Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinteoplast poly(A) polymerase complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKQ8_LEIBR

TriTrypDb:

LbrM.32.2910 , LBRM2903_320036900

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HKQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.727
CLV_C14_Caspase3-7	298	302	PF00656	0.438
CLV_C14_Caspase3-7	489	493	PF00656	0.497
CLV_C14_Caspase3-7	514	518	PF00656	0.412
CLV_C14_Caspase3-7	573	577	PF00656	0.619
CLV_C14_Caspase3-7	614	618	PF00656	0.491
CLV_C14_Caspase3-7	647	651	PF00656	0.516
CLV_C14_Caspase3-7	87	91	PF00656	0.488
CLV_NRD_NRD_1	120	122	PF00675	0.490
CLV_NRD_NRD_1	130	132	PF00675	0.312
CLV_NRD_NRD_1	166	168	PF00675	0.542
CLV_NRD_NRD_1	178	180	PF00675	0.441
CLV_NRD_NRD_1	243	245	PF00675	0.441
CLV_NRD_NRD_1	308	310	PF00675	0.419
CLV_NRD_NRD_1	358	360	PF00675	0.379
CLV_NRD_NRD_1	38	40	PF00675	0.435
CLV_NRD_NRD_1	429	431	PF00675	0.437
CLV_NRD_NRD_1	466	468	PF00675	0.430
CLV_NRD_NRD_1	474	476	PF00675	0.353
CLV_NRD_NRD_1	552	554	PF00675	0.491
CLV_NRD_NRD_1	660	662	PF00675	0.461
CLV_NRD_NRD_1	708	710	PF00675	0.459
CLV_PCSK_FUR_1	118	122	PF00082	0.500
CLV_PCSK_FUR_1	176	180	PF00082	0.524
CLV_PCSK_FUR_1	706	710	PF00082	0.456
CLV_PCSK_KEX2_1	120	122	PF00082	0.437
CLV_PCSK_KEX2_1	130	132	PF00082	0.312
CLV_PCSK_KEX2_1	168	170	PF00082	0.527
CLV_PCSK_KEX2_1	178	180	PF00082	0.460
CLV_PCSK_KEX2_1	242	244	PF00082	0.499
CLV_PCSK_KEX2_1	248	250	PF00082	0.428
CLV_PCSK_KEX2_1	308	310	PF00082	0.546
CLV_PCSK_KEX2_1	340	342	PF00082	0.320
CLV_PCSK_KEX2_1	358	360	PF00082	0.400
CLV_PCSK_KEX2_1	37	39	PF00082	0.443
CLV_PCSK_KEX2_1	429	431	PF00082	0.398
CLV_PCSK_KEX2_1	466	468	PF00082	0.373
CLV_PCSK_KEX2_1	551	553	PF00082	0.530
CLV_PCSK_KEX2_1	706	708	PF00082	0.427
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.518
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.499
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.428
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.320
CLV_PCSK_PC7_1	164	170	PF00082	0.606
CLV_PCSK_PC7_1	244	250	PF00082	0.436
CLV_PCSK_SKI1_1	110	114	PF00082	0.368
CLV_PCSK_SKI1_1	14	18	PF00082	0.405
CLV_PCSK_SKI1_1	237	241	PF00082	0.584
CLV_PCSK_SKI1_1	244	248	PF00082	0.565
CLV_PCSK_SKI1_1	681	685	PF00082	0.387
CLV_PCSK_SKI1_1	727	731	PF00082	0.419
CLV_Separin_Metazoa	23	27	PF03568	0.536
DEG_APCC_DBOX_1	129	137	PF00400	0.411
DEG_APCC_DBOX_1	623	631	PF00400	0.430
DEG_SPOP_SBC_1	181	185	PF00917	0.410
DOC_CYCLIN_RxL_1	248	260	PF00134	0.582
DOC_CYCLIN_RxL_1	559	573	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.274
DOC_MAPK_gen_1	63	72	PF00069	0.491
DOC_MAPK_MEF2A_6	253	261	PF00069	0.501
DOC_MAPK_MEF2A_6	364	373	PF00069	0.318
DOC_MAPK_MEF2A_6	63	72	PF00069	0.516
DOC_MAPK_NFAT4_5	63	71	PF00069	0.491
DOC_PP1_RVXF_1	679	686	PF00149	0.385
DOC_PP2B_LxvP_1	347	350	PF13499	0.268
DOC_PP2B_LxvP_1	628	631	PF13499	0.431
DOC_PP2B_LxvP_1	713	716	PF13499	0.444
DOC_PP4_FxxP_1	415	418	PF00568	0.427
DOC_PP4_FxxP_1	672	675	PF00568	0.446
DOC_USP7_MATH_1	189	193	PF00917	0.719
DOC_USP7_MATH_1	213	217	PF00917	0.716
DOC_USP7_MATH_1	480	484	PF00917	0.363
DOC_USP7_MATH_1	502	506	PF00917	0.698
DOC_USP7_MATH_1	575	579	PF00917	0.636
DOC_USP7_MATH_1	75	79	PF00917	0.565
DOC_USP7_UBL2_3	555	559	PF12436	0.561
DOC_WW_Pin1_4	187	192	PF00397	0.724
DOC_WW_Pin1_4	194	199	PF00397	0.764
DOC_WW_Pin1_4	229	234	PF00397	0.701
DOC_WW_Pin1_4	351	356	PF00397	0.296
LIG_14-3-3_CanoR_1	146	154	PF00244	0.534
LIG_14-3-3_CanoR_1	169	177	PF00244	0.542
LIG_14-3-3_CanoR_1	284	288	PF00244	0.330
LIG_14-3-3_CanoR_1	308	314	PF00244	0.419
LIG_14-3-3_CanoR_1	422	427	PF00244	0.482
LIG_14-3-3_CanoR_1	537	543	PF00244	0.510
LIG_14-3-3_CanoR_1	653	660	PF00244	0.432
LIG_Actin_WH2_2	234	250	PF00022	0.490
LIG_Actin_WH2_2	419	434	PF00022	0.529
LIG_ActinCP_TwfCPI_2	415	424	PF01115	0.509
LIG_AP2alpha_2	658	660	PF02296	0.563
LIG_BRCT_BRCA1_1	148	152	PF00533	0.575
LIG_BRCT_BRCA1_1	189	193	PF00533	0.494
LIG_BRCT_BRCA1_1	287	291	PF00533	0.425
LIG_deltaCOP1_diTrp_1	337	342	PF00928	0.314
LIG_deltaCOP1_diTrp_1	721	726	PF00928	0.405
LIG_FHA_1	112	118	PF00498	0.521
LIG_FHA_1	302	308	PF00498	0.452
LIG_FHA_1	318	324	PF00498	0.280
LIG_FHA_1	41	47	PF00498	0.481
LIG_FHA_1	482	488	PF00498	0.602
LIG_FHA_1	537	543	PF00498	0.377
LIG_FHA_1	688	694	PF00498	0.512
LIG_FHA_2	265	271	PF00498	0.496
LIG_FHA_2	42	48	PF00498	0.481
LIG_FHA_2	487	493	PF00498	0.640
LIG_FHA_2	54	60	PF00498	0.495
LIG_FHA_2	571	577	PF00498	0.543
LIG_GBD_Chelix_1	261	269	PF00786	0.511
LIG_GBD_Chelix_1	597	605	PF00786	0.519
LIG_LIR_Apic_2	412	418	PF02991	0.436
LIG_LIR_Gen_1	273	283	PF02991	0.331
LIG_LIR_Gen_1	3	12	PF02991	0.444
LIG_LIR_Gen_1	59	69	PF02991	0.488
LIG_LIR_Nem_3	273	278	PF02991	0.342
LIG_LIR_Nem_3	280	285	PF02991	0.312
LIG_LIR_Nem_3	3	9	PF02991	0.430
LIG_LIR_Nem_3	354	360	PF02991	0.375
LIG_LIR_Nem_3	59	64	PF02991	0.518
LIG_MYND_1	625	629	PF01753	0.431
LIG_NRBOX	585	591	PF00104	0.581
LIG_Pex14_2	278	282	PF04695	0.311
LIG_Pex14_2	672	676	PF04695	0.506
LIG_SH2_CRK	469	473	PF00017	0.372
LIG_SH2_STAP1	303	307	PF00017	0.390
LIG_SH2_STAP1	311	315	PF00017	0.423
LIG_SH2_STAP1	343	347	PF00017	0.329
LIG_SH2_STAP1	469	473	PF00017	0.461
LIG_SH2_STAT3	116	119	PF00017	0.516
LIG_SH2_STAT5	116	119	PF00017	0.418
LIG_SH2_STAT5	303	306	PF00017	0.345
LIG_SH2_STAT5	326	329	PF00017	0.509
LIG_SH2_STAT5	40	43	PF00017	0.489
LIG_SH2_STAT5	433	436	PF00017	0.352
LIG_SH2_STAT5	636	639	PF00017	0.362
LIG_SH3_1	709	715	PF00018	0.463
LIG_SH3_1	717	723	PF00018	0.404
LIG_SH3_3	227	233	PF00018	0.479
LIG_SH3_3	378	384	PF00018	0.550
LIG_SH3_3	415	421	PF00018	0.567
LIG_SH3_3	623	629	PF00018	0.430
LIG_SH3_3	676	682	PF00018	0.371
LIG_SH3_3	709	715	PF00018	0.443
LIG_SH3_3	717	723	PF00018	0.396
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.529
LIG_SUMO_SIM_anti_2	319	325	PF11976	0.368
LIG_TRAF2_1	101	104	PF00917	0.325
LIG_TRAF2_1	163	166	PF00917	0.524
LIG_TRAF2_1	329	332	PF00917	0.478
LIG_TRAF2_2	675	680	PF00917	0.346
LIG_UBA3_1	265	274	PF00899	0.411
LIG_UBA3_1	601	610	PF00899	0.422
MOD_CDK_SPxK_1	231	237	PF00069	0.542
MOD_CDK_SPxxK_3	351	358	PF00069	0.315
MOD_CK1_1	125	131	PF00069	0.480
MOD_CK1_1	182	188	PF00069	0.567
MOD_CK1_1	192	198	PF00069	0.643
MOD_CK1_1	264	270	PF00069	0.506
MOD_CK1_1	536	542	PF00069	0.473
MOD_CK1_1	635	641	PF00069	0.374
MOD_CK2_1	202	208	PF00069	0.774
MOD_CK2_1	213	219	PF00069	0.531
MOD_CK2_1	264	270	PF00069	0.481
MOD_CK2_1	422	428	PF00069	0.385
MOD_CK2_1	608	614	PF00069	0.392
MOD_CK2_1	699	705	PF00069	0.341
MOD_GlcNHglycan	385	388	PF01048	0.663
MOD_GlcNHglycan	492	496	PF01048	0.634
MOD_GlcNHglycan	498	502	PF01048	0.630
MOD_GlcNHglycan	504	507	PF01048	0.689
MOD_GlcNHglycan	637	640	PF01048	0.362
MOD_GlcNHglycan	655	658	PF01048	0.398
MOD_GSK3_1	122	129	PF00069	0.336
MOD_GSK3_1	189	196	PF00069	0.749
MOD_GSK3_1	198	205	PF00069	0.792
MOD_GSK3_1	493	500	PF00069	0.621
MOD_GSK3_1	507	514	PF00069	0.587
MOD_GSK3_1	538	545	PF00069	0.481
MOD_GSK3_1	547	554	PF00069	0.489
MOD_GSK3_1	75	82	PF00069	0.609
MOD_GSK3_1	85	92	PF00069	0.523
MOD_NEK2_1	180	185	PF00069	0.587
MOD_NEK2_1	193	198	PF00069	0.706
MOD_NEK2_1	247	252	PF00069	0.557
MOD_NEK2_1	285	290	PF00069	0.407
MOD_NEK2_1	41	46	PF00069	0.472
MOD_NEK2_1	685	690	PF00069	0.421
MOD_NEK2_1	79	84	PF00069	0.553
MOD_NEK2_2	303	308	PF00069	0.443
MOD_NEK2_2	53	58	PF00069	0.514
MOD_NEK2_2	89	94	PF00069	0.434
MOD_PIKK_1	104	110	PF00454	0.299
MOD_PIKK_1	141	147	PF00454	0.394
MOD_PIKK_1	401	407	PF00454	0.558
MOD_PIKK_1	544	550	PF00454	0.607
MOD_PIKK_1	79	85	PF00454	0.515
MOD_PK_1	309	315	PF00069	0.577
MOD_PKA_1	551	557	PF00069	0.596
MOD_PKA_2	283	289	PF00069	0.335
MOD_PKA_2	536	542	PF00069	0.562
MOD_PKA_2	551	557	PF00069	0.479
MOD_PKB_1	167	175	PF00069	0.544
MOD_Plk_1	202	208	PF00069	0.493
MOD_Plk_1	41	47	PF00069	0.480
MOD_Plk_1	89	95	PF00069	0.428
MOD_Plk_2-3	608	614	PF00069	0.392
MOD_Plk_4	261	267	PF00069	0.414
MOD_Plk_4	41	47	PF00069	0.495
MOD_Plk_4	538	544	PF00069	0.487
MOD_Plk_4	632	638	PF00069	0.390
MOD_Plk_4	89	95	PF00069	0.437
MOD_ProDKin_1	187	193	PF00069	0.728
MOD_ProDKin_1	194	200	PF00069	0.761
MOD_ProDKin_1	229	235	PF00069	0.697
MOD_ProDKin_1	351	357	PF00069	0.293
MOD_SUMO_for_1	329	332	PF00179	0.527
MOD_SUMO_for_1	558	561	PF00179	0.544
MOD_SUMO_rev_2	606	611	PF00179	0.383
TRG_AP2beta_CARGO_1	280	289	PF09066	0.246
TRG_DiLeu_BaEn_1	585	590	PF01217	0.505
TRG_DiLeu_BaEn_4	463	469	PF01217	0.348
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.249
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.400
TRG_DiLeu_BaLyEn_6	679	684	PF01217	0.392
TRG_DiLeu_LyEn_5	585	590	PF01217	0.505
TRG_DiLeu_LyEn_5	623	628	PF01217	0.445
TRG_ENDOCYTIC_2	343	346	PF00928	0.409
TRG_ENDOCYTIC_2	357	360	PF00928	0.317
TRG_ENDOCYTIC_2	436	439	PF00928	0.443
TRG_ENDOCYTIC_2	469	472	PF00928	0.370
TRG_ENDOCYTIC_2	61	64	PF00928	0.479
TRG_ER_diArg_1	117	120	PF00400	0.533
TRG_ER_diArg_1	176	179	PF00400	0.536
TRG_ER_diArg_1	307	309	PF00400	0.522
TRG_ER_diArg_1	357	359	PF00400	0.373
TRG_ER_diArg_1	37	39	PF00400	0.443
TRG_ER_diArg_1	429	432	PF00400	0.383
TRG_ER_diArg_1	466	468	PF00400	0.445
TRG_ER_diArg_1	551	553	PF00400	0.533
TRG_ER_diArg_1	706	709	PF00400	0.462
TRG_NLS_MonoExtC_3	660	665	PF00514	0.565
TRG_NLS_MonoExtN_4	240	246	PF00514	0.525
TRG_NLS_MonoExtN_4	659	665	PF00514	0.461
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I355	Leptomonas seymouri	72%	87%
A0A0S4JPP8	Bodo saltans	43%	93%
A0A1X0NS88	Trypanosomatidae	50%	92%
A0A3R7LBC9	Trypanosoma rangeli	53%	97%
A0A3S7X5U8	Leishmania donovani	85%	93%
A4I888	Leishmania infantum	85%	93%
D0AAF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9B346	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	93%
Q4Q508	Leishmania major	85%	100%
V5AUT0	Trypanosoma cruzi	54%	89%