Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKP1_LEIBR

TriTrypDb:

LbrM.32.2740 , LBRM2903_320034900

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP1

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.620
CLV_C14_Caspase3-7	388	392	PF00656	0.454
CLV_NRD_NRD_1	138	140	PF00675	0.567
CLV_NRD_NRD_1	184	186	PF00675	0.582
CLV_NRD_NRD_1	256	258	PF00675	0.541
CLV_NRD_NRD_1	302	304	PF00675	0.391
CLV_NRD_NRD_1	305	307	PF00675	0.418
CLV_NRD_NRD_1	349	351	PF00675	0.309
CLV_NRD_NRD_1	428	430	PF00675	0.433
CLV_NRD_NRD_1	94	96	PF00675	0.501
CLV_PCSK_FUR_1	303	307	PF00082	0.419
CLV_PCSK_KEX2_1	137	139	PF00082	0.716
CLV_PCSK_KEX2_1	184	186	PF00082	0.582
CLV_PCSK_KEX2_1	255	257	PF00082	0.538
CLV_PCSK_KEX2_1	268	270	PF00082	0.578
CLV_PCSK_KEX2_1	304	306	PF00082	0.436
CLV_PCSK_KEX2_1	349	351	PF00082	0.452
CLV_PCSK_KEX2_1	427	429	PF00082	0.459
CLV_PCSK_KEX2_1	94	96	PF00082	0.623
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.639
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.336
CLV_PCSK_PC7_1	134	140	PF00082	0.552
CLV_PCSK_PC7_1	345	351	PF00082	0.452
CLV_PCSK_SKI1_1	125	129	PF00082	0.576
CLV_PCSK_SKI1_1	26	30	PF00082	0.502
CLV_PCSK_SKI1_1	306	310	PF00082	0.411
CLV_PCSK_SKI1_1	313	317	PF00082	0.495
CLV_PCSK_SKI1_1	345	349	PF00082	0.463
CLV_PCSK_SKI1_1	375	379	PF00082	0.496
CLV_PCSK_SKI1_1	453	457	PF00082	0.588
CLV_PCSK_SKI1_1	512	516	PF00082	0.457
CLV_PCSK_SKI1_1	520	524	PF00082	0.364
CLV_PCSK_SKI1_1	619	623	PF00082	0.570
DEG_APCC_DBOX_1	114	122	PF00400	0.558
DEG_APCC_DBOX_1	642	650	PF00400	0.363
DEG_ODPH_VHL_1	476	487	PF01847	0.483
DEG_SPOP_SBC_1	489	493	PF00917	0.496
DEG_SPOP_SBC_1	624	628	PF00917	0.325
DEG_SPOP_SBC_1	636	640	PF00917	0.438
DOC_CYCLIN_RxL_1	120	132	PF00134	0.504
DOC_MAPK_DCC_7	224	234	PF00069	0.441
DOC_MAPK_gen_1	120	129	PF00069	0.425
DOC_MAPK_gen_1	427	436	PF00069	0.401
DOC_MAPK_MEF2A_6	123	131	PF00069	0.498
DOC_MAPK_MEF2A_6	174	183	PF00069	0.495
DOC_MAPK_MEF2A_6	427	436	PF00069	0.337
DOC_MAPK_MEF2A_6	516	523	PF00069	0.271
DOC_MAPK_MEF2A_6	573	582	PF00069	0.411
DOC_MAPK_MEF2A_6	643	652	PF00069	0.416
DOC_PP1_RVXF_1	518	524	PF00149	0.406
DOC_PP2B_LxvP_1	456	459	PF13499	0.617
DOC_PP4_FxxP_1	663	666	PF00568	0.358
DOC_USP7_MATH_1	145	149	PF00917	0.499
DOC_USP7_MATH_1	218	222	PF00917	0.770
DOC_USP7_MATH_1	261	265	PF00917	0.774
DOC_USP7_MATH_1	274	278	PF00917	0.669
DOC_USP7_MATH_1	381	385	PF00917	0.510
DOC_USP7_MATH_1	445	449	PF00917	0.460
DOC_USP7_MATH_1	481	485	PF00917	0.644
DOC_USP7_MATH_1	488	492	PF00917	0.652
DOC_USP7_MATH_1	636	640	PF00917	0.671
DOC_USP7_MATH_1	80	84	PF00917	0.607
DOC_WW_Pin1_4	327	332	PF00397	0.430
DOC_WW_Pin1_4	490	495	PF00397	0.615
DOC_WW_Pin1_4	497	502	PF00397	0.440
DOC_WW_Pin1_4	632	637	PF00397	0.570
LIG_14-3-3_CanoR_1	149	155	PF00244	0.493
LIG_14-3-3_CanoR_1	619	624	PF00244	0.496
LIG_Actin_WH2_2	364	381	PF00022	0.388
LIG_BIR_III_4	164	168	PF00653	0.475
LIG_deltaCOP1_diTrp_1	435	441	PF00928	0.251
LIG_FHA_1	221	227	PF00498	0.646
LIG_FHA_1	27	33	PF00498	0.581
LIG_FHA_1	421	427	PF00498	0.446
LIG_FHA_1	471	477	PF00498	0.669
LIG_FHA_1	490	496	PF00498	0.481
LIG_FHA_1	51	57	PF00498	0.581
LIG_FHA_1	603	609	PF00498	0.439
LIG_FHA_1	616	622	PF00498	0.515
LIG_FHA_1	625	631	PF00498	0.446
LIG_FHA_2	105	111	PF00498	0.541
LIG_FHA_2	564	570	PF00498	0.566
LIG_FHA_2	97	103	PF00498	0.704
LIG_IRF3_LxIS_1	578	583	PF10401	0.281
LIG_LIR_Gen_1	435	445	PF02991	0.265
LIG_LIR_Gen_1	503	509	PF02991	0.532
LIG_LIR_LC3C_4	627	632	PF02991	0.355
LIG_LIR_Nem_3	435	441	PF02991	0.440
LIG_LIR_Nem_3	503	507	PF02991	0.543
LIG_NRBOX	563	569	PF00104	0.351
LIG_PCNA_PIPBox_1	649	658	PF02747	0.272
LIG_RPA_C_Fungi	144	156	PF08784	0.472
LIG_SH2_GRB2like	294	297	PF00017	0.328
LIG_SH2_PTP2	328	331	PF00017	0.513
LIG_SH2_STAT3	39	42	PF00017	0.423
LIG_SH2_STAT5	310	313	PF00017	0.442
LIG_SH2_STAT5	328	331	PF00017	0.513
LIG_SH2_STAT5	39	42	PF00017	0.351
LIG_SH2_STAT5	399	402	PF00017	0.264
LIG_SH3_3	320	326	PF00018	0.496
LIG_SH3_3	461	467	PF00018	0.627
LIG_SH3_3	482	488	PF00018	0.490
LIG_SH3_3	618	624	PF00018	0.509
LIG_SH3_3	642	648	PF00018	0.391
LIG_SUMO_SIM_par_1	604	609	PF11976	0.402
LIG_TRAF2_1	332	335	PF00917	0.468
LIG_TRAF2_1	553	556	PF00917	0.294
LIG_TYR_ITIM	292	297	PF00017	0.349
LIG_WRC_WIRS_1	382	387	PF05994	0.396
LIG_WRC_WIRS_1	544	549	PF05994	0.358
MOD_CK1_1	132	138	PF00069	0.436
MOD_CK1_1	148	154	PF00069	0.584
MOD_CK1_1	169	175	PF00069	0.511
MOD_CK1_1	277	283	PF00069	0.664
MOD_CK1_1	448	454	PF00069	0.605
MOD_CK1_1	493	499	PF00069	0.673
MOD_CK1_1	557	563	PF00069	0.557
MOD_CK1_1	626	632	PF00069	0.469
MOD_CK1_1	635	641	PF00069	0.601
MOD_CK1_1	93	99	PF00069	0.587
MOD_CK2_1	216	222	PF00069	0.600
MOD_CK2_1	338	344	PF00069	0.589
MOD_CK2_1	381	387	PF00069	0.440
MOD_CK2_1	550	556	PF00069	0.281
MOD_CK2_1	563	569	PF00069	0.558
MOD_CK2_1	580	586	PF00069	0.476
MOD_CK2_1	96	102	PF00069	0.509
MOD_Cter_Amidation	266	269	PF01082	0.649
MOD_GlcNHglycan	131	134	PF01048	0.567
MOD_GlcNHglycan	151	154	PF01048	0.444
MOD_GlcNHglycan	263	266	PF01048	0.497
MOD_GlcNHglycan	276	279	PF01048	0.566
MOD_GlcNHglycan	313	316	PF01048	0.447
MOD_GlcNHglycan	394	397	PF01048	0.299
MOD_GlcNHglycan	443	446	PF01048	0.495
MOD_GlcNHglycan	528	531	PF01048	0.348
MOD_GlcNHglycan	590	593	PF01048	0.504
MOD_GlcNHglycan	632	635	PF01048	0.685
MOD_GlcNHglycan	76	79	PF01048	0.557
MOD_GlcNHglycan	82	85	PF01048	0.578
MOD_GSK3_1	145	152	PF00069	0.645
MOD_GSK3_1	216	223	PF00069	0.692
MOD_GSK3_1	277	284	PF00069	0.573
MOD_GSK3_1	381	388	PF00069	0.604
MOD_GSK3_1	441	448	PF00069	0.453
MOD_GSK3_1	46	53	PF00069	0.534
MOD_GSK3_1	489	496	PF00069	0.635
MOD_GSK3_1	546	553	PF00069	0.390
MOD_GSK3_1	576	583	PF00069	0.404
MOD_GSK3_1	611	618	PF00069	0.478
MOD_GSK3_1	619	626	PF00069	0.410
MOD_GSK3_1	632	639	PF00069	0.547
MOD_GSK3_1	80	87	PF00069	0.595
MOD_N-GLC_2	225	227	PF02516	0.446
MOD_NEK2_1	193	198	PF00069	0.612
MOD_NEK2_1	27	32	PF00069	0.369
MOD_NEK2_1	281	286	PF00069	0.542
MOD_NEK2_1	297	302	PF00069	0.348
MOD_NEK2_1	309	314	PF00069	0.483
MOD_NEK2_1	385	390	PF00069	0.547
MOD_NEK2_1	440	445	PF00069	0.457
MOD_NEK2_1	449	454	PF00069	0.546
MOD_NEK2_1	554	559	PF00069	0.458
MOD_NEK2_1	580	585	PF00069	0.449
MOD_NEK2_1	587	592	PF00069	0.507
MOD_NEK2_1	625	630	PF00069	0.563
MOD_NEK2_1	90	95	PF00069	0.505
MOD_NEK2_2	21	26	PF00069	0.401
MOD_NEK2_2	481	486	PF00069	0.487
MOD_PIKK_1	297	303	PF00454	0.470
MOD_PIKK_1	385	391	PF00454	0.519
MOD_PIKK_1	546	552	PF00454	0.331
MOD_PIKK_1	573	579	PF00454	0.337
MOD_PKA_2	148	154	PF00069	0.617
MOD_PKA_2	16	22	PF00069	0.595
MOD_PKA_2	611	617	PF00069	0.471
MOD_PKA_2	93	99	PF00069	0.514
MOD_PKB_1	137	145	PF00069	0.508
MOD_Plk_1	145	151	PF00069	0.585
MOD_Plk_1	420	426	PF00069	0.312
MOD_Plk_4	445	451	PF00069	0.517
MOD_Plk_4	500	506	PF00069	0.520
MOD_Plk_4	554	560	PF00069	0.444
MOD_Plk_4	563	569	PF00069	0.434
MOD_Plk_4	597	603	PF00069	0.391
MOD_Plk_4	626	632	PF00069	0.582
MOD_Plk_4	65	71	PF00069	0.492
MOD_ProDKin_1	327	333	PF00069	0.432
MOD_ProDKin_1	490	496	PF00069	0.613
MOD_ProDKin_1	497	503	PF00069	0.429
MOD_ProDKin_1	632	638	PF00069	0.572
MOD_SUMO_for_1	70	73	PF00179	0.626
TRG_DiLeu_BaEn_2	341	347	PF01217	0.369
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.508
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.488
TRG_ENDOCYTIC_2	294	297	PF00928	0.528
TRG_ENDOCYTIC_2	399	402	PF00928	0.459
TRG_ER_diArg_1	114	117	PF00400	0.568
TRG_ER_diArg_1	137	139	PF00400	0.568
TRG_ER_diArg_1	183	185	PF00400	0.590
TRG_ER_diArg_1	254	257	PF00400	0.536
TRG_ER_diArg_1	303	306	PF00400	0.415
TRG_ER_diArg_1	348	350	PF00400	0.312
TRG_ER_diArg_1	426	429	PF00400	0.561
TRG_NLS_MonoCore_2	302	307	PF00514	0.334
TRG_NLS_MonoExtN_4	303	308	PF00514	0.345
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A1	Leptomonas seymouri	45%	100%
A0A1X0NRK2	Trypanosomatidae	30%	100%
A0A3Q8IG27	Leishmania donovani	73%	100%
A4I872	Leishmania infantum	73%	100%
D0AAE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B330	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q524	Leishmania major	72%	100%
V5AUP9	Trypanosoma cruzi	31%	100%