Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKN8_LEIBR

TriTrypDb:

LbrM.32.2710 , LBRM2903_320034500

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.518
CLV_C14_Caspase3-7	34	38	PF00656	0.705
CLV_C14_Caspase3-7	50	54	PF00656	0.545
CLV_PCSK_SKI1_1	111	115	PF00082	0.376
CLV_PCSK_SKI1_1	90	94	PF00082	0.423
DEG_SPOP_SBC_1	30	34	PF00917	0.558
DOC_CYCLIN_RxL_1	87	96	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.365
DOC_MAPK_MEF2A_6	127	136	PF00069	0.525
DOC_PP1_RVXF_1	109	115	PF00149	0.389
DOC_PP4_FxxP_1	68	71	PF00568	0.354
DOC_USP7_MATH_1	123	127	PF00917	0.327
DOC_USP7_MATH_1	26	30	PF00917	0.656
DOC_USP7_MATH_1	31	35	PF00917	0.671
DOC_USP7_MATH_1	39	43	PF00917	0.668
DOC_USP7_MATH_1	62	66	PF00917	0.492
LIG_14-3-3_CanoR_1	5	12	PF00244	0.492
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	64	68	PF00533	0.458
LIG_BRCT_BRCA1_1	76	80	PF00533	0.294
LIG_CtBP_PxDLS_1	116	120	PF00389	0.511
LIG_FHA_1	103	109	PF00498	0.409
LIG_FHA_1	46	52	PF00498	0.515
LIG_LIR_Apic_2	16	21	PF02991	0.556
LIG_LIR_Apic_2	65	71	PF02991	0.493
LIG_SH2_STAP1	76	80	PF00017	0.377
LIG_SH2_STAT5	107	110	PF00017	0.532
LIG_SH3_3	18	24	PF00018	0.472
LIG_SUMO_SIM_par_1	115	121	PF11976	0.382
MOD_CK1_1	29	35	PF00069	0.707
MOD_CK1_1	7	13	PF00069	0.646
MOD_CK1_1	72	78	PF00069	0.395
MOD_CK2_1	11	17	PF00069	0.568
MOD_CK2_1	123	129	PF00069	0.368
MOD_GlcNHglycan	13	16	PF01048	0.526
MOD_GlcNHglycan	2	5	PF01048	0.709
MOD_GlcNHglycan	33	36	PF01048	0.759
MOD_GlcNHglycan	41	44	PF01048	0.687
MOD_GlcNHglycan	71	74	PF01048	0.412
MOD_GlcNHglycan	76	79	PF01048	0.383
MOD_GSK3_1	25	32	PF00069	0.749
MOD_GSK3_1	7	14	PF00069	0.600
MOD_N-GLC_1	5	10	PF02516	0.708
MOD_PKA_2	4	10	PF00069	0.600
MOD_Plk_1	101	107	PF00069	0.419
MOD_Plk_2-3	115	121	PF00069	0.382
MOD_Plk_4	102	108	PF00069	0.411
MOD_Plk_4	62	68	PF00069	0.558
MOD_SUMO_for_1	132	135	PF00179	0.407
MOD_SUMO_rev_2	120	128	PF00179	0.482
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I3	Leptomonas seymouri	62%	100%
A0A0S4IYR4	Bodo saltans	41%	95%
A0A1X0NRU4	Trypanosomatidae	38%	100%
A0A3R7MFQ9	Trypanosoma rangeli	44%	100%
A0A3S7X5R6	Leishmania donovani	74%	100%
A4I869	Leishmania infantum	74%	100%
D0AAD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B327	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q527	Leishmania major	71%	96%