SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

A4HKN4_LEIBR

TriTrypDb:

LbrM.32.2670 , LBRM2903_320034000

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HKN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.453
CLV_MEL_PAP_1	65	71	PF00089	0.464
CLV_NRD_NRD_1	213	215	PF00675	0.235
CLV_NRD_NRD_1	60	62	PF00675	0.450
CLV_PCSK_FUR_1	211	215	PF00082	0.221
CLV_PCSK_KEX2_1	213	215	PF00082	0.220
CLV_PCSK_SKI1_1	23	27	PF00082	0.511
CLV_PCSK_SKI1_1	256	260	PF00082	0.247
CLV_PCSK_SKI1_1	285	289	PF00082	0.253
CLV_PCSK_SKI1_1	329	333	PF00082	0.339
CLV_PCSK_SKI1_1	381	385	PF00082	0.426
CLV_PCSK_SKI1_1	62	66	PF00082	0.360
DEG_SCF_FBW7_1	345	350	PF00400	0.472
DEG_SPOP_SBC_1	331	335	PF00917	0.352
DEG_SPOP_SBC_1	409	413	PF00917	0.705
DOC_CYCLIN_RxL_1	378	387	PF00134	0.448
DOC_MAPK_gen_1	323	330	PF00069	0.416
DOC_PP2B_LxvP_1	382	385	PF13499	0.421
DOC_PP4_FxxP_1	192	195	PF00568	0.477
DOC_PP4_FxxP_1	93	96	PF00568	0.292
DOC_USP7_MATH_1	102	106	PF00917	0.623
DOC_USP7_MATH_1	127	131	PF00917	0.478
DOC_USP7_MATH_1	251	255	PF00917	0.477
DOC_USP7_MATH_1	340	344	PF00917	0.648
DOC_USP7_MATH_1	354	358	PF00917	0.741
DOC_USP7_MATH_1	409	413	PF00917	0.508
DOC_USP7_MATH_1	7	11	PF00917	0.579
DOC_USP7_UBL2_3	23	27	PF12436	0.653
DOC_USP7_UBL2_3	29	33	PF12436	0.635
DOC_WW_Pin1_4	191	196	PF00397	0.477
DOC_WW_Pin1_4	306	311	PF00397	0.421
DOC_WW_Pin1_4	343	348	PF00397	0.675
DOC_WW_Pin1_4	364	369	PF00397	0.562
LIG_14-3-3_CanoR_1	300	310	PF00244	0.448
LIG_14-3-3_CanoR_1	329	337	PF00244	0.434
LIG_14-3-3_CanoR_1	68	74	PF00244	0.505
LIG_BIR_III_4	146	150	PF00653	0.459
LIG_FHA_1	20	26	PF00498	0.598
LIG_FHA_1	275	281	PF00498	0.472
LIG_FHA_1	292	298	PF00498	0.406
LIG_FHA_1	303	309	PF00498	0.378
LIG_FHA_1	367	373	PF00498	0.658
LIG_FHA_1	76	82	PF00498	0.505
LIG_FHA_2	117	123	PF00498	0.440
LIG_FHA_2	172	178	PF00498	0.464
LIG_FHA_2	198	204	PF00498	0.453
LIG_FHA_2	228	234	PF00498	0.440
LIG_FHA_2	34	40	PF00498	0.442
LIG_FHA_2	409	415	PF00498	0.580
LIG_LIR_Apic_2	236	240	PF02991	0.423
LIG_LIR_Gen_1	242	251	PF02991	0.357
LIG_LIR_Gen_1	38	45	PF02991	0.309
LIG_LIR_Nem_3	242	246	PF02991	0.397
LIG_LIR_Nem_3	36	40	PF02991	0.338
LIG_LIR_Nem_3	377	382	PF02991	0.329
LIG_LIR_Nem_3	47	52	PF02991	0.282
LIG_Pex14_1	391	395	PF04695	0.413
LIG_Rb_LxCxE_1	194	207	PF01857	0.512
LIG_SH2_CRK	379	383	PF00017	0.438
LIG_SH2_NCK_1	41	45	PF00017	0.433
LIG_SH2_STAP1	41	45	PF00017	0.433
LIG_SH2_STAT3	238	241	PF00017	0.559
LIG_SH2_STAT5	154	157	PF00017	0.310
LIG_SH2_STAT5	224	227	PF00017	0.456
LIG_SH3_3	245	251	PF00018	0.410
LIG_TRAF2_1	73	76	PF00917	0.441
MOD_CK1_1	273	279	PF00069	0.480
MOD_CK1_1	304	310	PF00069	0.417
MOD_CK1_1	335	341	PF00069	0.455
MOD_CK1_1	343	349	PF00069	0.665
MOD_CK1_1	357	363	PF00069	0.560
MOD_CK1_1	410	416	PF00069	0.599
MOD_CK2_1	116	122	PF00069	0.441
MOD_CK2_1	197	203	PF00069	0.461
MOD_CK2_1	265	271	PF00069	0.479
MOD_CK2_1	306	312	PF00069	0.460
MOD_CK2_1	33	39	PF00069	0.512
MOD_CK2_1	408	414	PF00069	0.542
MOD_GlcNHglycan	100	103	PF01048	0.642
MOD_GlcNHglycan	159	162	PF01048	0.366
MOD_GlcNHglycan	261	264	PF01048	0.280
MOD_GSK3_1	197	204	PF00069	0.506
MOD_GSK3_1	25	32	PF00069	0.686
MOD_GSK3_1	270	277	PF00069	0.457
MOD_GSK3_1	302	309	PF00069	0.446
MOD_GSK3_1	331	338	PF00069	0.458
MOD_GSK3_1	341	348	PF00069	0.618
MOD_GSK3_1	364	371	PF00069	0.411
MOD_GSK3_1	75	82	PF00069	0.521
MOD_GSK3_1	98	105	PF00069	0.699
MOD_N-GLC_1	201	206	PF02516	0.213
MOD_NEK2_1	259	264	PF00069	0.477
MOD_NEK2_1	321	326	PF00069	0.407
MOD_NEK2_1	408	413	PF00069	0.590
MOD_PIKK_1	227	233	PF00454	0.421
MOD_PIKK_1	67	73	PF00454	0.471
MOD_PKA_2	227	233	PF00069	0.551
MOD_PKA_2	67	73	PF00069	0.414
MOD_Plk_1	102	108	PF00069	0.646
MOD_Plk_1	116	122	PF00069	0.441
MOD_Plk_1	273	279	PF00069	0.413
MOD_Plk_1	341	347	PF00069	0.464
MOD_Plk_1	374	380	PF00069	0.363
MOD_Plk_2-3	103	109	PF00069	0.467
MOD_Plk_2-3	233	239	PF00069	0.514
MOD_Plk_4	171	177	PF00069	0.391
MOD_Plk_4	233	239	PF00069	0.439
MOD_Plk_4	368	374	PF00069	0.493
MOD_Plk_4	85	91	PF00069	0.422
MOD_ProDKin_1	191	197	PF00069	0.477
MOD_ProDKin_1	306	312	PF00069	0.421
MOD_ProDKin_1	343	349	PF00069	0.676
MOD_ProDKin_1	364	370	PF00069	0.557
MOD_SUMO_rev_2	400	408	PF00179	0.453
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.451
TRG_ENDOCYTIC_2	153	156	PF00928	0.317
TRG_ENDOCYTIC_2	379	382	PF00928	0.336
TRG_ENDOCYTIC_2	41	44	PF00928	0.367
TRG_ER_diArg_1	211	214	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.210
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.210
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK00	Leptomonas seymouri	65%	100%
A0A0S4J448	Bodo saltans	40%	100%
A0A1X0NRJ9	Trypanosomatidae	40%	100%
A0A3Q8ID92	Leishmania donovani	80%	100%
A0A3R7K4S3	Trypanosoma rangeli	46%	100%
A4I865	Leishmania infantum	80%	100%
D0AAD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B323	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q0P5D8	Bos taurus	31%	100%
Q0V8R7	Bos taurus	28%	100%
Q4KMK0	Danio rerio	30%	100%
Q4Q532	Leishmania major	80%	99%
Q5M7E3	Xenopus laevis	29%	100%
Q5SII2	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	27%	93%
Q66KI9	Xenopus tropicalis	30%	100%
Q8CCT7	Mus musculus	29%	100%
Q96CB9	Homo sapiens	27%	100%
Q9CZ57	Mus musculus	28%	100%
Q9H649	Homo sapiens	29%	100%
V5B8C1	Trypanosoma cruzi	44%	100%