Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKT0_LEIBR

TriTrypDb:

LbrM.32.3130 , LBRM2903_320039200

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.490
CLV_C14_Caspase3-7	413	417	PF00656	0.628
CLV_C14_Caspase3-7	95	99	PF00656	0.672
CLV_NRD_NRD_1	331	333	PF00675	0.549
CLV_PCSK_FUR_1	329	333	PF00082	0.586
CLV_PCSK_KEX2_1	331	333	PF00082	0.544
CLV_PCSK_PC7_1	327	333	PF00082	0.592
DOC_MAPK_gen_1	117	124	PF00069	0.321
DOC_PP1_RVXF_1	106	113	PF00149	0.572
DOC_PP2B_PxIxI_1	43	49	PF00149	0.437
DOC_PP4_FxxP_1	118	121	PF00568	0.319
DOC_PP4_FxxP_1	154	157	PF00568	0.473
DOC_PP4_FxxP_1	50	53	PF00568	0.484
DOC_USP7_MATH_1	159	163	PF00917	0.581
DOC_USP7_MATH_1	191	195	PF00917	0.530
DOC_USP7_MATH_1	218	222	PF00917	0.707
DOC_USP7_MATH_1	292	296	PF00917	0.418
DOC_USP7_MATH_1	30	34	PF00917	0.521
DOC_USP7_MATH_1	319	323	PF00917	0.599
DOC_USP7_MATH_1	385	389	PF00917	0.559
DOC_USP7_MATH_1	433	437	PF00917	0.605
DOC_USP7_MATH_1	85	89	PF00917	0.656
DOC_WW_Pin1_4	117	122	PF00397	0.520
DOC_WW_Pin1_4	209	214	PF00397	0.683
DOC_WW_Pin1_4	88	93	PF00397	0.703
LIG_14-3-3_CanoR_1	304	308	PF00244	0.487
LIG_14-3-3_CanoR_1	334	343	PF00244	0.571
LIG_14-3-3_CanoR_1	36	40	PF00244	0.390
LIG_14-3-3_CanoR_1	434	438	PF00244	0.412
LIG_14-3-3_CanoR_1	74	80	PF00244	0.698
LIG_Actin_RPEL_3	110	129	PF02755	0.337
LIG_APCC_ABBA_1	239	244	PF00400	0.405
LIG_BIR_III_4	84	88	PF00653	0.617
LIG_BRCT_BRCA1_1	193	197	PF00533	0.568
LIG_FHA_1	15	21	PF00498	0.535
LIG_FHA_1	55	61	PF00498	0.382
LIG_FHA_1	84	90	PF00498	0.548
LIG_FHA_2	210	216	PF00498	0.665
LIG_FHA_2	411	417	PF00498	0.592
LIG_FHA_2	99	105	PF00498	0.612
LIG_GBD_Chelix_1	178	186	PF00786	0.467
LIG_LIR_Gen_1	109	118	PF02991	0.587
LIG_LIR_Gen_1	172	183	PF02991	0.453
LIG_LIR_Gen_1	3	9	PF02991	0.462
LIG_LIR_Gen_1	306	314	PF02991	0.303
LIG_LIR_Nem_3	109	115	PF02991	0.590
LIG_LIR_Nem_3	172	178	PF02991	0.378
LIG_LIR_Nem_3	3	8	PF02991	0.464
LIG_LIR_Nem_3	306	310	PF02991	0.401
LIG_LIR_Nem_3	387	393	PF02991	0.502
LIG_LIR_Nem_3	41	45	PF02991	0.377
LIG_LIR_Nem_3	78	82	PF02991	0.616
LIG_LYPXL_yS_3	79	82	PF13949	0.633
LIG_NRBOX	309	315	PF00104	0.537
LIG_Pex14_2	112	116	PF04695	0.583
LIG_SH2_PTP2	5	8	PF00017	0.449
LIG_SH2_STAP1	16	20	PF00017	0.502
LIG_SH2_STAP1	390	394	PF00017	0.393
LIG_SH2_STAP1	61	65	PF00017	0.405
LIG_SH2_STAT5	16	19	PF00017	0.422
LIG_SH2_STAT5	188	191	PF00017	0.514
LIG_SH2_STAT5	339	342	PF00017	0.447
LIG_SH2_STAT5	393	396	PF00017	0.472
LIG_SH2_STAT5	437	440	PF00017	0.461
LIG_SH2_STAT5	5	8	PF00017	0.421
LIG_SH3_2	347	352	PF14604	0.611
LIG_SH3_3	337	343	PF00018	0.455
LIG_SH3_3	344	350	PF00018	0.491
LIG_SH3_3	86	92	PF00018	0.690
LIG_SUMO_SIM_par_1	289	296	PF11976	0.468
LIG_TRAF2_1	131	134	PF00917	0.550
LIG_UBA3_1	366	371	PF00899	0.488
LIG_WW_3	231	235	PF00397	0.660
LIG_WW_3	349	353	PF00397	0.449
MOD_CK1_1	166	172	PF00069	0.678
MOD_CK1_1	221	227	PF00069	0.759
MOD_CK1_1	235	241	PF00069	0.330
MOD_CK1_1	243	249	PF00069	0.433
MOD_CK1_1	83	89	PF00069	0.728
MOD_CK2_1	209	215	PF00069	0.687
MOD_CK2_1	243	249	PF00069	0.454
MOD_CK2_1	405	411	PF00069	0.540
MOD_GlcNHglycan	142	145	PF01048	0.607
MOD_GlcNHglycan	156	160	PF01048	0.745
MOD_GlcNHglycan	161	164	PF01048	0.636
MOD_GlcNHglycan	223	226	PF01048	0.770
MOD_GlcNHglycan	228	231	PF01048	0.728
MOD_GlcNHglycan	234	237	PF01048	0.540
MOD_GlcNHglycan	244	248	PF01048	0.357
MOD_GlcNHglycan	253	256	PF01048	0.429
MOD_GlcNHglycan	317	320	PF01048	0.608
MOD_GlcNHglycan	37	40	PF01048	0.441
MOD_GlcNHglycan	62	65	PF01048	0.622
MOD_GSK3_1	155	162	PF00069	0.704
MOD_GSK3_1	165	172	PF00069	0.695
MOD_GSK3_1	31	38	PF00069	0.384
MOD_GSK3_1	315	322	PF00069	0.564
MOD_GSK3_1	358	365	PF00069	0.500
MOD_GSK3_1	385	392	PF00069	0.472
MOD_GSK3_1	406	413	PF00069	0.619
MOD_N-GLC_1	135	140	PF02516	0.572
MOD_N-GLC_2	13	15	PF02516	0.284
MOD_NEK2_1	140	145	PF00069	0.630
MOD_NEK2_1	174	179	PF00069	0.407
MOD_NEK2_1	182	187	PF00069	0.405
MOD_NEK2_1	264	269	PF00069	0.402
MOD_NEK2_1	293	298	PF00069	0.383
MOD_NEK2_1	8	13	PF00069	0.353
MOD_NEK2_2	303	308	PF00069	0.477
MOD_NEK2_2	85	90	PF00069	0.596
MOD_PIKK_1	334	340	PF00454	0.562
MOD_PKA_2	303	309	PF00069	0.483
MOD_PKA_2	35	41	PF00069	0.440
MOD_PKA_2	406	412	PF00069	0.678
MOD_PKA_2	424	430	PF00069	0.511
MOD_PKA_2	433	439	PF00069	0.385
MOD_PKA_2	54	60	PF00069	0.559
MOD_PKB_1	332	340	PF00069	0.564
MOD_Plk_1	106	112	PF00069	0.686
MOD_Plk_1	135	141	PF00069	0.556
MOD_Plk_1	146	152	PF00069	0.512
MOD_Plk_1	362	368	PF00069	0.718
MOD_Plk_2-3	98	104	PF00069	0.472
MOD_Plk_4	1	7	PF00069	0.490
MOD_Plk_4	135	141	PF00069	0.432
MOD_Plk_4	235	241	PF00069	0.512
MOD_Plk_4	319	325	PF00069	0.679
MOD_Plk_4	341	347	PF00069	0.560
MOD_Plk_4	362	368	PF00069	0.735
MOD_Plk_4	389	395	PF00069	0.537
MOD_Plk_4	85	91	PF00069	0.723
MOD_ProDKin_1	117	123	PF00069	0.518
MOD_ProDKin_1	209	215	PF00069	0.684
MOD_ProDKin_1	88	94	PF00069	0.706
MOD_SUMO_rev_2	363	372	PF00179	0.578
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.322
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.306
TRG_ENDOCYTIC_2	5	8	PF00928	0.449
TRG_ENDOCYTIC_2	79	82	PF00928	0.602
TRG_ER_diArg_1	329	332	PF00400	0.596
TRG_NLS_MonoExtC_3	369	375	PF00514	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME3	Leptomonas seymouri	53%	100%
A0A1X0NTD1	Trypanosomatidae	31%	100%
A0A3S7X601	Leishmania donovani	79%	99%
A0A422NZX0	Trypanosoma rangeli	30%	100%
A4I8A9	Leishmania infantum	79%	99%
D0AAI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B368	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4Y6	Leishmania major	79%	100%
V5DE70	Trypanosoma cruzi	28%	100%