HDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKP4_LEIBR

TriTrypDb:

LbrM.32.2770 , LBRM2903_320035200

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006203	dGTP catabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009143	nucleoside triphosphate catabolic process	6	2
GO:0009144	purine nucleoside triphosphate metabolic process	6	2
GO:0009146	purine nucleoside triphosphate catabolic process	7	2
GO:0009151	purine deoxyribonucleotide metabolic process	6	2
GO:0009155	purine deoxyribonucleotide catabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009200	deoxyribonucleoside triphosphate metabolic process	6	2
GO:0009204	deoxyribonucleoside triphosphate catabolic process	7	2
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	7	2
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	8	2
GO:0009262	deoxyribonucleotide metabolic process	4	2
GO:0009264	deoxyribonucleotide catabolic process	5	2
GO:0009394	2'-deoxyribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019692	deoxyribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046070	dGTP metabolic process	7	2
GO:0046386	deoxyribose phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008832	dGTPase activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016793	triphosphoric monoester hydrolase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.489
CLV_C14_Caspase3-7	92	96	PF00656	0.398
CLV_NRD_NRD_1	13	15	PF00675	0.705
CLV_NRD_NRD_1	157	159	PF00675	0.368
CLV_NRD_NRD_1	170	172	PF00675	0.335
CLV_NRD_NRD_1	256	258	PF00675	0.363
CLV_NRD_NRD_1	360	362	PF00675	0.399
CLV_NRD_NRD_1	376	378	PF00675	0.393
CLV_NRD_NRD_1	384	386	PF00675	0.332
CLV_PCSK_KEX2_1	13	15	PF00082	0.638
CLV_PCSK_KEX2_1	227	229	PF00082	0.438
CLV_PCSK_KEX2_1	24	26	PF00082	0.531
CLV_PCSK_KEX2_1	256	258	PF00082	0.363
CLV_PCSK_KEX2_1	376	378	PF00082	0.559
CLV_PCSK_KEX2_1	384	386	PF00082	0.466
CLV_PCSK_KEX2_1	426	428	PF00082	0.567
CLV_PCSK_KEX2_1	478	480	PF00082	0.420
CLV_PCSK_KEX2_1	608	610	PF00082	0.694
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.438
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.567
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.460
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.420
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.694
CLV_PCSK_SKI1_1	256	260	PF00082	0.299
CLV_PCSK_SKI1_1	384	388	PF00082	0.369
CLV_PCSK_SKI1_1	44	48	PF00082	0.425
CLV_PCSK_SKI1_1	608	612	PF00082	0.692
DEG_APCC_DBOX_1	290	298	PF00400	0.467
DEG_APCC_DBOX_1	383	391	PF00400	0.440
DEG_COP1_1	99	109	PF00400	0.305
DEG_SCF_FBW7_1	583	589	PF00400	0.494
DOC_ANK_TNKS_1	90	97	PF00023	0.305
DOC_CKS1_1	247	252	PF01111	0.490
DOC_CKS1_1	583	588	PF01111	0.496
DOC_CYCLIN_RxL_1	605	615	PF00134	0.591
DOC_CYCLIN_RxL_1	638	648	PF00134	0.497
DOC_MAPK_gen_1	227	233	PF00069	0.422
DOC_MAPK_gen_1	302	312	PF00069	0.426
DOC_MAPK_gen_1	608	614	PF00069	0.595
DOC_MAPK_MEF2A_6	534	541	PF00069	0.565
DOC_PP1_RVXF_1	536	542	PF00149	0.418
DOC_PP2B_PxIxI_1	40	46	PF00149	0.398
DOC_PP4_FxxP_1	104	107	PF00568	0.398
DOC_PP4_FxxP_1	488	491	PF00568	0.463
DOC_PP4_MxPP_1	1	4	PF00568	0.583
DOC_USP7_MATH_1	23	27	PF00917	0.411
DOC_USP7_MATH_1	333	337	PF00917	0.466
DOC_USP7_MATH_1	491	495	PF00917	0.596
DOC_USP7_MATH_1	517	521	PF00917	0.512
DOC_USP7_MATH_1	567	571	PF00917	0.807
DOC_USP7_MATH_1	573	577	PF00917	0.758
DOC_USP7_MATH_1	586	590	PF00917	0.492
DOC_USP7_MATH_1	71	75	PF00917	0.445
DOC_USP7_MATH_2	531	537	PF00917	0.420
DOC_WW_Pin1_4	246	251	PF00397	0.488
DOC_WW_Pin1_4	46	51	PF00397	0.428
DOC_WW_Pin1_4	527	532	PF00397	0.471
DOC_WW_Pin1_4	556	561	PF00397	0.574
DOC_WW_Pin1_4	582	587	PF00397	0.775
LIG_14-3-3_CanoR_1	158	167	PF00244	0.376
LIG_14-3-3_CanoR_1	171	181	PF00244	0.374
LIG_14-3-3_CanoR_1	218	224	PF00244	0.432
LIG_14-3-3_CanoR_1	25	30	PF00244	0.563
LIG_14-3-3_CanoR_1	393	402	PF00244	0.508
LIG_14-3-3_CanoR_1	403	410	PF00244	0.483
LIG_14-3-3_CanoR_1	414	419	PF00244	0.664
LIG_14-3-3_CanoR_1	44	52	PF00244	0.349
LIG_14-3-3_CanoR_1	492	501	PF00244	0.595
LIG_14-3-3_CanoR_1	526	530	PF00244	0.524
LIG_14-3-3_CanoR_1	538	548	PF00244	0.496
LIG_Actin_WH2_2	177	194	PF00022	0.441
LIG_Actin_WH2_2	300	318	PF00022	0.440
LIG_BRCT_BRCA1_1	138	142	PF00533	0.326
LIG_Clathr_ClatBox_1	309	313	PF01394	0.424
LIG_EVH1_2	3	7	PF00568	0.459
LIG_FHA_1	218	224	PF00498	0.432
LIG_FHA_1	302	308	PF00498	0.481
LIG_FHA_1	506	512	PF00498	0.627
LIG_FHA_1	591	597	PF00498	0.755
LIG_FHA_1	665	671	PF00498	0.627
LIG_FHA_2	185	191	PF00498	0.415
LIG_FHA_2	439	445	PF00498	0.415
LIG_FHA_2	470	476	PF00498	0.487
LIG_FHA_2	528	534	PF00498	0.458
LIG_LIR_Apic_2	103	107	PF02991	0.305
LIG_LIR_Apic_2	486	491	PF02991	0.473
LIG_LIR_Apic_2	64	69	PF02991	0.405
LIG_LIR_Gen_1	139	150	PF02991	0.326
LIG_LIR_Gen_1	183	194	PF02991	0.331
LIG_LIR_Gen_1	249	259	PF02991	0.488
LIG_LIR_Gen_1	348	356	PF02991	0.378
LIG_LIR_Gen_1	509	518	PF02991	0.652
LIG_LIR_Gen_1	540	548	PF02991	0.542
LIG_LIR_LC3C_4	519	523	PF02991	0.393
LIG_LIR_Nem_3	139	145	PF02991	0.326
LIG_LIR_Nem_3	183	189	PF02991	0.357
LIG_LIR_Nem_3	190	196	PF02991	0.283
LIG_LIR_Nem_3	31	37	PF02991	0.438
LIG_LIR_Nem_3	348	353	PF02991	0.372
LIG_LIR_Nem_3	38	42	PF02991	0.369
LIG_LIR_Nem_3	540	544	PF02991	0.530
LIG_LIR_Nem_3	64	68	PF02991	0.401
LIG_LIR_Nem_3	88	93	PF02991	0.392
LIG_PCNA_yPIPBox_3	296	307	PF02747	0.365
LIG_PTB_Apo_2	60	67	PF02174	0.453
LIG_PTB_Phospho_1	60	66	PF10480	0.450
LIG_SH2_CRK	396	400	PF00017	0.362
LIG_SH2_CRK	90	94	PF00017	0.398
LIG_SH2_NCK_1	396	400	PF00017	0.387
LIG_SH2_NCK_1	619	623	PF00017	0.467
LIG_SH2_PTP2	193	196	PF00017	0.419
LIG_SH2_PTP2	66	69	PF00017	0.484
LIG_SH2_SRC	344	347	PF00017	0.333
LIG_SH2_SRC	66	69	PF00017	0.395
LIG_SH2_STAT5	193	196	PF00017	0.419
LIG_SH2_STAT5	238	241	PF00017	0.377
LIG_SH2_STAT5	344	347	PF00017	0.373
LIG_SH2_STAT5	396	399	PF00017	0.421
LIG_SH2_STAT5	487	490	PF00017	0.506
LIG_SH2_STAT5	66	69	PF00017	0.370
LIG_SH2_STAT5	84	87	PF00017	0.285
LIG_SH3_3	17	23	PF00018	0.615
LIG_SH3_3	335	341	PF00018	0.448
LIG_SH3_3	580	586	PF00018	0.502
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.407
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.375
LIG_SUMO_SIM_par_1	304	311	PF11976	0.336
LIG_TRAF2_1	421	424	PF00917	0.606
LIG_TRAF2_1	530	533	PF00917	0.425
LIG_TYR_ITIM	191	196	PF00017	0.423
LIG_UBA3_1	167	172	PF00899	0.305
LIG_UBA3_1	197	205	PF00899	0.383
LIG_WRC_WIRS_1	142	147	PF05994	0.398
MOD_CDK_SPxxK_3	527	534	PF00069	0.491
MOD_CK1_1	369	375	PF00069	0.414
MOD_CK1_1	405	411	PF00069	0.496
MOD_CK1_1	540	546	PF00069	0.511
MOD_CK1_1	554	560	PF00069	0.686
MOD_CK1_1	582	588	PF00069	0.624
MOD_CK1_1	599	605	PF00069	0.517
MOD_CK1_1	636	642	PF00069	0.741
MOD_CK2_1	172	178	PF00069	0.251
MOD_CK2_1	418	424	PF00069	0.570
MOD_CK2_1	433	439	PF00069	0.438
MOD_CK2_1	527	533	PF00069	0.452
MOD_CK2_1	586	592	PF00069	0.534
MOD_CK2_1	71	77	PF00069	0.371
MOD_GlcNHglycan	228	231	PF01048	0.448
MOD_GlcNHglycan	369	372	PF01048	0.640
MOD_GlcNHglycan	483	486	PF01048	0.541
MOD_GlcNHglycan	575	578	PF01048	0.637
MOD_GlcNHglycan	635	638	PF01048	0.642
MOD_GlcNHglycan	647	650	PF01048	0.467
MOD_GSK3_1	141	148	PF00069	0.398
MOD_GSK3_1	172	179	PF00069	0.403
MOD_GSK3_1	25	32	PF00069	0.570
MOD_GSK3_1	363	370	PF00069	0.448
MOD_GSK3_1	394	401	PF00069	0.429
MOD_GSK3_1	414	421	PF00069	0.549
MOD_GSK3_1	501	508	PF00069	0.572
MOD_GSK3_1	533	540	PF00069	0.416
MOD_GSK3_1	548	555	PF00069	0.630
MOD_GSK3_1	582	589	PF00069	0.729
MOD_GSK3_1	590	597	PF00069	0.708
MOD_GSK3_1	664	671	PF00069	0.627
MOD_N-GLC_1	110	115	PF02516	0.363
MOD_N-GLC_1	176	181	PF02516	0.498
MOD_N-GLC_1	505	510	PF02516	0.647
MOD_N-GLC_1	586	591	PF02516	0.551
MOD_NEK2_1	141	146	PF00069	0.374
MOD_NEK2_1	289	294	PF00069	0.418
MOD_NEK2_1	322	327	PF00069	0.462
MOD_NEK2_1	356	361	PF00069	0.430
MOD_NEK2_1	367	372	PF00069	0.433
MOD_NEK2_1	395	400	PF00069	0.481
MOD_NEK2_1	443	448	PF00069	0.408
MOD_NEK2_1	537	542	PF00069	0.521
MOD_NEK2_1	590	595	PF00069	0.757
MOD_NEK2_1	596	601	PF00069	0.728
MOD_NEK2_1	61	66	PF00069	0.378
MOD_NEK2_1	645	650	PF00069	0.740
MOD_NEK2_1	76	81	PF00069	0.282
MOD_NEK2_1	89	94	PF00069	0.345
MOD_NEK2_2	586	591	PF00069	0.483
MOD_OFUCOSY	330	337	PF10250	0.239
MOD_PIKK_1	419	425	PF00454	0.615
MOD_PIKK_1	467	473	PF00454	0.672
MOD_PIKK_1	559	565	PF00454	0.699
MOD_PIKK_1	568	574	PF00454	0.677
MOD_PIKK_1	655	661	PF00454	0.676
MOD_PK_1	25	31	PF00069	0.515
MOD_PK_1	414	420	PF00069	0.542
MOD_PK_1	8	14	PF00069	0.681
MOD_PKA_1	158	164	PF00069	0.305
MOD_PKA_2	217	223	PF00069	0.451
MOD_PKA_2	240	246	PF00069	0.364
MOD_PKA_2	29	35	PF00069	0.570
MOD_PKA_2	301	307	PF00069	0.397
MOD_PKA_2	402	408	PF00069	0.502
MOD_PKA_2	491	497	PF00069	0.599
MOD_PKA_2	525	531	PF00069	0.560
MOD_PKA_2	537	543	PF00069	0.500
MOD_PKA_2	590	596	PF00069	0.721
MOD_Plk_1	269	275	PF00069	0.483
MOD_Plk_1	405	411	PF00069	0.627
MOD_Plk_1	443	449	PF00069	0.427
MOD_Plk_1	551	557	PF00069	0.560
MOD_Plk_1	579	585	PF00069	0.555
MOD_Plk_1	586	592	PF00069	0.536
MOD_Plk_1	76	82	PF00069	0.345
MOD_Plk_2-3	308	314	PF00069	0.333
MOD_Plk_2-3	433	439	PF00069	0.398
MOD_Plk_2-3	627	633	PF00069	0.749
MOD_Plk_4	141	147	PF00069	0.398
MOD_Plk_4	163	169	PF00069	0.398
MOD_Plk_4	248	254	PF00069	0.504
MOD_Plk_4	29	35	PF00069	0.562
MOD_Plk_4	405	411	PF00069	0.532
MOD_Plk_4	483	489	PF00069	0.448
MOD_Plk_4	507	513	PF00069	0.616
MOD_Plk_4	517	523	PF00069	0.403
MOD_Plk_4	61	67	PF00069	0.400
MOD_ProDKin_1	246	252	PF00069	0.483
MOD_ProDKin_1	46	52	PF00069	0.424
MOD_ProDKin_1	527	533	PF00069	0.464
MOD_ProDKin_1	556	562	PF00069	0.573
MOD_ProDKin_1	582	588	PF00069	0.775
MOD_SUMO_for_1	425	428	PF00179	0.565
MOD_SUMO_for_1	7	10	PF00179	0.463
MOD_SUMO_rev_2	16	26	PF00179	0.644
TRG_DiLeu_BaEn_4	665	671	PF01217	0.627
TRG_ENDOCYTIC_2	193	196	PF00928	0.419
TRG_ENDOCYTIC_2	34	37	PF00928	0.411
TRG_ENDOCYTIC_2	396	399	PF00928	0.342
TRG_ENDOCYTIC_2	84	87	PF00928	0.398
TRG_ENDOCYTIC_2	90	93	PF00928	0.398
TRG_ER_diArg_1	12	14	PF00400	0.711
TRG_ER_diArg_1	255	257	PF00400	0.326
TRG_ER_diArg_1	375	377	PF00400	0.375
TRG_ER_diArg_1	384	386	PF00400	0.435
TRG_NLS_MonoExtC_3	607	613	PF00514	0.687
TRG_NLS_MonoExtN_4	605	612	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD02	Leptomonas seymouri	66%	100%
A0A0S4J2F4	Bodo saltans	30%	100%
A0A0S4J714	Bodo saltans	34%	95%
A0A1X0P1Y8	Trypanosomatidae	34%	87%
A0A3Q8IGB9	Leishmania donovani	89%	100%
A0A3R7LQB8	Trypanosoma rangeli	33%	89%
A0A3R7NIH1	Trypanosoma rangeli	29%	100%
A0A3S7WPC5	Leishmania donovani	34%	100%
A4H4I2	Leishmania braziliensis	35%	100%
A4HSQ7	Leishmania infantum	34%	100%
A4I875	Leishmania infantum	89%	100%
C9ZTA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AKP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B333	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q09374	Caenorhabditis elegans	26%	100%
Q4Q521	Leishmania major	88%	100%
Q4QJ63	Leishmania major	34%	100%
Q60710	Mus musculus	30%	100%
V5BPJ7	Trypanosoma cruzi	34%	83%