Soluble NSF attachment protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNAP protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKT1_LEIBR

TriTrypDb:

LbrM.32.3140 , LBRM2903_320039300

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HKT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0035494	SNARE complex disassembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.389
CLV_NRD_NRD_1	189	191	PF00675	0.264
CLV_PCSK_KEX2_1	18	20	PF00082	0.356
CLV_PCSK_KEX2_1	57	59	PF00082	0.347
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.356
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.347
CLV_PCSK_SKI1_1	14	18	PF00082	0.269
CLV_PCSK_SKI1_1	177	181	PF00082	0.274
CLV_PCSK_SKI1_1	190	194	PF00082	0.217
CLV_PCSK_SKI1_1	274	278	PF00082	0.275
CLV_PCSK_SKI1_1	280	284	PF00082	0.267
DEG_Nend_UBRbox_2	1	3	PF02207	0.477
DOC_CKS1_1	203	208	PF01111	0.329
DOC_PP1_RVXF_1	188	195	PF00149	0.253
DOC_USP7_UBL2_3	14	18	PF12436	0.281
DOC_USP7_UBL2_3	274	278	PF12436	0.329
DOC_USP7_UBL2_3	81	85	PF12436	0.297
DOC_WW_Pin1_4	202	207	PF00397	0.329
LIG_14-3-3_CanoR_1	19	29	PF00244	0.397
LIG_CaM_IQ_9	129	144	PF13499	0.397
LIG_FHA_1	193	199	PF00498	0.347
LIG_FHA_1	239	245	PF00498	0.347
LIG_FHA_2	121	127	PF00498	0.331
LIG_FHA_2	145	151	PF00498	0.309
LIG_FHA_2	25	31	PF00498	0.393
LIG_Integrin_RGD_1	4	6	PF01839	0.397
LIG_LIR_Gen_1	222	230	PF02991	0.256
LIG_LIR_Gen_1	261	268	PF02991	0.254
LIG_LIR_Nem_3	217	223	PF02991	0.257
LIG_LIR_Nem_3	261	265	PF02991	0.257
LIG_Rb_pABgroove_1	97	105	PF01858	0.347
LIG_SH2_CRK	262	266	PF00017	0.253
LIG_SH2_GRB2like	109	112	PF00017	0.397
LIG_SH2_NCK_1	103	107	PF00017	0.360
LIG_SH2_NCK_1	109	113	PF00017	0.331
LIG_SH2_STAP1	109	113	PF00017	0.312
LIG_SH2_STAP1	172	176	PF00017	0.253
LIG_SH2_STAT5	109	112	PF00017	0.345
LIG_SH2_STAT5	138	141	PF00017	0.329
LIG_SH2_STAT5	83	86	PF00017	0.331
MOD_CK1_1	20	26	PF00069	0.345
MOD_CK1_1	32	38	PF00069	0.288
MOD_CK1_1	60	66	PF00069	0.338
MOD_CK1_1	91	97	PF00069	0.292
MOD_CK2_1	144	150	PF00069	0.284
MOD_CK2_1	205	211	PF00069	0.297
MOD_GlcNHglycan	161	164	PF01048	0.325
MOD_GlcNHglycan	90	93	PF01048	0.420
MOD_GSK3_1	17	24	PF00069	0.368
MOD_N-GLC_1	47	52	PF02516	0.360
MOD_N-GLC_1	65	70	PF02516	0.396
MOD_NEK2_1	192	197	PF00069	0.375
MOD_PIKK_1	225	231	PF00454	0.309
MOD_PIKK_1	38	44	PF00454	0.269
MOD_PKA_1	17	23	PF00069	0.318
MOD_PKA_1	57	63	PF00069	0.397
MOD_PKA_2	285	291	PF00069	0.557
MOD_PKA_2	57	63	PF00069	0.358
MOD_Plk_1	120	126	PF00069	0.397
MOD_Plk_1	249	255	PF00069	0.350
MOD_Plk_4	114	120	PF00069	0.381
MOD_Plk_4	205	211	PF00069	0.269
MOD_Plk_4	32	38	PF00069	0.447
MOD_Plk_4	91	97	PF00069	0.297
MOD_ProDKin_1	202	208	PF00069	0.329
MOD_SUMO_rev_2	11	16	PF00179	0.342
MOD_SUMO_rev_2	20	29	PF00179	0.311
TRG_ENDOCYTIC_2	172	175	PF00928	0.269
TRG_ENDOCYTIC_2	223	226	PF00928	0.253
TRG_ENDOCYTIC_2	262	265	PF00928	0.253
TRG_NLS_MonoExtN_4	14	21	PF00514	0.397
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW7	Leptomonas seymouri	25%	100%
A0A0N1PFE2	Leptomonas seymouri	83%	100%
A0A0S4J4X9	Bodo saltans	54%	100%
A0A0S4JSU5	Bodo saltans	27%	100%
A0A0S4JTB3	Bodo saltans	27%	100%
A0A1X0NRZ7	Trypanosomatidae	54%	100%
A0A1X0NWB5	Trypanosomatidae	26%	100%
A0A3R7P116	Trypanosoma rangeli	48%	100%
A0A3S5IRU0	Trypanosoma rangeli	27%	100%
A0A3S7WW84	Leishmania donovani	24%	100%
A0A3S7X611	Leishmania donovani	91%	100%
A4HYZ8	Leishmania infantum	24%	100%
A4I8B0	Leishmania infantum	91%	100%
C9ZIM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0AAI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AIL7	Leishmania braziliensis	25%	100%
E9AUV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B369	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O90758	Fowlpox virus (strain NVSL)	22%	100%
P28663	Mus musculus	25%	98%
P32602	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P54920	Homo sapiens	25%	99%
P54921	Rattus norvegicus	25%	99%
P78603	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	100%
P81125	Bos taurus	25%	99%
P81126	Bos taurus	25%	98%
P85969	Rattus norvegicus	25%	98%
P93798	Vitis vinifera	26%	100%
Q23983	Drosophila melanogaster	27%	100%
Q4Q4Y5	Leishmania major	90%	100%
Q4QCN3	Leishmania major	25%	100%
Q54NP6	Dictyostelium discoideum	27%	100%
Q75D68	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	100%
Q9DB05	Mus musculus	26%	99%
Q9H115	Homo sapiens	25%	98%
Q9J5J0	Fowlpox virus (strain NVSL)	21%	100%
Q9LXZ5	Arabidopsis thaliana	24%	76%
Q9M5P8	Solanum tuberosum	27%	100%
Q9P4D0	Komagataella phaffii (strain GS115 / ATCC 20864)	27%	98%
Q9P4X4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9P6A5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q9SPE6	Arabidopsis thaliana	29%	100%
V5BCV5	Trypanosoma cruzi	25%	100%
V5BHZ3	Trypanosoma cruzi	49%	100%