Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKQ0_LEIBR

TriTrypDb:

LbrM.32.2830 , LBRM2903_320035800

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.413
CLV_NRD_NRD_1	391	393	PF00675	0.570
CLV_NRD_NRD_1	437	439	PF00675	0.692
CLV_NRD_NRD_1	441	443	PF00675	0.542
CLV_NRD_NRD_1	516	518	PF00675	0.757
CLV_NRD_NRD_1	542	544	PF00675	0.607
CLV_NRD_NRD_1	697	699	PF00675	0.690
CLV_NRD_NRD_1	705	707	PF00675	0.542
CLV_PCSK_KEX2_1	390	392	PF00082	0.565
CLV_PCSK_KEX2_1	441	443	PF00082	0.553
CLV_PCSK_KEX2_1	516	518	PF00082	0.655
CLV_PCSK_KEX2_1	542	544	PF00082	0.607
CLV_PCSK_KEX2_1	697	699	PF00082	0.622
CLV_PCSK_KEX2_1	705	707	PF00082	0.523
CLV_PCSK_PC7_1	386	392	PF00082	0.545
CLV_PCSK_SKI1_1	12	16	PF00082	0.442
CLV_PCSK_SKI1_1	237	241	PF00082	0.531
CLV_PCSK_SKI1_1	441	445	PF00082	0.568
CLV_PCSK_SKI1_1	5	9	PF00082	0.444
CLV_PCSK_SKI1_1	528	532	PF00082	0.553
CLV_PCSK_SKI1_1	534	538	PF00082	0.597
CLV_PCSK_SKI1_1	64	68	PF00082	0.474
CLV_PCSK_SKI1_1	698	702	PF00082	0.501
DEG_APCC_DBOX_1	312	320	PF00400	0.484
DEG_APCC_DBOX_1	391	399	PF00400	0.568
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DEG_SCF_FBW7_1	560	565	PF00400	0.544
DEG_SPOP_SBC_1	401	405	PF00917	0.804
DEG_SPOP_SBC_1	552	556	PF00917	0.483
DEG_SPOP_SBC_1	590	594	PF00917	0.804
DEG_SPOP_SBC_1	664	668	PF00917	0.814
DEG_SPOP_SBC_1	72	76	PF00917	0.473
DOC_CKS1_1	684	689	PF01111	0.583
DOC_CYCLIN_RxL_1	438	447	PF00134	0.565
DOC_CYCLIN_RxL_1	528	541	PF00134	0.682
DOC_CYCLIN_RxL_1	695	703	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	16	19	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.542
DOC_MAPK_FxFP_2	424	427	PF00069	0.569
DOC_MAPK_MEF2A_6	473	480	PF00069	0.645
DOC_MAPK_MEF2A_6	97	106	PF00069	0.605
DOC_PP1_RVXF_1	285	291	PF00149	0.344
DOC_PP2B_LxvP_1	102	105	PF13499	0.500
DOC_PP2B_LxvP_1	15	18	PF13499	0.470
DOC_PP2B_LxvP_1	634	637	PF13499	0.540
DOC_PP4_FxxP_1	116	119	PF00568	0.593
DOC_PP4_FxxP_1	424	427	PF00568	0.569
DOC_PP4_FxxP_1	52	55	PF00568	0.486
DOC_PP4_FxxP_1	684	687	PF00568	0.586
DOC_USP7_MATH_1	128	132	PF00917	0.594
DOC_USP7_MATH_1	321	325	PF00917	0.682
DOC_USP7_MATH_1	333	337	PF00917	0.676
DOC_USP7_MATH_1	362	366	PF00917	0.737
DOC_USP7_MATH_1	367	371	PF00917	0.700
DOC_USP7_MATH_1	409	413	PF00917	0.665
DOC_USP7_MATH_1	45	49	PF00917	0.472
DOC_USP7_MATH_1	497	501	PF00917	0.628
DOC_USP7_MATH_1	562	566	PF00917	0.582
DOC_USP7_MATH_1	570	574	PF00917	0.829
DOC_USP7_MATH_1	629	633	PF00917	0.718
DOC_USP7_MATH_1	637	641	PF00917	0.768
DOC_USP7_MATH_1	664	668	PF00917	0.744
DOC_USP7_MATH_1	677	681	PF00917	0.703
DOC_USP7_MATH_1	73	77	PF00917	0.473
DOC_WW_Pin1_4	18	23	PF00397	0.467
DOC_WW_Pin1_4	344	349	PF00397	0.700
DOC_WW_Pin1_4	425	430	PF00397	0.803
DOC_WW_Pin1_4	558	563	PF00397	0.531
DOC_WW_Pin1_4	572	577	PF00397	0.563
DOC_WW_Pin1_4	59	64	PF00397	0.484
DOC_WW_Pin1_4	591	596	PF00397	0.577
DOC_WW_Pin1_4	620	625	PF00397	0.723
DOC_WW_Pin1_4	632	637	PF00397	0.703
DOC_WW_Pin1_4	639	644	PF00397	0.607
DOC_WW_Pin1_4	645	650	PF00397	0.626
DOC_WW_Pin1_4	683	688	PF00397	0.835
LIG_14-3-3_CanoR_1	320	328	PF00244	0.769
LIG_14-3-3_CanoR_1	329	337	PF00244	0.657
LIG_14-3-3_CanoR_1	390	396	PF00244	0.568
LIG_14-3-3_CanoR_1	441	450	PF00244	0.544
LIG_14-3-3_CanoR_1	54	63	PF00244	0.486
LIG_14-3-3_CanoR_1	705	714	PF00244	0.543
LIG_Actin_WH2_2	174	189	PF00022	0.471
LIG_Actin_WH2_2	307	322	PF00022	0.600
LIG_BRCT_BRCA1_1	112	116	PF00533	0.605
LIG_BRCT_BRCA1_1	324	328	PF00533	0.539
LIG_BRCT_BRCA1_1	369	373	PF00533	0.756
LIG_BRCT_BRCA1_1	599	603	PF00533	0.620
LIG_BRCT_BRCA1_1	61	65	PF00533	0.479
LIG_BRCT_BRCA1_1	610	614	PF00533	0.727
LIG_BRCT_BRCA1_1	641	645	PF00533	0.770
LIG_BRCT_BRCA1_2	610	616	PF00533	0.571
LIG_Clathr_ClatBox_1	227	231	PF01394	0.334
LIG_deltaCOP1_diTrp_1	498	508	PF00928	0.629
LIG_EH1_1	212	220	PF00400	0.576
LIG_EH1_1	221	229	PF00400	0.407
LIG_FHA_1	161	167	PF00498	0.492
LIG_FHA_1	175	181	PF00498	0.491
LIG_FHA_1	25	31	PF00498	0.449
LIG_FHA_1	266	272	PF00498	0.574
LIG_FHA_1	301	307	PF00498	0.558
LIG_FHA_1	445	451	PF00498	0.630
LIG_FHA_1	561	567	PF00498	0.765
LIG_FHA_1	652	658	PF00498	0.571
LIG_FHA_2	367	373	PF00498	0.763
LIG_FHA_2	524	530	PF00498	0.689
LIG_LIR_Apic_2	113	119	PF02991	0.601
LIG_LIR_Apic_2	50	55	PF02991	0.483
LIG_LIR_Apic_2	682	687	PF02991	0.588
LIG_LIR_Gen_1	110	120	PF02991	0.431
LIG_LIR_Gen_1	289	297	PF02991	0.350
LIG_LIR_Gen_1	47	57	PF02991	0.481
LIG_LIR_Gen_1	507	512	PF02991	0.465
LIG_LIR_Gen_1	94	103	PF02991	0.571
LIG_LIR_LC3C_4	163	167	PF02991	0.558
LIG_LIR_Nem_3	110	115	PF02991	0.582
LIG_LIR_Nem_3	241	247	PF02991	0.538
LIG_LIR_Nem_3	289	293	PF02991	0.353
LIG_LIR_Nem_3	47	52	PF02991	0.476
LIG_LIR_Nem_3	472	477	PF02991	0.754
LIG_LIR_Nem_3	487	492	PF02991	0.530
LIG_LIR_Nem_3	507	511	PF02991	0.490
LIG_LIR_Nem_3	600	606	PF02991	0.545
LIG_LIR_Nem_3	94	98	PF02991	0.463
LIG_LYPXL_yS_3	244	247	PF13949	0.521
LIG_PCNA_yPIPBox_3	705	714	PF02747	0.543
LIG_Pex14_2	52	56	PF04695	0.487
LIG_Pex14_2	65	69	PF04695	0.436
LIG_SH2_CRK	112	116	PF00017	0.605
LIG_SH2_SRC	201	204	PF00017	0.390
LIG_SH2_STAP1	112	116	PF00017	0.352
LIG_SH2_STAP1	95	99	PF00017	0.572
LIG_SH2_STAT5	254	257	PF00017	0.412
LIG_SH2_STAT5	39	42	PF00017	0.460
LIG_SH2_STAT5	57	60	PF00017	0.437
LIG_SH2_STAT5	87	90	PF00017	0.502
LIG_SH3_3	16	22	PF00018	0.469
LIG_SH3_3	315	321	PF00018	0.526
LIG_SH3_3	342	348	PF00018	0.687
LIG_SH3_3	563	569	PF00018	0.562
LIG_SH3_3	573	579	PF00018	0.639
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.567
LIG_SUMO_SIM_par_1	226	232	PF11976	0.465
LIG_TRAF2_1	692	695	PF00917	0.662
LIG_UBA3_1	293	300	PF00899	0.607
LIG_WRC_WIRS_1	46	51	PF05994	0.474
MOD_CDK_SPK_2	59	64	PF00069	0.484
MOD_CDK_SPK_2	620	625	PF00069	0.585
MOD_CDK_SPK_2	639	644	PF00069	0.503
MOD_CDK_SPxxK_3	620	627	PF00069	0.587
MOD_CDK_SPxxK_3	683	690	PF00069	0.833
MOD_CK1_1	139	145	PF00069	0.691
MOD_CK1_1	146	152	PF00069	0.675
MOD_CK1_1	189	195	PF00069	0.462
MOD_CK1_1	338	344	PF00069	0.757
MOD_CK1_1	347	353	PF00069	0.713
MOD_CK1_1	399	405	PF00069	0.724
MOD_CK1_1	412	418	PF00069	0.763
MOD_CK1_1	47	53	PF00069	0.477
MOD_CK1_1	510	516	PF00069	0.695
MOD_CK1_1	556	562	PF00069	0.696
MOD_CK1_1	597	603	PF00069	0.751
MOD_CK1_1	610	616	PF00069	0.724
MOD_CK1_1	632	638	PF00069	0.714
MOD_CK1_1	666	672	PF00069	0.837
MOD_CK1_1	675	681	PF00069	0.723
MOD_CK1_1	683	689	PF00069	0.691
MOD_CK1_1	75	81	PF00069	0.478
MOD_CK2_1	523	529	PF00069	0.702
MOD_CK2_1	620	626	PF00069	0.703
MOD_CK2_1	689	695	PF00069	0.781
MOD_Cter_Amidation	388	391	PF01082	0.549
MOD_Cter_Amidation	514	517	PF01082	0.495
MOD_GlcNHglycan	12	15	PF01048	0.460
MOD_GlcNHglycan	307	310	PF01048	0.653
MOD_GlcNHglycan	33	36	PF01048	0.439
MOD_GlcNHglycan	337	340	PF01048	0.713
MOD_GlcNHglycan	406	409	PF01048	0.817
MOD_GlcNHglycan	414	417	PF01048	0.735
MOD_GlcNHglycan	484	487	PF01048	0.492
MOD_GlcNHglycan	49	52	PF01048	0.434
MOD_GlcNHglycan	555	558	PF01048	0.582
MOD_GlcNHglycan	675	678	PF01048	0.701
MOD_GlcNHglycan	679	682	PF01048	0.737
MOD_GSK3_1	133	140	PF00069	0.555
MOD_GSK3_1	142	149	PF00069	0.586
MOD_GSK3_1	18	25	PF00069	0.465
MOD_GSK3_1	31	38	PF00069	0.409
MOD_GSK3_1	329	336	PF00069	0.693
MOD_GSK3_1	340	347	PF00069	0.598
MOD_GSK3_1	362	369	PF00069	0.749
MOD_GSK3_1	396	403	PF00069	0.735
MOD_GSK3_1	506	513	PF00069	0.559
MOD_GSK3_1	542	549	PF00069	0.608
MOD_GSK3_1	55	62	PF00069	0.485
MOD_GSK3_1	552	559	PF00069	0.701
MOD_GSK3_1	560	567	PF00069	0.647
MOD_GSK3_1	585	592	PF00069	0.730
MOD_GSK3_1	593	600	PF00069	0.730
MOD_GSK3_1	635	642	PF00069	0.780
MOD_GSK3_1	653	660	PF00069	0.809
MOD_GSK3_1	663	670	PF00069	0.832
MOD_GSK3_1	672	679	PF00069	0.717
MOD_GSK3_1	685	692	PF00069	0.590
MOD_GSK3_1	705	712	PF00069	0.665
MOD_GSK3_1	71	78	PF00069	0.447
MOD_N-GLC_1	384	389	PF02516	0.623
MOD_N-GLC_1	412	417	PF02516	0.599
MOD_N-GLC_1	638	643	PF02516	0.572
MOD_NEK2_1	143	148	PF00069	0.496
MOD_NEK2_1	186	191	PF00069	0.457
MOD_NEK2_1	229	234	PF00069	0.352
MOD_NEK2_1	265	270	PF00069	0.439
MOD_NEK2_1	305	310	PF00069	0.567
MOD_NEK2_1	328	333	PF00069	0.544
MOD_NEK2_1	444	449	PF00069	0.642
MOD_NEK2_1	511	516	PF00069	0.486
MOD_NEK2_1	544	549	PF00069	0.669
MOD_NEK2_1	551	556	PF00069	0.654
MOD_NEK2_1	589	594	PF00069	0.715
MOD_OFUCOSY	53	59	PF10250	0.488
MOD_PIKK_1	22	28	PF00454	0.455
MOD_PIKK_1	322	328	PF00454	0.573
MOD_PIKK_1	579	585	PF00454	0.558
MOD_PIKK_1	657	663	PF00454	0.734
MOD_PKA_1	390	396	PF00069	0.568
MOD_PKA_1	542	548	PF00069	0.624
MOD_PKA_1	705	711	PF00069	0.583
MOD_PKA_2	186	192	PF00069	0.463
MOD_PKA_2	328	334	PF00069	0.589
MOD_PKA_2	390	396	PF00069	0.584
MOD_PKA_2	542	548	PF00069	0.617
MOD_PKA_2	705	711	PF00069	0.532
MOD_Plk_1	375	381	PF00069	0.582
MOD_Plk_1	497	503	PF00069	0.513
MOD_Plk_4	139	145	PF00069	0.503
MOD_Plk_4	174	180	PF00069	0.533
MOD_Plk_4	186	192	PF00069	0.385
MOD_Plk_4	223	229	PF00069	0.399
MOD_Plk_4	653	659	PF00069	0.572
MOD_Plk_4	709	715	PF00069	0.559
MOD_ProDKin_1	18	24	PF00069	0.466
MOD_ProDKin_1	344	350	PF00069	0.702
MOD_ProDKin_1	425	431	PF00069	0.797
MOD_ProDKin_1	558	564	PF00069	0.535
MOD_ProDKin_1	572	578	PF00069	0.563
MOD_ProDKin_1	59	65	PF00069	0.482
MOD_ProDKin_1	591	597	PF00069	0.576
MOD_ProDKin_1	620	626	PF00069	0.723
MOD_ProDKin_1	632	638	PF00069	0.701
MOD_ProDKin_1	639	645	PF00069	0.609
MOD_ProDKin_1	683	689	PF00069	0.833
TRG_DiLeu_BaEn_1	174	179	PF01217	0.578
TRG_DiLeu_BaEn_2	469	475	PF01217	0.521
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.619
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.354
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.347
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.558
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.566
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.654
TRG_ENDOCYTIC_2	112	115	PF00928	0.355
TRG_ENDOCYTIC_2	244	247	PF00928	0.521
TRG_ENDOCYTIC_2	95	98	PF00928	0.574
TRG_ER_diArg_1	302	305	PF00400	0.493
TRG_ER_diArg_1	390	392	PF00400	0.565
TRG_ER_diArg_1	441	443	PF00400	0.580
TRG_ER_diArg_1	516	518	PF00400	0.757
TRG_ER_diArg_1	542	544	PF00400	0.607
TRG_ER_diArg_1	696	698	PF00400	0.600
TRG_NLS_MonoExtC_3	437	442	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K7	Leptomonas seymouri	44%	100%
A0A3Q8IGY3	Leishmania donovani	64%	100%
A4I881	Leishmania infantum	64%	100%
E9B339	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q515	Leishmania major	63%	100%