Exonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKS0_LEIBR

TriTrypDb:

LbrM.32.3030 , LBRM2903_320038100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKS0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004527	exonuclease activity	5	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.226
CLV_PCSK_KEX2_1	130	132	PF00082	0.226
CLV_PCSK_SKI1_1	130	134	PF00082	0.164
DOC_CKS1_1	30	35	PF01111	0.524
DOC_PP2B_LxvP_1	11	14	PF13499	0.590
DOC_PP4_FxxP_1	219	222	PF00568	0.426
DOC_USP7_MATH_1	22	26	PF00917	0.762
DOC_USP7_MATH_1	34	38	PF00917	0.569
DOC_WW_Pin1_4	18	23	PF00397	0.642
DOC_WW_Pin1_4	29	34	PF00397	0.718
DOC_WW_Pin1_4	60	65	PF00397	0.396
DOC_WW_Pin1_4	77	82	PF00397	0.442
LIG_14-3-3_CanoR_1	130	139	PF00244	0.426
LIG_14-3-3_CanoR_1	84	88	PF00244	0.459
LIG_Actin_WH2_2	65	80	PF00022	0.343
LIG_BIR_III_2	92	96	PF00653	0.479
LIG_CSL_BTD_1	219	222	PF09270	0.401
LIG_DCNL_PONY_1	1	4	PF03556	0.421
LIG_deltaCOP1_diTrp_1	110	120	PF00928	0.315
LIG_FHA_1	172	178	PF00498	0.512
LIG_FHA_1	271	277	PF00498	0.426
LIG_FHA_1	30	36	PF00498	0.547
LIG_FHA_1	6	12	PF00498	0.681
LIG_FHA_2	63	69	PF00498	0.386
LIG_GBD_Chelix_1	156	164	PF00786	0.257
LIG_LIR_Gen_1	143	152	PF02991	0.414
LIG_LIR_Gen_1	229	240	PF02991	0.431
LIG_LIR_Nem_3	143	147	PF02991	0.414
LIG_LIR_Nem_3	229	235	PF02991	0.414
LIG_LYPXL_yS_3	237	240	PF13949	0.457
LIG_NRBOX	271	277	PF00104	0.426
LIG_Pex14_1	220	224	PF04695	0.457
LIG_Pex14_1	284	288	PF04695	0.565
LIG_Pex14_2	202	206	PF04695	0.391
LIG_RPA_C_Fungi	200	212	PF08784	0.184
LIG_SH2_CRK	163	167	PF00017	0.306
LIG_SH2_PTP2	123	126	PF00017	0.315
LIG_SH2_STAT5	123	126	PF00017	0.315
LIG_SH2_STAT6	215	219	PF00017	0.271
LIG_SH3_1	123	129	PF00018	0.315
LIG_SH3_2	126	131	PF14604	0.271
LIG_SH3_3	123	129	PF00018	0.254
LIG_SH3_3	187	193	PF00018	0.257
LIG_SH3_3	219	225	PF00018	0.418
LIG_SH3_3	232	238	PF00018	0.239
LIG_SH3_3	27	33	PF00018	0.699
LIG_SH3_3	92	98	PF00018	0.563
LIG_SUMO_SIM_par_1	53	60	PF11976	0.401
LIG_TYR_ITIM	161	166	PF00017	0.271
LIG_TYR_ITIM	235	240	PF00017	0.271
MOD_CDK_SPxxK_3	77	84	PF00069	0.318
MOD_CK1_1	39	45	PF00069	0.545
MOD_CK1_1	82	88	PF00069	0.520
MOD_CK2_1	62	68	PF00069	0.400
MOD_GlcNHglycan	187	190	PF01048	0.184
MOD_GlcNHglycan	36	39	PF01048	0.616
MOD_GlcNHglycan	41	44	PF01048	0.513
MOD_GlcNHglycan	46	49	PF01048	0.342
MOD_GSK3_1	130	137	PF00069	0.219
MOD_GSK3_1	18	25	PF00069	0.631
MOD_GSK3_1	44	51	PF00069	0.419
MOD_GSK3_1	56	63	PF00069	0.231
MOD_GSK3_1	79	86	PF00069	0.453
MOD_LATS_1	128	134	PF00433	0.184
MOD_NEK2_1	173	178	PF00069	0.289
MOD_NEK2_1	226	231	PF00069	0.300
MOD_NEK2_1	5	10	PF00069	0.542
MOD_NEK2_1	57	62	PF00069	0.342
MOD_OFUCOSY	45	52	PF10250	0.432
MOD_PKA_1	130	136	PF00069	0.324
MOD_PKA_2	124	130	PF00069	0.254
MOD_PKA_2	258	264	PF00069	0.184
MOD_PKA_2	282	288	PF00069	0.479
MOD_PKA_2	83	89	PF00069	0.451
MOD_Plk_1	268	274	PF00069	0.271
MOD_Plk_4	162	168	PF00069	0.200
MOD_ProDKin_1	18	24	PF00069	0.644
MOD_ProDKin_1	29	35	PF00069	0.717
MOD_ProDKin_1	60	66	PF00069	0.399
MOD_ProDKin_1	77	83	PF00069	0.458
TRG_ENDOCYTIC_2	163	166	PF00928	0.306
TRG_ENDOCYTIC_2	216	219	PF00928	0.271
TRG_ENDOCYTIC_2	237	240	PF00928	0.356
TRG_ER_diArg_1	129	131	PF00400	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBJ5	Leptomonas seymouri	42%	72%
D0AAH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
E9B358	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	84%
Q9CPE0	Pasteurella multocida (strain Pm70)	26%	100%
V5BHY6	Trypanosoma cruzi	34%	100%