Unconventional prefoldin RPB5 interactor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKS5_LEIBR

TriTrypDb:

LbrM.32.3080 , LBRM2903_320038700

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS5

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010563	negative regulation of phosphorus metabolic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010921	regulation of phosphatase activity	5	1
GO:0010923	negative regulation of phosphatase activity	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035305	negative regulation of dephosphorylation	8	1
GO:0043086	negative regulation of catalytic activity	4	1
GO:0044092	negative regulation of molecular function	3	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045936	negative regulation of phosphate metabolic process	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051346	negative regulation of hydrolase activity	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0003712	transcription coregulator activity	2	1
GO:0003714	transcription corepressor activity	3	1
GO:0004857	enzyme inhibitor activity	3	1
GO:0005488	binding	1	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140110	transcription regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.396
CLV_C14_Caspase3-7	189	193	PF00656	0.508
CLV_C14_Caspase3-7	343	347	PF00656	0.685
CLV_C14_Caspase3-7	397	401	PF00656	0.510
CLV_NRD_NRD_1	101	103	PF00675	0.291
CLV_NRD_NRD_1	107	109	PF00675	0.291
CLV_NRD_NRD_1	284	286	PF00675	0.467
CLV_NRD_NRD_1	292	294	PF00675	0.528
CLV_NRD_NRD_1	30	32	PF00675	0.320
CLV_NRD_NRD_1	444	446	PF00675	0.701
CLV_NRD_NRD_1	513	515	PF00675	0.590
CLV_NRD_NRD_1	55	57	PF00675	0.306
CLV_NRD_NRD_1	553	555	PF00675	0.431
CLV_PCSK_FUR_1	52	56	PF00082	0.306
CLV_PCSK_KEX2_1	101	103	PF00082	0.291
CLV_PCSK_KEX2_1	107	109	PF00082	0.291
CLV_PCSK_KEX2_1	284	286	PF00082	0.467
CLV_PCSK_KEX2_1	292	294	PF00082	0.528
CLV_PCSK_KEX2_1	30	32	PF00082	0.318
CLV_PCSK_KEX2_1	54	56	PF00082	0.309
CLV_PCSK_KEX2_1	553	555	PF00082	0.431
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.431
CLV_PCSK_SKI1_1	272	276	PF00082	0.493
CLV_PCSK_SKI1_1	55	59	PF00082	0.307
CLV_PCSK_SKI1_1	555	559	PF00082	0.437
DEG_APCC_DBOX_1	54	62	PF00400	0.507
DEG_Nend_UBRbox_4	1	3	PF02207	0.453
DEG_SCF_FBW7_1	209	214	PF00400	0.653
DEG_SPOP_SBC_1	172	176	PF00917	0.604
DEG_SPOP_SBC_1	217	221	PF00917	0.670
DEG_SPOP_SBC_1	403	407	PF00917	0.650
DOC_CKS1_1	188	193	PF01111	0.508
DOC_CKS1_1	360	365	PF01111	0.569
DOC_CYCLIN_RxL_1	551	561	PF00134	0.441
DOC_MAPK_gen_1	121	128	PF00069	0.426
DOC_MAPK_gen_1	445	452	PF00069	0.653
DOC_PP1_RVXF_1	446	453	PF00149	0.493
DOC_PP1_RVXF_1	99	106	PF00149	0.439
DOC_PP2B_LxvP_1	539	542	PF13499	0.503
DOC_PP4_FxxP_1	188	191	PF00568	0.504
DOC_USP7_MATH_1	151	155	PF00917	0.602
DOC_USP7_MATH_1	171	175	PF00917	0.681
DOC_USP7_MATH_1	211	215	PF00917	0.671
DOC_USP7_MATH_1	224	228	PF00917	0.776
DOC_USP7_MATH_1	345	349	PF00917	0.536
DOC_USP7_MATH_1	375	379	PF00917	0.669
DOC_USP7_MATH_1	431	435	PF00917	0.566
DOC_USP7_MATH_1	530	534	PF00917	0.505
DOC_USP7_MATH_1	88	92	PF00917	0.466
DOC_USP7_UBL2_3	551	555	PF12436	0.550
DOC_WW_Pin1_4	156	161	PF00397	0.653
DOC_WW_Pin1_4	187	192	PF00397	0.710
DOC_WW_Pin1_4	207	212	PF00397	0.677
DOC_WW_Pin1_4	213	218	PF00397	0.705
DOC_WW_Pin1_4	220	225	PF00397	0.537
DOC_WW_Pin1_4	312	317	PF00397	0.524
DOC_WW_Pin1_4	359	364	PF00397	0.611
DOC_WW_Pin1_4	391	396	PF00397	0.558
DOC_WW_Pin1_4	404	409	PF00397	0.500
DOC_WW_Pin1_4	427	432	PF00397	0.622
DOC_WW_Pin1_4	440	445	PF00397	0.491
LIG_14-3-3_CanoR_1	272	279	PF00244	0.516
LIG_14-3-3_CanoR_1	292	300	PF00244	0.359
LIG_14-3-3_CanoR_1	303	313	PF00244	0.630
LIG_14-3-3_CanoR_1	503	507	PF00244	0.535
LIG_14-3-3_CanoR_1	554	558	PF00244	0.402
LIG_Actin_WH2_2	14	32	PF00022	0.219
LIG_Clathr_ClatBox_1	253	257	PF01394	0.435
LIG_EH1_1	505	513	PF00400	0.579
LIG_EVH1_1	539	543	PF00568	0.502
LIG_FHA_1	108	114	PF00498	0.563
LIG_FHA_1	224	230	PF00498	0.669
LIG_FHA_1	326	332	PF00498	0.499
LIG_FHA_1	379	385	PF00498	0.707
LIG_FHA_1	419	425	PF00498	0.562
LIG_FHA_1	43	49	PF00498	0.506
LIG_FHA_1	503	509	PF00498	0.586
LIG_FHA_1	73	79	PF00498	0.463
LIG_FHA_2	11	17	PF00498	0.462
LIG_FHA_2	238	244	PF00498	0.494
LIG_FHA_2	247	253	PF00498	0.409
LIG_FHA_2	360	366	PF00498	0.569
LIG_FHA_2	39	45	PF00498	0.517
LIG_FHA_2	423	429	PF00498	0.506
LIG_FHA_2	476	482	PF00498	0.507
LIG_FHA_2	505	511	PF00498	0.508
LIG_LIR_Apic_2	186	191	PF02991	0.503
LIG_LIR_Gen_1	16	22	PF02991	0.454
LIG_LIR_Gen_1	240	248	PF02991	0.370
LIG_LIR_Gen_1	365	375	PF02991	0.503
LIG_LIR_Gen_1	38	46	PF02991	0.463
LIG_LIR_Nem_3	16	21	PF02991	0.459
LIG_LIR_Nem_3	240	245	PF02991	0.389
LIG_LIR_Nem_3	365	371	PF02991	0.497
LIG_LIR_Nem_3	38	42	PF02991	0.463
LIG_PCNA_yPIPBox_3	135	148	PF02747	0.521
LIG_PDZ_Class_3	562	567	PF00595	0.601
LIG_SH2_CRK	360	364	PF00017	0.627
LIG_SH2_CRK	39	43	PF00017	0.463
LIG_SH2_STAP1	233	237	PF00017	0.428
LIG_SH2_STAT5	18	21	PF00017	0.455
LIG_SH2_STAT5	269	272	PF00017	0.435
LIG_SH2_STAT5	458	461	PF00017	0.467
LIG_SH2_STAT5	506	509	PF00017	0.683
LIG_SH3_3	191	197	PF00018	0.577
LIG_SH3_3	310	316	PF00018	0.550
LIG_SH3_3	468	474	PF00018	0.588
LIG_SH3_3	492	498	PF00018	0.539
LIG_SH3_3	537	543	PF00018	0.552
LIG_SH3_3	54	60	PF00018	0.463
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.506
LIG_SUMO_SIM_par_1	249	257	PF11976	0.441
LIG_SUMO_SIM_par_1	77	84	PF11976	0.465
LIG_TRAF2_1	122	125	PF00917	0.500
LIG_WRC_WIRS_1	202	207	PF05994	0.507
LIG_WRC_WIRS_1	239	244	PF05994	0.524
MOD_CDC14_SPxK_1	443	446	PF00782	0.506
MOD_CDK_SPK_2	440	445	PF00069	0.514
MOD_CDK_SPxK_1	440	446	PF00069	0.514
MOD_CK1_1	156	162	PF00069	0.782
MOD_CK1_1	175	181	PF00069	0.534
MOD_CK1_1	204	210	PF00069	0.736
MOD_CK1_1	220	226	PF00069	0.739
MOD_CK1_1	304	310	PF00069	0.597
MOD_CK1_1	315	321	PF00069	0.571
MOD_CK1_1	348	354	PF00069	0.594
MOD_CK1_1	378	384	PF00069	0.616
MOD_CK1_1	389	395	PF00069	0.708
MOD_CK1_1	406	412	PF00069	0.655
MOD_CK1_1	435	441	PF00069	0.664
MOD_CK1_1	490	496	PF00069	0.524
MOD_CK1_1	504	510	PF00069	0.459
MOD_CK2_1	10	16	PF00069	0.450
MOD_CK2_1	171	177	PF00069	0.627
MOD_CK2_1	238	244	PF00069	0.488
MOD_CK2_1	246	252	PF00069	0.417
MOD_CK2_1	391	397	PF00069	0.714
MOD_CK2_1	475	481	PF00069	0.596
MOD_CK2_1	530	536	PF00069	0.504
MOD_Cter_Amidation	99	102	PF01082	0.263
MOD_GlcNHglycan	180	183	PF01048	0.692
MOD_GlcNHglycan	226	229	PF01048	0.670
MOD_GlcNHglycan	294	297	PF01048	0.549
MOD_GlcNHglycan	318	321	PF01048	0.674
MOD_GlcNHglycan	377	380	PF01048	0.687
MOD_GlcNHglycan	388	391	PF01048	0.548
MOD_GlcNHglycan	408	411	PF01048	0.646
MOD_GlcNHglycan	414	417	PF01048	0.732
MOD_GlcNHglycan	435	438	PF01048	0.665
MOD_GlcNHglycan	478	481	PF01048	0.720
MOD_GlcNHglycan	536	539	PF01048	0.520
MOD_GlcNHglycan	89	93	PF01048	0.263
MOD_GSK3_1	171	178	PF00069	0.620
MOD_GSK3_1	207	214	PF00069	0.709
MOD_GSK3_1	216	223	PF00069	0.708
MOD_GSK3_1	311	318	PF00069	0.624
MOD_GSK3_1	337	344	PF00069	0.599
MOD_GSK3_1	345	352	PF00069	0.598
MOD_GSK3_1	366	373	PF00069	0.631
MOD_GSK3_1	38	45	PF00069	0.517
MOD_GSK3_1	402	409	PF00069	0.621
MOD_GSK3_1	418	425	PF00069	0.597
MOD_GSK3_1	427	434	PF00069	0.641
MOD_GSK3_1	497	504	PF00069	0.642
MOD_GSK3_1	530	537	PF00069	0.680
MOD_GSK3_1	549	556	PF00069	0.495
MOD_N-GLC_1	72	77	PF02516	0.306
MOD_NEK2_1	370	375	PF00069	0.678
MOD_NEK2_1	42	47	PF00069	0.506
MOD_NEK2_1	501	506	PF00069	0.647
MOD_NEK2_1	549	554	PF00069	0.568
MOD_NEK2_1	72	77	PF00069	0.463
MOD_PIKK_1	153	159	PF00454	0.663
MOD_PIKK_1	166	172	PF00454	0.692
MOD_PKA_1	107	113	PF00069	0.474
MOD_PKA_1	144	150	PF00069	0.520
MOD_PKA_1	292	298	PF00069	0.397
MOD_PKA_1	553	559	PF00069	0.410
MOD_PKA_2	107	113	PF00069	0.563
MOD_PKA_2	291	297	PF00069	0.552
MOD_PKA_2	348	354	PF00069	0.518
MOD_PKA_2	502	508	PF00069	0.633
MOD_PKA_2	553	559	PF00069	0.412
MOD_Plk_1	231	237	PF00069	0.637
MOD_Plk_1	345	351	PF00069	0.567
MOD_Plk_1	88	94	PF00069	0.498
MOD_Plk_2-3	246	252	PF00069	0.434
MOD_Plk_2-3	38	44	PF00069	0.517
MOD_Plk_4	408	414	PF00069	0.492
MOD_Plk_4	497	503	PF00069	0.641
MOD_Plk_4	553	559	PF00069	0.443
MOD_Plk_4	74	80	PF00069	0.506
MOD_ProDKin_1	156	162	PF00069	0.654
MOD_ProDKin_1	187	193	PF00069	0.710
MOD_ProDKin_1	207	213	PF00069	0.678
MOD_ProDKin_1	220	226	PF00069	0.536
MOD_ProDKin_1	312	318	PF00069	0.527
MOD_ProDKin_1	359	365	PF00069	0.612
MOD_ProDKin_1	391	397	PF00069	0.560
MOD_ProDKin_1	404	410	PF00069	0.501
MOD_ProDKin_1	427	433	PF00069	0.623
MOD_ProDKin_1	440	446	PF00069	0.491
MOD_SUMO_for_1	122	125	PF00179	0.500
MOD_SUMO_for_1	143	146	PF00179	0.383
MOD_SUMO_for_1	280	283	PF00179	0.471
TRG_ENDOCYTIC_2	18	21	PF00928	0.455
TRG_ENDOCYTIC_2	39	42	PF00928	0.463
TRG_ER_diArg_1	101	103	PF00400	0.488
TRG_ER_diArg_1	106	108	PF00400	0.496
TRG_ER_diArg_1	284	287	PF00400	0.476
TRG_ER_diArg_1	29	31	PF00400	0.487
TRG_ER_diArg_1	52	55	PF00400	0.463
TRG_NLS_MonoExtN_4	551	557	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M6	Leptomonas seymouri	46%	100%
A0A3R7KPD3	Trypanosoma rangeli	36%	100%
A0A3S7X5Y7	Leishmania donovani	70%	99%
A4I8A5	Leishmania infantum	70%	99%
E9B363	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q4Z1	Leishmania major	68%	100%