Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania braziliensis

UniProt:

A4HKS9_LEIBR

TriTrypDb:

LbrM.32.3120 , LBRM2903_320039100

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HKS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.660
CLV_C14_Caspase3-7	28	32	PF00656	0.661
CLV_C14_Caspase3-7	435	439	PF00656	0.438
CLV_C14_Caspase3-7	582	586	PF00656	0.534
CLV_C14_Caspase3-7	606	610	PF00656	0.534
CLV_C14_Caspase3-7	82	86	PF00656	0.659
CLV_NRD_NRD_1	182	184	PF00675	0.460
CLV_NRD_NRD_1	472	474	PF00675	0.334
CLV_NRD_NRD_1	509	511	PF00675	0.334
CLV_NRD_NRD_1	512	514	PF00675	0.314
CLV_NRD_NRD_1	566	568	PF00675	0.300
CLV_NRD_NRD_1	742	744	PF00675	0.486
CLV_PCSK_FUR_1	507	511	PF00082	0.334
CLV_PCSK_FUR_1	739	743	PF00082	0.397
CLV_PCSK_KEX2_1	181	183	PF00082	0.517
CLV_PCSK_KEX2_1	186	188	PF00082	0.488
CLV_PCSK_KEX2_1	472	474	PF00082	0.346
CLV_PCSK_KEX2_1	509	511	PF00082	0.334
CLV_PCSK_KEX2_1	512	514	PF00082	0.314
CLV_PCSK_KEX2_1	566	568	PF00082	0.305
CLV_PCSK_KEX2_1	741	743	PF00082	0.492
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.497
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.401
CLV_PCSK_PC7_1	182	188	PF00082	0.454
CLV_PCSK_SKI1_1	360	364	PF00082	0.272
CLV_PCSK_SKI1_1	500	504	PF00082	0.382
CLV_PCSK_SKI1_1	726	730	PF00082	0.334
DEG_APCC_DBOX_1	404	412	PF00400	0.518
DEG_Kelch_Keap1_1	594	599	PF01344	0.438
DEG_SPOP_SBC_1	227	231	PF00917	0.688
DEG_SPOP_SBC_1	390	394	PF00917	0.438
DEG_SPOP_SBC_1	412	416	PF00917	0.515
DEG_SPOP_SBC_1	556	560	PF00917	0.467
DOC_ANK_TNKS_1	627	634	PF00023	0.534
DOC_CDC14_PxL_1	212	220	PF14671	0.637
DOC_CYCLIN_RxL_1	721	732	PF00134	0.534
DOC_MAPK_DCC_7	495	504	PF00069	0.534
DOC_MAPK_FxFP_2	334	337	PF00069	0.674
DOC_PP1_RVXF_1	724	730	PF00149	0.534
DOC_PP4_FxxP_1	334	337	PF00568	0.674
DOC_USP7_MATH_1	122	126	PF00917	0.652
DOC_USP7_MATH_1	162	166	PF00917	0.660
DOC_USP7_MATH_1	170	174	PF00917	0.643
DOC_USP7_MATH_1	222	226	PF00917	0.757
DOC_USP7_MATH_1	248	252	PF00917	0.734
DOC_USP7_MATH_1	284	288	PF00917	0.645
DOC_USP7_MATH_1	339	343	PF00917	0.518
DOC_USP7_MATH_1	34	38	PF00917	0.688
DOC_USP7_MATH_1	356	360	PF00917	0.475
DOC_USP7_MATH_1	401	405	PF00917	0.438
DOC_USP7_MATH_1	420	424	PF00917	0.449
DOC_USP7_MATH_1	43	47	PF00917	0.712
DOC_USP7_MATH_1	434	438	PF00917	0.488
DOC_USP7_MATH_1	457	461	PF00917	0.500
DOC_USP7_MATH_1	481	485	PF00917	0.452
DOC_USP7_MATH_1	554	558	PF00917	0.458
DOC_USP7_MATH_1	591	595	PF00917	0.534
DOC_USP7_MATH_1	631	635	PF00917	0.534
DOC_USP7_MATH_1	690	694	PF00917	0.501
DOC_USP7_MATH_1	710	714	PF00917	0.467
DOC_USP7_MATH_2	710	716	PF00917	0.438
DOC_USP7_UBL2_3	674	678	PF12436	0.534
DOC_WW_Pin1_4	101	106	PF00397	0.645
DOC_WW_Pin1_4	185	190	PF00397	0.762
DOC_WW_Pin1_4	276	281	PF00397	0.825
DOC_WW_Pin1_4	307	312	PF00397	0.719
DOC_WW_Pin1_4	36	41	PF00397	0.668
DOC_WW_Pin1_4	397	402	PF00397	0.479
DOC_WW_Pin1_4	416	421	PF00397	0.406
DOC_WW_Pin1_4	440	445	PF00397	0.534
DOC_WW_Pin1_4	511	516	PF00397	0.534
DOC_WW_Pin1_4	60	65	PF00397	0.714
DOC_WW_Pin1_4	634	639	PF00397	0.534
DOC_WW_Pin1_4	68	73	PF00397	0.728
DOC_WW_Pin1_4	685	690	PF00397	0.472
DOC_WW_Pin1_4	91	96	PF00397	0.668
LIG_14-3-3_CanoR_1	156	162	PF00244	0.663
LIG_14-3-3_CanoR_1	181	189	PF00244	0.653
LIG_14-3-3_CanoR_1	25	33	PF00244	0.663
LIG_14-3-3_CanoR_1	317	324	PF00244	0.672
LIG_14-3-3_CanoR_1	360	365	PF00244	0.515
LIG_14-3-3_CanoR_1	391	396	PF00244	0.505
LIG_14-3-3_CanoR_1	418	426	PF00244	0.438
LIG_14-3-3_CanoR_1	44	49	PF00244	0.622
LIG_14-3-3_CanoR_1	465	471	PF00244	0.524
LIG_14-3-3_CanoR_1	77	84	PF00244	0.656
LIG_BIR_III_2	707	711	PF00653	0.534
LIG_BIR_III_4	583	587	PF00653	0.534
LIG_BRCT_BRCA1_1	187	191	PF00533	0.648
LIG_BRCT_BRCA1_1	341	345	PF00533	0.534
LIG_BRCT_BRCA1_1	358	362	PF00533	0.420
LIG_BRCT_BRCA1_1	458	462	PF00533	0.534
LIG_BRCT_BRCA1_1	646	650	PF00533	0.534
LIG_Clathr_ClatBox_1	361	365	PF01394	0.438
LIG_deltaCOP1_diTrp_1	717	729	PF00928	0.526
LIG_DLG_GKlike_1	187	195	PF00625	0.650
LIG_eIF4E_1	768	774	PF01652	0.375
LIG_FHA_1	135	141	PF00498	0.687
LIG_FHA_1	253	259	PF00498	0.732
LIG_FHA_1	261	267	PF00498	0.683
LIG_FHA_1	290	296	PF00498	0.661
LIG_FHA_1	302	308	PF00498	0.617
LIG_FHA_1	390	396	PF00498	0.496
LIG_FHA_1	456	462	PF00498	0.549
LIG_FHA_1	489	495	PF00498	0.534
LIG_FHA_1	559	565	PF00498	0.521
LIG_FHA_1	621	627	PF00498	0.534
LIG_FHA_1	79	85	PF00498	0.657
LIG_FHA_2	119	125	PF00498	0.666
LIG_FHA_2	145	151	PF00498	0.661
LIG_FHA_2	320	326	PF00498	0.685
LIG_FHA_2	80	86	PF00498	0.672
LIG_GBD_Chelix_1	375	383	PF00786	0.238
LIG_LIR_Apic_2	342	346	PF02991	0.534
LIG_LIR_Gen_1	604	613	PF02991	0.529
LIG_LIR_Gen_1	646	655	PF02991	0.534
LIG_LIR_Gen_1	757	768	PF02991	0.516
LIG_LIR_Nem_3	211	215	PF02991	0.647
LIG_LIR_Nem_3	297	302	PF02991	0.626
LIG_LIR_Nem_3	604	608	PF02991	0.529
LIG_LIR_Nem_3	646	651	PF02991	0.611
LIG_LIR_Nem_3	757	763	PF02991	0.516
LIG_NRBOX	533	539	PF00104	0.630
LIG_PDZ_Class_2	771	776	PF00595	0.469
LIG_Pex14_2	336	340	PF04695	0.534
LIG_Pex14_2	771	775	PF04695	0.463
LIG_SH2_STAP1	264	268	PF00017	0.642
LIG_SH2_STAT5	132	135	PF00017	0.752
LIG_SH2_STAT5	152	155	PF00017	0.673
LIG_SH2_STAT5	369	372	PF00017	0.438
LIG_SH2_STAT5	575	578	PF00017	0.525
LIG_SH2_STAT5	770	773	PF00017	0.455
LIG_SH3_2	673	678	PF14604	0.534
LIG_SH3_3	210	216	PF00018	0.651
LIG_SH3_3	277	283	PF00018	0.701
LIG_SH3_3	305	311	PF00018	0.731
LIG_SH3_3	37	43	PF00018	0.660
LIG_SH3_3	384	390	PF00018	0.438
LIG_SH3_3	66	72	PF00018	0.651
LIG_SH3_3	667	673	PF00018	0.534
LIG_SH3_3	684	690	PF00018	0.420
LIG_SH3_4	674	681	PF00018	0.438
LIG_SUMO_SIM_par_1	372	380	PF11976	0.534
LIG_TRAF2_1	597	600	PF00917	0.534
LIG_TRAF2_1	715	718	PF00917	0.456
LIG_WRC_WIRS_1	361	366	PF05994	0.388
MOD_CDK_SPK_2	39	44	PF00069	0.565
MOD_CDK_SPxK_1	685	691	PF00069	0.300
MOD_CK1_1	101	107	PF00069	0.564
MOD_CK1_1	165	171	PF00069	0.666
MOD_CK1_1	190	196	PF00069	0.690
MOD_CK1_1	226	232	PF00069	0.663
MOD_CK1_1	251	257	PF00069	0.734
MOD_CK1_1	287	293	PF00069	0.701
MOD_CK1_1	319	325	PF00069	0.513
MOD_CK1_1	39	45	PF00069	0.581
MOD_CK1_1	419	425	PF00069	0.358
MOD_CK1_1	432	438	PF00069	0.251
MOD_CK1_1	445	451	PF00069	0.315
MOD_CK1_1	456	462	PF00069	0.412
MOD_CK1_1	464	470	PF00069	0.296
MOD_CK1_1	516	522	PF00069	0.253
MOD_CK1_1	541	547	PF00069	0.368
MOD_CK1_1	557	563	PF00069	0.257
MOD_CK1_1	594	600	PF00069	0.253
MOD_CK1_1	63	69	PF00069	0.586
MOD_CK1_1	634	640	PF00069	0.388
MOD_CK1_1	646	652	PF00069	0.275
MOD_CK1_1	668	674	PF00069	0.388
MOD_CK1_1	693	699	PF00069	0.265
MOD_CK1_1	713	719	PF00069	0.314
MOD_CK1_1	752	758	PF00069	0.388
MOD_CK1_1	78	84	PF00069	0.517
MOD_CK2_1	319	325	PF00069	0.634
MOD_CK2_1	351	357	PF00069	0.388
MOD_CK2_1	401	407	PF00069	0.361
MOD_CK2_1	593	599	PF00069	0.381
MOD_CK2_1	712	718	PF00069	0.407
MOD_Cter_Amidation	507	510	PF01082	0.388
MOD_Cter_Amidation	739	742	PF01082	0.477
MOD_DYRK1A_RPxSP_1	276	280	PF00069	0.553
MOD_GlcNHglycan	100	103	PF01048	0.583
MOD_GlcNHglycan	164	167	PF01048	0.618
MOD_GlcNHglycan	172	175	PF01048	0.572
MOD_GlcNHglycan	192	195	PF01048	0.594
MOD_GlcNHglycan	200	203	PF01048	0.611
MOD_GlcNHglycan	218	221	PF01048	0.689
MOD_GlcNHglycan	230	233	PF01048	0.663
MOD_GlcNHglycan	237	240	PF01048	0.558
MOD_GlcNHglycan	276	279	PF01048	0.670
MOD_GlcNHglycan	433	437	PF01048	0.388
MOD_GlcNHglycan	446	450	PF01048	0.265
MOD_GlcNHglycan	455	458	PF01048	0.303
MOD_GlcNHglycan	466	469	PF01048	0.246
MOD_GlcNHglycan	478	481	PF01048	0.419
MOD_GlcNHglycan	483	486	PF01048	0.238
MOD_GlcNHglycan	546	549	PF01048	0.348
MOD_GlcNHglycan	576	579	PF01048	0.361
MOD_GlcNHglycan	588	591	PF01048	0.490
MOD_GlcNHglycan	596	599	PF01048	0.361
MOD_GlcNHglycan	629	632	PF01048	0.388
MOD_GlcNHglycan	670	673	PF01048	0.380
MOD_GlcNHglycan	679	684	PF01048	0.295
MOD_GlcNHglycan	692	695	PF01048	0.287
MOD_GlcNHglycan	754	757	PF01048	0.502
MOD_GSK3_1	118	125	PF00069	0.553
MOD_GSK3_1	156	163	PF00069	0.567
MOD_GSK3_1	17	24	PF00069	0.694
MOD_GSK3_1	181	188	PF00069	0.619
MOD_GSK3_1	200	207	PF00069	0.569
MOD_GSK3_1	222	229	PF00069	0.608
MOD_GSK3_1	231	238	PF00069	0.644
MOD_GSK3_1	248	255	PF00069	0.695
MOD_GSK3_1	258	265	PF00069	0.675
MOD_GSK3_1	267	274	PF00069	0.573
MOD_GSK3_1	283	290	PF00069	0.501
MOD_GSK3_1	303	310	PF00069	0.655
MOD_GSK3_1	34	41	PF00069	0.551
MOD_GSK3_1	356	363	PF00069	0.506
MOD_GSK3_1	397	404	PF00069	0.365
MOD_GSK3_1	412	419	PF00069	0.369
MOD_GSK3_1	440	447	PF00069	0.334
MOD_GSK3_1	453	460	PF00069	0.251
MOD_GSK3_1	513	520	PF00069	0.253
MOD_GSK3_1	538	545	PF00069	0.388
MOD_GSK3_1	550	557	PF00069	0.275
MOD_GSK3_1	574	581	PF00069	0.369
MOD_GSK3_1	60	67	PF00069	0.635
MOD_GSK3_1	627	634	PF00069	0.388
MOD_GSK3_1	698	705	PF00069	0.280
MOD_GSK3_1	75	82	PF00069	0.574
MOD_GSK3_1	91	98	PF00069	0.535
MOD_N-GLC_1	134	139	PF02516	0.567
MOD_N-GLC_1	170	175	PF02516	0.634
MOD_N-GLC_1	274	279	PF02516	0.687
MOD_N-GLC_1	620	625	PF02516	0.388
MOD_N-GLC_1	666	671	PF02516	0.265
MOD_N-GLC_1	96	101	PF02516	0.589
MOD_NEK2_1	198	203	PF00069	0.584
MOD_NEK2_1	295	300	PF00069	0.621
MOD_NEK2_1	302	307	PF00069	0.688
MOD_NEK2_1	316	321	PF00069	0.619
MOD_NEK2_1	364	369	PF00069	0.523
MOD_NEK2_1	453	458	PF00069	0.253
MOD_NEK2_1	503	508	PF00069	0.469
MOD_NEK2_1	593	598	PF00069	0.354
MOD_NEK2_1	620	625	PF00069	0.388
MOD_NEK2_1	729	734	PF00069	0.388
MOD_NEK2_2	457	462	PF00069	0.253
MOD_PIKK_1	127	133	PF00454	0.556
MOD_PIKK_1	258	264	PF00454	0.534
MOD_PIKK_1	406	412	PF00454	0.294
MOD_PIKK_1	420	426	PF00454	0.350
MOD_PIKK_1	488	494	PF00454	0.421
MOD_PIKK_1	517	523	PF00454	0.388
MOD_PIKK_1	659	665	PF00454	0.516
MOD_PK_1	374	380	PF00069	0.388
MOD_PKA_1	181	187	PF00069	0.560
MOD_PKA_1	566	572	PF00069	0.271
MOD_PKA_2	181	187	PF00069	0.606
MOD_PKA_2	24	30	PF00069	0.565
MOD_PKA_2	316	322	PF00069	0.519
MOD_PKA_2	390	396	PF00069	0.253
MOD_PKA_2	43	49	PF00069	0.510
MOD_PKA_2	464	470	PF00069	0.397
MOD_PKA_2	508	514	PF00069	0.388
MOD_PKA_2	565	571	PF00069	0.350
MOD_PKA_2	573	579	PF00069	0.393
MOD_PKA_2	627	633	PF00069	0.401
MOD_PKA_2	76	82	PF00069	0.560
MOD_Plk_1	127	133	PF00069	0.657
MOD_Plk_1	364	370	PF00069	0.392
MOD_Plk_1	406	412	PF00069	0.361
MOD_Plk_1	620	626	PF00069	0.388
MOD_Plk_1	666	672	PF00069	0.253
MOD_Plk_4	175	181	PF00069	0.559
MOD_Plk_4	254	260	PF00069	0.636
MOD_Plk_4	339	345	PF00069	0.388
MOD_Plk_4	364	370	PF00069	0.388
MOD_Plk_4	374	380	PF00069	0.294
MOD_Plk_4	391	397	PF00069	0.361
MOD_Plk_4	457	463	PF00069	0.268
MOD_Plk_4	560	566	PF00069	0.253
MOD_Plk_4	729	735	PF00069	0.388
MOD_Plk_4	754	760	PF00069	0.516
MOD_ProDKin_1	101	107	PF00069	0.537
MOD_ProDKin_1	185	191	PF00069	0.709
MOD_ProDKin_1	276	282	PF00069	0.787
MOD_ProDKin_1	307	313	PF00069	0.647
MOD_ProDKin_1	36	42	PF00069	0.574
MOD_ProDKin_1	397	403	PF00069	0.311
MOD_ProDKin_1	416	422	PF00069	0.209
MOD_ProDKin_1	440	446	PF00069	0.388
MOD_ProDKin_1	511	517	PF00069	0.388
MOD_ProDKin_1	60	66	PF00069	0.638
MOD_ProDKin_1	634	640	PF00069	0.388
MOD_ProDKin_1	68	74	PF00069	0.661
MOD_ProDKin_1	685	691	PF00069	0.300
MOD_ProDKin_1	91	97	PF00069	0.577
MOD_SUMO_for_1	677	680	PF00179	0.253
MOD_SUMO_rev_2	366	376	PF00179	0.388
MOD_SUMO_rev_2	9	19	PF00179	0.562
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.388
TRG_ENDOCYTIC_2	605	608	PF00928	0.388
TRG_ENDOCYTIC_2	768	771	PF00928	0.542
TRG_ER_diArg_1	180	183	PF00400	0.565
TRG_ER_diArg_1	471	473	PF00400	0.267
TRG_ER_diArg_1	507	510	PF00400	0.435
TRG_ER_diArg_1	565	567	PF00400	0.334
TRG_ER_diArg_1	742	744	PF00400	0.600
TRG_NLS_MonoExtN_4	739	745	PF00514	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5W7	Leishmania donovani	73%	100%
A4I8A8	Leishmania infantum	73%	100%
E9B367	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q4Y7	Leishmania major	72%	100%