Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

As/Sb Reductase

Species:

Leishmania braziliensis

UniProt:

A4HKR5_LEIBR

TriTrypDb:

LbrM.32.2980 , LBRM2903_320037600

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKR5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008794	arsenate reductase (glutaredoxin) activity	4	2
GO:0016491	oxidoreductase activity	2	2
GO:0030611	arsenate reductase activity	3	2
GO:0030613	oxidoreductase activity, acting on phosphorus or arsenic in donors	3	2
GO:0030614	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.497
CLV_C14_Caspase3-7	29	33	PF00656	0.534
CLV_PCSK_SKI1_1	61	65	PF00082	0.214
CLV_PCSK_SKI1_1	88	92	PF00082	0.354
DOC_CYCLIN_RxL_1	58	66	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.503
DOC_MAPK_DCC_7	95	105	PF00069	0.549
DOC_MAPK_gen_1	94	102	PF00069	0.460
LIG_14-3-3_CanoR_1	50	59	PF00244	0.463
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_LIR_Apic_2	5	9	PF02991	0.434
LIG_LIR_Gen_1	20	28	PF02991	0.547
LIG_LIR_Nem_3	111	117	PF02991	0.498
LIG_LIR_Nem_3	20	25	PF02991	0.375
LIG_LIR_Nem_3	53	59	PF02991	0.477
LIG_NRBOX	11	17	PF00104	0.417
LIG_Pex14_1	110	114	PF04695	0.526
LIG_SH2_GRB2like	6	9	PF00017	0.246
LIG_SH2_STAT5	104	107	PF00017	0.462
LIG_SH2_STAT5	4	7	PF00017	0.379
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.446
LIG_SUMO_SIM_par_1	10	17	PF11976	0.446
MOD_CK1_1	45	51	PF00069	0.526
MOD_GSK3_1	45	52	PF00069	0.463
MOD_N-GLC_1	2	7	PF02516	0.473
MOD_PKA_2	30	36	PF00069	0.545
MOD_PKA_2	49	55	PF00069	0.313
MOD_Plk_1	2	8	PF00069	0.468
MOD_Plk_4	2	8	PF00069	0.450
MOD_Plk_4	75	81	PF00069	0.549
MOD_SUMO_rev_2	65	70	PF00179	0.526
TRG_DiLeu_BaEn_1	11	16	PF01217	0.419
TRG_ENDOCYTIC_2	117	120	PF00928	0.465
TRG_ENDOCYTIC_2	4	7	PF00928	0.357
TRG_ENDOCYTIC_2	56	59	PF00928	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD0	Leptomonas seymouri	72%	100%
A0A0S4IHU2	Bodo saltans	36%	91%
A0A1X0NRP2	Trypanosomatidae	45%	86%
A0A3Q8IGZ4	Leishmania donovani	81%	100%
A0A3R7KPC6	Trypanosoma rangeli	50%	99%
A4I895	Leishmania infantum	82%	100%
E9B353	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q8WZK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	92%
V5AXX4	Trypanosoma cruzi	54%	100%