Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKP3_LEIBR

TriTrypDb:

LbrM.32.2760 , LBRM2903_320035100

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.790
CLV_NRD_NRD_1	197	199	PF00675	0.571
CLV_NRD_NRD_1	339	341	PF00675	0.299
CLV_NRD_NRD_1	461	463	PF00675	0.561
CLV_PCSK_KEX2_1	182	184	PF00082	0.770
CLV_PCSK_KEX2_1	197	199	PF00082	0.514
CLV_PCSK_KEX2_1	339	341	PF00082	0.299
CLV_PCSK_KEX2_1	461	463	PF00082	0.556
CLV_PCSK_SKI1_1	197	201	PF00082	0.500
CLV_PCSK_SKI1_1	284	288	PF00082	0.284
CLV_PCSK_SKI1_1	361	365	PF00082	0.267
CLV_PCSK_SKI1_1	46	50	PF00082	0.448
CLV_PCSK_SKI1_1	461	465	PF00082	0.487
CLV_Separin_Metazoa	41	45	PF03568	0.442
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DEG_SCF_FBW7_1	26	33	PF00400	0.484
DEG_SCF_TRCP1_1	11	16	PF00400	0.524
DEG_SPOP_SBC_1	507	511	PF00917	0.504
DOC_CYCLIN_RxL_1	281	290	PF00134	0.279
DOC_MAPK_gen_1	111	120	PF00069	0.424
DOC_MAPK_gen_1	270	276	PF00069	0.419
DOC_MAPK_gen_1	342	350	PF00069	0.349
DOC_PP1_RVXF_1	282	289	PF00149	0.297
DOC_PP2B_LxvP_1	40	43	PF13499	0.455
DOC_USP7_MATH_1	205	209	PF00917	0.638
DOC_USP7_MATH_1	244	248	PF00917	0.570
DOC_USP7_MATH_1	405	409	PF00917	0.434
DOC_WW_Pin1_4	166	171	PF00397	0.589
DOC_WW_Pin1_4	21	26	PF00397	0.732
DOC_WW_Pin1_4	30	35	PF00397	0.539
DOC_WW_Pin1_4	317	322	PF00397	0.474
LIG_14-3-3_CanoR_1	17	22	PF00244	0.521
LIG_14-3-3_CanoR_1	191	195	PF00244	0.674
LIG_14-3-3_CanoR_1	231	240	PF00244	0.384
LIG_14-3-3_CanoR_1	258	267	PF00244	0.403
LIG_14-3-3_CanoR_1	44	49	PF00244	0.451
LIG_14-3-3_CanoR_1	444	449	PF00244	0.679
LIG_14-3-3_CanoR_1	461	466	PF00244	0.551
LIG_14-3-3_CanoR_1	480	487	PF00244	0.475
LIG_14-3-3_CanoR_1	69	76	PF00244	0.389
LIG_APCC_ABBA_1	199	204	PF00400	0.473
LIG_APCC_ABBA_1	285	290	PF00400	0.277
LIG_APCC_ABBAyCdc20_2	198	204	PF00400	0.476
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.276
LIG_Clathr_ClatBox_1	286	290	PF01394	0.285
LIG_deltaCOP1_diTrp_1	112	120	PF00928	0.429
LIG_deltaCOP1_diTrp_1	355	364	PF00928	0.250
LIG_FHA_1	342	348	PF00498	0.318
LIG_FHA_1	368	374	PF00498	0.517
LIG_FHA_1	379	385	PF00498	0.529
LIG_FHA_1	56	62	PF00498	0.330
LIG_FHA_2	198	204	PF00498	0.476
LIG_FHA_2	52	58	PF00498	0.357
LIG_FHA_2	63	69	PF00498	0.380
LIG_FHA_2	72	78	PF00498	0.372
LIG_HP1_1	244	248	PF01393	0.344
LIG_LIR_Apic_2	77	82	PF02991	0.408
LIG_LIR_Gen_1	106	114	PF02991	0.507
LIG_LIR_Gen_1	33	43	PF02991	0.461
LIG_LIR_Gen_1	68	78	PF02991	0.383
LIG_LIR_Nem_3	106	110	PF02991	0.375
LIG_LIR_Nem_3	112	118	PF02991	0.403
LIG_LIR_Nem_3	261	267	PF02991	0.390
LIG_LIR_Nem_3	33	38	PF02991	0.477
LIG_LIR_Nem_3	398	402	PF02991	0.479
LIG_LIR_Nem_3	68	73	PF02991	0.387
LIG_MYND_1	401	405	PF01753	0.404
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.342
LIG_REV1ctd_RIR_1	286	296	PF16727	0.281
LIG_SH2_CRK	335	339	PF00017	0.266
LIG_SH2_CRK	399	403	PF00017	0.387
LIG_SH2_CRK	70	74	PF00017	0.611
LIG_SH2_GRB2like	35	38	PF00017	0.470
LIG_SH2_NCK_1	70	74	PF00017	0.521
LIG_SH2_STAT5	109	112	PF00017	0.390
LIG_SH2_STAT5	335	338	PF00017	0.260
LIG_SH2_STAT5	35	38	PF00017	0.616
LIG_SH2_STAT5	70	73	PF00017	0.424
LIG_SH2_STAT5	79	82	PF00017	0.315
LIG_SH3_3	170	176	PF00018	0.498
LIG_SH3_3	19	25	PF00018	0.598
LIG_SH3_3	323	329	PF00018	0.364
LIG_SH3_3	381	387	PF00018	0.611
LIG_SH3_3	427	433	PF00018	0.523
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.401
LIG_SUMO_SIM_par_1	346	351	PF11976	0.283
LIG_SUMO_SIM_par_1	352	358	PF11976	0.310
LIG_SUMO_SIM_par_1	420	425	PF11976	0.479
LIG_TRAF2_1	103	106	PF00917	0.365
LIG_TRAF2_1	389	392	PF00917	0.417
LIG_TYR_ITIM	333	338	PF00017	0.259
LIG_TYR_ITIM	397	402	PF00017	0.389
LIG_UBA3_1	86	91	PF00899	0.328
LIG_ULM_U2AF65_1	339	344	PF00076	0.312
MOD_CK1_1	169	175	PF00069	0.717
MOD_CK1_1	177	183	PF00069	0.729
MOD_CK1_1	208	214	PF00069	0.569
MOD_CK1_1	409	415	PF00069	0.430
MOD_CK1_1	467	473	PF00069	0.728
MOD_CK1_1	495	501	PF00069	0.529
MOD_CK2_1	100	106	PF00069	0.370
MOD_CK2_1	197	203	PF00069	0.473
MOD_CK2_1	275	281	PF00069	0.311
MOD_CK2_1	482	488	PF00069	0.690
MOD_CK2_1	51	57	PF00069	0.374
MOD_GlcNHglycan	102	105	PF01048	0.379
MOD_GlcNHglycan	11	14	PF01048	0.531
MOD_GlcNHglycan	153	156	PF01048	0.753
MOD_GlcNHglycan	179	182	PF01048	0.564
MOD_GlcNHglycan	192	195	PF01048	0.654
MOD_GlcNHglycan	207	210	PF01048	0.643
MOD_GlcNHglycan	216	219	PF01048	0.636
MOD_GlcNHglycan	233	236	PF01048	0.574
MOD_GlcNHglycan	250	253	PF01048	0.463
MOD_GlcNHglycan	277	280	PF01048	0.472
MOD_GlcNHglycan	307	310	PF01048	0.475
MOD_GlcNHglycan	317	320	PF01048	0.458
MOD_GlcNHglycan	427	430	PF01048	0.449
MOD_GlcNHglycan	456	459	PF01048	0.667
MOD_GlcNHglycan	466	469	PF01048	0.502
MOD_GlcNHglycan	482	485	PF01048	0.667
MOD_GlcNHglycan	497	500	PF01048	0.599
MOD_GlcNHglycan	97	100	PF01048	0.428
MOD_GSK3_1	17	24	PF00069	0.488
MOD_GSK3_1	244	251	PF00069	0.413
MOD_GSK3_1	26	33	PF00069	0.427
MOD_GSK3_1	405	412	PF00069	0.540
MOD_GSK3_1	444	451	PF00069	0.666
MOD_GSK3_1	488	495	PF00069	0.557
MOD_GSK3_1	51	58	PF00069	0.498
MOD_GSK3_1	9	16	PF00069	0.525
MOD_N-GLC_1	17	22	PF02516	0.491
MOD_N-GLC_1	36	41	PF02516	0.466
MOD_N-GLC_1	425	430	PF02516	0.440
MOD_N-GLC_1	44	49	PF02516	0.391
MOD_N-GLC_1	9	14	PF02516	0.530
MOD_NEK2_1	144	149	PF00069	0.530
MOD_NEK2_1	367	372	PF00069	0.332
MOD_NEK2_1	449	454	PF00069	0.643
MOD_NEK2_1	466	471	PF00069	0.467
MOD_NEK2_1	487	492	PF00069	0.521
MOD_NEK2_1	62	67	PF00069	0.430
MOD_PIKK_1	258	264	PF00454	0.296
MOD_PK_1	3	9	PF00069	0.520
MOD_PK_1	44	50	PF00069	0.419
MOD_PK_1	444	450	PF00069	0.465
MOD_PK_1	472	478	PF00069	0.489
MOD_PKA_1	197	203	PF00069	0.560
MOD_PKA_1	461	467	PF00069	0.670
MOD_PKA_2	151	157	PF00069	0.526
MOD_PKA_2	190	196	PF00069	0.584
MOD_PKA_2	197	203	PF00069	0.487
MOD_PKA_2	230	236	PF00069	0.431
MOD_PKA_2	341	347	PF00069	0.533
MOD_PKA_2	461	467	PF00069	0.667
MOD_PKA_2	495	501	PF00069	0.517
MOD_PKA_2	68	74	PF00069	0.386
MOD_PKB_1	480	488	PF00069	0.513
MOD_Plk_1	105	111	PF00069	0.374
MOD_Plk_1	3	9	PF00069	0.520
MOD_Plk_1	36	42	PF00069	0.594
MOD_Plk_1	425	431	PF00069	0.549
MOD_Plk_1	44	50	PF00069	0.596
MOD_Plk_1	488	494	PF00069	0.521
MOD_Plk_1	56	62	PF00069	0.255
MOD_Plk_2-3	51	57	PF00069	0.374
MOD_Plk_4	197	203	PF00069	0.560
MOD_Plk_4	244	250	PF00069	0.500
MOD_Plk_4	406	412	PF00069	0.417
MOD_Plk_4	444	450	PF00069	0.589
MOD_Plk_4	461	467	PF00069	0.419
MOD_ProDKin_1	166	172	PF00069	0.590
MOD_ProDKin_1	21	27	PF00069	0.730
MOD_ProDKin_1	30	36	PF00069	0.537
MOD_ProDKin_1	317	323	PF00069	0.467
MOD_SUMO_for_1	90	93	PF00179	0.338
TRG_DiLeu_BaEn_1	281	286	PF01217	0.299
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.579
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.395
TRG_DiLeu_LyEn_5	281	286	PF01217	0.355
TRG_ENDOCYTIC_2	335	338	PF00928	0.260
TRG_ENDOCYTIC_2	35	38	PF00928	0.480
TRG_ENDOCYTIC_2	399	402	PF00928	0.388
TRG_ENDOCYTIC_2	70	73	PF00928	0.467
TRG_ER_diArg_1	197	199	PF00400	0.577
TRG_ER_diArg_1	338	340	PF00400	0.292
TRG_ER_diArg_1	43	46	PF00400	0.520
TRG_ER_diArg_1	493	496	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRJ2	Trypanosomatidae	40%	72%
A0A3R7KN76	Trypanosoma rangeli	36%	100%
D0AAE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	74%
V5DAR5	Trypanosoma cruzi	37%	72%