Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKN5_LEIBR

TriTrypDb:

LbrM.32.2680 , LBRM2903_320034100

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.731
CLV_NRD_NRD_1	173	175	PF00675	0.397
CLV_NRD_NRD_1	200	202	PF00675	0.336
CLV_NRD_NRD_1	89	91	PF00675	0.354
CLV_PCSK_KEX2_1	173	175	PF00082	0.398
CLV_PCSK_KEX2_1	200	202	PF00082	0.336
CLV_PCSK_SKI1_1	147	151	PF00082	0.350
CLV_PCSK_SKI1_1	184	188	PF00082	0.464
CLV_PCSK_SKI1_1	90	94	PF00082	0.365
DEG_APCC_DBOX_1	57	65	PF00400	0.540
DOC_CKS1_1	52	57	PF01111	0.586
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.302
DOC_MAPK_DCC_7	207	216	PF00069	0.374
DOC_MAPK_gen_1	104	113	PF00069	0.362
DOC_MAPK_HePTP_8	103	115	PF00069	0.278
DOC_MAPK_MEF2A_6	104	113	PF00069	0.397
DOC_MAPK_MEF2A_6	207	216	PF00069	0.374
DOC_PP2B_LxvP_1	121	124	PF13499	0.533
DOC_PP2B_LxvP_1	206	209	PF13499	0.429
DOC_PP2B_LxvP_1	216	219	PF13499	0.276
DOC_PP4_FxxP_1	361	364	PF00568	0.524
DOC_USP7_MATH_1	405	409	PF00917	0.738
DOC_USP7_UBL2_3	217	221	PF12436	0.305
DOC_WW_Pin1_4	184	189	PF00397	0.499
DOC_WW_Pin1_4	301	306	PF00397	0.398
DOC_WW_Pin1_4	345	350	PF00397	0.376
DOC_WW_Pin1_4	374	379	PF00397	0.626
DOC_WW_Pin1_4	51	56	PF00397	0.607
LIG_14-3-3_CanoR_1	120	124	PF00244	0.446
LIG_Actin_WH2_2	286	304	PF00022	0.465
LIG_Actin_WH2_2	322	340	PF00022	0.286
LIG_APCC_ABBAyCdc20_2	106	112	PF00400	0.352
LIG_EVH1_2	67	71	PF00568	0.389
LIG_FHA_1	137	143	PF00498	0.319
LIG_FHA_1	18	24	PF00498	0.586
LIG_FHA_1	242	248	PF00498	0.385
LIG_FHA_1	251	257	PF00498	0.359
LIG_FHA_1	73	79	PF00498	0.526
LIG_FHA_2	156	162	PF00498	0.487
LIG_FHA_2	234	240	PF00498	0.318
LIG_FHA_2	380	386	PF00498	0.757
LIG_LIR_Apic_2	262	268	PF02991	0.355
LIG_LIR_Apic_2	345	350	PF02991	0.396
LIG_LIR_Gen_1	163	172	PF02991	0.231
LIG_LIR_Gen_1	193	202	PF02991	0.368
LIG_LIR_Gen_1	309	318	PF02991	0.364
LIG_LIR_Nem_3	163	169	PF02991	0.234
LIG_LIR_Nem_3	193	199	PF02991	0.364
LIG_LIR_Nem_3	223	229	PF02991	0.334
LIG_LIR_Nem_3	262	267	PF02991	0.358
LIG_LIR_Nem_3	309	315	PF02991	0.369
LIG_PCNA_yPIPBox_3	36	49	PF02747	0.534
LIG_Pex14_1	222	226	PF04695	0.342
LIG_PTB_Apo_2	257	264	PF02174	0.446
LIG_SH2_CRK	347	351	PF00017	0.414
LIG_SH2_CRK	352	356	PF00017	0.439
LIG_SH2_NCK_1	130	134	PF00017	0.354
LIG_SH2_NCK_1	347	351	PF00017	0.359
LIG_SH2_PTP2	166	169	PF00017	0.317
LIG_SH2_STAT3	278	281	PF00017	0.510
LIG_SH2_STAT3	80	83	PF00017	0.367
LIG_SH2_STAT5	141	144	PF00017	0.306
LIG_SH2_STAT5	166	169	PF00017	0.317
LIG_SH2_STAT5	271	274	PF00017	0.294
LIG_SH2_STAT5	347	350	PF00017	0.348
LIG_SH2_STAT5	80	83	PF00017	0.323
LIG_SH3_3	206	212	PF00018	0.391
LIG_SH3_3	279	285	PF00018	0.382
LIG_SH3_3	89	95	PF00018	0.370
LIG_TYR_ITSM	260	267	PF00017	0.360
LIG_WW_1	349	352	PF00397	0.389
MOD_CDK_SPK_2	184	189	PF00069	0.484
MOD_CDK_SPxxK_3	51	58	PF00069	0.602
MOD_CK1_1	25	31	PF00069	0.747
MOD_CK1_1	376	382	PF00069	0.752
MOD_CK2_1	233	239	PF00069	0.316
MOD_CK2_1	379	385	PF00069	0.670
MOD_DYRK1A_RPxSP_1	184	188	PF00069	0.464
MOD_GlcNHglycan	18	23	PF01048	0.659
MOD_GlcNHglycan	379	382	PF01048	0.646
MOD_GlcNHglycan	55	58	PF01048	0.565
MOD_GSK3_1	14	21	PF00069	0.634
MOD_GSK3_1	373	380	PF00069	0.703
MOD_N-GLC_1	35	40	PF02516	0.676
MOD_N-GLC_1	405	410	PF02516	0.514
MOD_NEK2_1	119	124	PF00069	0.312
MOD_NEK2_1	155	160	PF00069	0.483
MOD_NEK2_1	359	364	PF00069	0.391
MOD_NEK2_1	43	48	PF00069	0.679
MOD_NEK2_1	74	79	PF00069	0.394
MOD_PIKK_1	350	356	PF00454	0.592
MOD_PIKK_1	41	47	PF00454	0.672
MOD_PKA_1	90	96	PF00069	0.346
MOD_PKA_2	119	125	PF00069	0.344
MOD_Plk_1	136	142	PF00069	0.308
MOD_Plk_1	296	302	PF00069	0.470
MOD_Plk_1	35	41	PF00069	0.674
MOD_Plk_1	405	411	PF00069	0.595
MOD_Plk_4	136	142	PF00069	0.474
MOD_Plk_4	259	265	PF00069	0.371
MOD_Plk_4	288	294	PF00069	0.489
MOD_Plk_4	296	302	PF00069	0.505
MOD_Plk_4	43	49	PF00069	0.726
MOD_Plk_4	74	80	PF00069	0.444
MOD_ProDKin_1	184	190	PF00069	0.490
MOD_ProDKin_1	301	307	PF00069	0.400
MOD_ProDKin_1	345	351	PF00069	0.382
MOD_ProDKin_1	374	380	PF00069	0.629
MOD_ProDKin_1	51	57	PF00069	0.598
MOD_SUMO_rev_2	366	374	PF00179	0.465
MOD_SUMO_rev_2	386	395	PF00179	0.518
TRG_ENDOCYTIC_2	166	169	PF00928	0.317
TRG_ENDOCYTIC_2	264	267	PF00928	0.337
TRG_ENDOCYTIC_2	352	355	PF00928	0.473
TRG_ER_diArg_1	172	174	PF00400	0.375
TRG_ER_diArg_1	199	201	PF00400	0.327
TRG_NES_CRM1_1	114	127	PF08389	0.312
TRG_NES_CRM1_1	26	40	PF08389	0.453
TRG_NES_CRM1_1	354	366	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN5	Leptomonas seymouri	74%	82%
A0A0S4IUS1	Bodo saltans	56%	100%
A0A1X0NRZ1	Trypanosomatidae	58%	100%
A0A3Q8IH54	Leishmania donovani	85%	100%
A0A422N863	Trypanosoma rangeli	62%	100%
A4I866	Leishmania infantum	85%	100%
D0AAD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B324	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q531	Leishmania major	87%	100%
V5BCX1	Trypanosoma cruzi	64%	100%