LeishMANIAdb
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Phosphatidate cytidylyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidate cytidylyltransferase
Gene product:
phosphatidate cytidylyltransferase-like protein
Species:
Leishmania braziliensis
UniProt:
A4HKS8_LEIBR
TriTrypDb:
LbrM.32.3110 , LBRM2903_320039000
Length:
470

Annotations

LeishMANIAdb annotations

Related to bacterial cytidyltransferase enzymes. Relatively conserved architecture, with the expection of an insertion of 2 helices.. Might have been acquired by horizontal gene transfer in the ancestors of Kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HKS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009987 cellular process 1 7
GO:0016024 CDP-diacylglycerol biosynthetic process 6 7
GO:0019637 organophosphate metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046341 CDP-diacylglycerol metabolic process 6 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004605 phosphatidate cytidylyltransferase activity 6 8
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016779 nucleotidyltransferase activity 4 10
GO:0070567 cytidylyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.458
CLV_PCSK_KEX2_1 328 330 PF00082 0.425
CLV_PCSK_KEX2_1 424 426 PF00082 0.242
CLV_PCSK_KEX2_1 70 72 PF00082 0.286
CLV_PCSK_PC1ET2_1 328 330 PF00082 0.425
CLV_PCSK_PC1ET2_1 424 426 PF00082 0.242
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.304
CLV_PCSK_SKI1_1 216 220 PF00082 0.364
CLV_PCSK_SKI1_1 29 33 PF00082 0.328
CLV_PCSK_SKI1_1 297 301 PF00082 0.331
CLV_PCSK_SKI1_1 329 333 PF00082 0.429
CLV_PCSK_SKI1_1 339 343 PF00082 0.389
CLV_PCSK_SKI1_1 381 385 PF00082 0.425
CLV_PCSK_SKI1_1 71 75 PF00082 0.288
DEG_COP1_1 4 12 PF00400 0.585
DEG_MDM2_SWIB_1 253 261 PF02201 0.276
DEG_SPOP_SBC_1 84 88 PF00917 0.586
DOC_CKS1_1 261 266 PF01111 0.341
DOC_CYCLIN_RxL_1 336 344 PF00134 0.573
DOC_CYCLIN_yCln2_LP_2 261 267 PF00134 0.349
DOC_CYCLIN_yCln2_LP_2 451 457 PF00134 0.525
DOC_MAPK_gen_1 428 436 PF00069 0.386
DOC_MAPK_gen_1 70 77 PF00069 0.478
DOC_MAPK_MEF2A_6 445 453 PF00069 0.442
DOC_MAPK_MEF2A_6 70 79 PF00069 0.480
DOC_PP1_RVXF_1 116 123 PF00149 0.393
DOC_PP4_FxxP_1 384 387 PF00568 0.241
DOC_USP7_MATH_1 354 358 PF00917 0.447
DOC_USP7_MATH_1 395 399 PF00917 0.202
DOC_USP7_MATH_1 84 88 PF00917 0.607
DOC_USP7_UBL2_3 70 74 PF12436 0.488
DOC_WW_Pin1_4 12 17 PF00397 0.639
DOC_WW_Pin1_4 260 265 PF00397 0.428
DOC_WW_Pin1_4 341 346 PF00397 0.557
DOC_WW_Pin1_4 350 355 PF00397 0.412
DOC_WW_Pin1_4 88 93 PF00397 0.698
LIG_14-3-3_CanoR_1 329 338 PF00244 0.478
LIG_14-3-3_CanoR_1 82 92 PF00244 0.520
LIG_Actin_WH2_2 411 426 PF00022 0.282
LIG_Clathr_ClatBox_1 137 141 PF01394 0.341
LIG_EH1_1 146 154 PF00400 0.285
LIG_FHA_1 260 266 PF00498 0.228
LIG_FHA_1 28 34 PF00498 0.308
LIG_FHA_1 4 10 PF00498 0.637
LIG_FHA_1 430 436 PF00498 0.400
LIG_FHA_2 311 317 PF00498 0.638
LIG_LIR_Apic_2 102 107 PF02991 0.528
LIG_LIR_Apic_2 382 387 PF02991 0.186
LIG_LIR_Gen_1 112 120 PF02991 0.467
LIG_LIR_Gen_1 133 144 PF02991 0.233
LIG_LIR_Gen_1 289 299 PF02991 0.199
LIG_LIR_Gen_1 335 345 PF02991 0.513
LIG_LIR_Nem_3 112 117 PF02991 0.453
LIG_LIR_Nem_3 141 147 PF02991 0.333
LIG_LIR_Nem_3 226 230 PF02991 0.529
LIG_LIR_Nem_3 251 256 PF02991 0.326
LIG_LIR_Nem_3 289 294 PF02991 0.459
LIG_LIR_Nem_3 304 309 PF02991 0.602
LIG_LIR_Nem_3 335 340 PF02991 0.521
LIG_LIR_Nem_3 371 375 PF02991 0.379
LIG_LIR_Nem_3 65 69 PF02991 0.259
LIG_LIR_Nem_3 97 103 PF02991 0.626
LIG_LYPXL_S_1 348 352 PF13949 0.186
LIG_LYPXL_S_1 99 103 PF13949 0.259
LIG_LYPXL_SIV_4 395 403 PF13949 0.186
LIG_LYPXL_yS_3 100 103 PF13949 0.464
LIG_LYPXL_yS_3 349 352 PF13949 0.386
LIG_MAD2 339 347 PF02301 0.471
LIG_NRBOX 400 406 PF00104 0.444
LIG_NRBOX 418 424 PF00104 0.380
LIG_PDZ_Class_1 465 470 PF00595 0.475
LIG_Pex14_2 253 257 PF04695 0.276
LIG_PTB_Apo_2 285 292 PF02174 0.199
LIG_PTB_Apo_2 390 397 PF02174 0.274
LIG_PTB_Phospho_1 390 396 PF10480 0.186
LIG_SH2_CRK 104 108 PF00017 0.504
LIG_SH2_CRK 114 118 PF00017 0.279
LIG_SH2_CRK 306 310 PF00017 0.581
LIG_SH2_CRK 380 384 PF00017 0.225
LIG_SH2_CRK 396 400 PF00017 0.169
LIG_SH2_STAT5 130 133 PF00017 0.402
LIG_SH2_STAT5 227 230 PF00017 0.573
LIG_SH2_STAT5 49 52 PF00017 0.205
LIG_SH3_1 104 110 PF00018 0.528
LIG_SH3_3 104 110 PF00018 0.523
LIG_SH3_3 270 276 PF00018 0.339
LIG_SH3_3 344 350 PF00018 0.386
LIG_SH3_3 431 437 PF00018 0.386
LIG_SH3_3 95 101 PF00018 0.578
LIG_SUMO_SIM_par_1 136 141 PF11976 0.455
LIG_UBA3_1 418 424 PF00899 0.442
MOD_CDC14_SPxK_1 353 356 PF00782 0.442
MOD_CDK_SPxK_1 350 356 PF00069 0.442
MOD_Cter_Amidation 326 329 PF01082 0.382
MOD_GlcNHglycan 10 13 PF01048 0.431
MOD_GlcNHglycan 126 129 PF01048 0.464
MOD_GlcNHglycan 319 322 PF01048 0.392
MOD_GSK3_1 277 284 PF00069 0.199
MOD_GSK3_1 350 357 PF00069 0.442
MOD_GSK3_1 8 15 PF00069 0.625
MOD_GSK3_1 84 91 PF00069 0.683
MOD_N-GLC_1 178 183 PF02516 0.313
MOD_N-GLC_1 354 359 PF02516 0.325
MOD_NEK2_1 124 129 PF00069 0.266
MOD_NEK2_1 177 182 PF00069 0.593
MOD_NEK2_1 379 384 PF00069 0.214
MOD_NEK2_1 418 423 PF00069 0.430
MOD_NEK2_1 429 434 PF00069 0.459
MOD_NEK2_1 77 82 PF00069 0.646
MOD_NEK2_2 44 49 PF00069 0.302
MOD_PIKK_1 86 92 PF00454 0.533
MOD_PKA_2 212 218 PF00069 0.507
MOD_PKA_2 464 470 PF00069 0.469
MOD_Plk_1 205 211 PF00069 0.710
MOD_Plk_1 332 338 PF00069 0.571
MOD_Plk_1 354 360 PF00069 0.543
MOD_Plk_2-3 311 317 PF00069 0.517
MOD_Plk_4 148 154 PF00069 0.231
MOD_Plk_4 278 284 PF00069 0.300
MOD_Plk_4 418 424 PF00069 0.411
MOD_Plk_4 44 50 PF00069 0.414
MOD_ProDKin_1 12 18 PF00069 0.636
MOD_ProDKin_1 260 266 PF00069 0.428
MOD_ProDKin_1 341 347 PF00069 0.560
MOD_ProDKin_1 350 356 PF00069 0.412
MOD_ProDKin_1 88 94 PF00069 0.689
MOD_SUMO_rev_2 208 218 PF00179 0.574
TRG_DiLeu_BaEn_1 133 138 PF01217 0.325
TRG_DiLeu_BaEn_1 141 146 PF01217 0.393
TRG_DiLeu_BaEn_2 332 338 PF01217 0.479
TRG_ENDOCYTIC_2 100 103 PF00928 0.641
TRG_ENDOCYTIC_2 114 117 PF00928 0.375
TRG_ENDOCYTIC_2 227 230 PF00928 0.546
TRG_ENDOCYTIC_2 306 309 PF00928 0.616
TRG_ENDOCYTIC_2 349 352 PF00928 0.525
TRG_ENDOCYTIC_2 380 383 PF00928 0.298
TRG_ENDOCYTIC_2 396 399 PF00928 0.210
TRG_Pf-PMV_PEXEL_1 300 304 PF00026 0.379
TRG_Pf-PMV_PEXEL_1 329 333 PF00026 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEC8 Leptomonas seymouri 56% 99%
A0A1X0NT53 Trypanosomatidae 33% 100%
A0A3Q8IDC1 Leishmania donovani 69% 95%
A0A422NZP0 Trypanosoma rangeli 36% 100%
E9AHM2 Leishmania infantum 69% 95%
E9B366 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 94%
Q4Q4Y8 Leishmania major 67% 100%
V5AXY5 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS