SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

A4HKN4_LEIBR

TriTrypDb:

LbrM.32.2670 , LBRM2903_320034000

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A4HKN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN4

Function

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Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	1
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.453
CLV_MEL_PAP_1	65	71	PF00089	0.464
CLV_NRD_NRD_1	213	215	PF00675	0.235
CLV_NRD_NRD_1	60	62	PF00675	0.450
CLV_PCSK_FUR_1	211	215	PF00082	0.221
CLV_PCSK_KEX2_1	213	215	PF00082	0.220
CLV_PCSK_SKI1_1	23	27	PF00082	0.511
CLV_PCSK_SKI1_1	256	260	PF00082	0.247
CLV_PCSK_SKI1_1	285	289	PF00082	0.253
CLV_PCSK_SKI1_1	329	333	PF00082	0.339

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK00	Leptomonas seymouri	65%	100%
A0A0S4J448	Bodo saltans	40%	100%
A0A1X0NRJ9	Trypanosomatidae	40%	100%
A0A3Q8ID92	Leishmania donovani	80%	100%
A0A3R7K4S3	Trypanosoma rangeli	46%	100%
A4I865	Leishmania infantum	80%	100%
D0AAD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B323	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q0P5D8	Bos taurus	31%	100%
Q0V8R7	Bos taurus	28%	100%

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