Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKP7_LEIBR

TriTrypDb:

LbrM.32.2800 , LBRM2903_320035500

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.602
CLV_C14_Caspase3-7	431	435	PF00656	0.514
CLV_C14_Caspase3-7	454	458	PF00656	0.527
CLV_C14_Caspase3-7	646	650	PF00656	0.593
CLV_C14_Caspase3-7	756	760	PF00656	0.451
CLV_NRD_NRD_1	183	185	PF00675	0.697
CLV_NRD_NRD_1	446	448	PF00675	0.670
CLV_NRD_NRD_1	480	482	PF00675	0.756
CLV_NRD_NRD_1	532	534	PF00675	0.641
CLV_NRD_NRD_1	694	696	PF00675	0.577
CLV_NRD_NRD_1	83	85	PF00675	0.595
CLV_PCSK_FUR_1	181	185	PF00082	0.515
CLV_PCSK_FUR_1	478	482	PF00082	0.749
CLV_PCSK_FUR_1	529	533	PF00082	0.620
CLV_PCSK_FUR_1	692	696	PF00082	0.579
CLV_PCSK_KEX2_1	183	185	PF00082	0.636
CLV_PCSK_KEX2_1	446	448	PF00082	0.669
CLV_PCSK_KEX2_1	480	482	PF00082	0.756
CLV_PCSK_KEX2_1	531	533	PF00082	0.661
CLV_PCSK_KEX2_1	57	59	PF00082	0.557
CLV_PCSK_KEX2_1	616	618	PF00082	0.828
CLV_PCSK_KEX2_1	694	696	PF00082	0.577
CLV_PCSK_KEX2_1	83	85	PF00082	0.629
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.557
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.731
CLV_PCSK_SKI1_1	231	235	PF00082	0.555
CLV_PCSK_SKI1_1	240	244	PF00082	0.511
CLV_PCSK_SKI1_1	28	32	PF00082	0.544
CLV_PCSK_SKI1_1	450	454	PF00082	0.540
CLV_PCSK_SKI1_1	555	559	PF00082	0.632
DEG_SCF_FBW7_1	159	166	PF00400	0.533
DEG_SCF_FBW7_1	302	307	PF00400	0.601
DEG_SCF_FBW7_1	719	726	PF00400	0.578
DEG_SPOP_SBC_1	153	157	PF00917	0.724
DOC_ANK_TNKS_1	386	393	PF00023	0.717
DOC_ANK_TNKS_1	45	52	PF00023	0.567
DOC_CKS1_1	160	165	PF01111	0.791
DOC_CKS1_1	296	301	PF01111	0.846
DOC_CKS1_1	720	725	PF01111	0.581
DOC_MAPK_FxFP_2	517	520	PF00069	0.540
DOC_MAPK_gen_1	568	575	PF00069	0.784
DOC_MAPK_gen_1	616	626	PF00069	0.781
DOC_PP1_RVXF_1	512	518	PF00149	0.544
DOC_PP4_FxxP_1	296	299	PF00568	0.717
DOC_PP4_FxxP_1	517	520	PF00568	0.730
DOC_USP7_MATH_1	153	157	PF00917	0.672
DOC_USP7_MATH_1	163	167	PF00917	0.594
DOC_USP7_MATH_1	23	27	PF00917	0.633
DOC_USP7_MATH_1	304	308	PF00917	0.859
DOC_USP7_MATH_1	410	414	PF00917	0.571
DOC_USP7_MATH_1	53	57	PF00917	0.668
DOC_USP7_MATH_1	647	651	PF00917	0.758
DOC_USP7_MATH_1	656	660	PF00917	0.676
DOC_USP7_MATH_1	723	727	PF00917	0.716
DOC_USP7_MATH_1	743	747	PF00917	0.626
DOC_WW_Pin1_4	12	17	PF00397	0.691
DOC_WW_Pin1_4	159	164	PF00397	0.798
DOC_WW_Pin1_4	201	206	PF00397	0.603
DOC_WW_Pin1_4	266	271	PF00397	0.790
DOC_WW_Pin1_4	289	294	PF00397	0.780
DOC_WW_Pin1_4	295	300	PF00397	0.833
DOC_WW_Pin1_4	38	43	PF00397	0.816
DOC_WW_Pin1_4	413	418	PF00397	0.765
DOC_WW_Pin1_4	615	620	PF00397	0.739
DOC_WW_Pin1_4	658	663	PF00397	0.812
DOC_WW_Pin1_4	683	688	PF00397	0.848
DOC_WW_Pin1_4	719	724	PF00397	0.782
LIG_14-3-3_CanoR_1	123	132	PF00244	0.782
LIG_14-3-3_CanoR_1	152	159	PF00244	0.612
LIG_14-3-3_CanoR_1	341	348	PF00244	0.700
LIG_14-3-3_CanoR_1	4	10	PF00244	0.587
LIG_14-3-3_CanoR_1	494	500	PF00244	0.720
LIG_14-3-3_CanoR_1	514	520	PF00244	0.466
LIG_14-3-3_CanoR_1	568	573	PF00244	0.641
LIG_BIR_III_2	290	294	PF00653	0.605
LIG_BIR_III_4	503	507	PF00653	0.524
LIG_BRCT_BRCA1_1	229	233	PF00533	0.766
LIG_FHA_1	267	273	PF00498	0.844
LIG_FHA_1	313	319	PF00498	0.611
LIG_FHA_1	537	543	PF00498	0.641
LIG_FHA_2	213	219	PF00498	0.725
LIG_FHA_2	429	435	PF00498	0.773
LIG_FHA_2	452	458	PF00498	0.532
LIG_FHA_2	57	63	PF00498	0.712
LIG_FHA_2	673	679	PF00498	0.550
LIG_Integrin_isoDGR_2	711	713	PF01839	0.570
LIG_LIR_Apic_2	219	225	PF02991	0.592
LIG_LIR_Apic_2	295	299	PF02991	0.706
LIG_LIR_Apic_2	434	440	PF02991	0.520
LIG_LIR_Gen_1	571	579	PF02991	0.521
LIG_LIR_Gen_1	652	662	PF02991	0.785
LIG_LIR_Nem_3	518	522	PF02991	0.532
LIG_LIR_Nem_3	571	575	PF02991	0.541
LIG_LIR_Nem_3	652	657	PF02991	0.793
LIG_MYND_1	198	202	PF01753	0.595
LIG_NRBOX	537	543	PF00104	0.641
LIG_NRBOX	580	586	PF00104	0.492
LIG_Pex14_2	331	335	PF04695	0.702
LIG_RPA_C_Fungi	147	159	PF08784	0.570
LIG_SH2_CRK	222	226	PF00017	0.589
LIG_SH2_GRB2like	672	675	PF00017	0.557
LIG_SH2_NCK_1	437	441	PF00017	0.523
LIG_SH2_PTP2	572	575	PF00017	0.541
LIG_SH2_SRC	427	430	PF00017	0.537
LIG_SH2_SRC	437	440	PF00017	0.482
LIG_SH2_STAP1	679	683	PF00017	0.572
LIG_SH2_STAT3	378	381	PF00017	0.590
LIG_SH2_STAT3	749	752	PF00017	0.606
LIG_SH2_STAT5	216	219	PF00017	0.713
LIG_SH2_STAT5	572	575	PF00017	0.571
LIG_SH2_STAT5	672	675	PF00017	0.557
LIG_SH2_STAT5	749	752	PF00017	0.642
LIG_SH3_1	553	559	PF00018	0.566
LIG_SH3_2	255	260	PF14604	0.612
LIG_SH3_3	13	19	PF00018	0.671
LIG_SH3_3	199	205	PF00018	0.601
LIG_SH3_3	252	258	PF00018	0.716
LIG_SH3_3	296	302	PF00018	0.683
LIG_SH3_3	388	394	PF00018	0.735
LIG_SH3_3	414	420	PF00018	0.584
LIG_SH3_3	490	496	PF00018	0.539
LIG_SH3_3	553	559	PF00018	0.566
LIG_SH3_3	657	663	PF00018	0.803
LIG_SH3_3	717	723	PF00018	0.608
LIG_SH3_4	280	287	PF00018	0.585
LIG_Sin3_3	27	34	PF02671	0.540
LIG_Sin3_3	344	351	PF02671	0.523
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.548
LIG_SUMO_SIM_par_1	105	111	PF11976	0.548
LIG_TRAF2_1	282	285	PF00917	0.591
LIG_TRAF2_1	561	564	PF00917	0.557
LIG_UBA3_1	347	352	PF00899	0.523
LIG_WRC_WIRS_1	519	524	PF05994	0.556
MOD_CDC14_SPxK_1	41	44	PF00782	0.823
MOD_CDK_SPK_2	201	206	PF00069	0.603
MOD_CDK_SPK_2	615	620	PF00069	0.820
MOD_CDK_SPxK_1	295	301	PF00069	0.720
MOD_CDK_SPxK_1	38	44	PF00069	0.819
MOD_CDK_SPxxK_3	201	208	PF00069	0.601
MOD_CDK_SPxxK_3	615	622	PF00069	0.742
MOD_CK1_1	146	152	PF00069	0.584
MOD_CK1_1	196	202	PF00069	0.786
MOD_CK1_1	204	210	PF00069	0.731
MOD_CK1_1	263	269	PF00069	0.601
MOD_CK1_1	286	292	PF00069	0.853
MOD_CK1_1	295	301	PF00069	0.758
MOD_CK1_1	363	369	PF00069	0.771
MOD_CK1_1	396	402	PF00069	0.545
MOD_CK1_1	413	419	PF00069	0.540
MOD_CK1_1	518	524	PF00069	0.594
MOD_CK1_1	56	62	PF00069	0.686
MOD_CK1_1	593	599	PF00069	0.585
MOD_CK1_1	628	634	PF00069	0.664
MOD_CK1_1	643	649	PF00069	0.707
MOD_CK1_1	661	667	PF00069	0.702
MOD_CK2_1	212	218	PF00069	0.728
MOD_CK2_1	279	285	PF00069	0.727
MOD_CK2_1	499	505	PF00069	0.791
MOD_CK2_1	672	678	PF00069	0.594
MOD_CK2_1	683	689	PF00069	0.636
MOD_CK2_1	723	729	PF00069	0.568
MOD_DYRK1A_RPxSP_1	12	16	PF00069	0.580
MOD_GlcNHglycan	12	15	PF01048	0.764
MOD_GlcNHglycan	125	128	PF01048	0.840
MOD_GlcNHglycan	133	136	PF01048	0.730
MOD_GlcNHglycan	144	148	PF01048	0.520
MOD_GlcNHglycan	156	159	PF01048	0.679
MOD_GlcNHglycan	243	246	PF01048	0.602
MOD_GlcNHglycan	25	28	PF01048	0.537
MOD_GlcNHglycan	262	265	PF01048	0.576
MOD_GlcNHglycan	306	309	PF01048	0.724
MOD_GlcNHglycan	337	340	PF01048	0.609
MOD_GlcNHglycan	342	345	PF01048	0.656
MOD_GlcNHglycan	372	375	PF01048	0.761
MOD_GlcNHglycan	384	387	PF01048	0.819
MOD_GlcNHglycan	486	489	PF01048	0.540
MOD_GlcNHglycan	592	595	PF01048	0.599
MOD_GlcNHglycan	628	631	PF01048	0.746
MOD_GlcNHglycan	641	645	PF01048	0.545
MOD_GlcNHglycan	649	652	PF01048	0.535
MOD_GlcNHglycan	713	716	PF01048	0.706
MOD_GSK3_1	159	166	PF00069	0.692
MOD_GSK3_1	189	196	PF00069	0.764
MOD_GSK3_1	249	256	PF00069	0.699
MOD_GSK3_1	262	269	PF00069	0.587
MOD_GSK3_1	279	286	PF00069	0.744
MOD_GSK3_1	300	307	PF00069	0.743
MOD_GSK3_1	312	319	PF00069	0.739
MOD_GSK3_1	480	487	PF00069	0.666
MOD_GSK3_1	49	56	PF00069	0.724
MOD_GSK3_1	495	502	PF00069	0.608
MOD_GSK3_1	559	566	PF00069	0.810
MOD_GSK3_1	624	631	PF00069	0.664
MOD_GSK3_1	643	650	PF00069	0.660
MOD_GSK3_1	703	710	PF00069	0.764
MOD_GSK3_1	719	726	PF00069	0.529
MOD_GSK3_1	741	748	PF00069	0.646
MOD_GSK3_1	98	105	PF00069	0.715
MOD_N-GLC_1	23	28	PF02516	0.540
MOD_N-GLC_1	568	573	PF02516	0.548
MOD_N-GLC_1	590	595	PF02516	0.662
MOD_N-GLC_1	98	103	PF02516	0.717
MOD_N-GLC_2	699	701	PF02516	0.574
MOD_NEK2_1	272	277	PF00069	0.756
MOD_NEK2_1	360	365	PF00069	0.814
MOD_NEK2_1	624	629	PF00069	0.593
MOD_NEK2_2	489	494	PF00069	0.754
MOD_NEK2_2	98	103	PF00069	0.756
MOD_PIKK_1	116	122	PF00454	0.679
MOD_PIKK_1	279	285	PF00454	0.587
MOD_PIKK_1	661	667	PF00454	0.593
MOD_PKA_1	446	452	PF00069	0.538
MOD_PKA_1	480	486	PF00069	0.741
MOD_PKA_2	115	121	PF00069	0.618
MOD_PKA_2	151	157	PF00069	0.701
MOD_PKA_2	189	195	PF00069	0.737
MOD_PKA_2	335	341	PF00069	0.688
MOD_PKA_2	382	388	PF00069	0.843
MOD_PKA_2	446	452	PF00069	0.538
MOD_PKA_2	480	486	PF00069	0.780
MOD_PKA_2	510	516	PF00069	0.572
MOD_PKA_2	707	713	PF00069	0.565
MOD_PKA_2	85	91	PF00069	0.625
MOD_PKB_1	114	122	PF00069	0.740
MOD_PKB_1	478	486	PF00069	0.663
MOD_Plk_1	428	434	PF00069	0.758
MOD_Plk_1	568	574	PF00069	0.547
MOD_Plk_1	723	729	PF00069	0.568
MOD_Plk_1	98	104	PF00069	0.624
MOD_Plk_4	102	108	PF00069	0.531
MOD_Plk_4	196	202	PF00069	0.770
MOD_Plk_4	212	218	PF00069	0.650
MOD_Plk_4	249	255	PF00069	0.577
MOD_Plk_4	272	278	PF00069	0.682
MOD_Plk_4	428	434	PF00069	0.668
MOD_Plk_4	609	615	PF00069	0.573
MOD_Plk_4	745	751	PF00069	0.603
MOD_ProDKin_1	12	18	PF00069	0.689
MOD_ProDKin_1	159	165	PF00069	0.793
MOD_ProDKin_1	201	207	PF00069	0.602
MOD_ProDKin_1	266	272	PF00069	0.792
MOD_ProDKin_1	289	295	PF00069	0.780
MOD_ProDKin_1	300	306	PF00069	0.748
MOD_ProDKin_1	38	44	PF00069	0.819
MOD_ProDKin_1	413	419	PF00069	0.765
MOD_ProDKin_1	615	621	PF00069	0.737
MOD_ProDKin_1	658	664	PF00069	0.812
MOD_ProDKin_1	683	689	PF00069	0.845
MOD_ProDKin_1	719	725	PF00069	0.781
TRG_DiLeu_BaEn_2	447	453	PF01217	0.539
TRG_ENDOCYTIC_2	519	522	PF00928	0.558
TRG_ENDOCYTIC_2	572	575	PF00928	0.571
TRG_ENDOCYTIC_2	654	657	PF00928	0.798
TRG_ER_diArg_1	183	185	PF00400	0.750
TRG_ER_diArg_1	387	390	PF00400	0.749
TRG_ER_diArg_1	43	46	PF00400	0.579
TRG_ER_diArg_1	478	481	PF00400	0.738
TRG_ER_diArg_1	531	533	PF00400	0.649
TRG_ER_diArg_1	619	622	PF00400	0.794
TRG_ER_diArg_1	692	695	PF00400	0.582
TRG_ER_diArg_1	83	86	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	751	756	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGB2	Leptomonas seymouri	31%	81%
A0A3S7X5S6	Leishmania donovani	55%	100%
A4I878	Leishmania infantum	54%	82%
E9B336	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4Q518	Leishmania major	51%	98%