Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKP0_LEIBR

TriTrypDb:

LbrM.32.2730 , LBRM2903_320034700

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HKP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.642
CLV_NRD_NRD_1	147	149	PF00675	0.403
CLV_NRD_NRD_1	63	65	PF00675	0.584
CLV_PCSK_KEX2_1	147	149	PF00082	0.411
CLV_PCSK_KEX2_1	63	65	PF00082	0.584
CLV_PCSK_SKI1_1	11	15	PF00082	0.607
CLV_PCSK_SKI1_1	50	54	PF00082	0.553
DEG_SCF_FBW7_1	1	8	PF00400	0.368
DOC_MAPK_MEF2A_6	39	48	PF00069	0.391
DOC_PP1_RVXF_1	103	109	PF00149	0.361
DOC_USP7_MATH_1	5	9	PF00917	0.366
DOC_WW_Pin1_4	1	6	PF00397	0.376
LIG_14-3-3_CanoR_1	128	133	PF00244	0.509
LIG_14-3-3_CanoR_1	139	145	PF00244	0.584
LIG_14-3-3_CanoR_1	50	55	PF00244	0.293
LIG_Actin_WH2_2	77	92	PF00022	0.388
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.593
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BRCT_BRCA1_1	5	9	PF00533	0.421
LIG_deltaCOP1_diTrp_1	107	113	PF00928	0.265
LIG_FHA_1	12	18	PF00498	0.405
LIG_FHA_1	29	35	PF00498	0.417
LIG_FHA_1	84	90	PF00498	0.378
LIG_LIR_Gen_1	40	51	PF02991	0.378
LIG_LIR_Nem_3	107	111	PF02991	0.272
LIG_LIR_Nem_3	40	46	PF02991	0.393
LIG_LIR_Nem_3	79	84	PF02991	0.397
LIG_NRBOX	128	134	PF00104	0.556
LIG_NRP_CendR_1	160	162	PF00754	0.453
LIG_PTB_Apo_2	149	156	PF02174	0.548
LIG_PTB_Phospho_1	149	155	PF10480	0.544
LIG_SH2_SRC	43	46	PF00017	0.325
LIG_SH2_STAP1	115	119	PF00017	0.308
LIG_SH2_STAT3	65	68	PF00017	0.385
LIG_SH2_STAT5	121	124	PF00017	0.291
LIG_SH2_STAT5	155	158	PF00017	0.708
LIG_SH2_STAT5	43	46	PF00017	0.382
LIG_SH2_STAT5	65	68	PF00017	0.446
LIG_TRAF2_2	102	107	PF00917	0.366
MOD_CMANNOS	110	113	PF00535	0.308
MOD_GSK3_1	1	8	PF00069	0.435
MOD_GSK3_1	50	57	PF00069	0.385
MOD_GSK3_1	9	16	PF00069	0.368
MOD_NEK2_1	22	27	PF00069	0.319
MOD_NEK2_1	89	94	PF00069	0.373
MOD_NEK2_1	9	14	PF00069	0.406
MOD_PKA_2	66	72	PF00069	0.472
MOD_PKA_2	89	95	PF00069	0.374
MOD_Plk_4	128	134	PF00069	0.556
MOD_Plk_4	5	11	PF00069	0.487
MOD_Plk_4	89	95	PF00069	0.374
MOD_ProDKin_1	1	7	PF00069	0.373
MOD_SUMO_rev_2	79	84	PF00179	0.480
TRG_ENDOCYTIC_2	115	118	PF00928	0.284
TRG_ENDOCYTIC_2	43	46	PF00928	0.370
TRG_ENDOCYTIC_2	59	62	PF00928	0.362
TRG_ER_diArg_1	159	162	PF00400	0.646
TRG_ER_diArg_1	62	64	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P2	Leptomonas seymouri	85%	100%
A0A1X0NS66	Trypanosomatidae	66%	100%
A0A3Q8ILB8	Leishmania donovani	89%	100%
A0A3R7L0F6	Trypanosoma rangeli	66%	99%
A4I871	Leishmania infantum	90%	100%
D0AAE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B329	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q525	Leishmania major	90%	100%