Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKN0_LEIBR

TriTrypDb:

LbrM.32.2620 , LBRM2903_320033500

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.777
CLV_NRD_NRD_1	138	140	PF00675	0.675
CLV_NRD_NRD_1	142	144	PF00675	0.580
CLV_NRD_NRD_1	146	148	PF00675	0.644
CLV_NRD_NRD_1	226	228	PF00675	0.738
CLV_NRD_NRD_1	319	321	PF00675	0.662
CLV_NRD_NRD_1	67	69	PF00675	0.685
CLV_PCSK_FUR_1	139	143	PF00082	0.724
CLV_PCSK_FUR_1	317	321	PF00082	0.514
CLV_PCSK_FUR_1	65	69	PF00082	0.672
CLV_PCSK_KEX2_1	140	142	PF00082	0.623
CLV_PCSK_KEX2_1	146	148	PF00082	0.696
CLV_PCSK_KEX2_1	226	228	PF00082	0.797
CLV_PCSK_KEX2_1	319	321	PF00082	0.654
CLV_PCSK_KEX2_1	470	472	PF00082	0.409
CLV_PCSK_KEX2_1	67	69	PF00082	0.685
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.824
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.441
CLV_PCSK_PC7_1	142	148	PF00082	0.707
CLV_PCSK_SKI1_1	142	146	PF00082	0.648
CLV_PCSK_SKI1_1	227	231	PF00082	0.688
CLV_PCSK_SKI1_1	28	32	PF00082	0.561
CLV_PCSK_SKI1_1	332	336	PF00082	0.579
CLV_PCSK_SKI1_1	339	343	PF00082	0.558
CLV_PCSK_SKI1_1	460	464	PF00082	0.584
CLV_PCSK_SKI1_1	470	474	PF00082	0.461
CLV_PCSK_SKI1_1	67	71	PF00082	0.777
CLV_Separin_Metazoa	148	152	PF03568	0.683
DEG_SCF_FBW7_2	171	178	PF00400	0.780
DEG_SPOP_SBC_1	211	215	PF00917	0.643
DOC_CDC14_PxL_1	186	194	PF14671	0.502
DOC_CKS1_1	172	177	PF01111	0.777
DOC_CKS1_1	219	224	PF01111	0.536
DOC_CKS1_1	410	415	PF01111	0.760
DOC_MAPK_gen_1	141	152	PF00069	0.678
DOC_MAPK_gen_1	226	232	PF00069	0.796
DOC_MAPK_MEF2A_6	384	392	PF00069	0.784
DOC_PP2B_LxvP_1	187	190	PF13499	0.744
DOC_PP4_FxxP_1	219	222	PF00568	0.541
DOC_PP4_FxxP_1	354	357	PF00568	0.835
DOC_USP7_MATH_1	131	135	PF00917	0.832
DOC_USP7_MATH_1	20	24	PF00917	0.726
DOC_USP7_MATH_1	211	215	PF00917	0.626
DOC_USP7_MATH_1	241	245	PF00917	0.639
DOC_USP7_MATH_1	26	30	PF00917	0.741
DOC_USP7_MATH_1	260	264	PF00917	0.781
DOC_USP7_MATH_1	310	314	PF00917	0.536
DOC_USP7_MATH_1	422	426	PF00917	0.730
DOC_USP7_MATH_1	48	52	PF00917	0.543
DOC_USP7_MATH_1	480	484	PF00917	0.630
DOC_USP7_MATH_1	516	520	PF00917	0.420
DOC_USP7_UBL2_3	163	167	PF12436	0.545
DOC_USP7_UBL2_3	380	384	PF12436	0.818
DOC_WW_Pin1_4	156	161	PF00397	0.666
DOC_WW_Pin1_4	171	176	PF00397	0.613
DOC_WW_Pin1_4	207	212	PF00397	0.576
DOC_WW_Pin1_4	218	223	PF00397	0.509
DOC_WW_Pin1_4	363	368	PF00397	0.564
DOC_WW_Pin1_4	409	414	PF00397	0.711
DOC_WW_Pin1_4	415	420	PF00397	0.711
DOC_WW_Pin1_4	77	82	PF00397	0.639
LIG_14-3-3_CanoR_1	170	175	PF00244	0.700
LIG_14-3-3_CanoR_1	28	33	PF00244	0.562
LIG_14-3-3_CanoR_1	460	466	PF00244	0.517
LIG_BRCT_BRCA1_1	215	219	PF00533	0.599
LIG_BRCT_BRCA1_1	88	92	PF00533	0.656
LIG_FHA_1	189	195	PF00498	0.685
LIG_FHA_1	387	393	PF00498	0.805
LIG_FHA_1	40	46	PF00498	0.734
LIG_FHA_1	410	416	PF00498	0.762
LIG_FHA_1	503	509	PF00498	0.334
LIG_FHA_2	462	468	PF00498	0.619
LIG_FHA_2	489	495	PF00498	0.533
LIG_LIR_Apic_2	216	222	PF02991	0.547
LIG_LIR_Apic_2	351	357	PF02991	0.820
LIG_LIR_Gen_1	153	160	PF02991	0.619
LIG_LIR_Gen_1	177	187	PF02991	0.596
LIG_LIR_Gen_1	478	486	PF02991	0.615
LIG_LIR_Nem_3	153	157	PF02991	0.648
LIG_LIR_Nem_3	177	182	PF02991	0.603
LIG_LIR_Nem_3	522	528	PF02991	0.532
LIG_MLH1_MIPbox_1	88	92	PF16413	0.656
LIG_SH2_CRK	154	158	PF00017	0.616
LIG_SH2_CRK	5	9	PF00017	0.679
LIG_SH2_STAP1	83	87	PF00017	0.521
LIG_SH2_STAT5	297	300	PF00017	0.573
LIG_SH2_STAT5	44	47	PF00017	0.678
LIG_SH2_STAT5	91	94	PF00017	0.614
LIG_SH3_3	169	175	PF00018	0.806
LIG_SH3_3	237	243	PF00018	0.562
LIG_SH3_3	370	376	PF00018	0.688
LIG_SH3_3	402	408	PF00018	0.622
LIG_SH3_3	42	48	PF00018	0.642
LIG_TRAF2_1	491	494	PF00917	0.632
LIG_TYR_ITIM	152	157	PF00017	0.609
LIG_UBA3_1	465	470	PF00899	0.570
MOD_CDK_SPxK_1	220	226	PF00069	0.568
MOD_CDK_SPxxK_3	156	163	PF00069	0.582
MOD_CDK_SPxxK_3	220	227	PF00069	0.570
MOD_CDK_SPxxK_3	409	416	PF00069	0.610
MOD_CK1_1	15	21	PF00069	0.576
MOD_CK1_1	156	162	PF00069	0.545
MOD_CK1_1	177	183	PF00069	0.650
MOD_CK1_1	210	216	PF00069	0.674
MOD_CK1_1	218	224	PF00069	0.592
MOD_CK1_1	250	256	PF00069	0.714
MOD_CK1_1	263	269	PF00069	0.523
MOD_CK1_1	393	399	PF00069	0.691
MOD_CK1_1	425	431	PF00069	0.653
MOD_CK1_1	488	494	PF00069	0.542
MOD_CK1_1	51	57	PF00069	0.656
MOD_CK1_1	519	525	PF00069	0.511
MOD_CK2_1	158	164	PF00069	0.658
MOD_CK2_1	196	202	PF00069	0.653
MOD_CK2_1	461	467	PF00069	0.632
MOD_CK2_1	488	494	PF00069	0.542
MOD_GlcNHglycan	106	109	PF01048	0.682
MOD_GlcNHglycan	135	138	PF01048	0.747
MOD_GlcNHglycan	14	17	PF01048	0.617
MOD_GlcNHglycan	22	25	PF01048	0.671
MOD_GlcNHglycan	249	252	PF01048	0.686
MOD_GlcNHglycan	257	260	PF01048	0.721
MOD_GlcNHglycan	28	31	PF01048	0.621
MOD_GlcNHglycan	314	317	PF01048	0.714
MOD_GlcNHglycan	369	372	PF01048	0.782
MOD_GlcNHglycan	395	398	PF01048	0.787
MOD_GlcNHglycan	424	427	PF01048	0.746
MOD_GSK3_1	100	107	PF00069	0.675
MOD_GSK3_1	170	177	PF00069	0.647
MOD_GSK3_1	20	27	PF00069	0.686
MOD_GSK3_1	207	214	PF00069	0.729
MOD_GSK3_1	28	35	PF00069	0.542
MOD_GSK3_1	363	370	PF00069	0.600
MOD_GSK3_1	386	393	PF00069	0.708
MOD_GSK3_1	425	432	PF00069	0.645
MOD_GSK3_1	442	449	PF00069	0.585
MOD_GSK3_1	454	461	PF00069	0.500
MOD_GSK3_1	494	501	PF00069	0.345
MOD_N-GLC_1	288	293	PF02516	0.707
MOD_NEK2_1	390	395	PF00069	0.569
MOD_NEK2_1	401	406	PF00069	0.541
MOD_NEK2_1	442	447	PF00069	0.541
MOD_NEK2_1	85	90	PF00069	0.766
MOD_NEK2_2	502	507	PF00069	0.330
MOD_PIKK_1	480	486	PF00454	0.630
MOD_PK_1	485	491	PF00069	0.393
MOD_PKA_2	12	18	PF00069	0.536
MOD_Plk_1	177	183	PF00069	0.752
MOD_Plk_1	234	240	PF00069	0.563
MOD_Plk_1	263	269	PF00069	0.524
MOD_Plk_1	310	316	PF00069	0.686
MOD_Plk_1	36	42	PF00069	0.536
MOD_Plk_1	92	98	PF00069	0.682
MOD_Plk_2-3	273	279	PF00069	0.655
MOD_Plk_4	153	159	PF00069	0.697
MOD_Plk_4	188	194	PF00069	0.581
MOD_Plk_4	215	221	PF00069	0.630
MOD_Plk_4	446	452	PF00069	0.597
MOD_Plk_4	461	467	PF00069	0.384
MOD_Plk_4	494	500	PF00069	0.347
MOD_ProDKin_1	156	162	PF00069	0.661
MOD_ProDKin_1	171	177	PF00069	0.607
MOD_ProDKin_1	207	213	PF00069	0.573
MOD_ProDKin_1	218	224	PF00069	0.508
MOD_ProDKin_1	363	369	PF00069	0.566
MOD_ProDKin_1	409	415	PF00069	0.713
MOD_ProDKin_1	77	83	PF00069	0.640
TRG_DiLeu_BaEn_1	153	158	PF01217	0.591
TRG_ENDOCYTIC_2	154	157	PF00928	0.646
TRG_ENDOCYTIC_2	179	182	PF00928	0.652
TRG_ENDOCYTIC_2	5	8	PF00928	0.680
TRG_ER_diArg_1	139	142	PF00400	0.727
TRG_ER_diArg_1	145	147	PF00400	0.689
TRG_ER_diArg_1	225	227	PF00400	0.781
TRG_ER_diArg_1	267	270	PF00400	0.521
TRG_ER_diArg_1	317	320	PF00400	0.519
TRG_ER_diArg_1	67	69	PF00400	0.685
TRG_NLS_MonoCore_2	138	143	PF00514	0.822
TRG_NLS_MonoExtC_3	138	143	PF00514	0.822
TRG_NLS_MonoExtN_4	139	144	PF00514	0.819
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P596	Leptomonas seymouri	40%	97%
A0A3Q8IL99	Leishmania donovani	73%	100%
A4I857	Leishmania infantum	73%	100%
E9B318	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q536	Leishmania major	71%	99%