WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKP8_LEIBR

TriTrypDb:

LbrM.32.2810 , LBRM2903_320035600

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.532
CLV_NRD_NRD_1	351	353	PF00675	0.718
CLV_NRD_NRD_1	358	360	PF00675	0.590
CLV_PCSK_KEX2_1	351	353	PF00082	0.660
CLV_PCSK_KEX2_1	358	360	PF00082	0.543
CLV_PCSK_SKI1_1	292	296	PF00082	0.384
DEG_Nend_UBRbox_3	1	3	PF02207	0.402
DOC_CKS1_1	63	68	PF01111	0.479
DOC_MAPK_gen_1	277	287	PF00069	0.469
DOC_MAPK_MEF2A_6	280	289	PF00069	0.420
DOC_PP1_RVXF_1	147	153	PF00149	0.324
DOC_PP1_RVXF_1	88	95	PF00149	0.451
DOC_USP7_MATH_1	103	107	PF00917	0.417
DOC_USP7_MATH_1	331	335	PF00917	0.721
DOC_USP7_MATH_1	67	71	PF00917	0.423
DOC_WW_Pin1_4	108	113	PF00397	0.348
DOC_WW_Pin1_4	62	67	PF00397	0.465
LIG_14-3-3_CanoR_1	131	137	PF00244	0.381
LIG_BIR_III_2	258	262	PF00653	0.524
LIG_FHA_1	202	208	PF00498	0.390
LIG_FHA_1	232	238	PF00498	0.277
LIG_FHA_1	270	276	PF00498	0.452
LIG_FHA_1	33	39	PF00498	0.486
LIG_FHA_1	54	60	PF00498	0.393
LIG_FHA_2	293	299	PF00498	0.334
LIG_FHA_2	7	13	PF00498	0.446
LIG_GBD_Chelix_1	285	293	PF00786	0.387
LIG_LIR_Apic_2	211	217	PF02991	0.347
LIG_LIR_Apic_2	224	230	PF02991	0.409
LIG_LIR_Gen_1	130	139	PF02991	0.490
LIG_LIR_Gen_1	238	246	PF02991	0.467
LIG_LIR_Nem_3	130	136	PF02991	0.518
LIG_LIR_Nem_3	231	235	PF02991	0.487
LIG_LIR_Nem_3	238	242	PF02991	0.444
LIG_PTAP_UEV_1	111	116	PF05743	0.439
LIG_SH2_CRK	227	231	PF00017	0.519
LIG_SH2_NCK_1	227	231	PF00017	0.414
LIG_SH2_SRC	11	14	PF00017	0.569
LIG_SH2_STAP1	41	45	PF00017	0.461
LIG_SH2_STAT3	41	44	PF00017	0.438
LIG_SH2_STAT3	73	76	PF00017	0.347
LIG_SH2_STAT5	16	19	PF00017	0.359
LIG_SH2_STAT5	214	217	PF00017	0.339
LIG_SH2_STAT5	235	238	PF00017	0.344
LIG_SH3_3	109	115	PF00018	0.433
LIG_SH3_3	315	321	PF00018	0.703
LIG_SH3_3	60	66	PF00018	0.415
LIG_TRAF2_1	171	174	PF00917	0.473
MOD_CK1_1	228	234	PF00069	0.294
MOD_CK1_1	32	38	PF00069	0.378
MOD_CK2_1	157	163	PF00069	0.322
MOD_CK2_1	168	174	PF00069	0.352
MOD_CK2_1	184	190	PF00069	0.315
MOD_CK2_1	292	298	PF00069	0.333
MOD_CK2_1	331	337	PF00069	0.521
MOD_CK2_1	6	12	PF00069	0.416
MOD_Cter_Amidation	349	352	PF01082	0.541
MOD_GlcNHglycan	100	103	PF01048	0.479
MOD_GlcNHglycan	112	115	PF01048	0.440
MOD_GlcNHglycan	159	162	PF01048	0.315
MOD_GlcNHglycan	242	245	PF01048	0.498
MOD_GlcNHglycan	249	252	PF01048	0.485
MOD_GlcNHglycan	321	324	PF01048	0.728
MOD_GlcNHglycan	353	356	PF01048	0.777
MOD_GSK3_1	104	111	PF00069	0.342
MOD_GSK3_1	153	160	PF00069	0.301
MOD_GSK3_1	25	32	PF00069	0.350
MOD_GSK3_1	310	317	PF00069	0.614
MOD_GSK3_1	319	326	PF00069	0.611
MOD_GSK3_1	67	74	PF00069	0.383
MOD_GSK3_1	7	14	PF00069	0.332
MOD_N-GLC_1	153	158	PF02516	0.248
MOD_N-GLC_1	23	28	PF02516	0.473
MOD_NEK2_1	127	132	PF00069	0.381
MOD_NEK2_1	153	158	PF00069	0.299
MOD_NEK2_1	201	206	PF00069	0.332
MOD_NEK2_1	29	34	PF00069	0.350
MOD_NEK2_1	71	76	PF00069	0.409
MOD_NEK2_1	98	103	PF00069	0.430
MOD_PIKK_1	269	275	PF00454	0.515
MOD_PIKK_1	32	38	PF00454	0.474
MOD_PIKK_1	53	59	PF00454	0.454
MOD_PKA_1	351	357	PF00069	0.535
MOD_PKA_2	222	228	PF00069	0.484
MOD_PKA_2	323	329	PF00069	0.614
MOD_PKA_2	351	357	PF00069	0.701
MOD_Plk_1	145	151	PF00069	0.321
MOD_Plk_1	153	159	PF00069	0.329
MOD_Plk_1	280	286	PF00069	0.384
MOD_Plk_4	12	18	PF00069	0.419
MOD_Plk_4	153	159	PF00069	0.272
MOD_Plk_4	231	237	PF00069	0.285
MOD_Plk_4	314	320	PF00069	0.714
MOD_Plk_4	67	73	PF00069	0.364
MOD_ProDKin_1	108	114	PF00069	0.346
MOD_ProDKin_1	62	68	PF00069	0.465
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.440
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.454
TRG_ER_diArg_1	149	152	PF00400	0.315
TRG_ER_diArg_1	357	359	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A3	Leptomonas seymouri	74%	100%
A0A0S4J2R9	Bodo saltans	43%	96%
A0A1X0NRV1	Trypanosomatidae	43%	100%
A0A3Q8IDA1	Leishmania donovani	84%	83%
A0A3R7L0G4	Trypanosoma rangeli	52%	100%
A4I879	Leishmania infantum	84%	83%
D0AAE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B337	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q517	Leishmania major	86%	100%
V5BET5	Trypanosoma cruzi	52%	88%