Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKN1_LEIBR

TriTrypDb:

LbrM.32.2630 , LBRM2903_320033600

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.347
CLV_NRD_NRD_1	133	135	PF00675	0.526
CLV_PCSK_KEX2_1	133	135	PF00082	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_SPOP_SBC_1	183	187	PF00917	0.549
DEG_SPOP_SBC_1	199	203	PF00917	0.381
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.239
DOC_MAPK_gen_1	133	141	PF00069	0.452
DOC_MAPK_MEF2A_6	220	228	PF00069	0.291
DOC_MAPK_MEF2A_6	283	291	PF00069	0.357
DOC_MAPK_MEF2A_6	3	10	PF00069	0.347
DOC_PP2B_LxvP_1	2	5	PF13499	0.259
DOC_PP2B_LxvP_1	207	210	PF13499	0.451
DOC_USP7_MATH_1	188	192	PF00917	0.543
DOC_USP7_MATH_1	199	203	PF00917	0.474
DOC_USP7_MATH_1	277	281	PF00917	0.611
DOC_WW_Pin1_4	254	259	PF00397	0.374
LIG_14-3-3_CanoR_1	101	110	PF00244	0.544
LIG_14-3-3_CanoR_1	244	253	PF00244	0.438
LIG_14-3-3_CanoR_1	28	32	PF00244	0.474
LIG_14-3-3_CanoR_1	3	9	PF00244	0.445
LIG_FHA_1	18	24	PF00498	0.482
LIG_FHA_1	316	322	PF00498	0.501
LIG_FHA_1	48	54	PF00498	0.301
LIG_FHA_1	95	101	PF00498	0.291
LIG_FHA_2	86	92	PF00498	0.532
LIG_LIR_Apic_2	250	256	PF02991	0.586
LIG_LIR_Gen_1	136	144	PF02991	0.432
LIG_LIR_Gen_1	271	277	PF02991	0.347
LIG_LIR_Gen_1	29	35	PF02991	0.450
LIG_LIR_Gen_1	7	17	PF02991	0.352
LIG_LIR_Gen_1	94	104	PF02991	0.402
LIG_LIR_Nem_3	136	141	PF02991	0.438
LIG_LIR_Nem_3	176	182	PF02991	0.450
LIG_LIR_Nem_3	29	34	PF02991	0.453
LIG_LIR_Nem_3	7	13	PF02991	0.342
LIG_LIR_Nem_3	94	99	PF02991	0.370
LIG_SH2_CRK	253	257	PF00017	0.434
LIG_SH2_NCK_1	104	108	PF00017	0.373
LIG_SH2_NCK_1	253	257	PF00017	0.434
LIG_SH2_STAP1	104	108	PF00017	0.452
LIG_SH2_STAP1	31	35	PF00017	0.406
LIG_SH2_STAT5	104	107	PF00017	0.371
LIG_SH2_STAT5	138	141	PF00017	0.476
LIG_SH2_STAT5	312	315	PF00017	0.388
LIG_SH3_3	190	196	PF00018	0.584
LIG_SUMO_SIM_par_1	4	9	PF11976	0.343
LIG_TRAF2_1	88	91	PF00917	0.491
LIG_WRC_WIRS_1	92	97	PF05994	0.486
MOD_CK1_1	200	206	PF00069	0.475
MOD_CK1_1	29	35	PF00069	0.369
MOD_CK1_1	94	100	PF00069	0.498
MOD_CK2_1	169	175	PF00069	0.561
MOD_CK2_1	85	91	PF00069	0.497
MOD_GlcNHglycan	105	108	PF01048	0.554
MOD_GlcNHglycan	174	178	PF01048	0.674
MOD_GlcNHglycan	179	182	PF01048	0.751
MOD_GlcNHglycan	188	191	PF01048	0.493
MOD_GlcNHglycan	235	238	PF01048	0.552
MOD_GlcNHglycan	246	249	PF01048	0.383
MOD_GlcNHglycan	272	275	PF01048	0.504
MOD_GlcNHglycan	31	34	PF01048	0.293
MOD_GlcNHglycan	338	341	PF01048	0.594
MOD_GlcNHglycan	75	78	PF01048	0.587
MOD_GSK3_1	144	151	PF00069	0.536
MOD_GSK3_1	169	176	PF00069	0.600
MOD_GSK3_1	182	189	PF00069	0.707
MOD_GSK3_1	240	247	PF00069	0.395
MOD_GSK3_1	332	339	PF00069	0.305
MOD_N-GLC_1	47	52	PF02516	0.487
MOD_NEK2_1	100	105	PF00069	0.449
MOD_NEK2_1	144	149	PF00069	0.476
MOD_NEK2_1	182	187	PF00069	0.651
MOD_NEK2_1	212	217	PF00069	0.476
MOD_NEK2_1	336	341	PF00069	0.532
MOD_NEK2_1	42	47	PF00069	0.476
MOD_OFUCOSY	46	51	PF10250	0.474
MOD_PKA_2	100	106	PF00069	0.379
MOD_PKA_2	27	33	PF00069	0.462
MOD_PKA_2	277	283	PF00069	0.513
MOD_Plk_4	12	18	PF00069	0.340
MOD_Plk_4	148	154	PF00069	0.441
MOD_Plk_4	200	206	PF00069	0.446
MOD_ProDKin_1	254	260	PF00069	0.370
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.436
TRG_ENDOCYTIC_2	138	141	PF00928	0.483
TRG_ENDOCYTIC_2	272	275	PF00928	0.333
TRG_ENDOCYTIC_2	31	34	PF00928	0.375
TRG_ER_diArg_1	132	134	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N9	Leptomonas seymouri	54%	100%
A0A1X0NS57	Trypanosomatidae	28%	100%
A0A3Q8IG17	Leishmania donovani	77%	97%
A0A422N888	Trypanosoma rangeli	30%	100%
D0AAC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B319	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q535	Leishmania major	76%	100%
V5BCW8	Trypanosoma cruzi	32%	100%