Dynein axonemal assembly factor 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain/TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HKS6_LEIBR

TriTrypDb:

LbrM.32.3090 , LBRM2903_320038800

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0042995	cell projection	2	11
GO:0043005	neuron projection	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0120293	dynein axonemal particle	5	11
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HKS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS6

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007399	nervous system development	4	11
GO:0009987	cellular process	1	11
GO:0032502	developmental process	1	11
GO:0048731	system development	3	11
GO:0048856	anatomical structure development	2	11
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036158	outer dynein arm assembly	7	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.396
CLV_C14_Caspase3-7	509	513	PF00656	0.674
CLV_C14_Caspase3-7	540	544	PF00656	0.538
CLV_C14_Caspase3-7	68	72	PF00656	0.583
CLV_NRD_NRD_1	106	108	PF00675	0.486
CLV_NRD_NRD_1	112	114	PF00675	0.488
CLV_NRD_NRD_1	134	136	PF00675	0.580
CLV_NRD_NRD_1	370	372	PF00675	0.369
CLV_NRD_NRD_1	549	551	PF00675	0.505
CLV_PCSK_FUR_1	547	551	PF00082	0.622
CLV_PCSK_KEX2_1	106	108	PF00082	0.475
CLV_PCSK_KEX2_1	112	114	PF00082	0.472
CLV_PCSK_KEX2_1	116	118	PF00082	0.483
CLV_PCSK_KEX2_1	133	135	PF00082	0.574
CLV_PCSK_KEX2_1	311	313	PF00082	0.430
CLV_PCSK_KEX2_1	334	336	PF00082	0.420
CLV_PCSK_KEX2_1	370	372	PF00082	0.369
CLV_PCSK_KEX2_1	549	551	PF00082	0.576
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.441
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.540
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.419
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.420
CLV_PCSK_PC7_1	112	118	PF00082	0.579
CLV_PCSK_PC7_1	129	135	PF00082	0.533
CLV_PCSK_SKI1_1	134	138	PF00082	0.548
CLV_PCSK_SKI1_1	417	421	PF00082	0.539
CLV_PCSK_SKI1_1	480	484	PF00082	0.221
CLV_PCSK_SKI1_1	528	532	PF00082	0.514
DEG_SCF_FBW7_1	224	230	PF00400	0.663
DEG_SCF_FBW7_2	347	354	PF00400	0.506
DEG_SPOP_SBC_1	188	192	PF00917	0.547
DEG_SPOP_SBC_1	227	231	PF00917	0.659
DOC_CKS1_1	224	229	PF01111	0.677
DOC_MAPK_gen_1	23	32	PF00069	0.487
DOC_MAPK_gen_1	270	279	PF00069	0.610
DOC_MAPK_gen_1	359	367	PF00069	0.324
DOC_MAPK_gen_1	475	485	PF00069	0.475
DOC_MAPK_gen_1	613	622	PF00069	0.438
DOC_MAPK_MEF2A_6	240	249	PF00069	0.554
DOC_MAPK_MEF2A_6	26	34	PF00069	0.495
DOC_PP2B_LxvP_1	216	219	PF13499	0.507
DOC_PP4_FxxP_1	256	259	PF00568	0.694
DOC_USP7_MATH_1	188	192	PF00917	0.584
DOC_USP7_MATH_1	208	212	PF00917	0.528
DOC_USP7_MATH_1	227	231	PF00917	0.562
DOC_USP7_MATH_1	259	263	PF00917	0.600
DOC_USP7_MATH_1	539	543	PF00917	0.654
DOC_USP7_MATH_1	59	63	PF00917	0.503
DOC_USP7_MATH_1	621	625	PF00917	0.467
DOC_USP7_UBL2_3	23	27	PF12436	0.501
DOC_USP7_UBL2_3	480	484	PF12436	0.223
DOC_USP7_UBL2_3	581	585	PF12436	0.463
DOC_WW_Pin1_4	172	177	PF00397	0.689
DOC_WW_Pin1_4	181	186	PF00397	0.730
DOC_WW_Pin1_4	189	194	PF00397	0.685
DOC_WW_Pin1_4	223	228	PF00397	0.704
DOC_WW_Pin1_4	232	237	PF00397	0.707
DOC_WW_Pin1_4	249	254	PF00397	0.412
DOC_WW_Pin1_4	279	284	PF00397	0.480
DOC_WW_Pin1_4	347	352	PF00397	0.477
DOC_WW_Pin1_4	594	599	PF00397	0.449
LIG_14-3-3_CanoR_1	417	422	PF00244	0.538
LIG_14-3-3_CanoR_1	538	546	PF00244	0.421
LIG_AP2alpha_2	459	461	PF02296	0.223
LIG_CaM_IQ_9	146	161	PF13499	0.391
LIG_Clathr_ClatBox_1	48	52	PF01394	0.487
LIG_FHA_1	173	179	PF00498	0.467
LIG_FHA_1	242	248	PF00498	0.523
LIG_FHA_2	10	16	PF00498	0.487
LIG_FHA_2	125	131	PF00498	0.631
LIG_FHA_2	147	153	PF00498	0.596
LIG_FHA_2	418	424	PF00498	0.658
LIG_FHA_2	529	535	PF00498	0.621
LIG_FHA_2	595	601	PF00498	0.454
LIG_Integrin_RGD_1	263	265	PF01839	0.539
LIG_LIR_Apic_2	255	259	PF02991	0.692
LIG_LIR_Gen_1	324	333	PF02991	0.529
LIG_LIR_Gen_1	36	45	PF02991	0.501
LIG_LIR_Gen_1	449	460	PF02991	0.475
LIG_LIR_Gen_1	85	93	PF02991	0.381
LIG_LIR_Nem_3	272	277	PF02991	0.601
LIG_LIR_Nem_3	324	330	PF02991	0.269
LIG_LIR_Nem_3	358	363	PF02991	0.459
LIG_LIR_Nem_3	36	41	PF02991	0.508
LIG_LIR_Nem_3	449	455	PF02991	0.388
LIG_LIR_Nem_3	85	91	PF02991	0.381
LIG_RPA_C_Fungi	102	114	PF08784	0.487
LIG_SH2_CRK	274	278	PF00017	0.591
LIG_SH2_CRK	360	364	PF00017	0.433
LIG_SH2_CRK	452	456	PF00017	0.385
LIG_SH2_CRK	564	568	PF00017	0.414
LIG_SH2_GRB2like	599	602	PF00017	0.545
LIG_SH2_NCK_1	445	449	PF00017	0.363
LIG_SH2_PTP2	570	573	PF00017	0.258
LIG_SH2_STAP1	199	203	PF00017	0.544
LIG_SH2_STAP1	306	310	PF00017	0.389
LIG_SH2_STAP1	452	456	PF00017	0.362
LIG_SH2_STAP1	599	603	PF00017	0.452
LIG_SH2_STAT3	118	121	PF00017	0.619
LIG_SH2_STAT3	268	271	PF00017	0.671
LIG_SH2_STAT3	294	297	PF00017	0.521
LIG_SH2_STAT5	327	330	PF00017	0.541
LIG_SH2_STAT5	375	378	PF00017	0.472
LIG_SH2_STAT5	47	50	PF00017	0.344
LIG_SH2_STAT5	570	573	PF00017	0.459
LIG_SH2_STAT5	589	592	PF00017	0.505
LIG_SH2_STAT5	65	68	PF00017	0.328
LIG_SH3_3	182	188	PF00018	0.682
LIG_SH3_3	190	196	PF00018	0.696
LIG_SH3_3	231	237	PF00018	0.647
LIG_SH3_3	38	44	PF00018	0.413
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.441
LIG_SUMO_SIM_par_1	275	282	PF11976	0.585
LIG_SUMO_SIM_par_1	47	52	PF11976	0.348
LIG_SUMO_SIM_par_1	617	624	PF11976	0.498
LIG_TRAF2_1	532	535	PF00917	0.708
LIG_UBA3_1	17	23	PF00899	0.413
LIG_UBA3_1	53	61	PF00899	0.385
LIG_WW_1	44	47	PF00397	0.413
MOD_CDK_SPK_2	249	254	PF00069	0.554
MOD_CK1_1	172	178	PF00069	0.691
MOD_CK1_1	197	203	PF00069	0.715
MOD_CK1_1	223	229	PF00069	0.748
MOD_CK1_1	232	238	PF00069	0.703
MOD_CK1_1	353	359	PF00069	0.500
MOD_CK1_1	623	629	PF00069	0.581
MOD_CK2_1	124	130	PF00069	0.657
MOD_CK2_1	146	152	PF00069	0.587
MOD_CK2_1	510	516	PF00069	0.672
MOD_CK2_1	528	534	PF00069	0.677
MOD_GlcNHglycan	199	202	PF01048	0.707
MOD_GlcNHglycan	231	234	PF01048	0.498
MOD_GlcNHglycan	323	326	PF01048	0.500
MOD_GlcNHglycan	382	385	PF01048	0.461
MOD_GlcNHglycan	452	455	PF01048	0.411
MOD_GlcNHglycan	558	562	PF01048	0.470
MOD_GlcNHglycan	623	626	PF01048	0.537
MOD_GSK3_1	223	230	PF00069	0.781
MOD_GSK3_1	241	248	PF00069	0.547
MOD_GSK3_1	275	282	PF00069	0.620
MOD_GSK3_1	338	345	PF00069	0.417
MOD_GSK3_1	5	12	PF00069	0.480
MOD_GSK3_1	524	531	PF00069	0.734
MOD_GSK3_1	60	67	PF00069	0.419
MOD_GSK3_1	89	96	PF00069	0.609
MOD_N-GLC_1	245	250	PF02516	0.624
MOD_N-GLC_1	321	326	PF02516	0.506
MOD_NEK2_1	18	23	PF00069	0.363
MOD_NEK2_1	321	326	PF00069	0.506
MOD_NEK2_1	342	347	PF00069	0.412
MOD_NEK2_1	93	98	PF00069	0.553
MOD_NEK2_2	306	311	PF00069	0.399
MOD_PIKK_1	124	130	PF00454	0.630
MOD_PIKK_1	146	152	PF00454	0.400
MOD_PIKK_1	353	359	PF00454	0.500
MOD_PIKK_1	60	66	PF00454	0.475
MOD_PK_1	275	281	PF00069	0.592
MOD_PKA_2	124	130	PF00069	0.591
MOD_PKA_2	269	275	PF00069	0.531
MOD_PKA_2	537	543	PF00069	0.438
MOD_Plk_1	245	251	PF00069	0.642
MOD_Plk_1	338	344	PF00069	0.410
MOD_Plk_1	448	454	PF00069	0.399
MOD_Plk_2-3	396	402	PF00069	0.585
MOD_Plk_4	220	226	PF00069	0.740
MOD_Plk_4	342	348	PF00069	0.421
MOD_Plk_4	615	621	PF00069	0.462
MOD_ProDKin_1	172	178	PF00069	0.697
MOD_ProDKin_1	181	187	PF00069	0.729
MOD_ProDKin_1	189	195	PF00069	0.683
MOD_ProDKin_1	223	229	PF00069	0.704
MOD_ProDKin_1	232	238	PF00069	0.705
MOD_ProDKin_1	249	255	PF00069	0.416
MOD_ProDKin_1	279	285	PF00069	0.476
MOD_ProDKin_1	347	353	PF00069	0.488
MOD_ProDKin_1	594	600	PF00069	0.450
MOD_SUMO_for_1	155	158	PF00179	0.528
MOD_SUMO_rev_2	379	383	PF00179	0.555
TRG_ENDOCYTIC_2	274	277	PF00928	0.596
TRG_ENDOCYTIC_2	327	330	PF00928	0.541
TRG_ENDOCYTIC_2	360	363	PF00928	0.441
TRG_ENDOCYTIC_2	394	397	PF00928	0.491
TRG_ENDOCYTIC_2	452	455	PF00928	0.328
TRG_ENDOCYTIC_2	564	567	PF00928	0.397
TRG_ENDOCYTIC_2	570	573	PF00928	0.364
TRG_ER_diArg_1	111	113	PF00400	0.432
TRG_ER_diArg_1	134	136	PF00400	0.606
TRG_ER_diArg_1	546	549	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE30	Leptomonas seymouri	70%	100%
A0A0S4IMJ5	Bodo saltans	46%	100%
A0A1X0NRQ0	Trypanosomatidae	50%	100%
A0A3R7LBE5	Trypanosoma rangeli	48%	100%
A0A3S7X5V3	Leishmania donovani	83%	99%
A4I8A6	Leishmania infantum	83%	99%
D0AAH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B364	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4Z0	Leishmania major	83%	100%
V5BMH6	Trypanosoma cruzi	50%	100%