Soluble NSF attachment protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNAP protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKT1_LEIBR

TriTrypDb:

LbrM.32.3140 , LBRM2903_320039300

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

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Expansion

Sequence features

A4HKT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT1

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0033036	macromolecule localization	2	12
GO:0035494	SNARE complex disassembly	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.389
CLV_NRD_NRD_1	189	191	PF00675	0.264
CLV_PCSK_KEX2_1	18	20	PF00082	0.356
CLV_PCSK_KEX2_1	57	59	PF00082	0.347
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.356
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.347
CLV_PCSK_SKI1_1	14	18	PF00082	0.269
CLV_PCSK_SKI1_1	177	181	PF00082	0.274
CLV_PCSK_SKI1_1	190	194	PF00082	0.217
CLV_PCSK_SKI1_1	274	278	PF00082	0.275

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW7	Leptomonas seymouri	25%	100%
A0A0N1PFE2	Leptomonas seymouri	83%	100%
A0A0S4J4X9	Bodo saltans	54%	100%
A0A0S4JSU5	Bodo saltans	27%	100%
A0A0S4JTB3	Bodo saltans	27%	100%
A0A1X0NRZ7	Trypanosomatidae	54%	100%
A0A1X0NWB5	Trypanosomatidae	26%	100%
A0A3R7P116	Trypanosoma rangeli	48%	100%
A0A3S5IRU0	Trypanosoma rangeli	27%	100%
A0A3S7WW84	Leishmania donovani	24%	100%

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