Putative GPI transamidase component Tta1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta1, putative

Species:

Leishmania braziliensis

UniProt:

A4HKP6_LEIBR

TriTrypDb:

LbrM.32.2790 , LBRM2903_320035400

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0008303	caspase complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0042765	GPI-anchor transamidase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A4HKP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003923	GPI-anchor transamidase activity	6	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.515
CLV_C14_Caspase3-7	427	431	PF00656	0.599
CLV_NRD_NRD_1	21	23	PF00675	0.462
CLV_NRD_NRD_1	405	407	PF00675	0.302
CLV_PCSK_KEX2_1	21	23	PF00082	0.455
CLV_PCSK_KEX2_1	302	304	PF00082	0.591
CLV_PCSK_KEX2_1	405	407	PF00082	0.309
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.611
CLV_PCSK_SKI1_1	182	186	PF00082	0.664
CLV_PCSK_SKI1_1	277	281	PF00082	0.592
CLV_PCSK_SKI1_1	350	354	PF00082	0.547
CLV_PCSK_SKI1_1	419	423	PF00082	0.377
DEG_APCC_DBOX_1	276	284	PF00400	0.392
DEG_SCF_FBW7_1	70	77	PF00400	0.568
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.450
DOC_MAPK_DCC_7	224	234	PF00069	0.249
DOC_MAPK_gen_1	354	364	PF00069	0.388
DOC_MAPK_MEF2A_6	49	56	PF00069	0.403
DOC_PP2B_LxvP_1	176	179	PF13499	0.447
DOC_PP2B_LxvP_1	372	375	PF13499	0.382
DOC_PP4_FxxP_1	201	204	PF00568	0.337
DOC_PP4_MxPP_1	80	83	PF00568	0.289
DOC_SPAK_OSR1_1	399	403	PF12202	0.551
DOC_USP7_MATH_1	13	17	PF00917	0.763
DOC_USP7_MATH_1	235	239	PF00917	0.541
DOC_USP7_MATH_1	389	393	PF00917	0.447
DOC_USP7_MATH_1	65	69	PF00917	0.460
DOC_USP7_UBL2_3	419	423	PF12436	0.615
DOC_WW_Pin1_4	1	6	PF00397	0.740
DOC_WW_Pin1_4	258	263	PF00397	0.493
DOC_WW_Pin1_4	366	371	PF00397	0.442
DOC_WW_Pin1_4	70	75	PF00397	0.573
DOC_WW_Pin1_4	91	96	PF00397	0.394
LIG_14-3-3_CanoR_1	21	28	PF00244	0.593
LIG_14-3-3_CanoR_1	268	273	PF00244	0.480
LIG_14-3-3_CanoR_1	334	340	PF00244	0.340
LIG_Actin_WH2_2	253	270	PF00022	0.314
LIG_Actin_WH2_2	307	324	PF00022	0.407
LIG_Actin_WH2_2	339	356	PF00022	0.432
LIG_BRCT_BRCA1_1	348	352	PF00533	0.450
LIG_FHA_1	125	131	PF00498	0.421
LIG_FHA_1	144	150	PF00498	0.300
LIG_FHA_1	251	257	PF00498	0.435
LIG_FHA_1	283	289	PF00498	0.420
LIG_FHA_1	316	322	PF00498	0.432
LIG_FHA_1	367	373	PF00498	0.442
LIG_FHA_1	71	77	PF00498	0.532
LIG_GBD_Chelix_1	380	388	PF00786	0.399
LIG_LIR_Apic_2	199	204	PF02991	0.334
LIG_LIR_Gen_1	129	136	PF02991	0.434
LIG_LIR_Gen_1	25	36	PF02991	0.562
LIG_LIR_Gen_1	337	347	PF02991	0.421
LIG_LIR_Gen_1	41	52	PF02991	0.509
LIG_LIR_Gen_1	430	439	PF02991	0.527
LIG_LIR_Nem_3	129	134	PF02991	0.429
LIG_LIR_Nem_3	25	31	PF02991	0.562
LIG_LIR_Nem_3	337	343	PF02991	0.431
LIG_LIR_Nem_3	430	435	PF02991	0.521
LIG_MYND_1	366	370	PF01753	0.367
LIG_MYND_1	74	78	PF01753	0.435
LIG_MYND_1	95	99	PF01753	0.412
LIG_RPA_C_Fungi	394	406	PF08784	0.333
LIG_SH2_CRK	131	135	PF00017	0.475
LIG_SH2_CRK	227	231	PF00017	0.387
LIG_SH2_NCK_1	312	316	PF00017	0.409
LIG_SH2_STAT5	227	230	PF00017	0.365
LIG_SH2_STAT5	312	315	PF00017	0.406
LIG_SH2_STAT5	373	376	PF00017	0.443
LIG_SH3_3	120	126	PF00018	0.659
LIG_SH3_3	200	206	PF00018	0.477
LIG_SH3_3	229	235	PF00018	0.476
LIG_SH3_3	383	389	PF00018	0.383
LIG_SH3_3	49	55	PF00018	0.620
LIG_SH3_3	89	95	PF00018	0.468
LIG_SUMO_SIM_par_1	230	236	PF11976	0.462
LIG_SUMO_SIM_par_1	279	285	PF11976	0.479
LIG_TYR_ITSM	127	134	PF00017	0.493
LIG_WRC_WIRS_1	290	295	PF05994	0.423
MOD_CDC14_SPxK_1	4	7	PF00782	0.661
MOD_CDK_SPxK_1	1	7	PF00069	0.750
MOD_CK1_1	115	121	PF00069	0.686
MOD_CK1_1	16	22	PF00069	0.703
MOD_CK1_1	199	205	PF00069	0.472
MOD_CK1_1	24	30	PF00069	0.332
MOD_CK1_1	282	288	PF00069	0.490
MOD_CK1_1	316	322	PF00069	0.490
MOD_GlcNHglycan	117	120	PF01048	0.501
MOD_GlcNHglycan	153	156	PF01048	0.660
MOD_GlcNHglycan	220	223	PF01048	0.505
MOD_GSK3_1	1	8	PF00069	0.669
MOD_GSK3_1	126	133	PF00069	0.411
MOD_GSK3_1	256	263	PF00069	0.472
MOD_GSK3_1	313	320	PF00069	0.503
MOD_GSK3_1	38	45	PF00069	0.354
MOD_GSK3_1	70	77	PF00069	0.683
MOD_N-GLC_1	22	27	PF02516	0.627
MOD_NEK2_1	112	117	PF00069	0.529
MOD_NEK2_1	130	135	PF00069	0.238
MOD_NEK2_1	196	201	PF00069	0.503
MOD_NEK2_1	250	255	PF00069	0.667
MOD_NEK2_1	256	261	PF00069	0.359
MOD_NEK2_1	281	286	PF00069	0.378
MOD_NEK2_1	346	351	PF00069	0.460
MOD_NEK2_1	63	68	PF00069	0.544
MOD_NEK2_2	126	131	PF00069	0.555
MOD_PIKK_1	169	175	PF00454	0.326
MOD_PIKK_1	282	288	PF00454	0.540
MOD_PKA_1	21	27	PF00069	0.566
MOD_PKA_2	21	27	PF00069	0.511
MOD_PKA_2	333	339	PF00069	0.458
MOD_PKA_2	428	434	PF00069	0.390
MOD_PKB_1	266	274	PF00069	0.609
MOD_Plk_4	126	132	PF00069	0.537
MOD_Plk_4	196	202	PF00069	0.433
MOD_Plk_4	76	82	PF00069	0.511
MOD_ProDKin_1	1	7	PF00069	0.696
MOD_ProDKin_1	258	264	PF00069	0.619
MOD_ProDKin_1	366	372	PF00069	0.565
MOD_ProDKin_1	70	76	PF00069	0.742
MOD_ProDKin_1	91	97	PF00069	0.490
MOD_SUMO_rev_2	417	424	PF00179	0.392
TRG_ENDOCYTIC_2	131	134	PF00928	0.469
TRG_ENDOCYTIC_2	227	230	PF00928	0.351
TRG_ER_diArg_1	20	22	PF00400	0.569
TRG_ER_diArg_1	265	268	PF00400	0.592
TRG_ER_diLys_1	437	440	PF00400	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I345	Leptomonas seymouri	56%	100%
A0A1X0NT15	Trypanosomatidae	28%	100%
A0A3S5IR84	Trypanosoma rangeli	29%	100%
A0A3S7X5V4	Leishmania donovani	77%	100%
A4I877	Leishmania infantum	77%	100%
D0AAE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B335	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q519	Leishmania major	77%	100%
V5AUS2	Trypanosoma cruzi	31%	100%