Putative outer dynein arm docking complex

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

outer dynein arm docking complex, putative

Species:

Leishmania braziliensis

UniProt:

A4HKT2_LEIBR

TriTrypDb:

LbrM.32.3150 , LBRM2903_320039400

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HKT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.461
CLV_C14_Caspase3-7	327	331	PF00656	0.360
CLV_C14_Caspase3-7	567	571	PF00656	0.747
CLV_C14_Caspase3-7	74	78	PF00656	0.514
CLV_NRD_NRD_1	108	110	PF00675	0.480
CLV_NRD_NRD_1	163	165	PF00675	0.403
CLV_NRD_NRD_1	17	19	PF00675	0.471
CLV_NRD_NRD_1	274	276	PF00675	0.752
CLV_NRD_NRD_1	588	590	PF00675	0.515
CLV_NRD_NRD_1	607	609	PF00675	0.385
CLV_NRD_NRD_1	81	83	PF00675	0.456
CLV_NRD_NRD_1	88	90	PF00675	0.450
CLV_PCSK_KEX2_1	108	110	PF00082	0.425
CLV_PCSK_KEX2_1	163	165	PF00082	0.418
CLV_PCSK_KEX2_1	17	19	PF00082	0.462
CLV_PCSK_KEX2_1	171	173	PF00082	0.438
CLV_PCSK_KEX2_1	181	183	PF00082	0.463
CLV_PCSK_KEX2_1	274	276	PF00082	0.724
CLV_PCSK_KEX2_1	386	388	PF00082	0.372
CLV_PCSK_KEX2_1	81	83	PF00082	0.474
CLV_PCSK_KEX2_1	95	97	PF00082	0.460
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.480
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.504
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.423
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.545
CLV_PCSK_PC7_1	382	388	PF00082	0.476
CLV_PCSK_SKI1_1	108	112	PF00082	0.485
CLV_PCSK_SKI1_1	163	167	PF00082	0.402
CLV_PCSK_SKI1_1	209	213	PF00082	0.472
CLV_PCSK_SKI1_1	321	325	PF00082	0.410
CLV_PCSK_SKI1_1	357	361	PF00082	0.491
CLV_PCSK_SKI1_1	449	453	PF00082	0.552
DEG_APCC_DBOX_1	95	103	PF00400	0.544
DEG_SPOP_SBC_1	288	292	PF00917	0.775
DOC_MAPK_gen_1	108	116	PF00069	0.551
DOC_MAPK_gen_1	150	158	PF00069	0.418
DOC_MAPK_gen_1	160	169	PF00069	0.417
DOC_MAPK_MEF2A_6	160	169	PF00069	0.551
DOC_MAPK_MEF2A_6	203	212	PF00069	0.315
DOC_MAPK_MEF2A_6	458	466	PF00069	0.542
DOC_USP7_MATH_1	270	274	PF00917	0.720
DOC_USP7_MATH_1	279	283	PF00917	0.758
DOC_USP7_MATH_1	323	327	PF00917	0.382
DOC_USP7_MATH_1	436	440	PF00917	0.453
DOC_USP7_MATH_1	480	484	PF00917	0.671
DOC_USP7_MATH_1	558	562	PF00917	0.709
DOC_USP7_UBL2_3	357	361	PF12436	0.541
LIG_14-3-3_CanoR_1	17	25	PF00244	0.515
LIG_14-3-3_CanoR_1	257	263	PF00244	0.469
LIG_14-3-3_CanoR_1	415	424	PF00244	0.498
LIG_14-3-3_CanoR_1	442	448	PF00244	0.526
LIG_14-3-3_CanoR_1	458	466	PF00244	0.340
LIG_14-3-3_CanoR_1	477	487	PF00244	0.512
LIG_14-3-3_CanoR_1	595	600	PF00244	0.625
LIG_Actin_WH2_2	346	363	PF00022	0.565
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_FHA_1	218	224	PF00498	0.582
LIG_FHA_1	312	318	PF00498	0.594
LIG_FHA_1	337	343	PF00498	0.489
LIG_FHA_1	404	410	PF00498	0.478
LIG_FHA_1	458	464	PF00498	0.452
LIG_FHA_2	290	296	PF00498	0.717
LIG_FHA_2	417	423	PF00498	0.519
LIG_FHA_2	497	503	PF00498	0.702
LIG_FHA_2	565	571	PF00498	0.733
LIG_FHA_2	596	602	PF00498	0.635
LIG_LIR_Gen_1	401	412	PF02991	0.437
LIG_LIR_Gen_1	421	432	PF02991	0.523
LIG_LIR_Gen_1	473	480	PF02991	0.404
LIG_LIR_Nem_3	341	347	PF02991	0.436
LIG_LIR_Nem_3	401	407	PF02991	0.440
LIG_LIR_Nem_3	421	427	PF02991	0.362
LIG_LIR_Nem_3	473	478	PF02991	0.492
LIG_NRBOX	366	372	PF00104	0.566
LIG_NRP_CendR_1	616	618	PF00754	0.628
LIG_PCNA_yPIPBox_3	343	357	PF02747	0.459
LIG_SH2_CRK	347	351	PF00017	0.446
LIG_SH2_CRK	404	408	PF00017	0.439
LIG_SH2_CRK	475	479	PF00017	0.417
LIG_SH2_CRK	61	65	PF00017	0.473
LIG_SH2_GRB2like	349	352	PF00017	0.471
LIG_SH2_NCK_1	424	428	PF00017	0.541
LIG_SH2_NCK_1	475	479	PF00017	0.598
LIG_SH2_SRC	424	427	PF00017	0.557
LIG_SH2_SRC	61	64	PF00017	0.475
LIG_SH2_STAP1	219	223	PF00017	0.495
LIG_SH2_STAT3	219	222	PF00017	0.536
LIG_SH2_STAT3	574	577	PF00017	0.717
LIG_SH2_STAT5	219	222	PF00017	0.583
LIG_SH2_STAT5	336	339	PF00017	0.535
LIG_SH2_STAT5	349	352	PF00017	0.404
LIG_SH2_STAT5	63	66	PF00017	0.444
LIG_SH3_3	530	536	PF00018	0.638
LIG_SUMO_SIM_anti_2	154	162	PF11976	0.436
LIG_SUMO_SIM_par_1	302	307	PF11976	0.424
LIG_TRAF2_1	266	269	PF00917	0.779
LIG_TRAF2_1	499	502	PF00917	0.571
LIG_UBA3_1	230	234	PF00899	0.580
LIG_UBA3_1	316	321	PF00899	0.582
MOD_CK1_1	280	286	PF00069	0.664
MOD_CK1_1	312	318	PF00069	0.511
MOD_CK1_1	473	479	PF00069	0.654
MOD_CK1_1	544	550	PF00069	0.722
MOD_CK1_1	71	77	PF00069	0.566
MOD_CK2_1	280	286	PF00069	0.659
MOD_CK2_1	289	295	PF00069	0.760
MOD_CK2_1	496	502	PF00069	0.488
MOD_CK2_1	512	518	PF00069	0.570
MOD_CK2_1	595	601	PF00069	0.596
MOD_GlcNHglycan	26	29	PF01048	0.472
MOD_GlcNHglycan	279	282	PF01048	0.700
MOD_GlcNHglycan	352	356	PF01048	0.561
MOD_GlcNHglycan	478	481	PF01048	0.570
MOD_GlcNHglycan	543	546	PF01048	0.630
MOD_GlcNHglycan	558	561	PF01048	0.493
MOD_GlcNHglycan	56	59	PF01048	0.507
MOD_GSK3_1	12	19	PF00069	0.603
MOD_GSK3_1	403	410	PF00069	0.401
MOD_GSK3_1	476	483	PF00069	0.636
MOD_GSK3_1	505	512	PF00069	0.664
MOD_N-GLC_1	342	347	PF02516	0.422
MOD_N-GLC_1	509	514	PF02516	0.754
MOD_NEK2_1	104	109	PF00069	0.458
MOD_NEK2_1	135	140	PF00069	0.556
MOD_NEK2_1	16	21	PF00069	0.575
MOD_NEK2_1	277	282	PF00069	0.761
MOD_NEK2_1	311	316	PF00069	0.361
MOD_NEK2_1	342	347	PF00069	0.470
MOD_NEK2_1	360	365	PF00069	0.558
MOD_NEK2_2	480	485	PF00069	0.442
MOD_PIKK_1	16	22	PF00454	0.516
MOD_PKA_2	16	22	PF00069	0.519
MOD_PKA_2	256	262	PF00069	0.704
MOD_PKA_2	441	447	PF00069	0.533
MOD_PKA_2	457	463	PF00069	0.315
MOD_PKA_2	476	482	PF00069	0.527
MOD_PKA_2	594	600	PF00069	0.380
MOD_Plk_1	135	141	PF00069	0.557
MOD_Plk_1	29	35	PF00069	0.603
MOD_Plk_1	342	348	PF00069	0.422
MOD_Plk_4	312	318	PF00069	0.512
MOD_SUMO_for_1	355	358	PF00179	0.540
MOD_SUMO_for_1	49	52	PF00179	0.488
MOD_SUMO_rev_2	174	179	PF00179	0.527
MOD_SUMO_rev_2	227	236	PF00179	0.515
MOD_SUMO_rev_2	390	399	PF00179	0.577
TRG_DiLeu_BaEn_3	161	167	PF01217	0.550
TRG_DiLeu_BaEn_3	529	535	PF01217	0.623
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.535
TRG_ENDOCYTIC_2	347	350	PF00928	0.460
TRG_ENDOCYTIC_2	404	407	PF00928	0.439
TRG_ENDOCYTIC_2	424	427	PF00928	0.509
TRG_ENDOCYTIC_2	475	478	PF00928	0.415
TRG_ENDOCYTIC_2	61	64	PF00928	0.475
TRG_ER_diArg_1	108	110	PF00400	0.402
TRG_ER_diArg_1	16	18	PF00400	0.504
TRG_ER_diArg_1	163	165	PF00400	0.418
TRG_ER_diArg_1	207	210	PF00400	0.317
TRG_ER_diArg_1	81	83	PF00400	0.474
TRG_NES_CRM1_1	201	214	PF08389	0.318
TRG_NLS_Bipartite_1	163	184	PF00514	0.436
TRG_NLS_MonoExtN_4	178	184	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M7	Leptomonas seymouri	67%	97%
A0A0S4IU95	Bodo saltans	32%	100%
A0A1X0NRP3	Trypanosomatidae	47%	90%
A0A3Q8IH93	Leishmania donovani	85%	100%
A0A3R7MTI3	Trypanosoma rangeli	41%	96%
A4I8B1	Leishmania infantum	84%	100%
A8JF70	Chlamydomonas reinhardtii	27%	100%
D0AAI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9B370	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9U1E6	Leishmania major	84%	100%
V5BMI0	Trypanosoma cruzi	42%	95%