LeishMANIAdb
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Aquaporin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aquaporin-like protein
Gene product:
aquaporin-like protein
Species:
Leishmania braziliensis
UniProt:
A4HKM9_LEIBR
TriTrypDb:
LbrM.32.2610 , LBRM2903_320033400 *
Length:
404

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 20

Expansion

Sequence features

A4HKM9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006833 water transport 5 1
GO:0042044 fluid transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 20
GO:0015267 channel activity 4 20
GO:0022803 passive transmembrane transporter activity 3 20
GO:0022857 transmembrane transporter activity 2 20
GO:0005372 water transmembrane transporter activity 4 1
GO:0015250 water channel activity 5 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 343 347 PF00656 0.543
CLV_C14_Caspase3-7 397 401 PF00656 0.629
CLV_NRD_NRD_1 379 381 PF00675 0.406
CLV_NRD_NRD_1 65 67 PF00675 0.347
CLV_PCSK_KEX2_1 315 317 PF00082 0.375
CLV_PCSK_KEX2_1 379 381 PF00082 0.406
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.375
CLV_PCSK_SKI1_1 159 163 PF00082 0.219
CLV_PCSK_SKI1_1 191 195 PF00082 0.437
CLV_PCSK_SKI1_1 315 319 PF00082 0.389
CLV_PCSK_SKI1_1 382 386 PF00082 0.468
CLV_Separin_Metazoa 386 390 PF03568 0.604
DEG_ODPH_VHL_1 287 300 PF01847 0.345
DOC_MAPK_MEF2A_6 31 38 PF00069 0.558
DOC_PP2B_LxvP_1 75 78 PF13499 0.519
DOC_USP7_MATH_1 105 109 PF00917 0.345
DOC_USP7_MATH_1 149 153 PF00917 0.490
DOC_USP7_MATH_1 261 265 PF00917 0.337
DOC_USP7_MATH_1 340 344 PF00917 0.563
LIG_14-3-3_CanoR_1 366 372 PF00244 0.634
LIG_14-3-3_CanoR_1 379 385 PF00244 0.616
LIG_14-3-3_CanoR_1 66 75 PF00244 0.504
LIG_Actin_WH2_2 265 282 PF00022 0.290
LIG_AP2alpha_2 50 52 PF02296 0.530
LIG_BRCT_BRCA1_1 126 130 PF00533 0.422
LIG_BRCT_BRCA1_1 133 137 PF00533 0.385
LIG_BRCT_BRCA1_1 204 208 PF00533 0.211
LIG_BRCT_BRCA1_1 229 233 PF00533 0.411
LIG_FHA_1 101 107 PF00498 0.314
LIG_FHA_1 152 158 PF00498 0.474
LIG_FHA_1 307 313 PF00498 0.596
LIG_FHA_1 31 37 PF00498 0.561
LIG_FHA_1 340 346 PF00498 0.544
LIG_FHA_2 381 387 PF00498 0.621
LIG_FHA_2 393 399 PF00498 0.611
LIG_GBD_Chelix_1 290 298 PF00786 0.350
LIG_LIR_Gen_1 127 137 PF02991 0.285
LIG_LIR_Gen_1 205 216 PF02991 0.263
LIG_LIR_Gen_1 70 78 PF02991 0.557
LIG_LIR_Gen_1 79 87 PF02991 0.564
LIG_LIR_Gen_1 89 98 PF02991 0.423
LIG_LIR_Nem_3 138 142 PF02991 0.306
LIG_LIR_Nem_3 205 211 PF02991 0.301
LIG_LIR_Nem_3 70 75 PF02991 0.567
LIG_LIR_Nem_3 79 83 PF02991 0.575
LIG_LIR_Nem_3 89 94 PF02991 0.423
LIG_LIR_Nem_3 97 101 PF02991 0.420
LIG_MAD2 20 28 PF02301 0.590
LIG_NRBOX 294 300 PF00104 0.218
LIG_PDZ_Class_3 399 404 PF00595 0.587
LIG_Pex14_2 233 237 PF04695 0.279
LIG_PTB_Apo_2 220 227 PF02174 0.234
LIG_PTB_Apo_2 3 10 PF02174 0.562
LIG_PTB_Phospho_1 220 226 PF10480 0.234
LIG_SH2_CRK 72 76 PF00017 0.617
LIG_SH2_STAP1 72 76 PF00017 0.617
LIG_SH2_STAT3 226 229 PF00017 0.449
LIG_SH2_STAT5 141 144 PF00017 0.323
LIG_SH2_STAT5 169 172 PF00017 0.312
LIG_SH2_STAT5 202 205 PF00017 0.240
LIG_SH2_STAT5 90 93 PF00017 0.296
LIG_SH3_3 18 24 PF00018 0.712
LIG_SH3_3 193 199 PF00018 0.183
LIG_SUMO_SIM_par_1 102 108 PF11976 0.293
LIG_SUMO_SIM_par_1 218 224 PF11976 0.263
LIG_TRAF2_1 395 398 PF00917 0.618
LIG_TRFH_1 285 289 PF08558 0.345
LIG_WRC_WIRS_1 136 141 PF05994 0.297
LIG_WRC_WIRS_1 212 217 PF05994 0.287
LIG_WRC_WIRS_1 95 100 PF05994 0.323
LIG_WW_3 386 390 PF00397 0.647
MOD_CK1_1 118 124 PF00069 0.265
MOD_CK1_1 15 21 PF00069 0.561
MOD_CK1_1 224 230 PF00069 0.430
MOD_CK1_1 244 250 PF00069 0.222
MOD_CK1_1 356 362 PF00069 0.717
MOD_CK1_1 370 376 PF00069 0.800
MOD_CK2_1 359 365 PF00069 0.610
MOD_CK2_1 380 386 PF00069 0.617
MOD_CK2_1 392 398 PF00069 0.613
MOD_CMANNOS 283 286 PF00535 0.316
MOD_Cter_Amidation 188 191 PF01082 0.367
MOD_GlcNHglycan 142 145 PF01048 0.315
MOD_GlcNHglycan 204 207 PF01048 0.449
MOD_GlcNHglycan 223 226 PF01048 0.287
MOD_GlcNHglycan 229 232 PF01048 0.209
MOD_GlcNHglycan 243 246 PF01048 0.352
MOD_GlcNHglycan 253 256 PF01048 0.494
MOD_GlcNHglycan 263 266 PF01048 0.538
MOD_GlcNHglycan 342 345 PF01048 0.501
MOD_GlcNHglycan 348 351 PF01048 0.502
MOD_GlcNHglycan 375 378 PF01048 0.394
MOD_GSK3_1 118 125 PF00069 0.271
MOD_GSK3_1 12 19 PF00069 0.586
MOD_GSK3_1 131 138 PF00069 0.364
MOD_GSK3_1 202 209 PF00069 0.193
MOD_GSK3_1 336 343 PF00069 0.679
MOD_GSK3_1 353 360 PF00069 0.662
MOD_GSK3_1 361 368 PF00069 0.710
MOD_GSK3_1 369 376 PF00069 0.591
MOD_N-GLC_1 110 115 PF02516 0.411
MOD_N-GLC_1 121 126 PF02516 0.411
MOD_NEK2_1 131 136 PF00069 0.309
MOD_NEK2_1 174 179 PF00069 0.389
MOD_NEK2_1 211 216 PF00069 0.297
MOD_NEK2_1 241 246 PF00069 0.399
MOD_NEK2_1 298 303 PF00069 0.368
MOD_NEK2_1 30 35 PF00069 0.620
MOD_NEK2_1 355 360 PF00069 0.597
MOD_NEK2_1 369 374 PF00069 0.604
MOD_NEK2_1 86 91 PF00069 0.447
MOD_NEK2_1 94 99 PF00069 0.346
MOD_NEK2_2 105 110 PF00069 0.345
MOD_PIKK_1 298 304 PF00454 0.339
MOD_PIKK_1 306 312 PF00454 0.564
MOD_PK_1 110 116 PF00069 0.225
MOD_PKA_2 12 18 PF00069 0.771
MOD_PKA_2 227 233 PF00069 0.411
MOD_PKA_2 340 346 PF00069 0.584
MOD_PKA_2 365 371 PF00069 0.600
MOD_Plk_1 110 116 PF00069 0.211
MOD_Plk_1 121 127 PF00069 0.211
MOD_Plk_1 353 359 PF00069 0.588
MOD_Plk_4 110 116 PF00069 0.248
MOD_Plk_4 131 137 PF00069 0.403
MOD_Plk_4 278 284 PF00069 0.256
MOD_Plk_4 30 36 PF00069 0.518
MOD_Plk_4 330 336 PF00069 0.503
MOD_Plk_4 86 92 PF00069 0.452
MOD_SUMO_rev_2 308 317 PF00179 0.641
TRG_DiLeu_BaLyEn_6 82 87 PF01217 0.513
TRG_ENDOCYTIC_2 72 75 PF00928 0.622
TRG_ER_diArg_1 326 329 PF00400 0.551
TRG_ER_diArg_1 379 382 PF00400 0.617
TRG_Pf-PMV_PEXEL_1 389 394 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I348 Leptomonas seymouri 66% 67%
A0A0S4JRP5 Bodo saltans 26% 100%
A0A1X0NRT6 Trypanosomatidae 61% 90%
A0A3Q8IFK5 Leishmania donovani 76% 68%
A0A3S5H7B2 Leishmania donovani 36% 100%
A0A3S5H7S4 Leishmania donovani 36% 100%
A0A422N886 Trypanosoma rangeli 57% 96%
A4HCI0 Leishmania braziliensis 32% 97%
A4HKM8 Leishmania braziliensis 38% 100%
A4I001 Leishmania infantum 36% 100%
A4I858 Leishmania infantum 76% 68%
A4I859 Leishmania infantum 36% 100%
E9AVX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B316 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B317 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 68%
G5CTG4 Milnesium tardigradum 25% 100%
Q4Q537 Leishmania major 76% 100%
Q4Q538 Leishmania major 37% 100%
Q4QBK5 Leishmania major 37% 100%
Q54WT8 Dictyostelium discoideum 26% 100%
V5D449 Trypanosoma cruzi 63% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS