60S ribosomal protein L27

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L27, putative

Species:

Leishmania braziliensis

UniProt:

A4HKR2_LEIBR

TriTrypDb:

LbrM.32.2950 , LBRM2903_320037100

Length:

134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HKR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKR2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.270
CLV_NRD_NRD_1	64	66	PF00675	0.265
CLV_PCSK_KEX2_1	104	106	PF00082	0.352
CLV_PCSK_KEX2_1	113	115	PF00082	0.295
CLV_PCSK_KEX2_1	64	66	PF00082	0.274
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.352
CLV_PCSK_SKI1_1	113	117	PF00082	0.273
CLV_PCSK_SKI1_1	3	7	PF00082	0.410
CLV_PCSK_SKI1_1	78	82	PF00082	0.281
DOC_MAPK_gen_1	3	13	PF00069	0.312
DOC_MAPK_gen_1	64	72	PF00069	0.458
DOC_MAPK_gen_1	91	99	PF00069	0.458
DOC_MAPK_HePTP_8	62	74	PF00069	0.458
DOC_MAPK_MEF2A_6	64	72	PF00069	0.458
DOC_PP4_FxxP_1	4	7	PF00568	0.403
DOC_USP7_MATH_1	122	126	PF00917	0.565
DOC_USP7_MATH_1	63	67	PF00917	0.501
DOC_USP7_UBL2_3	47	51	PF12436	0.396
LIG_14-3-3_CanoR_1	64	72	PF00244	0.468
LIG_BRCT_BRCA1_1	124	128	PF00533	0.563
LIG_LIR_Apic_2	2	7	PF02991	0.554
LIG_PDZ_Class_2	129	134	PF00595	0.458
LIG_REV1ctd_RIR_1	126	134	PF16727	0.458
LIG_SUMO_SIM_par_1	9	14	PF11976	0.493
LIG_UBA3_1	42	51	PF00899	0.425
MOD_CK1_1	100	106	PF00069	0.468
MOD_CK1_1	58	64	PF00069	0.458
MOD_GlcNHglycan	124	127	PF01048	0.241
MOD_GSK3_1	26	33	PF00069	0.566
MOD_N-GLC_1	97	102	PF02516	0.258
MOD_PIKK_1	63	69	PF00454	0.468
MOD_PKA_2	63	69	PF00069	0.461
TRG_ER_diArg_1	112	114	PF00400	0.392
TRG_ER_diArg_1	131	134	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B0	Leptomonas seymouri	97%	100%
A0A0S4JTD6	Bodo saltans	80%	86%
A0A0S4JTD7	Bodo saltans	80%	86%
A0A0S4KKR9	Bodo saltans	79%	100%
A0A1D8PFG4	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	99%
A0A1X0NRX5	Trypanosomatidae	83%	100%
A0A3Q8IDB1	Leishmania donovani	96%	100%
A0A3S5ISF6	Trypanosoma rangeli	81%	100%
A1XQU5	Sus scrofa	47%	99%
A4I890	Leishmania infantum	96%	100%
D0AAG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	79%
E9B348	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B350	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O14388	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	99%
O74538	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	99%
P0C2H6	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	99%
P0C2H7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	99%
P0DJ19	Tetrahymena thermophila	39%	93%
P41101	Solanum tuberosum	43%	97%
P51419	Arabidopsis thaliana	41%	99%
P61353	Homo sapiens	47%	99%
P61354	Rattus norvegicus	47%	99%
P61355	Gallus gallus	47%	99%
P61356	Bos taurus	47%	99%
P61357	Cervus nippon	47%	99%
P61358	Mus musculus	47%	99%
P61359	Hippocampus comes	49%	99%
P91914	Caenorhabditis elegans	43%	99%
Q02984	Pyrobotrys stellata	40%	100%
Q05462	Pisum sativum	43%	99%
Q4Q504	Leishmania major	95%	100%
Q4R8Z4	Macaca fascicularis	47%	99%
Q55BE6	Dictyostelium discoideum	44%	93%
Q7ZV82	Danio rerio	48%	99%
Q8LCL3	Arabidopsis thaliana	41%	99%
Q90YU1	Ictalurus punctatus	46%	99%
Q9P843	Candida albicans	41%	99%
Q9SKX8	Arabidopsis thaliana	42%	99%
Q9XSU7	Canis lupus familiaris	46%	99%