Putative proteasome regulatory non-ATP-ase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKS3_LEIBR

TriTrypDb:

LbrM.32.3060 , LBRM2903_320038500

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12

Expansion

Sequence features

A4HKS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.431
CLV_C14_Caspase3-7	367	371	PF00656	0.516
CLV_NRD_NRD_1	197	199	PF00675	0.213
CLV_NRD_NRD_1	259	261	PF00675	0.496
CLV_NRD_NRD_1	301	303	PF00675	0.295
CLV_PCSK_KEX2_1	197	199	PF00082	0.231
CLV_PCSK_KEX2_1	258	260	PF00082	0.328
CLV_PCSK_PC7_1	254	260	PF00082	0.157
CLV_PCSK_SKI1_1	123	127	PF00082	0.309
CLV_PCSK_SKI1_1	181	185	PF00082	0.255
CLV_PCSK_SKI1_1	188	192	PF00082	0.182
CLV_PCSK_SKI1_1	387	391	PF00082	0.351
CLV_PCSK_SKI1_1	60	64	PF00082	0.464
DEG_SPOP_SBC_1	49	53	PF00917	0.606
DOC_MAPK_gen_1	166	173	PF00069	0.516
DOC_MAPK_gen_1	197	203	PF00069	0.413
DOC_MAPK_gen_1	387	396	PF00069	0.374
DOC_MAPK_MEF2A_6	166	173	PF00069	0.423
DOC_MAPK_MEF2A_6	289	296	PF00069	0.553
DOC_MAPK_MEF2A_6	69	78	PF00069	0.565
DOC_PP1_RVXF_1	317	324	PF00149	0.413
DOC_PP2B_LxvP_1	83	86	PF13499	0.568
DOC_PP4_FxxP_1	342	345	PF00568	0.413
DOC_USP7_MATH_1	309	313	PF00917	0.516
DOC_USP7_MATH_1	348	352	PF00917	0.510
DOC_USP7_MATH_1	49	53	PF00917	0.606
DOC_WW_Pin1_4	261	266	PF00397	0.343
DOC_WW_Pin1_4	305	310	PF00397	0.516
DOC_WW_Pin1_4	45	50	PF00397	0.595
LIG_14-3-3_CanoR_1	269	273	PF00244	0.297
LIG_14-3-3_CanoR_1	43	49	PF00244	0.420
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BRCT_BRCA1_1	311	315	PF00533	0.536
LIG_FAT_LD_1	349	357	PF03623	0.423
LIG_FHA_1	322	328	PF00498	0.437
LIG_FHA_2	143	149	PF00498	0.516
LIG_FHA_2	234	240	PF00498	0.510
LIG_FHA_2	268	274	PF00498	0.441
LIG_FHA_2	379	385	PF00498	0.384
LIG_Integrin_RGD_1	377	379	PF01839	0.429
LIG_LIR_Gen_1	131	141	PF02991	0.423
LIG_LIR_Gen_1	161	172	PF02991	0.413
LIG_LIR_Gen_1	205	215	PF02991	0.457
LIG_LIR_Gen_1	236	245	PF02991	0.442
LIG_LIR_Gen_1	284	294	PF02991	0.466
LIG_LIR_Gen_1	328	338	PF02991	0.413
LIG_LIR_Gen_1	384	389	PF02991	0.354
LIG_LIR_Nem_3	131	136	PF02991	0.423
LIG_LIR_Nem_3	161	167	PF02991	0.413
LIG_LIR_Nem_3	205	211	PF02991	0.414
LIG_LIR_Nem_3	236	240	PF02991	0.434
LIG_LIR_Nem_3	284	290	PF02991	0.445
LIG_LIR_Nem_3	328	333	PF02991	0.413
LIG_LIR_Nem_3	384	388	PF02991	0.358
LIG_MLH1_MIPbox_1	311	315	PF16413	0.536
LIG_Pex14_2	211	215	PF04695	0.423
LIG_PTB_Apo_2	277	284	PF02174	0.431
LIG_PTB_Phospho_1	277	283	PF10480	0.431
LIG_REV1ctd_RIR_1	312	320	PF16727	0.419
LIG_SH2_CRK	133	137	PF00017	0.480
LIG_SH2_CRK	287	291	PF00017	0.516
LIG_SH2_CRK	330	334	PF00017	0.413
LIG_SH2_CRK	385	389	PF00017	0.356
LIG_SH2_NCK_1	133	137	PF00017	0.480
LIG_SH2_NCK_1	287	291	PF00017	0.516
LIG_SH2_NCK_1	330	334	PF00017	0.413
LIG_SH2_PTP2	75	78	PF00017	0.456
LIG_SH2_STAP1	283	287	PF00017	0.480
LIG_SH2_STAT3	283	286	PF00017	0.536
LIG_SH2_STAT5	163	166	PF00017	0.516
LIG_SH2_STAT5	306	309	PF00017	0.429
LIG_SH2_STAT5	313	316	PF00017	0.408
LIG_SH2_STAT5	41	44	PF00017	0.405
LIG_SH2_STAT5	75	78	PF00017	0.449
LIG_SH3_3	1	7	PF00018	0.617
LIG_SH3_3	259	265	PF00018	0.409
LIG_SH3_3	29	35	PF00018	0.491
LIG_TRAF2_1	145	148	PF00917	0.516
LIG_TRAF2_1	236	239	PF00917	0.357
LIG_TRAF2_1	52	55	PF00917	0.588
LIG_UBA3_1	395	401	PF00899	0.335
LIG_UBA3_1	63	69	PF00899	0.486
LIG_WRC_WIRS_1	226	231	PF05994	0.248
LIG_WRC_WIRS_1	234	239	PF05994	0.248
LIG_WW_3	5	9	PF00397	0.609
MOD_CK1_1	225	231	PF00069	0.248
MOD_CK1_1	329	335	PF00069	0.248
MOD_CK1_1	372	378	PF00069	0.361
MOD_CK1_1	48	54	PF00069	0.536
MOD_CK2_1	142	148	PF00069	0.342
MOD_CK2_1	233	239	PF00069	0.354
MOD_CK2_1	250	256	PF00069	0.263
MOD_CK2_1	48	54	PF00069	0.526
MOD_GlcNHglycan	218	221	PF01048	0.369
MOD_GlcNHglycan	230	233	PF01048	0.337
MOD_GlcNHglycan	390	393	PF01048	0.498
MOD_GSK3_1	224	231	PF00069	0.243
MOD_GSK3_1	241	248	PF00069	0.388
MOD_GSK3_1	305	312	PF00069	0.392
MOD_GSK3_1	348	355	PF00069	0.342
MOD_GSK3_1	44	51	PF00069	0.490
MOD_N-GLC_1	267	272	PF02516	0.434
MOD_NEK2_1	222	227	PF00069	0.268
MOD_NEK2_1	278	283	PF00069	0.342
MOD_NEK2_1	321	326	PF00069	0.274
MOD_NEK2_1	352	357	PF00069	0.290
MOD_NEK2_1	87	92	PF00069	0.360
MOD_PIKK_1	321	327	PF00454	0.320
MOD_PKA_2	216	222	PF00069	0.326
MOD_PKA_2	268	274	PF00069	0.316
MOD_PKA_2	42	48	PF00069	0.427
MOD_Plk_1	267	273	PF00069	0.290
MOD_Plk_2-3	233	239	PF00069	0.392
MOD_Plk_4	278	284	PF00069	0.342
MOD_Plk_4	309	315	PF00069	0.392
MOD_Plk_4	348	354	PF00069	0.257
MOD_Plk_4	35	41	PF00069	0.518
MOD_ProDKin_1	261	267	PF00069	0.341
MOD_ProDKin_1	305	311	PF00069	0.392
MOD_ProDKin_1	45	51	PF00069	0.593
MOD_SUMO_rev_2	88	93	PF00179	0.307
TRG_DiLeu_BaEn_1	317	322	PF01217	0.263
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.410
TRG_ENDOCYTIC_2	133	136	PF00928	0.342
TRG_ENDOCYTIC_2	204	207	PF00928	0.248
TRG_ENDOCYTIC_2	208	211	PF00928	0.248
TRG_ENDOCYTIC_2	287	290	PF00928	0.272
TRG_ENDOCYTIC_2	330	333	PF00928	0.248
TRG_ENDOCYTIC_2	385	388	PF00928	0.361
TRG_ENDOCYTIC_2	75	78	PF00928	0.389
TRG_ER_diArg_1	166	169	PF00400	0.342
TRG_ER_diArg_1	197	200	PF00400	0.249
TRG_ER_diArg_1	257	260	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z9	Leptomonas seymouri	88%	100%
A0A0S4IM85	Bodo saltans	61%	100%
A0A1X0NRP1	Trypanosomatidae	68%	100%
A0A3Q8IJI2	Leishmania donovani	96%	100%
A0A3R7NSJ6	Trypanosoma rangeli	68%	100%
A4I8A3	Leishmania infantum	97%	100%
D0AAH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B361	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P97834	Rattus norvegicus	22%	87%
Q06103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	95%
Q10335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q15008	Homo sapiens	38%	100%
Q20585	Caenorhabditis elegans	36%	100%
Q3T0B2	Bos taurus	37%	100%
Q4Q4Z3	Leishmania major	97%	100%
Q54QX3	Dictyostelium discoideum	21%	89%
Q55C75	Dictyostelium discoideum	36%	100%
Q8W425	Oryza sativa subsp. japonica	38%	100%
Q93Y35	Arabidopsis thaliana	37%	100%
Q99JI4	Mus musculus	37%	100%
Q99LD4	Mus musculus	23%	87%
Q9V3G7	Drosophila melanogaster	38%	100%
Q9VVU5	Drosophila melanogaster	21%	78%
V5AXY2	Trypanosoma cruzi	69%	100%