Bipartite_1	297	312	PF00514	0.377
TRG_NLS_MonoExtC_3	296	301	PF00514	0.516
TRG_NLS_MonoExtN_4	295	302	PF00514	0.451
TRG_NLS_MonoExtN_4	306	312	PF00514	0.452
TRG_NLS_MonoExtN_4	715	722	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML4	Leptomonas seymouri	63%	100%
A0A0S4JLI3	Bodo saltans	34%	93%
A0A1X0NRQ2	Trypanosomatidae	42%	100%
A0A3R7KWB9	Trypanosoma rangeli	41%	100%
A0A3S7X607	Leishmania donovani	86%	100%
A4I8B3	Leishmania infantum	86%	100%
D0AAI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B372	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9U1E4	Leishmania major	84%	100%
V5AXZ0	Trypanosoma cruzi	41%	100%