Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP109

Species:

Leishmania braziliensis

UniProt:

A4HKR9_LEIBR

TriTrypDb:

LbrM.32.3020 , LBRM2903_320038000

Length:

1092

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HKR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	274	280	PF00089	0.418
CLV_NRD_NRD_1	5	7	PF00675	0.539
CLV_NRD_NRD_1	617	619	PF00675	0.638
CLV_PCSK_KEX2_1	312	314	PF00082	0.530
CLV_PCSK_KEX2_1	4	6	PF00082	0.561
CLV_PCSK_KEX2_1	617	619	PF00082	0.627
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.514
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.619
CLV_PCSK_PC7_1	613	619	PF00082	0.415
CLV_PCSK_SKI1_1	115	119	PF00082	0.501
CLV_PCSK_SKI1_1	5	9	PF00082	0.528
CLV_PCSK_SKI1_1	557	561	PF00082	0.336
CLV_PCSK_SKI1_1	586	590	PF00082	0.415
CLV_PCSK_SKI1_1	930	934	PF00082	0.518
CLV_Separin_Metazoa	831	835	PF03568	0.462
DEG_SCF_FBW7_1	92	97	PF00400	0.426
DEG_SPOP_SBC_1	1072	1076	PF00917	0.716
DOC_CYCLIN_RxL_1	267	276	PF00134	0.370
DOC_CYCLIN_RxL_1	927	937	PF00134	0.521
DOC_MAPK_gen_1	586	594	PF00069	0.449
DOC_MAPK_gen_1	707	717	PF00069	0.427
DOC_MAPK_gen_1	885	894	PF00069	0.339
DOC_MAPK_MEF2A_6	137	144	PF00069	0.443
DOC_MAPK_MEF2A_6	161	168	PF00069	0.602
DOC_MAPK_MEF2A_6	885	894	PF00069	0.449
DOC_MAPK_NFAT4_5	137	145	PF00069	0.445
DOC_PP1_RVXF_1	113	120	PF00149	0.509
DOC_PP1_RVXF_1	141	147	PF00149	0.441
DOC_PP1_RVXF_1	284	290	PF00149	0.507
DOC_PP2B_LxvP_1	272	275	PF13499	0.515
DOC_PP2B_LxvP_1	49	52	PF13499	0.631
DOC_PP2B_LxvP_1	762	765	PF13499	0.507
DOC_PP2B_LxvP_1	770	773	PF13499	0.438
DOC_PP2B_LxvP_1	971	974	PF13499	0.597
DOC_PP4_FxxP_1	474	477	PF00568	0.508
DOC_PP4_FxxP_1	717	720	PF00568	0.420
DOC_USP7_MATH_1	1012	1016	PF00917	0.661
DOC_USP7_MATH_1	1068	1072	PF00917	0.748
DOC_USP7_MATH_1	1073	1077	PF00917	0.703
DOC_USP7_MATH_1	126	130	PF00917	0.504
DOC_USP7_MATH_1	24	28	PF00917	0.556
DOC_USP7_MATH_1	245	249	PF00917	0.681
DOC_USP7_MATH_1	341	345	PF00917	0.674
DOC_USP7_MATH_1	360	364	PF00917	0.446
DOC_USP7_MATH_1	393	397	PF00917	0.555
DOC_USP7_MATH_1	463	467	PF00917	0.654
DOC_USP7_MATH_1	468	472	PF00917	0.601
DOC_USP7_MATH_1	50	54	PF00917	0.577
DOC_USP7_MATH_1	550	554	PF00917	0.532
DOC_USP7_MATH_1	688	692	PF00917	0.611
DOC_USP7_MATH_1	695	699	PF00917	0.599
DOC_USP7_MATH_1	773	777	PF00917	0.357
DOC_USP7_MATH_1	820	824	PF00917	0.559
DOC_USP7_MATH_1	990	994	PF00917	0.533
DOC_WW_Pin1_4	1075	1080	PF00397	0.717
DOC_WW_Pin1_4	179	184	PF00397	0.532
DOC_WW_Pin1_4	276	281	PF00397	0.536
DOC_WW_Pin1_4	409	414	PF00397	0.586
DOC_WW_Pin1_4	633	638	PF00397	0.492
DOC_WW_Pin1_4	666	671	PF00397	0.558
DOC_WW_Pin1_4	833	838	PF00397	0.349
DOC_WW_Pin1_4	865	870	PF00397	0.454
DOC_WW_Pin1_4	90	95	PF00397	0.642
DOC_WW_Pin1_4	909	914	PF00397	0.584
DOC_WW_Pin1_4	98	103	PF00397	0.614
LIG_14-3-3_CanoR_1	1034	1038	PF00244	0.490
LIG_14-3-3_CanoR_1	1054	1059	PF00244	0.582
LIG_14-3-3_CanoR_1	254	258	PF00244	0.672
LIG_14-3-3_CanoR_1	263	267	PF00244	0.537
LIG_14-3-3_CanoR_1	462	470	PF00244	0.510
LIG_14-3-3_CanoR_1	5	10	PF00244	0.530
LIG_14-3-3_CanoR_1	524	533	PF00244	0.502
LIG_14-3-3_CanoR_1	687	697	PF00244	0.469
LIG_14-3-3_CanoR_1	748	752	PF00244	0.433
LIG_14-3-3_CanoR_1	930	936	PF00244	0.574
LIG_14-3-3_CanoR_1	96	102	PF00244	0.712
LIG_Actin_RPEL_3	878	897	PF02755	0.359
LIG_Actin_WH2_2	271	288	PF00022	0.392
LIG_Actin_WH2_2	573	591	PF00022	0.477
LIG_Actin_WH2_2	774	791	PF00022	0.485
LIG_APCC_ABBA_1	373	378	PF00400	0.545
LIG_BIR_III_4	392	396	PF00653	0.521
LIG_BRCT_BRCA1_1	470	474	PF00533	0.537
LIG_FAT_LD_1	640	648	PF03623	0.292
LIG_FHA_1	102	108	PF00498	0.590
LIG_FHA_1	112	118	PF00498	0.522
LIG_FHA_1	180	186	PF00498	0.530
LIG_FHA_1	210	216	PF00498	0.458
LIG_FHA_1	269	275	PF00498	0.447
LIG_FHA_1	346	352	PF00498	0.557
LIG_FHA_1	403	409	PF00498	0.527
LIG_FHA_1	448	454	PF00498	0.599
LIG_FHA_1	571	577	PF00498	0.433
LIG_FHA_2	233	239	PF00498	0.499
LIG_FHA_2	623	629	PF00498	0.406
LIG_FHA_2	70	76	PF00498	0.582
LIG_FHA_2	910	916	PF00498	0.549
LIG_GBD_Chelix_1	870	878	PF00786	0.436
LIG_LIR_Apic_2	471	477	PF02991	0.521
LIG_LIR_Gen_1	264	274	PF02991	0.360
LIG_LIR_Gen_1	339	350	PF02991	0.454
LIG_LIR_Gen_1	570	580	PF02991	0.333
LIG_LIR_Gen_1	711	721	PF02991	0.453
LIG_LIR_Gen_1	827	837	PF02991	0.443
LIG_LIR_Gen_1	893	901	PF02991	0.350
LIG_LIR_Gen_1	979	988	PF02991	0.443
LIG_LIR_Nem_3	264	269	PF02991	0.396
LIG_LIR_Nem_3	293	299	PF02991	0.556
LIG_LIR_Nem_3	570	575	PF02991	0.470
LIG_LIR_Nem_3	606	611	PF02991	0.556
LIG_LIR_Nem_3	680	684	PF02991	0.502
LIG_LIR_Nem_3	711	716	PF02991	0.453
LIG_LIR_Nem_3	725	731	PF02991	0.510
LIG_LIR_Nem_3	893	898	PF02991	0.334
LIG_LIR_Nem_3	979	983	PF02991	0.440
LIG_NRBOX	531	537	PF00104	0.517
LIG_NRBOX	783	789	PF00104	0.464
LIG_NRBOX	928	934	PF00104	0.537
LIG_PCNA_yPIPBox_3	16	29	PF02747	0.608
LIG_PCNA_yPIPBox_3	524	536	PF02747	0.475
LIG_Pex14_1	709	713	PF04695	0.457
LIG_Pex14_2	713	717	PF04695	0.416
LIG_SH2_CRK	403	407	PF00017	0.517
LIG_SH2_CRK	533	537	PF00017	0.483
LIG_SH2_CRK	679	683	PF00017	0.461
LIG_SH2_CRK	849	853	PF00017	0.497
LIG_SH2_GRB2like	622	625	PF00017	0.407
LIG_SH2_PTP2	681	684	PF00017	0.487
LIG_SH2_PTP2	895	898	PF00017	0.424
LIG_SH2_SRC	240	243	PF00017	0.662
LIG_SH2_SRC	901	904	PF00017	0.400
LIG_SH2_STAP1	240	244	PF00017	0.663
LIG_SH2_STAP1	533	537	PF00017	0.346
LIG_SH2_STAP1	572	576	PF00017	0.445
LIG_SH2_STAP1	901	905	PF00017	0.398
LIG_SH2_STAT3	426	429	PF00017	0.488
LIG_SH2_STAT5	454	457	PF00017	0.564
LIG_SH2_STAT5	572	575	PF00017	0.280
LIG_SH2_STAT5	681	684	PF00017	0.465
LIG_SH2_STAT5	895	898	PF00017	0.364
LIG_SH2_STAT5	928	931	PF00017	0.487
LIG_SH3_3	200	206	PF00018	0.387
LIG_SH3_3	224	230	PF00018	0.456
LIG_SH3_3	241	247	PF00018	0.504
LIG_SH3_3	376	382	PF00018	0.493
LIG_SH3_3	581	587	PF00018	0.360
LIG_SH3_3	863	869	PF00018	0.471
LIG_SH3_3	950	956	PF00018	0.673
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.416
LIG_SUMO_SIM_par_1	162	167	PF11976	0.602
LIG_SUMO_SIM_par_1	210	216	PF11976	0.321
LIG_SUMO_SIM_par_1	454	461	PF11976	0.412
LIG_SUMO_SIM_par_1	719	725	PF11976	0.500
LIG_SUMO_SIM_par_1	931	937	PF11976	0.420
LIG_TRAF2_1	321	324	PF00917	0.545
LIG_TRAF2_1	72	75	PF00917	0.616
LIG_TRFH_1	753	757	PF08558	0.421
LIG_TYR_ITIM	401	406	PF00017	0.508
LIG_TYR_ITIM	677	682	PF00017	0.439
LIG_TYR_ITIM	847	852	PF00017	0.480
LIG_WRC_WIRS_1	25	30	PF05994	0.535
LIG_WRC_WIRS_1	891	896	PF05994	0.386
MOD_CDK_SPxK_1	280	286	PF00069	0.405
MOD_CDK_SPxK_1	90	96	PF00069	0.567
MOD_CK1_1	1015	1021	PF00069	0.541
MOD_CK1_1	1071	1077	PF00069	0.652
MOD_CK1_1	136	142	PF00069	0.490
MOD_CK1_1	156	162	PF00069	0.512
MOD_CK1_1	276	282	PF00069	0.448
MOD_CK1_1	290	296	PF00069	0.454
MOD_CK1_1	329	335	PF00069	0.705
MOD_CK1_1	475	481	PF00069	0.535
MOD_CK1_1	489	495	PF00069	0.484
MOD_CK1_1	570	576	PF00069	0.349
MOD_CK1_1	595	601	PF00069	0.578
MOD_CK1_1	652	658	PF00069	0.423
MOD_CK1_1	909	915	PF00069	0.587
MOD_CK1_1	931	937	PF00069	0.578
MOD_CK1_1	98	104	PF00069	0.741
MOD_CK2_1	1057	1063	PF00069	0.611
MOD_CK2_1	232	238	PF00069	0.598
MOD_CK2_1	314	320	PF00069	0.699
MOD_CK2_1	622	628	PF00069	0.633
MOD_CK2_1	69	75	PF00069	0.578
MOD_CK2_1	695	701	PF00069	0.595
MOD_CK2_1	990	996	PF00069	0.668
MOD_GlcNHglycan	1000	1003	PF01048	0.650
MOD_GlcNHglycan	1012	1015	PF01048	0.556
MOD_GlcNHglycan	1022	1025	PF01048	0.584
MOD_GlcNHglycan	1028	1032	PF01048	0.623
MOD_GlcNHglycan	1070	1073	PF01048	0.758
MOD_GlcNHglycan	1083	1086	PF01048	0.588
MOD_GlcNHglycan	247	250	PF01048	0.661
MOD_GlcNHglycan	280	283	PF01048	0.544
MOD_GlcNHglycan	289	292	PF01048	0.393
MOD_GlcNHglycan	316	319	PF01048	0.732
MOD_GlcNHglycan	331	334	PF01048	0.606
MOD_GlcNHglycan	395	398	PF01048	0.577
MOD_GlcNHglycan	445	448	PF01048	0.685
MOD_GlcNHglycan	466	469	PF01048	0.662
MOD_GlcNHglycan	470	473	PF01048	0.609
MOD_GlcNHglycan	474	477	PF01048	0.532
MOD_GlcNHglycan	568	572	PF01048	0.376
MOD_GlcNHglycan	698	701	PF01048	0.546
MOD_GlcNHglycan	775	778	PF01048	0.359
MOD_GlcNHglycan	857	860	PF01048	0.438
MOD_GlcNHglycan	879	882	PF01048	0.387
MOD_GlcNHglycan	909	912	PF01048	0.545
MOD_GlcNHglycan	960	963	PF01048	0.700
MOD_GlcNHglycan	992	995	PF01048	0.586
MOD_GSK3_1	1010	1017	PF00069	0.597
MOD_GSK3_1	1053	1060	PF00069	0.568
MOD_GSK3_1	1063	1070	PF00069	0.488
MOD_GSK3_1	1071	1078	PF00069	0.621
MOD_GSK3_1	1081	1088	PF00069	0.557
MOD_GSK3_1	209	216	PF00069	0.335
MOD_GSK3_1	228	235	PF00069	0.515
MOD_GSK3_1	276	283	PF00069	0.528
MOD_GSK3_1	287	294	PF00069	0.315
MOD_GSK3_1	314	321	PF00069	0.521
MOD_GSK3_1	341	348	PF00069	0.608
MOD_GSK3_1	443	450	PF00069	0.566
MOD_GSK3_1	464	471	PF00069	0.630
MOD_GSK3_1	475	482	PF00069	0.637
MOD_GSK3_1	486	493	PF00069	0.424
MOD_GSK3_1	603	610	PF00069	0.382
MOD_GSK3_1	722	729	PF00069	0.504
MOD_GSK3_1	742	749	PF00069	0.485
MOD_GSK3_1	870	877	PF00069	0.517
MOD_GSK3_1	90	97	PF00069	0.565
MOD_GSK3_1	924	931	PF00069	0.555
MOD_LATS_1	3	9	PF00433	0.456
MOD_LATS_1	400	406	PF00433	0.328
MOD_NEK2_1	232	237	PF00069	0.496
MOD_NEK2_1	345	350	PF00069	0.446
MOD_NEK2_1	355	360	PF00069	0.472
MOD_NEK2_1	443	448	PF00069	0.677
MOD_NEK2_1	479	484	PF00069	0.536
MOD_NEK2_1	525	530	PF00069	0.396
MOD_NEK2_1	612	617	PF00069	0.541
MOD_NEK2_1	677	682	PF00069	0.343
MOD_NEK2_1	933	938	PF00069	0.598
MOD_NEK2_1	95	100	PF00069	0.622
MOD_NEK2_1	976	981	PF00069	0.613
MOD_NEK2_2	726	731	PF00069	0.416
MOD_PIKK_1	336	342	PF00454	0.737
MOD_PIKK_1	345	351	PF00454	0.430
MOD_PIKK_1	441	447	PF00454	0.527
MOD_PIKK_1	525	531	PF00454	0.591
MOD_PIKK_1	69	75	PF00454	0.529
MOD_PIKK_1	914	920	PF00454	0.527
MOD_PK_1	617	623	PF00069	0.564
MOD_PKA_1	5	11	PF00069	0.532
MOD_PKA_1	617	623	PF00069	0.601
MOD_PKA_2	1033	1039	PF00069	0.613
MOD_PKA_2	1053	1059	PF00069	0.523
MOD_PKA_2	1063	1069	PF00069	0.696
MOD_PKA_2	253	259	PF00069	0.670
MOD_PKA_2	262	268	PF00069	0.538
MOD_PKA_2	447	453	PF00069	0.437
MOD_PKA_2	5	11	PF00069	0.532
MOD_PKA_2	612	618	PF00069	0.527
MOD_PKA_2	709	715	PF00069	0.475
MOD_PKA_2	747	753	PF00069	0.441
MOD_PKA_2	95	101	PF00069	0.726
MOD_Plk_1	1027	1033	PF00069	0.501
MOD_Plk_1	126	132	PF00069	0.398
MOD_Plk_1	156	162	PF00069	0.551
MOD_Plk_1	209	215	PF00069	0.373
MOD_Plk_1	261	267	PF00069	0.517
MOD_Plk_1	567	573	PF00069	0.296
MOD_Plk_1	595	601	PF00069	0.329
MOD_Plk_1	652	658	PF00069	0.500
MOD_Plk_1	874	880	PF00069	0.502
MOD_Plk_4	1054	1060	PF00069	0.597
MOD_Plk_4	209	215	PF00069	0.461
MOD_Plk_4	228	234	PF00069	0.629
MOD_Plk_4	24	30	PF00069	0.536
MOD_Plk_4	253	259	PF00069	0.582
MOD_Plk_4	291	297	PF00069	0.471
MOD_Plk_4	341	347	PF00069	0.448
MOD_Plk_4	454	460	PF00069	0.583
MOD_Plk_4	479	485	PF00069	0.642
MOD_Plk_4	570	576	PF00069	0.370
MOD_Plk_4	580	586	PF00069	0.392
MOD_Plk_4	607	613	PF00069	0.512
MOD_Plk_4	617	623	PF00069	0.564
MOD_Plk_4	657	663	PF00069	0.385
MOD_Plk_4	677	683	PF00069	0.399
MOD_Plk_4	709	715	PF00069	0.471
MOD_Plk_4	747	753	PF00069	0.603
MOD_Plk_4	924	930	PF00069	0.483
MOD_Plk_4	943	949	PF00069	0.542
MOD_ProDKin_1	1075	1081	PF00069	0.718
MOD_ProDKin_1	179	185	PF00069	0.542
MOD_ProDKin_1	276	282	PF00069	0.525
MOD_ProDKin_1	409	415	PF00069	0.586
MOD_ProDKin_1	633	639	PF00069	0.479
MOD_ProDKin_1	666	672	PF00069	0.550
MOD_ProDKin_1	833	839	PF00069	0.343
MOD_ProDKin_1	865	871	PF00069	0.445
MOD_ProDKin_1	90	96	PF00069	0.651
MOD_ProDKin_1	909	915	PF00069	0.587
MOD_ProDKin_1	98	104	PF00069	0.615
MOD_SUMO_rev_2	602	611	PF00179	0.356
TRG_DiLeu_BaEn_1	607	612	PF01217	0.361
TRG_DiLeu_BaEn_1	711	716	PF01217	0.479
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.479
TRG_DiLeu_BaLyEn_6	766	771	PF01217	0.466
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.480
TRG_DiLeu_BaLyEn_6	809	814	PF01217	0.471
TRG_DiLeu_BaLyEn_6	971	976	PF01217	0.604
TRG_ENDOCYTIC_2	1037	1040	PF00928	0.506
TRG_ENDOCYTIC_2	403	406	PF00928	0.508
TRG_ENDOCYTIC_2	533	536	PF00928	0.477
TRG_ENDOCYTIC_2	572	575	PF00928	0.332
TRG_ENDOCYTIC_2	679	682	PF00928	0.366
TRG_ENDOCYTIC_2	830	833	PF00928	0.465
TRG_ENDOCYTIC_2	849	852	PF00928	0.447
TRG_ENDOCYTIC_2	895	898	PF00928	0.366
TRG_ER_diArg_1	5	7	PF00400	0.545
TRG_ER_diArg_1	616	618	PF00400	0.601
TRG_ER_diArg_1	884	887	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML2	Leptomonas seymouri	54%	100%
A0A3S7X5V5	Leishmania donovani	79%	100%
A4I899	Leishmania infantum	78%	100%
D0AAH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B357	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4Z7	Leishmania major	78%	100%