Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKS7_LEIBR

TriTrypDb:

LbrM.32.3100 , LBRM2903_320038900

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.666
CLV_C14_Caspase3-7	220	224	PF00656	0.571
CLV_C14_Caspase3-7	226	230	PF00656	0.550
CLV_C14_Caspase3-7	272	276	PF00656	0.585
CLV_C14_Caspase3-7	4	8	PF00656	0.604
CLV_NRD_NRD_1	128	130	PF00675	0.544
CLV_NRD_NRD_1	167	169	PF00675	0.580
CLV_NRD_NRD_1	318	320	PF00675	0.741
CLV_NRD_NRD_1	387	389	PF00675	0.610
CLV_NRD_NRD_1	415	417	PF00675	0.584
CLV_NRD_NRD_1	716	718	PF00675	0.654
CLV_NRD_NRD_1	739	741	PF00675	0.754
CLV_PCSK_KEX2_1	128	130	PF00082	0.544
CLV_PCSK_KEX2_1	318	320	PF00082	0.741
CLV_PCSK_KEX2_1	387	389	PF00082	0.610
CLV_PCSK_KEX2_1	415	417	PF00082	0.681
CLV_PCSK_KEX2_1	432	434	PF00082	0.524
CLV_PCSK_KEX2_1	716	718	PF00082	0.654
CLV_PCSK_KEX2_1	739	741	PF00082	0.652
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.590
CLV_PCSK_SKI1_1	191	195	PF00082	0.648
CLV_PCSK_SKI1_1	318	322	PF00082	0.736
CLV_PCSK_SKI1_1	372	376	PF00082	0.618
CLV_PCSK_SKI1_1	379	383	PF00082	0.561
CLV_PCSK_SKI1_1	463	467	PF00082	0.526
CLV_PCSK_SKI1_1	472	476	PF00082	0.478
CLV_PCSK_SKI1_1	88	92	PF00082	0.663
CLV_PCSK_SKI1_1	96	100	PF00082	0.535
DEG_SPOP_SBC_1	172	176	PF00917	0.570
DEG_SPOP_SBC_1	354	358	PF00917	0.800
DEG_SPOP_SBC_1	440	444	PF00917	0.809
DOC_CKS1_1	235	240	PF01111	0.601
DOC_MAPK_gen_1	468	476	PF00069	0.509
DOC_PP2B_LxvP_1	547	550	PF13499	0.591
DOC_PP4_FxxP_1	235	238	PF00568	0.587
DOC_PP4_FxxP_1	580	583	PF00568	0.507
DOC_PP4_FxxP_1	75	78	PF00568	0.481
DOC_USP7_MATH_1	130	134	PF00917	0.678
DOC_USP7_MATH_1	181	185	PF00917	0.640
DOC_USP7_MATH_1	243	247	PF00917	0.655
DOC_USP7_MATH_1	353	357	PF00917	0.771
DOC_USP7_MATH_1	400	404	PF00917	0.630
DOC_USP7_MATH_1	405	409	PF00917	0.629
DOC_USP7_MATH_1	440	444	PF00917	0.745
DOC_USP7_MATH_1	446	450	PF00917	0.648
DOC_USP7_MATH_1	583	587	PF00917	0.375
DOC_USP7_MATH_1	59	63	PF00917	0.627
DOC_USP7_MATH_1	729	733	PF00917	0.645
DOC_WW_Pin1_4	173	178	PF00397	0.740
DOC_WW_Pin1_4	234	239	PF00397	0.665
DOC_WW_Pin1_4	248	253	PF00397	0.776
DOC_WW_Pin1_4	396	401	PF00397	0.700
DOC_WW_Pin1_4	5	10	PF00397	0.799
DOC_WW_Pin1_4	505	510	PF00397	0.691
DOC_WW_Pin1_4	74	79	PF00397	0.717
LIG_14-3-3_CanoR_1	129	135	PF00244	0.540
LIG_14-3-3_CanoR_1	282	288	PF00244	0.818
LIG_14-3-3_CanoR_1	372	378	PF00244	0.659
LIG_14-3-3_CanoR_1	47	55	PF00244	0.618
LIG_14-3-3_CanoR_1	551	555	PF00244	0.555
LIG_14-3-3_CanoR_1	601	605	PF00244	0.668
LIG_14-3-3_CanoR_1	678	687	PF00244	0.549
LIG_14-3-3_CanoR_1	692	701	PF00244	0.614
LIG_AP2alpha_2	70	72	PF02296	0.646
LIG_APCC_ABBA_1	114	119	PF00400	0.500
LIG_BIR_III_4	142	146	PF00653	0.575
LIG_BIR_III_4	324	328	PF00653	0.575
LIG_BRCT_BRCA1_1	231	235	PF00533	0.841
LIG_BRCT_BRCA1_1	76	80	PF00533	0.452
LIG_FHA_1	235	241	PF00498	0.665
LIG_FHA_1	249	255	PF00498	0.780
LIG_FHA_1	284	290	PF00498	0.764
LIG_FHA_1	300	306	PF00498	0.668
LIG_FHA_1	442	448	PF00498	0.686
LIG_FHA_1	483	489	PF00498	0.664
LIG_FHA_1	505	511	PF00498	0.551
LIG_FHA_1	525	531	PF00498	0.358
LIG_FHA_1	542	548	PF00498	0.609
LIG_FHA_2	106	112	PF00498	0.547
LIG_FHA_2	2	8	PF00498	0.644
LIG_FHA_2	218	224	PF00498	0.570
LIG_FHA_2	270	276	PF00498	0.838
LIG_FHA_2	334	340	PF00498	0.698
LIG_FHA_2	408	414	PF00498	0.854
LIG_FHA_2	453	459	PF00498	0.592
LIG_FHA_2	92	98	PF00498	0.641
LIG_LIR_Apic_2	232	238	PF02991	0.587
LIG_LIR_Apic_2	73	78	PF02991	0.479
LIG_LIR_Gen_1	111	120	PF02991	0.648
LIG_LIR_Gen_1	192	199	PF02991	0.511
LIG_LIR_Gen_1	373	382	PF02991	0.648
LIG_LIR_Gen_1	544	554	PF02991	0.704
LIG_LIR_Gen_1	70	80	PF02991	0.725
LIG_LIR_Nem_3	111	116	PF02991	0.744
LIG_LIR_Nem_3	373	377	PF02991	0.653
LIG_LIR_Nem_3	544	549	PF02991	0.701
LIG_LIR_Nem_3	603	609	PF02991	0.532
LIG_LIR_Nem_3	62	67	PF02991	0.581
LIG_LIR_Nem_3	697	703	PF02991	0.623
LIG_LIR_Nem_3	70	75	PF02991	0.670
LIG_NRBOX	513	519	PF00104	0.670
LIG_PTAP_UEV_1	401	406	PF05743	0.598
LIG_PTB_Apo_2	633	640	PF02174	0.498
LIG_REV1ctd_RIR_1	490	499	PF16727	0.615
LIG_SH2_SRC	115	118	PF00017	0.752
LIG_SH2_SRC	688	691	PF00017	0.584
LIG_SH2_STAT5	115	118	PF00017	0.752
LIG_SH2_STAT5	27	30	PF00017	0.696
LIG_SH2_STAT5	307	310	PF00017	0.612
LIG_SH2_STAT5	546	549	PF00017	0.689
LIG_SH2_STAT5	673	676	PF00017	0.660
LIG_SH2_STAT5	688	691	PF00017	0.410
LIG_SH3_3	237	243	PF00018	0.814
LIG_SH3_3	399	405	PF00018	0.592
LIG_SH3_3	537	543	PF00018	0.597
LIG_SUMO_SIM_anti_2	527	532	PF11976	0.581
LIG_SUMO_SIM_par_1	253	258	PF11976	0.816
LIG_SUMO_SIM_par_1	301	306	PF11976	0.632
LIG_SUMO_SIM_par_1	526	532	PF11976	0.692
LIG_SUMO_SIM_par_1	630	635	PF11976	0.618
LIG_TRAF2_1	320	323	PF00917	0.520
LIG_TRAF2_1	394	397	PF00917	0.552
LIG_TRAF2_1	410	413	PF00917	0.524
LIG_TRAF2_1	648	651	PF00917	0.768
LIG_TYR_ITSM	542	549	PF00017	0.705
LIG_WRC_WIRS_1	371	376	PF05994	0.658
LIG_WW_1	685	688	PF00397	0.627
MOD_CDK_SPK_2	173	178	PF00069	0.576
MOD_CDK_SPK_2	5	10	PF00069	0.546
MOD_CK1_1	133	139	PF00069	0.552
MOD_CK1_1	192	198	PF00069	0.672
MOD_CK1_1	201	207	PF00069	0.644
MOD_CK1_1	228	234	PF00069	0.844
MOD_CK1_1	246	252	PF00069	0.548
MOD_CK1_1	277	283	PF00069	0.639
MOD_CK1_1	299	305	PF00069	0.537
MOD_CK1_1	358	364	PF00069	0.787
MOD_CK1_1	373	379	PF00069	0.635
MOD_CK1_1	442	448	PF00069	0.772
MOD_CK1_1	49	55	PF00069	0.537
MOD_CK1_1	5	11	PF00069	0.793
MOD_CK1_1	63	69	PF00069	0.614
MOD_CK2_1	407	413	PF00069	0.810
MOD_CK2_1	655	661	PF00069	0.510
MOD_CK2_1	690	696	PF00069	0.593
MOD_CK2_1	79	85	PF00069	0.561
MOD_CK2_1	91	97	PF00069	0.597
MOD_Cter_Amidation	413	416	PF01082	0.592
MOD_GlcNHglycan	183	186	PF01048	0.751
MOD_GlcNHglycan	191	194	PF01048	0.641
MOD_GlcNHglycan	196	200	PF01048	0.570
MOD_GlcNHglycan	225	228	PF01048	0.797
MOD_GlcNHglycan	231	234	PF01048	0.766
MOD_GlcNHglycan	245	248	PF01048	0.676
MOD_GlcNHglycan	298	301	PF01048	0.803
MOD_GlcNHglycan	347	351	PF01048	0.826
MOD_GlcNHglycan	357	360	PF01048	0.678
MOD_GlcNHglycan	4	7	PF01048	0.556
MOD_GlcNHglycan	402	405	PF01048	0.632
MOD_GlcNHglycan	500	503	PF01048	0.456
MOD_GlcNHglycan	520	524	PF01048	0.531
MOD_GlcNHglycan	585	588	PF01048	0.357
MOD_GlcNHglycan	657	660	PF01048	0.466
MOD_GlcNHglycan	692	695	PF01048	0.718
MOD_GlcNHglycan	731	734	PF01048	0.683
MOD_GSK3_1	1	8	PF00069	0.814
MOD_GSK3_1	115	122	PF00069	0.538
MOD_GSK3_1	197	204	PF00069	0.629
MOD_GSK3_1	219	226	PF00069	0.729
MOD_GSK3_1	27	34	PF00069	0.650
MOD_GSK3_1	274	281	PF00069	0.825
MOD_GSK3_1	292	299	PF00069	0.478
MOD_GSK3_1	329	336	PF00069	0.700
MOD_GSK3_1	342	349	PF00069	0.680
MOD_GSK3_1	353	360	PF00069	0.674
MOD_GSK3_1	396	403	PF00069	0.740
MOD_GSK3_1	441	448	PF00069	0.632
MOD_GSK3_1	46	53	PF00069	0.693
MOD_GSK3_1	560	567	PF00069	0.525
MOD_GSK3_1	59	66	PF00069	0.662
MOD_GSK3_1	690	697	PF00069	0.655
MOD_GSK3_1	70	77	PF00069	0.609
MOD_N-GLC_1	172	177	PF02516	0.592
MOD_N-GLC_1	314	319	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	105	110	PF00069	0.659
MOD_NEK2_1	197	202	PF00069	0.734
MOD_NEK2_1	217	222	PF00069	0.530
MOD_NEK2_1	283	288	PF00069	0.824
MOD_NEK2_1	483	488	PF00069	0.693
MOD_NEK2_1	496	501	PF00069	0.504
MOD_NEK2_1	518	523	PF00069	0.665
MOD_NEK2_1	564	569	PF00069	0.577
MOD_NEK2_1	632	637	PF00069	0.704
MOD_NEK2_1	708	713	PF00069	0.724
MOD_NEK2_2	130	135	PF00069	0.754
MOD_NEK2_2	660	665	PF00069	0.693
MOD_NEK2_2	694	699	PF00069	0.454
MOD_PIKK_1	246	252	PF00454	0.616
MOD_PIKK_1	541	547	PF00454	0.720
MOD_PIKK_1	617	623	PF00454	0.510
MOD_PIKK_1	708	714	PF00454	0.624
MOD_PKA_2	201	207	PF00069	0.629
MOD_PKA_2	217	223	PF00069	0.774
MOD_PKA_2	414	420	PF00069	0.651
MOD_PKA_2	46	52	PF00069	0.606
MOD_PKA_2	550	556	PF00069	0.545
MOD_PKA_2	600	606	PF00069	0.671
MOD_PKA_2	617	623	PF00069	0.359
MOD_Plk_1	105	111	PF00069	0.546
MOD_Plk_1	483	489	PF00069	0.693
MOD_Plk_1	496	502	PF00069	0.570
MOD_Plk_1	519	525	PF00069	0.642
MOD_Plk_1	660	666	PF00069	0.693
MOD_Plk_1	86	92	PF00069	0.450
MOD_Plk_4	260	266	PF00069	0.544
MOD_Plk_4	483	489	PF00069	0.693
MOD_Plk_4	560	566	PF00069	0.422
MOD_ProDKin_1	173	179	PF00069	0.739
MOD_ProDKin_1	234	240	PF00069	0.667
MOD_ProDKin_1	248	254	PF00069	0.775
MOD_ProDKin_1	396	402	PF00069	0.702
MOD_ProDKin_1	5	11	PF00069	0.793
MOD_ProDKin_1	505	511	PF00069	0.692
MOD_ProDKin_1	74	80	PF00069	0.714
TRG_DiLeu_BaEn_1	520	525	PF01217	0.562
TRG_DiLeu_BaEn_2	461	467	PF01217	0.661
TRG_ENDOCYTIC_2	546	549	PF00928	0.689
TRG_ER_diArg_1	127	129	PF00400	0.547
TRG_ER_diArg_1	387	389	PF00400	0.610
TRG_ER_diArg_1	467	470	PF00400	0.505
TRG_ER_diArg_1	479	482	PF00400	0.476
TRG_ER_diArg_1	715	717	PF00400	0.657
TRG_NES_CRM1_1	97	111	PF08389	0.653
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B7	Leptomonas seymouri	44%	100%
A0A3Q8ITJ0	Leishmania donovani	75%	99%
A4I8A7	Leishmania infantum	75%	99%
E9B365	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q4Y9	Leishmania major	75%	100%