Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKS2_LEIBR

TriTrypDb:

LbrM.32.3050 , LBRM2903_320038300 , LBRM2903_320038400

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.602
CLV_NRD_NRD_1	15	17	PF00675	0.466
CLV_NRD_NRD_1	24	26	PF00675	0.445
CLV_NRD_NRD_1	248	250	PF00675	0.621
CLV_NRD_NRD_1	292	294	PF00675	0.341
CLV_NRD_NRD_1	324	326	PF00675	0.503
CLV_NRD_NRD_1	398	400	PF00675	0.381
CLV_NRD_NRD_1	60	62	PF00675	0.601
CLV_NRD_NRD_1	7	9	PF00675	0.534
CLV_PCSK_KEX2_1	138	140	PF00082	0.215
CLV_PCSK_KEX2_1	200	202	PF00082	0.451
CLV_PCSK_KEX2_1	247	249	PF00082	0.482
CLV_PCSK_KEX2_1	324	326	PF00082	0.503
CLV_PCSK_KEX2_1	398	400	PF00082	0.383
CLV_PCSK_KEX2_1	443	445	PF00082	0.419
CLV_PCSK_KEX2_1	57	59	PF00082	0.589
CLV_PCSK_KEX2_1	62	64	PF00082	0.587
CLV_PCSK_KEX2_1	7	9	PF00082	0.533
CLV_PCSK_KEX2_1	80	82	PF00082	0.471
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.289
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.451
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.482
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.407
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.589
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.587
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.550
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.471
CLV_PCSK_PC7_1	58	64	PF00082	0.605
CLV_PCSK_SKI1_1	138	142	PF00082	0.209
CLV_PCSK_SKI1_1	316	320	PF00082	0.383
CLV_PCSK_SKI1_1	324	328	PF00082	0.347
CLV_PCSK_SKI1_1	354	358	PF00082	0.209
CLV_PCSK_SKI1_1	40	44	PF00082	0.558
CLV_PCSK_SKI1_1	419	423	PF00082	0.500
CLV_PCSK_SKI1_1	8	12	PF00082	0.596
DEG_APCC_DBOX_1	39	47	PF00400	0.393
DOC_CYCLIN_RxL_1	112	123	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.421
DOC_MAPK_gen_1	221	230	PF00069	0.514
DOC_MAPK_gen_1	398	404	PF00069	0.333
DOC_MAPK_MEF2A_6	40	48	PF00069	0.396
DOC_MAPK_RevD_3	44	58	PF00069	0.441
DOC_PP2B_LxvP_1	267	270	PF13499	0.373
DOC_PP2B_LxvP_1	436	439	PF13499	0.419
DOC_USP7_MATH_1	10	14	PF00917	0.537
DOC_USP7_MATH_1	363	367	PF00917	0.420
DOC_USP7_MATH_1	442	446	PF00917	0.474
DOC_USP7_UBL2_3	247	251	PF12436	0.494
DOC_USP7_UBL2_3	3	7	PF12436	0.631
DOC_USP7_UBL2_3	31	35	PF12436	0.495
DOC_WW_Pin1_4	132	137	PF00397	0.416
DOC_WW_Pin1_4	8	13	PF00397	0.499
LIG_14-3-3_CanoR_1	146	152	PF00244	0.445
LIG_14-3-3_CanoR_1	308	312	PF00244	0.378
LIG_14-3-3_CanoR_1	316	323	PF00244	0.382
LIG_14-3-3_CanoR_1	399	405	PF00244	0.309
LIG_14-3-3_CterR_2	444	446	PF00244	0.412
LIG_Actin_WH2_2	408	424	PF00022	0.566
LIG_AP2alpha_2	215	217	PF02296	0.356
LIG_BRCT_BRCA1_1	299	303	PF00533	0.374
LIG_CaM_IQ_9	409	424	PF13499	0.362
LIG_FHA_1	152	158	PF00498	0.431
LIG_FHA_1	189	195	PF00498	0.483
LIG_FHA_1	360	366	PF00498	0.512
LIG_FHA_1	39	45	PF00498	0.390
LIG_FHA_1	407	413	PF00498	0.376
LIG_FHA_2	119	125	PF00498	0.421
LIG_FHA_2	315	321	PF00498	0.391
LIG_LIR_Gen_1	222	231	PF02991	0.391
LIG_LIR_Nem_3	132	137	PF02991	0.417
LIG_LIR_Nem_3	222	228	PF02991	0.409
LIG_LIR_Nem_3	366	372	PF02991	0.429
LIG_MLH1_MIPbox_1	299	303	PF16413	0.503
LIG_Pex14_2	130	134	PF04695	0.410
LIG_PTB_Apo_2	296	303	PF02174	0.499
LIG_REV1ctd_RIR_1	215	225	PF16727	0.255
LIG_REV1ctd_RIR_1	300	310	PF16727	0.241
LIG_SH2_CRK	350	354	PF00017	0.420
LIG_SH2_STAT3	171	174	PF00017	0.509
LIG_SH2_STAT3	261	264	PF00017	0.373
LIG_SH2_STAT5	129	132	PF00017	0.512
LIG_SH2_STAT5	261	264	PF00017	0.339
LIG_SH2_STAT5	282	285	PF00017	0.399
LIG_SH2_STAT5	334	337	PF00017	0.456
LIG_SH3_3	210	216	PF00018	0.544
LIG_TRAF2_1	121	124	PF00917	0.435
LIG_WRC_WIRS_1	401	406	PF05994	0.306
MOD_CDC14_SPxK_1	135	138	PF00782	0.256
MOD_CDK_SPxK_1	132	138	PF00069	0.256
MOD_CDK_SPxxK_3	132	139	PF00069	0.256
MOD_CK1_1	66	72	PF00069	0.547
MOD_CK2_1	118	124	PF00069	0.247
MOD_CK2_1	314	320	PF00069	0.381
MOD_GlcNHglycan	151	154	PF01048	0.282
MOD_GlcNHglycan	160	163	PF01048	0.326
MOD_GlcNHglycan	178	182	PF01048	0.382
MOD_GlcNHglycan	240	243	PF01048	0.464
MOD_GlcNHglycan	271	274	PF01048	0.458
MOD_GlcNHglycan	65	68	PF01048	0.732
MOD_GSK3_1	125	132	PF00069	0.384
MOD_GSK3_1	145	152	PF00069	0.119
MOD_GSK3_1	188	195	PF00069	0.483
MOD_GSK3_1	229	236	PF00069	0.455
MOD_GSK3_1	359	366	PF00069	0.261
MOD_N-GLC_2	408	410	PF02516	0.251
MOD_NEK2_1	151	156	PF00069	0.258
MOD_NEK2_1	220	225	PF00069	0.432
MOD_NEK2_1	297	302	PF00069	0.403
MOD_NEK2_1	359	364	PF00069	0.390
MOD_NEK2_1	400	405	PF00069	0.319
MOD_NEK2_2	2	7	PF00069	0.600
MOD_NEK2_2	380	385	PF00069	0.340
MOD_PIKK_1	107	113	PF00454	0.426
MOD_PIKK_1	233	239	PF00454	0.461
MOD_PKA_1	247	253	PF00069	0.503
MOD_PKA_1	57	63	PF00069	0.635
MOD_PKA_2	145	151	PF00069	0.308
MOD_PKA_2	220	226	PF00069	0.346
MOD_PKA_2	247	253	PF00069	0.385
MOD_PKA_2	307	313	PF00069	0.387
MOD_PKA_2	57	63	PF00069	0.484
MOD_PKB_1	61	69	PF00069	0.722
MOD_Plk_1	177	183	PF00069	0.507
MOD_Plk_1	73	79	PF00069	0.700
MOD_Plk_2-3	89	95	PF00069	0.545
MOD_Plk_4	125	131	PF00069	0.390
MOD_Plk_4	207	213	PF00069	0.598
MOD_Plk_4	389	395	PF00069	0.365
MOD_ProDKin_1	132	138	PF00069	0.256
MOD_ProDKin_1	8	14	PF00069	0.492
MOD_SUMO_rev_2	180	189	PF00179	0.589
TRG_DiLeu_BaEn_2	108	114	PF01217	0.405
TRG_ENDOCYTIC_2	282	285	PF00928	0.362
TRG_ENDOCYTIC_2	350	353	PF00928	0.261
TRG_ENDOCYTIC_2	369	372	PF00928	0.246
TRG_ER_diArg_1	143	146	PF00400	0.272
TRG_ER_diArg_1	323	325	PF00400	0.487
TRG_ER_diArg_1	398	400	PF00400	0.327
TRG_ER_diArg_1	61	64	PF00400	0.637
TRG_ER_diLys_1	441	446	PF00400	0.570
TRG_NLS_Bipartite_1	7	21	PF00514	0.486
TRG_NLS_MonoCore_2	15	20	PF00514	0.477
TRG_NLS_MonoCore_2	244	249	PF00514	0.484
TRG_NLS_MonoCore_2	61	66	PF00514	0.496
TRG_NLS_MonoExtC_3	244	249	PF00514	0.468
TRG_NLS_MonoExtC_3	60	65	PF00514	0.583
TRG_NLS_MonoExtN_4	16	21	PF00514	0.473
TRG_NLS_MonoExtN_4	245	251	PF00514	0.476
TRG_NLS_MonoExtN_4	31	38	PF00514	0.565
TRG_NLS_MonoExtN_4	58	65	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M4	Leptomonas seymouri	85%	100%
A0A0S4IWT2	Bodo saltans	55%	100%
A0A1X0NSA9	Trypanosomatidae	63%	100%
A0A3Q8IG48	Leishmania donovani	89%	100%
A0A3R7N0S8	Trypanosoma rangeli	62%	100%
A4I8A2	Leishmania infantum	89%	100%
D0AAH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B360	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O74400	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	66%
Q4Q4Z4	Leishmania major	88%	100%
V5BDC2	Trypanosoma cruzi	63%	92%