Putative superoxide dismutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

superoxide dismutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKQ3_LEIBR

TriTrypDb:

LbrM.32.2860 , LBRM2903_320036200

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004784	superoxide dismutase activity	2	6
GO:0005488	binding	1	6
GO:0016209	antioxidant activity	1	6
GO:0016491	oxidoreductase activity	2	6
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.324
CLV_PCSK_FUR_1	33	37	PF00082	0.349
CLV_PCSK_KEX2_1	103	105	PF00082	0.198
CLV_PCSK_KEX2_1	125	127	PF00082	0.291
CLV_PCSK_KEX2_1	35	37	PF00082	0.324
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.198
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.291
CLV_PCSK_SKI1_1	125	129	PF00082	0.301
DEG_MDM2_SWIB_1	50	58	PF02201	0.495
DOC_MAPK_MEF2A_6	2	11	PF00069	0.315
DOC_USP7_MATH_1	23	27	PF00917	0.415
DOC_WW_Pin1_4	81	86	PF00397	0.198
LIG_BRCT_BRCA1_1	108	112	PF00533	0.198
LIG_Clathr_ClatBox_1	86	90	PF01394	0.198
LIG_deltaCOP1_diTrp_1	116	124	PF00928	0.306
LIG_eIF4E_1	81	87	PF01652	0.198
LIG_FHA_1	22	28	PF00498	0.348
LIG_FHA_1	4	10	PF00498	0.308
LIG_FHA_1	82	88	PF00498	0.382
LIG_FHA_2	77	83	PF00498	0.320
LIG_HCF-1_HBM_1	93	96	PF13415	0.495
LIG_LIR_Gen_1	109	120	PF02991	0.345
LIG_LIR_Nem_3	109	115	PF02991	0.345
LIG_LIR_Nem_3	82	86	PF02991	0.198
LIG_MLH1_MIPbox_1	108	112	PF16413	0.198
LIG_Pex14_1	92	96	PF04695	0.495
LIG_Pex14_2	38	42	PF04695	0.407
LIG_Pex14_2	50	54	PF04695	0.340
LIG_PTB_Apo_2	77	84	PF02174	0.198
LIG_PTB_Phospho_1	77	83	PF10480	0.198
LIG_SH2_CRK	83	87	PF00017	0.198
LIG_SH2_GRB2like	100	103	PF00017	0.286
LIG_SH2_GRB2like	71	74	PF00017	0.198
LIG_SH2_NCK_1	71	75	PF00017	0.198
LIG_SH2_STAP1	133	137	PF00017	0.389
LIG_SH2_STAP1	59	63	PF00017	0.198
LIG_SH2_STAT5	107	110	PF00017	0.333
LIG_SH2_STAT5	111	114	PF00017	0.268
LIG_SH2_STAT5	83	86	PF00017	0.287
LIG_SH2_STAT5	97	100	PF00017	0.476
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.295
LIG_UBA3_1	7	13	PF00899	0.303
MOD_CK2_1	76	82	PF00069	0.198
MOD_CMANNOS	54	57	PF00535	0.198
MOD_GlcNHglycan	51	54	PF01048	0.495
MOD_LATS_1	123	129	PF00433	0.291
MOD_NEK2_1	49	54	PF00069	0.323
MOD_NEK2_2	23	28	PF00069	0.375
MOD_PKA_1	125	131	PF00069	0.313
MOD_PKA_2	125	131	PF00069	0.313
MOD_Plk_4	3	9	PF00069	0.318
MOD_ProDKin_1	81	87	PF00069	0.198
MOD_SUMO_rev_2	99	105	PF00179	0.198
TRG_DiLeu_LyEn_5	82	87	PF01217	0.198
TRG_ENDOCYTIC_2	111	114	PF00928	0.198
TRG_ENDOCYTIC_2	132	135	PF00928	0.361
TRG_ENDOCYTIC_2	83	86	PF00928	0.198
TRG_ER_diArg_1	32	35	PF00400	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5M7	Leishmania donovani	43%	66%
A0R652	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	67%
A4HKH0	Leishmania braziliensis	38%	71%
A4HKH1	Leishmania braziliensis	39%	66%
A4I7Z7	Leishmania infantum	38%	71%
A4I7Z8	Leishmania infantum	43%	66%
D3KVM5	Burkholderia sp.	37%	72%
E9B2V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	71%
E9B2W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	66%
O84296	Chlamydia trachomatis (strain D/UW-3/Cx)	30%	67%
O86165	Mycobacterium lepraemurium	32%	67%
P00448	Escherichia coli (strain K12)	34%	67%
P00449	Geobacillus stearothermophilus	38%	68%
P09213	Photobacterium leiognathi	38%	72%
P09223	Pseudomonas putida	41%	70%
P09224	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	29%	69%
P09737	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	28%	69%
P0C0F8	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	37%	68%
P0C0F9	Xanthomonas campestris pv. campestris (strain 8004)	37%	68%
P0C0I0	Streptococcus pyogenes	36%	69%
P0C0I1	Streptococcus pyogenes serotype M1	37%	69%
P13367	Mycobacterium leprae (strain TN)	31%	67%
P18868	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	67%
P19666	Tetrahymena pyriformis	36%	70%
P22302	Nicotiana plumbaginifolia	42%	68%
P22799	Raoultella planticola	34%	81%
P28760	Bacillus caldotenax	37%	68%
P28763	Listeria ivanovii	34%	68%
P28764	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	33%	68%
P41982	Oryctolagus cuniculus	31%	68%
P42821	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	30%	69%
P43019	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	67%
P46728	Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)	30%	67%
P47201	Mycobacterium avium	31%	67%
P50059	Leptolyngbya boryana	33%	67%
P50061	Leptolyngbya boryana	34%	69%
P50913	Mycobacterium scrofulaceum	33%	85%
P53647	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	31%	67%
P53649	Mycolicibacterium smegmatis	31%	67%
P53651	Nocardia asteroides	31%	67%
P53653	Thermus aquaticus	32%	68%
P53655	Yersinia enterocolitica	33%	67%
P54375	Bacillus subtilis (strain 168)	38%	68%
P57286	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	32%	68%
P61502	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	32%	68%
P61503	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	32%	68%
P66828	Escherichia coli O157:H7	35%	67%
P66829	Shigella flexneri	35%	67%
P80293	Propionibacterium freudenreichii subsp. shermanii	30%	69%
P9WGE6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	67%
P9WGE7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	67%
Q1RH88	Rickettsia bellii (strain RML369-C)	41%	66%
Q27740	Plasmodium falciparum (isolate HB3)	36%	70%
Q4Q596	Leishmania major	46%	66%
Q59519	Mycolicibacterium fortuitum	31%	67%
Q5XBF8	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	37%	69%
Q60036	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	28%	68%
Q71S88	Leishmania donovani	38%	71%
Q7SIC3	Virgibacillus halodenitrificans	36%	68%
Q7TVI9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	67%
Q838I4	Enterococcus faecalis (strain ATCC 700802 / V583)	35%	68%
Q88PD5	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	41%	70%
Q89AR7	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	35%	66%
Q8HXP0	Callithrix jacchus	32%	70%
Q8HXP1	Sapajus apella	32%	70%
Q8HXP2	Macaca mulatta	32%	70%
Q8HXP4	Macaca fuscata fuscata	32%	70%
Q8HXP5	Hylobates lar	29%	70%
Q8HXP7	Pan troglodytes	30%	70%
Q8IAY6	Plasmodium falciparum (isolate 3D7)	36%	70%
Q8K9V4	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	68%
Q8P0D4	Streptococcus pyogenes serotype M18 (strain MGAS8232)	36%	69%
Q8YSZ1	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	33%	69%
Q8Z2V9	Salmonella typhi	35%	67%
Q92429	Ganoderma microsporum	28%	69%
Q92BR6	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	35%	68%
Q9P4T6	Agaricus bisporus	32%	69%
Q9PKA0	Chlamydia muridarum (strain MoPn / Nigg)	31%	67%
Q9TW89	Plasmodium falciparum	36%	70%
Q9Y1A9	Plasmodium vivax	36%	70%
Q9Y1B0	Plasmodium malariae	35%	70%
Q9Z9C4	Chlamydia pneumoniae	32%	67%