LeishMANIAdb
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Soluble NSF attachment protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Soluble NSF attachment protein
Gene product:
SNAP protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HKT1_LEIBR
TriTrypDb:
LbrM.32.3140 , LBRM2903_320039300
Length:
291

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0031201 SNARE complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1
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Expansion

Sequence features

A4HKT1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT1

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0033036 macromolecule localization 2 12
GO:0035494 SNARE complex disassembly 6 1
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Molecular functions
TermNameLevelCount
GO:0000149 SNARE binding 3 1
GO:0005483 soluble NSF attachment protein activity 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019905 syntaxin binding 4 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 3 7 PF00656 0.389
CLV_NRD_NRD_1 189 191 PF00675 0.264
CLV_PCSK_KEX2_1 18 20 PF00082 0.356
CLV_PCSK_KEX2_1 57 59 PF00082 0.347
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.356
CLV_PCSK_PC1ET2_1 57 59 PF00082 0.347
CLV_PCSK_SKI1_1 14 18 PF00082 0.269
CLV_PCSK_SKI1_1 177 181 PF00082 0.274
CLV_PCSK_SKI1_1 190 194 PF00082 0.217
CLV_PCSK_SKI1_1 274 278 PF00082 0.275
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IHW7 Leptomonas seymouri 25% 100%
A0A0N1PFE2 Leptomonas seymouri 83% 100%
A0A0S4J4X9 Bodo saltans 54% 100%
A0A0S4JSU5 Bodo saltans 27% 100%
A0A0S4JTB3 Bodo saltans 27% 100%
A0A1X0NRZ7 Trypanosomatidae 54% 100%
A0A1X0NWB5 Trypanosomatidae 26% 100%
A0A3R7P116 Trypanosoma rangeli 48% 100%
A0A3S5IRU0 Trypanosoma rangeli 27% 100%
A0A3S7WW84 Leishmania donovani 24% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS