Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKR7_LEIBR

TriTrypDb:

LbrM.32.3000 , LBRM2903_320037800

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.617
CLV_C14_Caspase3-7	43	47	PF00656	0.644
CLV_C14_Caspase3-7	535	539	PF00656	0.559
CLV_C14_Caspase3-7	591	595	PF00656	0.642
CLV_C14_Caspase3-7	68	72	PF00656	0.628
CLV_C14_Caspase3-7	77	81	PF00656	0.650
CLV_NRD_NRD_1	217	219	PF00675	0.534
CLV_NRD_NRD_1	272	274	PF00675	0.494
CLV_NRD_NRD_1	29	31	PF00675	0.686
CLV_NRD_NRD_1	432	434	PF00675	0.514
CLV_NRD_NRD_1	49	51	PF00675	0.620
CLV_NRD_NRD_1	624	626	PF00675	0.691
CLV_NRD_NRD_1	732	734	PF00675	0.601
CLV_NRD_NRD_1	754	756	PF00675	0.561
CLV_NRD_NRD_1	8	10	PF00675	0.618
CLV_NRD_NRD_1	856	858	PF00675	0.571
CLV_PCSK_KEX2_1	171	173	PF00082	0.666
CLV_PCSK_KEX2_1	217	219	PF00082	0.534
CLV_PCSK_KEX2_1	272	274	PF00082	0.494
CLV_PCSK_KEX2_1	28	30	PF00082	0.693
CLV_PCSK_KEX2_1	432	434	PF00082	0.514
CLV_PCSK_KEX2_1	49	51	PF00082	0.693
CLV_PCSK_KEX2_1	508	510	PF00082	0.489
CLV_PCSK_KEX2_1	624	626	PF00082	0.705
CLV_PCSK_KEX2_1	732	734	PF00082	0.605
CLV_PCSK_KEX2_1	754	756	PF00082	0.561
CLV_PCSK_KEX2_1	856	858	PF00082	0.495
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.545
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.595
CLV_PCSK_SKI1_1	10	14	PF00082	0.619
CLV_PCSK_SKI1_1	217	221	PF00082	0.529
CLV_PCSK_SKI1_1	331	335	PF00082	0.427
CLV_PCSK_SKI1_1	49	53	PF00082	0.485
CLV_PCSK_SKI1_1	517	521	PF00082	0.538
CLV_Separin_Metazoa	413	417	PF03568	0.612
DEG_COP1_1	343	353	PF00400	0.464
DEG_SCF_FBW7_1	12	19	PF00400	0.697
DEG_SPOP_SBC_1	454	458	PF00917	0.535
DEG_SPOP_SBC_1	796	800	PF00917	0.556
DEG_SPOP_SBC_1	826	830	PF00917	0.556
DOC_CKS1_1	13	18	PF01111	0.696
DOC_CKS1_1	199	204	PF01111	0.626
DOC_CYCLIN_RxL_1	4	15	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.619
DOC_MAPK_gen_1	492	500	PF00069	0.470
DOC_MAPK_gen_1	764	772	PF00069	0.617
DOC_PP1_RVXF_1	766	773	PF00149	0.542
DOC_PP2B_LxvP_1	103	106	PF13499	0.592
DOC_PP2B_LxvP_1	306	309	PF13499	0.520
DOC_PP2B_LxvP_1	39	42	PF13499	0.555
DOC_PP4_FxxP_1	772	775	PF00568	0.529
DOC_USP7_MATH_1	118	122	PF00917	0.777
DOC_USP7_MATH_1	141	145	PF00917	0.640
DOC_USP7_MATH_1	147	151	PF00917	0.640
DOC_USP7_MATH_1	16	20	PF00917	0.702
DOC_USP7_MATH_1	162	166	PF00917	0.638
DOC_USP7_MATH_1	234	238	PF00917	0.471
DOC_USP7_MATH_1	340	344	PF00917	0.398
DOC_USP7_MATH_1	392	396	PF00917	0.502
DOC_USP7_MATH_1	459	463	PF00917	0.528
DOC_USP7_MATH_1	527	531	PF00917	0.637
DOC_USP7_MATH_1	607	611	PF00917	0.831
DOC_USP7_MATH_1	636	640	PF00917	0.681
DOC_USP7_MATH_1	667	671	PF00917	0.598
DOC_USP7_MATH_1	749	753	PF00917	0.654
DOC_USP7_MATH_1	76	80	PF00917	0.785
DOC_USP7_MATH_1	789	793	PF00917	0.593
DOC_USP7_MATH_1	796	800	PF00917	0.591
DOC_USP7_MATH_1	804	808	PF00917	0.569
DOC_USP7_MATH_1	826	830	PF00917	0.689
DOC_USP7_MATH_1	848	852	PF00917	0.471
DOC_USP7_MATH_2	632	638	PF00917	0.566
DOC_WW_Pin1_4	113	118	PF00397	0.619
DOC_WW_Pin1_4	12	17	PF00397	0.635
DOC_WW_Pin1_4	133	138	PF00397	0.643
DOC_WW_Pin1_4	176	181	PF00397	0.703
DOC_WW_Pin1_4	195	200	PF00397	0.688
DOC_WW_Pin1_4	23	28	PF00397	0.645
DOC_WW_Pin1_4	297	302	PF00397	0.644
DOC_WW_Pin1_4	304	309	PF00397	0.565
DOC_WW_Pin1_4	44	49	PF00397	0.569
DOC_WW_Pin1_4	446	451	PF00397	0.557
DOC_WW_Pin1_4	455	460	PF00397	0.604
DOC_WW_Pin1_4	563	568	PF00397	0.774
DOC_WW_Pin1_4	573	578	PF00397	0.675
DOC_WW_Pin1_4	584	589	PF00397	0.622
DOC_WW_Pin1_4	595	600	PF00397	0.719
DOC_WW_Pin1_4	624	629	PF00397	0.657
DOC_WW_Pin1_4	657	662	PF00397	0.852
DOC_WW_Pin1_4	739	744	PF00397	0.560
LIG_14-3-3_CanoR_1	22	27	PF00244	0.718
LIG_14-3-3_CanoR_1	432	436	PF00244	0.597
LIG_14-3-3_CanoR_1	481	490	PF00244	0.459
LIG_14-3-3_CanoR_1	49	55	PF00244	0.491
LIG_14-3-3_CanoR_1	501	505	PF00244	0.416
LIG_14-3-3_CanoR_1	580	589	PF00244	0.589
LIG_14-3-3_CanoR_1	684	690	PF00244	0.692
LIG_14-3-3_CanoR_1	768	773	PF00244	0.557
LIG_14-3-3_CanoR_1	784	788	PF00244	0.591
LIG_14-3-3_CanoR_1	868	872	PF00244	0.699
LIG_Actin_WH2_2	417	434	PF00022	0.585
LIG_APCC_ABBA_1	209	214	PF00400	0.547
LIG_BRCT_BRCA1_1	109	113	PF00533	0.622
LIG_BRCT_BRCA1_1	775	779	PF00533	0.591
LIG_CtBP_PxDLS_1	632	636	PF00389	0.623
LIG_EVH1_1	103	107	PF00568	0.535
LIG_EVH1_1	181	185	PF00568	0.582
LIG_FHA_1	199	205	PF00498	0.715
LIG_FHA_1	300	306	PF00498	0.504
LIG_FHA_1	310	316	PF00498	0.420
LIG_FHA_1	332	338	PF00498	0.441
LIG_FHA_1	438	444	PF00498	0.560
LIG_FHA_1	455	461	PF00498	0.592
LIG_FHA_1	520	526	PF00498	0.683
LIG_FHA_1	778	784	PF00498	0.537
LIG_FHA_1	808	814	PF00498	0.709
LIG_FHA_1	860	866	PF00498	0.468
LIG_FHA_2	247	253	PF00498	0.492
LIG_FHA_2	41	47	PF00498	0.658
LIG_FHA_2	415	421	PF00498	0.484
LIG_FHA_2	61	67	PF00498	0.475
LIG_FHA_2	75	81	PF00498	0.568
LIG_FHA_2	820	826	PF00498	0.564
LIG_GBD_Chelix_1	474	482	PF00786	0.553
LIG_GSK3_LRP6_1	133	138	PF00069	0.546
LIG_LIR_Apic_2	771	775	PF02991	0.527
LIG_LIR_Gen_1	359	370	PF02991	0.426
LIG_LIR_Gen_1	807	814	PF02991	0.552
LIG_LIR_Nem_3	359	365	PF02991	0.426
LIG_LIR_Nem_3	807	812	PF02991	0.553
LIG_PCNA_PIPBox_1	355	364	PF02747	0.482
LIG_PCNA_yPIPBox_3	355	367	PF02747	0.480
LIG_PDZ_Class_1	867	872	PF00595	0.603
LIG_PTB_Apo_2	477	484	PF02174	0.383
LIG_RPA_C_Fungi	489	501	PF08784	0.467
LIG_SH2_CRK	362	366	PF00017	0.345
LIG_SH2_GRB2like	362	365	PF00017	0.343
LIG_SH2_GRB2like	376	379	PF00017	0.326
LIG_SH2_NCK_1	14	18	PF00017	0.620
LIG_SH2_NCK_1	212	216	PF00017	0.408
LIG_SH2_STAP1	109	113	PF00017	0.554
LIG_SH2_STAP1	854	858	PF00017	0.576
LIG_SH2_STAT3	376	379	PF00017	0.360
LIG_SH2_STAT3	476	479	PF00017	0.558
LIG_SH2_STAT5	14	17	PF00017	0.812
LIG_SH2_STAT5	212	215	PF00017	0.595
LIG_SH2_STAT5	293	296	PF00017	0.501
LIG_SH2_STAT5	376	379	PF00017	0.360
LIG_SH2_STAT5	55	58	PF00017	0.531
LIG_SH2_STAT5	708	711	PF00017	0.559
LIG_SH3_2	524	529	PF14604	0.688
LIG_SH3_3	101	107	PF00018	0.575
LIG_SH3_3	131	137	PF00018	0.661
LIG_SH3_3	177	183	PF00018	0.692
LIG_SH3_3	196	202	PF00018	0.691
LIG_SH3_3	302	308	PF00018	0.505
LIG_SH3_3	518	524	PF00018	0.727
LIG_SH3_3	710	716	PF00018	0.613
LIG_SH3_3	844	850	PF00018	0.665
LIG_SUMO_SIM_anti_2	862	867	PF11976	0.564
LIG_SUMO_SIM_par_1	311	316	PF11976	0.433
LIG_SUMO_SIM_par_1	631	639	PF11976	0.626
LIG_SUMO_SIM_par_1	860	867	PF11976	0.466
LIG_TRAF2_1	259	262	PF00917	0.417
LIG_TRAF2_1	343	346	PF00917	0.390
LIG_TRAF2_1	423	426	PF00917	0.582
LIG_TRAF2_1	469	472	PF00917	0.548
LIG_TRAF2_1	503	506	PF00917	0.509
LIG_WW_1	106	109	PF00397	0.679
LIG_WW_3	761	765	PF00397	0.674
MOD_CDC14_SPxK_1	26	29	PF00782	0.730
MOD_CDC14_SPxK_1	47	50	PF00782	0.552
MOD_CDK_SPK_2	23	28	PF00069	0.720
MOD_CDK_SPK_2	44	49	PF00069	0.569
MOD_CDK_SPK_2	595	600	PF00069	0.566
MOD_CDK_SPxK_1	23	29	PF00069	0.707
MOD_CDK_SPxK_1	44	50	PF00069	0.567
MOD_CDK_SPxK_1	624	630	PF00069	0.663
MOD_CDK_SPxxK_3	113	120	PF00069	0.550
MOD_CDK_SPxxK_3	23	30	PF00069	0.725
MOD_CDK_SPxxK_3	297	304	PF00069	0.509
MOD_CDK_SPxxK_3	573	580	PF00069	0.565
MOD_CDK_SPxxK_3	657	664	PF00069	0.572
MOD_CK1_1	108	114	PF00069	0.642
MOD_CK1_1	116	122	PF00069	0.653
MOD_CK1_1	198	204	PF00069	0.729
MOD_CK1_1	207	213	PF00069	0.608
MOD_CK1_1	297	303	PF00069	0.668
MOD_CK1_1	3	9	PF00069	0.641
MOD_CK1_1	395	401	PF00069	0.502
MOD_CK1_1	437	443	PF00069	0.620
MOD_CK1_1	573	579	PF00069	0.807
MOD_CK1_1	582	588	PF00069	0.607
MOD_CK1_1	598	604	PF00069	0.622
MOD_CK1_1	610	616	PF00069	0.679
MOD_CK1_1	668	674	PF00069	0.839
MOD_CK1_1	72	78	PF00069	0.552
MOD_CK1_1	739	745	PF00069	0.642
MOD_CK1_1	799	805	PF00069	0.624
MOD_CK1_1	807	813	PF00069	0.569
MOD_CK1_1	828	834	PF00069	0.613
MOD_CK2_1	236	242	PF00069	0.551
MOD_CK2_1	246	252	PF00069	0.548
MOD_CK2_1	340	346	PF00069	0.495
MOD_CK2_1	414	420	PF00069	0.469
MOD_CK2_1	490	496	PF00069	0.460
MOD_CK2_1	500	506	PF00069	0.480
MOD_CK2_1	562	568	PF00069	0.597
MOD_CK2_1	60	66	PF00069	0.669
MOD_CK2_1	628	634	PF00069	0.561
MOD_CK2_1	797	803	PF00069	0.549
MOD_Cter_Amidation	752	755	PF01082	0.558
MOD_DYRK1A_RPxSP_1	195	199	PF00069	0.551
MOD_GlcNHglycan	128	131	PF01048	0.639
MOD_GlcNHglycan	147	150	PF01048	0.591
MOD_GlcNHglycan	394	397	PF01048	0.610
MOD_GlcNHglycan	5	8	PF01048	0.606
MOD_GlcNHglycan	572	575	PF01048	0.628
MOD_GlcNHglycan	582	585	PF01048	0.766
MOD_GlcNHglycan	609	612	PF01048	0.709
MOD_GlcNHglycan	615	618	PF01048	0.758
MOD_GlcNHglycan	638	641	PF01048	0.686
MOD_GlcNHglycan	71	74	PF01048	0.674
MOD_GlcNHglycan	720	724	PF01048	0.800
MOD_GlcNHglycan	734	737	PF01048	0.732
MOD_GlcNHglycan	738	741	PF01048	0.794
MOD_GlcNHglycan	751	754	PF01048	0.560
MOD_GlcNHglycan	803	807	PF01048	0.538
MOD_GlcNHglycan	837	841	PF01048	0.548
MOD_GSK3_1	12	19	PF00069	0.641
MOD_GSK3_1	141	148	PF00069	0.695
MOD_GSK3_1	162	169	PF00069	0.700
MOD_GSK3_1	170	177	PF00069	0.638
MOD_GSK3_1	200	207	PF00069	0.634
MOD_GSK3_1	316	323	PF00069	0.481
MOD_GSK3_1	395	402	PF00069	0.535
MOD_GSK3_1	40	47	PF00069	0.627
MOD_GSK3_1	455	462	PF00069	0.541
MOD_GSK3_1	50	57	PF00069	0.610
MOD_GSK3_1	528	535	PF00069	0.721
MOD_GSK3_1	568	575	PF00069	0.815
MOD_GSK3_1	580	587	PF00069	0.779
MOD_GSK3_1	603	610	PF00069	0.839
MOD_GSK3_1	624	631	PF00069	0.640
MOD_GSK3_1	653	660	PF00069	0.690
MOD_GSK3_1	668	675	PF00069	0.662
MOD_GSK3_1	72	79	PF00069	0.722
MOD_GSK3_1	732	739	PF00069	0.747
MOD_GSK3_1	773	780	PF00069	0.660
MOD_GSK3_1	795	802	PF00069	0.682
MOD_GSK3_1	836	843	PF00069	0.577
MOD_LATS_1	287	293	PF00433	0.505
MOD_N-GLC_1	653	658	PF02516	0.583
MOD_N-GLC_1	680	685	PF02516	0.575
MOD_N-GLC_1	818	823	PF02516	0.696
MOD_NEK2_1	174	179	PF00069	0.571
MOD_NEK2_1	189	194	PF00069	0.619
MOD_NEK2_1	320	325	PF00069	0.516
MOD_NEK2_1	414	419	PF00069	0.491
MOD_NEK2_1	431	436	PF00069	0.535
MOD_NEK2_1	453	458	PF00069	0.519
MOD_NEK2_1	490	495	PF00069	0.493
MOD_NEK2_1	579	584	PF00069	0.726
MOD_NEK2_1	685	690	PF00069	0.505
MOD_NEK2_1	700	705	PF00069	0.580
MOD_NEK2_1	795	800	PF00069	0.626
MOD_PIKK_1	187	193	PF00454	0.553
MOD_PIKK_1	467	473	PF00454	0.626
MOD_PIKK_1	598	604	PF00454	0.716
MOD_PIKK_1	668	674	PF00454	0.723
MOD_PIKK_1	812	818	PF00454	0.546
MOD_PKA_1	732	738	PF00069	0.577
MOD_PKA_2	123	129	PF00069	0.594
MOD_PKA_2	246	252	PF00069	0.456
MOD_PKA_2	3	9	PF00069	0.609
MOD_PKA_2	431	437	PF00069	0.598
MOD_PKA_2	500	506	PF00069	0.535
MOD_PKA_2	579	585	PF00069	0.562
MOD_PKA_2	603	609	PF00069	0.703
MOD_PKA_2	668	674	PF00069	0.602
MOD_PKA_2	732	738	PF00069	0.655
MOD_PKA_2	783	789	PF00069	0.770
MOD_PKB_1	20	28	PF00069	0.563
MOD_PKB_1	766	774	PF00069	0.596
MOD_Plk_1	162	168	PF00069	0.528
MOD_Plk_1	320	326	PF00069	0.515
MOD_Plk_1	653	659	PF00069	0.583
MOD_Plk_1	680	686	PF00069	0.570
MOD_Plk_2-3	316	322	PF00069	0.367
MOD_Plk_2-3	777	783	PF00069	0.536
MOD_Plk_4	141	147	PF00069	0.595
MOD_Plk_4	207	213	PF00069	0.474
MOD_Plk_4	289	295	PF00069	0.503
MOD_Plk_4	369	375	PF00069	0.429
MOD_Plk_4	437	443	PF00069	0.474
MOD_Plk_4	50	56	PF00069	0.439
MOD_Plk_4	610	616	PF00069	0.552
MOD_Plk_4	768	774	PF00069	0.631
MOD_ProDKin_1	113	119	PF00069	0.619
MOD_ProDKin_1	12	18	PF00069	0.635
MOD_ProDKin_1	133	139	PF00069	0.644
MOD_ProDKin_1	176	182	PF00069	0.699
MOD_ProDKin_1	195	201	PF00069	0.686
MOD_ProDKin_1	23	29	PF00069	0.648
MOD_ProDKin_1	297	303	PF00069	0.645
MOD_ProDKin_1	304	310	PF00069	0.563
MOD_ProDKin_1	44	50	PF00069	0.567
MOD_ProDKin_1	446	452	PF00069	0.558
MOD_ProDKin_1	455	461	PF00069	0.606
MOD_ProDKin_1	563	569	PF00069	0.766
MOD_ProDKin_1	573	579	PF00069	0.675
MOD_ProDKin_1	584	590	PF00069	0.623
MOD_ProDKin_1	595	601	PF00069	0.715
MOD_ProDKin_1	624	630	PF00069	0.658
MOD_ProDKin_1	657	663	PF00069	0.849
MOD_ProDKin_1	739	745	PF00069	0.558
TRG_DiLeu_BaEn_4	426	432	PF01217	0.509
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.543
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.504
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.616
TRG_ENDOCYTIC_2	362	365	PF00928	0.425
TRG_ER_diArg_1	20	23	PF00400	0.682
TRG_ER_diArg_1	217	219	PF00400	0.534
TRG_ER_diArg_1	27	30	PF00400	0.708
TRG_ER_diArg_1	271	273	PF00400	0.459
TRG_ER_diArg_1	431	433	PF00400	0.516
TRG_ER_diArg_1	48	50	PF00400	0.593
TRG_ER_diArg_1	515	518	PF00400	0.553
TRG_ER_diArg_1	623	625	PF00400	0.659
TRG_ER_diArg_1	763	766	PF00400	0.676
TRG_ER_diArg_1	856	858	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	811	816	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L2	Leptomonas seymouri	36%	100%
A0A3S5H7S7	Leishmania donovani	66%	100%
A4I897	Leishmania infantum	66%	99%
E9B355	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q4Z9	Leishmania major	66%	99%