Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HKP2_LEIBR

TriTrypDb:

LbrM.32.2750 , LBRM2903_320035000

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	639	643	PF00656	0.825
CLV_C14_Caspase3-7	707	711	PF00656	0.812
CLV_C14_Caspase3-7	874	878	PF00656	0.589
CLV_NRD_NRD_1	164	166	PF00675	0.688
CLV_NRD_NRD_1	209	211	PF00675	0.870
CLV_NRD_NRD_1	275	277	PF00675	0.846
CLV_NRD_NRD_1	278	280	PF00675	0.840
CLV_NRD_NRD_1	315	317	PF00675	0.800
CLV_NRD_NRD_1	350	352	PF00675	0.614
CLV_NRD_NRD_1	359	361	PF00675	0.588
CLV_NRD_NRD_1	455	457	PF00675	0.823
CLV_NRD_NRD_1	458	460	PF00675	0.770
CLV_NRD_NRD_1	513	515	PF00675	0.746
CLV_NRD_NRD_1	519	521	PF00675	0.689
CLV_NRD_NRD_1	574	576	PF00675	0.672
CLV_NRD_NRD_1	648	650	PF00675	0.781
CLV_NRD_NRD_1	686	688	PF00675	0.586
CLV_NRD_NRD_1	740	742	PF00675	0.612
CLV_NRD_NRD_1	840	842	PF00675	0.725
CLV_NRD_NRD_1	864	866	PF00675	0.720
CLV_NRD_NRD_1	886	888	PF00675	0.620
CLV_NRD_NRD_1	892	894	PF00675	0.598
CLV_PCSK_FUR_1	206	210	PF00082	0.621
CLV_PCSK_FUR_1	272	276	PF00082	0.863
CLV_PCSK_FUR_1	456	460	PF00082	0.606
CLV_PCSK_FUR_1	510	514	PF00082	0.775
CLV_PCSK_FUR_1	837	841	PF00082	0.641
CLV_PCSK_FUR_1	862	866	PF00082	0.819
CLV_PCSK_KEX2_1	208	210	PF00082	0.876
CLV_PCSK_KEX2_1	272	274	PF00082	0.860
CLV_PCSK_KEX2_1	275	277	PF00082	0.820
CLV_PCSK_KEX2_1	278	280	PF00082	0.768
CLV_PCSK_KEX2_1	315	317	PF00082	0.788
CLV_PCSK_KEX2_1	350	352	PF00082	0.614
CLV_PCSK_KEX2_1	359	361	PF00082	0.588
CLV_PCSK_KEX2_1	455	457	PF00082	0.818
CLV_PCSK_KEX2_1	458	460	PF00082	0.765
CLV_PCSK_KEX2_1	512	514	PF00082	0.745
CLV_PCSK_KEX2_1	519	521	PF00082	0.657
CLV_PCSK_KEX2_1	564	566	PF00082	0.685
CLV_PCSK_KEX2_1	574	576	PF00082	0.661
CLV_PCSK_KEX2_1	648	650	PF00082	0.780
CLV_PCSK_KEX2_1	686	688	PF00082	0.586
CLV_PCSK_KEX2_1	740	742	PF00082	0.743
CLV_PCSK_KEX2_1	799	801	PF00082	0.766
CLV_PCSK_KEX2_1	839	841	PF00082	0.715
CLV_PCSK_KEX2_1	864	866	PF00082	0.730
CLV_PCSK_KEX2_1	886	888	PF00082	0.736
CLV_PCSK_KEX2_1	891	893	PF00082	0.763
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.645
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.642
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.782
CLV_PCSK_PC7_1	274	280	PF00082	0.841
CLV_PCSK_PC7_1	355	361	PF00082	0.618
CLV_PCSK_PC7_1	736	742	PF00082	0.604
CLV_PCSK_PC7_1	887	893	PF00082	0.614
CLV_PCSK_SKI1_1	404	408	PF00082	0.589
CLV_PCSK_SKI1_1	429	433	PF00082	0.592
CLV_PCSK_SKI1_1	496	500	PF00082	0.583
CLV_PCSK_SKI1_1	696	700	PF00082	0.646
DEG_Nend_Nbox_1	1	3	PF02207	0.783
DEG_ODPH_VHL_1	746	758	PF01847	0.601
DEG_SPOP_SBC_1	187	191	PF00917	0.599
DOC_ANK_TNKS_1	47	54	PF00023	0.579
DOC_CKS1_1	390	395	PF01111	0.711
DOC_CKS1_1	406	411	PF01111	0.561
DOC_CKS1_1	612	617	PF01111	0.561
DOC_CKS1_1	759	764	PF01111	0.705
DOC_CYCLIN_yCln2_LP_2	600	606	PF00134	0.566
DOC_MAPK_gen_1	455	465	PF00069	0.605
DOC_MAPK_gen_1	563	572	PF00069	0.567
DOC_MAPK_gen_1	686	692	PF00069	0.567
DOC_PP2B_LxvP_1	600	603	PF13499	0.736
DOC_PP2B_LxvP_1	604	607	PF13499	0.761
DOC_PP4_FxxP_1	756	759	PF00568	0.625
DOC_PP4_MxPP_1	121	124	PF00568	0.581
DOC_SPAK_OSR1_1	755	759	PF12202	0.607
DOC_USP7_MATH_1	11	15	PF00917	0.817
DOC_USP7_MATH_1	145	149	PF00917	0.711
DOC_USP7_MATH_1	217	221	PF00917	0.619
DOC_USP7_MATH_1	256	260	PF00917	0.659
DOC_USP7_MATH_1	349	353	PF00917	0.796
DOC_USP7_MATH_1	416	420	PF00917	0.604
DOC_USP7_MATH_1	529	533	PF00917	0.870
DOC_USP7_MATH_1	56	60	PF00917	0.720
DOC_USP7_MATH_1	63	67	PF00917	0.783
DOC_USP7_MATH_1	748	752	PF00917	0.595
DOC_USP7_MATH_1	786	790	PF00917	0.823
DOC_USP7_MATH_1	803	807	PF00917	0.559
DOC_USP7_MATH_2	580	586	PF00917	0.586
DOC_WW_Pin1_4	132	137	PF00397	0.706
DOC_WW_Pin1_4	183	188	PF00397	0.649
DOC_WW_Pin1_4	241	246	PF00397	0.589
DOC_WW_Pin1_4	289	294	PF00397	0.873
DOC_WW_Pin1_4	333	338	PF00397	0.609
DOC_WW_Pin1_4	354	359	PF00397	0.805
DOC_WW_Pin1_4	389	394	PF00397	0.800
DOC_WW_Pin1_4	405	410	PF00397	0.564
DOC_WW_Pin1_4	498	503	PF00397	0.575
DOC_WW_Pin1_4	522	527	PF00397	0.740
DOC_WW_Pin1_4	58	63	PF00397	0.776
DOC_WW_Pin1_4	611	616	PF00397	0.570
DOC_WW_Pin1_4	677	682	PF00397	0.654
DOC_WW_Pin1_4	729	734	PF00397	0.734
DOC_WW_Pin1_4	758	763	PF00397	0.711
DOC_WW_Pin1_4	846	851	PF00397	0.866
DOC_WW_Pin1_4	864	869	PF00397	0.801
DOC_WW_Pin1_4	885	890	PF00397	0.606
LIG_14-3-3_CanoR_1	350	358	PF00244	0.614
LIG_14-3-3_CanoR_1	404	409	PF00244	0.592
LIG_14-3-3_CanoR_1	429	438	PF00244	0.662
LIG_14-3-3_CanoR_1	524	533	PF00244	0.736
LIG_14-3-3_CanoR_1	609	615	PF00244	0.560
LIG_14-3-3_CanoR_1	712	720	PF00244	0.587
LIG_14-3-3_CanoR_1	740	748	PF00244	0.633
LIG_BRCT_BRCA1_1	694	698	PF00533	0.551
LIG_FHA_1	10	16	PF00498	0.565
LIG_FHA_1	375	381	PF00498	0.700
LIG_FHA_1	401	407	PF00498	0.675
LIG_FHA_1	426	432	PF00498	0.685
LIG_FHA_1	544	550	PF00498	0.600
LIG_FHA_1	68	74	PF00498	0.543
LIG_FHA_2	231	237	PF00498	0.807
LIG_Integrin_RGD_1	178	180	PF01839	0.837
LIG_Integrin_RGD_1	279	281	PF01839	0.616
LIG_LIR_Apic_2	247	251	PF02991	0.612
LIG_LIR_Apic_2	419	425	PF02991	0.602
LIG_LIR_Apic_2	753	759	PF02991	0.604
LIG_LIR_Apic_2	93	99	PF02991	0.647
LIG_LIR_Nem_3	231	237	PF02991	0.726
LIG_Pex14_2	234	238	PF04695	0.852
LIG_Pex14_2	699	703	PF04695	0.812
LIG_REV1ctd_RIR_1	570	579	PF16727	0.823
LIG_SH2_CRK	100	104	PF00017	0.625
LIG_SH2_CRK	248	252	PF00017	0.613
LIG_SH2_CRK	39	43	PF00017	0.565
LIG_SH2_CRK	422	426	PF00017	0.597
LIG_SH2_CRK	612	616	PF00017	0.562
LIG_SH2_GRB2like	39	42	PF00017	0.567
LIG_SH2_NCK_1	39	43	PF00017	0.565
LIG_SH2_NCK_1	422	426	PF00017	0.597
LIG_SH2_STAP1	39	43	PF00017	0.565
LIG_SH2_STAP1	483	487	PF00017	0.715
LIG_SH2_STAT3	106	109	PF00017	0.573
LIG_SH2_STAT3	818	821	PF00017	0.568
LIG_SH2_STAT5	100	103	PF00017	0.555
LIG_SH2_STAT5	797	800	PF00017	0.582
LIG_SH3_1	209	215	PF00018	0.621
LIG_SH3_1	248	254	PF00018	0.611
LIG_SH3_2	759	764	PF14604	0.726
LIG_SH3_3	209	215	PF00018	0.631
LIG_SH3_3	248	254	PF00018	0.782
LIG_SH3_3	290	296	PF00018	0.868
LIG_SH3_3	30	36	PF00018	0.541
LIG_SH3_3	387	393	PF00018	0.799
LIG_SH3_3	403	409	PF00018	0.645
LIG_SH3_3	432	438	PF00018	0.647
LIG_SH3_3	532	538	PF00018	0.686
LIG_SH3_3	602	608	PF00018	0.646
LIG_SH3_3	756	762	PF00018	0.731
LIG_SUMO_SIM_par_1	396	403	PF11976	0.861
LIG_WRC_WIRS_1	1	6	PF05994	0.527
LIG_WW_3	606	610	PF00397	0.555
MOD_CDC14_SPxK_1	357	360	PF00782	0.805
MOD_CDC14_SPxK_1	888	891	PF00782	0.604
MOD_CDK_SPK_2	289	294	PF00069	0.659
MOD_CDK_SPK_2	333	338	PF00069	0.609
MOD_CDK_SPK_2	354	359	PF00069	0.615
MOD_CDK_SPK_2	498	503	PF00069	0.575
MOD_CDK_SPK_2	522	527	PF00069	0.740
MOD_CDK_SPxK_1	354	360	PF00069	0.806
MOD_CDK_SPxK_1	758	764	PF00069	0.708
MOD_CDK_SPxK_1	885	891	PF00069	0.609
MOD_CDK_SPxxK_3	729	736	PF00069	0.623
MOD_CDK_SPxxK_3	885	892	PF00069	0.611
MOD_CK1_1	156	162	PF00069	0.734
MOD_CK1_1	220	226	PF00069	0.762
MOD_CK1_1	241	247	PF00069	0.592
MOD_CK1_1	26	32	PF00069	0.551
MOD_CK1_1	353	359	PF00069	0.625
MOD_CK1_1	420	426	PF00069	0.599
MOD_CK1_1	445	451	PF00069	0.636
MOD_CK1_1	464	470	PF00069	0.767
MOD_CK1_1	481	487	PF00069	0.535
MOD_CK1_1	525	531	PF00069	0.824
MOD_CK1_1	548	554	PF00069	0.610
MOD_CK1_1	641	647	PF00069	0.829
MOD_CK1_1	677	683	PF00069	0.651
MOD_CK1_1	725	731	PF00069	0.682
MOD_CK1_1	732	738	PF00069	0.658
MOD_CK1_1	739	745	PF00069	0.757
MOD_CK1_1	881	887	PF00069	0.767
MOD_CK2_1	230	236	PF00069	0.806
MOD_CK2_1	583	589	PF00069	0.656
MOD_Cter_Amidation	270	273	PF01082	0.859
MOD_Cter_Amidation	517	520	PF01082	0.837
MOD_Cter_Amidation	862	865	PF01082	0.822
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.589
MOD_DYRK1A_RPxSP_1	527	531	PF00069	0.624
MOD_GlcNHglycan	113	116	PF01048	0.587
MOD_GlcNHglycan	143	146	PF01048	0.745
MOD_GlcNHglycan	172	175	PF01048	0.656
MOD_GlcNHglycan	200	203	PF01048	0.694
MOD_GlcNHglycan	26	29	PF01048	0.621
MOD_GlcNHglycan	333	336	PF01048	0.858
MOD_GlcNHglycan	419	422	PF01048	0.661
MOD_GlcNHglycan	439	442	PF01048	0.627
MOD_GlcNHglycan	467	470	PF01048	0.775
MOD_GlcNHglycan	488	491	PF01048	0.757
MOD_GlcNHglycan	492	495	PF01048	0.801
MOD_GlcNHglycan	527	530	PF01048	0.782
MOD_GlcNHglycan	576	580	PF01048	0.777
MOD_GlcNHglycan	65	68	PF01048	0.705
MOD_GlcNHglycan	660	663	PF01048	0.843
MOD_GlcNHglycan	724	727	PF01048	0.738
MOD_GlcNHglycan	73	76	PF01048	0.606
MOD_GlcNHglycan	750	753	PF01048	0.721
MOD_GlcNHglycan	768	771	PF01048	0.680
MOD_GlcNHglycan	858	861	PF01048	0.875
MOD_GlcNHglycan	880	883	PF01048	0.674
MOD_GlcNHglycan	893	896	PF01048	0.823
MOD_GlcNHglycan	92	95	PF01048	0.471
MOD_GSK3_1	137	144	PF00069	0.683
MOD_GSK3_1	153	160	PF00069	0.654
MOD_GSK3_1	183	190	PF00069	0.718
MOD_GSK3_1	252	259	PF00069	0.660
MOD_GSK3_1	329	336	PF00069	0.615
MOD_GSK3_1	349	356	PF00069	0.786
MOD_GSK3_1	370	377	PF00069	0.711
MOD_GSK3_1	385	392	PF00069	0.743
MOD_GSK3_1	396	403	PF00069	0.632
MOD_GSK3_1	416	423	PF00069	0.539
MOD_GSK3_1	425	432	PF00069	0.679
MOD_GSK3_1	459	466	PF00069	0.779
MOD_GSK3_1	468	475	PF00069	0.622
MOD_GSK3_1	477	484	PF00069	0.562
MOD_GSK3_1	486	493	PF00069	0.607
MOD_GSK3_1	525	532	PF00069	0.755
MOD_GSK3_1	544	551	PF00069	0.532
MOD_GSK3_1	63	70	PF00069	0.778
MOD_GSK3_1	634	641	PF00069	0.630
MOD_GSK3_1	649	656	PF00069	0.775
MOD_GSK3_1	673	680	PF00069	0.730
MOD_GSK3_1	718	725	PF00069	0.674
MOD_GSK3_1	731	738	PF00069	0.671
MOD_GSK3_1	773	780	PF00069	0.749
MOD_GSK3_1	867	874	PF00069	0.693
MOD_GSK3_1	878	885	PF00069	0.747
MOD_LATS_1	457	463	PF00433	0.807
MOD_LATS_1	647	653	PF00433	0.621
MOD_N-GLC_1	353	358	PF02516	0.664
MOD_N-GLC_1	445	450	PF02516	0.608
MOD_N-GLC_1	544	549	PF02516	0.745
MOD_N-GLC_1	553	558	PF02516	0.826
MOD_N-GLC_1	777	782	PF02516	0.595
MOD_NEK2_1	157	162	PF00069	0.585
MOD_NEK2_1	23	28	PF00069	0.581
MOD_NEK2_1	238	243	PF00069	0.590
MOD_NEK2_1	374	379	PF00069	0.610
MOD_NEK2_1	463	468	PF00069	0.711
MOD_NEK2_1	488	493	PF00069	0.620
MOD_NEK2_1	543	548	PF00069	0.608
MOD_NEK2_1	618	623	PF00069	0.722
MOD_NEK2_1	692	697	PF00069	0.557
MOD_NEK2_1	777	782	PF00069	0.803
MOD_NEK2_2	378	383	PF00069	0.589
MOD_NEK2_2	750	755	PF00069	0.719
MOD_PIKK_1	105	111	PF00454	0.548
MOD_PIKK_1	137	143	PF00454	0.821
MOD_PIKK_1	188	194	PF00454	0.585
MOD_PIKK_1	649	655	PF00454	0.728
MOD_PIKK_1	739	745	PF00454	0.609
MOD_PIKK_1	803	809	PF00454	0.587
MOD_PKA_1	350	356	PF00069	0.616
MOD_PKA_1	891	897	PF00069	0.776
MOD_PKA_2	288	294	PF00069	0.859
MOD_PKA_2	349	355	PF00069	0.612
MOD_PKA_2	634	640	PF00069	0.580
MOD_PKA_2	711	717	PF00069	0.590
MOD_PKA_2	735	741	PF00069	0.740
MOD_PKA_2	891	897	PF00069	0.776
MOD_PKA_2	906	912	PF00069	0.576
MOD_PKB_1	168	176	PF00069	0.611
MOD_Plk_1	472	478	PF00069	0.574
MOD_Plk_1	544	550	PF00069	0.739
MOD_Plk_1	553	559	PF00069	0.827
MOD_Plk_4	483	489	PF00069	0.581
MOD_ProDKin_1	132	138	PF00069	0.706
MOD_ProDKin_1	183	189	PF00069	0.650
MOD_ProDKin_1	241	247	PF00069	0.592
MOD_ProDKin_1	289	295	PF00069	0.874
MOD_ProDKin_1	333	339	PF00069	0.604
MOD_ProDKin_1	354	360	PF00069	0.806
MOD_ProDKin_1	389	395	PF00069	0.800
MOD_ProDKin_1	405	411	PF00069	0.565
MOD_ProDKin_1	498	504	PF00069	0.576
MOD_ProDKin_1	522	528	PF00069	0.740
MOD_ProDKin_1	58	64	PF00069	0.777
MOD_ProDKin_1	611	617	PF00069	0.569
MOD_ProDKin_1	677	683	PF00069	0.652
MOD_ProDKin_1	729	735	PF00069	0.737
MOD_ProDKin_1	758	764	PF00069	0.713
MOD_ProDKin_1	846	852	PF00069	0.868
MOD_ProDKin_1	864	870	PF00069	0.801
MOD_ProDKin_1	885	891	PF00069	0.609
TRG_ENDOCYTIC_2	100	103	PF00928	0.802
TRG_ENDOCYTIC_2	39	42	PF00928	0.664
TRG_ER_diArg_1	208	210	PF00400	0.779
TRG_ER_diArg_1	272	275	PF00400	0.860
TRG_ER_diArg_1	276	279	PF00400	0.807
TRG_ER_diArg_1	349	351	PF00400	0.602
TRG_ER_diArg_1	358	360	PF00400	0.580
TRG_ER_diArg_1	455	458	PF00400	0.819
TRG_ER_diArg_1	510	513	PF00400	0.795
TRG_ER_diArg_1	573	575	PF00400	0.660
TRG_ER_diArg_1	839	841	PF00400	0.634
TRG_ER_diArg_1	862	865	PF00400	0.790
TRG_NLS_MonoExtC_3	704	709	PF00514	0.559
TRG_NLS_MonoExtN_4	561	567	PF00514	0.572
TRG_NLS_MonoExtN_4	889	895	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJG2	Leishmania donovani	52%	100%
A4I873	Leishmania infantum	53%	100%
E9B331	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
Q4Q523	Leishmania major	50%	100%