PAP-associated domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cid1 family poly A polymerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKN6_LEIBR

TriTrypDb:

LbrM.32.2690 , LBRM2903_320034200

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HKN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.438
CLV_NRD_NRD_1	125	127	PF00675	0.433
CLV_NRD_NRD_1	151	153	PF00675	0.347
CLV_NRD_NRD_1	211	213	PF00675	0.460
CLV_NRD_NRD_1	29	31	PF00675	0.506
CLV_NRD_NRD_1	328	330	PF00675	0.411
CLV_PCSK_KEX2_1	113	115	PF00082	0.442
CLV_PCSK_KEX2_1	125	127	PF00082	0.358
CLV_PCSK_KEX2_1	151	153	PF00082	0.347
CLV_PCSK_KEX2_1	211	213	PF00082	0.461
CLV_PCSK_KEX2_1	29	31	PF00082	0.482
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.532
CLV_PCSK_SKI1_1	213	217	PF00082	0.435
CLV_PCSK_SKI1_1	280	284	PF00082	0.355
CLV_PCSK_SKI1_1	318	322	PF00082	0.383
CLV_PCSK_SKI1_1	324	328	PF00082	0.384
CLV_Separin_Metazoa	122	126	PF03568	0.540
DEG_APCC_DBOX_1	210	218	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.654
DOC_CKS1_1	237	242	PF01111	0.469
DOC_MAPK_DCC_7	125	134	PF00069	0.378
DOC_MAPK_gen_1	125	134	PF00069	0.365
DOC_MAPK_gen_1	211	220	PF00069	0.485
DOC_MAPK_MEF2A_6	125	134	PF00069	0.365
DOC_USP7_MATH_1	219	223	PF00917	0.515
DOC_USP7_MATH_1	5	9	PF00917	0.556
DOC_USP7_UBL2_3	179	183	PF12436	0.350
DOC_WW_Pin1_4	236	241	PF00397	0.450
DOC_WW_Pin1_4	260	265	PF00397	0.238
DOC_WW_Pin1_4	318	323	PF00397	0.371
DOC_WW_Pin1_4	52	57	PF00397	0.482
DOC_WW_Pin1_4	77	82	PF00397	0.506
LIG_14-3-3_CanoR_1	156	164	PF00244	0.340
LIG_14-3-3_CanoR_1	172	177	PF00244	0.322
LIG_Clathr_ClatBox_1	217	221	PF01394	0.513
LIG_FHA_1	31	37	PF00498	0.419
LIG_FHA_1	336	342	PF00498	0.380
LIG_FHA_1	343	349	PF00498	0.417
LIG_FHA_1	53	59	PF00498	0.466
LIG_FHA_1	60	66	PF00498	0.434
LIG_FHA_2	276	282	PF00498	0.313
LIG_LIR_Gen_1	170	178	PF02991	0.379
LIG_LIR_Gen_1	198	209	PF02991	0.316
LIG_LIR_Gen_1	73	84	PF02991	0.363
LIG_LIR_Nem_3	253	257	PF02991	0.305
LIG_LIR_Nem_3	73	79	PF02991	0.350
LIG_SH2_STAP1	310	314	PF00017	0.305
LIG_SH2_STAT3	164	167	PF00017	0.347
LIG_SH2_STAT5	117	120	PF00017	0.547
LIG_SH2_STAT5	164	167	PF00017	0.347
LIG_SH2_STAT5	208	211	PF00017	0.323
LIG_SH2_STAT5	258	261	PF00017	0.364
LIG_SH2_STAT5	57	60	PF00017	0.403
LIG_SH3_3	227	233	PF00018	0.383
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.272
LIG_SUMO_SIM_anti_2	337	345	PF11976	0.514
LIG_SUMO_SIM_par_1	337	345	PF11976	0.540
LIG_TYR_ITIM	205	210	PF00017	0.327
LIG_UBA3_1	105	113	PF00899	0.495
LIG_UBA3_1	325	330	PF00899	0.525
MOD_CDK_SPxK_1	318	324	PF00069	0.372
MOD_CK1_1	182	188	PF00069	0.414
MOD_CK2_1	275	281	PF00069	0.313
MOD_GlcNHglycan	101	104	PF01048	0.479
MOD_GlcNHglycan	157	160	PF01048	0.333
MOD_GlcNHglycan	348	351	PF01048	0.697
MOD_GlcNHglycan	353	356	PF01048	0.648
MOD_GlcNHglycan	43	46	PF01048	0.498
MOD_GSK3_1	141	148	PF00069	0.488
MOD_GSK3_1	263	270	PF00069	0.390
MOD_GSK3_1	342	349	PF00069	0.627
MOD_N-GLC_1	187	192	PF02516	0.422
MOD_N-GLC_1	318	323	PF02516	0.373
MOD_NEK2_1	145	150	PF00069	0.358
MOD_NEK2_1	269	274	PF00069	0.404
MOD_NEK2_1	283	288	PF00069	0.221
MOD_NEK2_1	342	347	PF00069	0.506
MOD_NEK2_1	59	64	PF00069	0.352
MOD_PIKK_1	163	169	PF00454	0.469
MOD_PIKK_1	342	348	PF00454	0.369
MOD_PKA_2	106	112	PF00069	0.434
MOD_PKA_2	124	130	PF00069	0.333
MOD_PKA_2	155	161	PF00069	0.333
MOD_Plk_1	187	193	PF00069	0.422
MOD_Plk_2-3	141	147	PF00069	0.481
MOD_Plk_2-3	69	75	PF00069	0.373
MOD_Plk_4	172	178	PF00069	0.415
MOD_Plk_4	253	259	PF00069	0.336
MOD_Plk_4	59	65	PF00069	0.288
MOD_ProDKin_1	236	242	PF00069	0.452
MOD_ProDKin_1	260	266	PF00069	0.238
MOD_ProDKin_1	318	324	PF00069	0.370
MOD_ProDKin_1	52	58	PF00069	0.477
MOD_ProDKin_1	77	83	PF00069	0.505
MOD_SUMO_for_1	112	115	PF00179	0.517
MOD_SUMO_rev_2	28	36	PF00179	0.433
MOD_SUMO_rev_2	80	90	PF00179	0.542
TRG_DiLeu_BaEn_1	337	342	PF01217	0.488
TRG_ENDOCYTIC_2	207	210	PF00928	0.313
TRG_ENDOCYTIC_2	234	237	PF00928	0.394
TRG_ER_diArg_1	124	126	PF00400	0.418
TRG_ER_diArg_1	210	212	PF00400	0.435
TRG_ER_diArg_1	29	31	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG2	Leptomonas seymouri	78%	100%
A0A0S4IXY7	Bodo saltans	44%	100%
A0A1X0NI50	Trypanosomatidae	24%	98%
A0A1X0NT04	Trypanosomatidae	62%	100%
A0A3Q8IGX2	Leishmania donovani	92%	100%
A0A3R7LQY4	Trypanosoma rangeli	62%	100%
A4I867	Leishmania infantum	92%	100%
D0AAD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B325	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O13833	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	88%
O74326	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	74%
Q0VFA3	Xenopus tropicalis	25%	67%
Q2HJ44	Bos taurus	24%	74%
Q381M1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	59%	100%
Q4Q530	Leishmania major	91%	100%
Q503I9	Danio rerio	24%	73%
Q5U315	Rattus norvegicus	24%	74%
Q641A1	Xenopus laevis	24%	70%
Q6DFA8	Xenopus laevis	26%	70%
Q6PIY7	Homo sapiens	24%	74%
Q91YI6	Mus musculus	24%	74%
V5B3T6	Trypanosoma cruzi	62%	100%