Aquaporin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aquaporin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKM8_LEIBR

TriTrypDb:

LbrM.32.2600 , LBRM2903_320033300

Length:

278

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HKM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006833	water transport	5	2
GO:0042044	fluid transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	33
GO:0015267	channel activity	4	33
GO:0022803	passive transmembrane transporter activity	3	33
GO:0022857	transmembrane transporter activity	2	33
GO:0005372	water transmembrane transporter activity	4	2
GO:0015250	water channel activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	15	19	PF00082	0.328
DEG_Nend_UBRbox_1	1	4	PF02207	0.530
DEG_ODPH_VHL_1	69	82	PF01847	0.253
DOC_PP4_FxxP_1	140	143	PF00568	0.280
LIG_14-3-3_CanoR_1	20	25	PF00244	0.622
LIG_DLG_GKlike_1	20	27	PF00625	0.456
LIG_FHA_1	162	168	PF00498	0.300
LIG_FHA_1	252	258	PF00498	0.587
LIG_FHA_1	45	51	PF00498	0.300
LIG_FHA_1	64	70	PF00498	0.267
LIG_FHA_1	96	102	PF00498	0.368
LIG_FHA_2	8	14	PF00498	0.626
LIG_LIR_Apic_2	137	143	PF02991	0.281
LIG_LIR_Gen_1	151	162	PF02991	0.286
LIG_LIR_Gen_1	231	240	PF02991	0.144
LIG_LIR_Gen_1	98	107	PF02991	0.298
LIG_LIR_Nem_3	151	157	PF02991	0.275
LIG_LIR_Nem_3	160	166	PF02991	0.298
LIG_LIR_Nem_3	183	187	PF02991	0.350
LIG_LIR_Nem_3	231	235	PF02991	0.221
LIG_LIR_Nem_3	84	88	PF02991	0.305
LIG_LIR_Nem_3	98	102	PF02991	0.316
LIG_SH2_SRC	198	201	PF00017	0.151
LIG_SH2_STAT3	176	179	PF00017	0.421
LIG_SH2_STAT3	226	229	PF00017	0.336
LIG_SH2_STAT5	226	229	PF00017	0.287
LIG_SH2_STAT5	232	235	PF00017	0.286
LIG_SH2_STAT5	87	90	PF00017	0.465
LIG_SUMO_SIM_par_1	164	169	PF11976	0.247
LIG_SUMO_SIM_par_1	45	52	PF11976	0.305
LIG_TRAF2_1	11	14	PF00917	0.532
LIG_TYR_ITIM	230	235	PF00017	0.342
LIG_WRC_WIRS_1	39	44	PF05994	0.302
LIG_WRC_WIRS_1	82	87	PF05994	0.263
MOD_CK2_1	7	13	PF00069	0.613
MOD_CMANNOS	234	237	PF00535	0.300
MOD_GlcNHglycan	154	157	PF01048	0.494
MOD_GlcNHglycan	203	206	PF01048	0.473
MOD_GlcNHglycan	275	278	PF01048	0.367
MOD_GlcNHglycan	88	91	PF01048	0.251
MOD_GlcNHglycan	9	13	PF01048	0.392
MOD_GSK3_1	1	8	PF00069	0.699
MOD_GSK3_1	38	45	PF00069	0.288
MOD_N-GLC_1	133	138	PF02516	0.416
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	166	171	PF00069	0.287
MOD_NEK2_1	193	198	PF00069	0.323
MOD_NEK2_1	249	254	PF00069	0.350
MOD_NEK2_1	42	47	PF00069	0.307
MOD_NEK2_1	81	86	PF00069	0.272
MOD_PIKK_1	1	7	PF00454	0.516
MOD_PIKK_1	174	180	PF00454	0.537
MOD_PIKK_1	193	199	PF00454	0.397
MOD_PIKK_1	225	231	PF00454	0.322
MOD_PKA_2	1	7	PF00069	0.746
MOD_PKA_2	25	31	PF00069	0.586
MOD_Plk_1	13	19	PF00069	0.530
MOD_Plk_4	111	117	PF00069	0.464
MOD_Plk_4	127	133	PF00069	0.361
MOD_Plk_4	13	19	PF00069	0.683
MOD_Plk_4	166	172	PF00069	0.299
MOD_Plk_4	228	234	PF00069	0.270
MOD_Plk_4	38	44	PF00069	0.308
MOD_SUMO_rev_2	7	17	PF00179	0.514
TRG_DiLeu_BaEn_2	12	18	PF01217	0.564
TRG_DiLeu_BaEn_4	13	19	PF01217	0.516
TRG_ENDOCYTIC_2	184	187	PF00928	0.207
TRG_ENDOCYTIC_2	232	235	PF00928	0.337
TRG_NES_CRM1_1	37	52	PF08389	0.195

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D2	Leptomonas seymouri	37%	98%
A0A0N1ILB4	Leptomonas seymouri	39%	100%
A0A0N1PB10	Leptomonas seymouri	77%	100%
A0A0S4IS36	Bodo saltans	44%	79%
A0A0S4IS78	Bodo saltans	56%	100%
A0A0S4JRP5	Bodo saltans	29%	83%
A0A0S4KLV5	Bodo saltans	39%	100%
A0A1X0ND19	Trypanosomatidae	36%	100%
A0A1X0NT73	Trypanosomatidae	64%	100%
A0A1X0NTY8	Trypanosomatidae	35%	100%
A0A3R7RFH0	Trypanosoma rangeli	66%	100%
A0A3S5H7B2	Leishmania donovani	36%	95%
A0A3S5H7S4	Leishmania donovani	80%	100%
A0A3S7X8F2	Leishmania donovani	40%	100%
A0A422N493	Trypanosoma rangeli	37%	100%
A0A422N886	Trypanosoma rangeli	40%	66%
A0A422NSX8	Trypanosoma rangeli	40%	100%
A0A804KTT0	Musa acuminata subsp. malaccensis	27%	97%
A2IBY8	Canis lupus familiaris	30%	100%
A4HBA6	Leishmania braziliensis	39%	95%
A4HCI0	Leishmania braziliensis	37%	100%
A4HIW6	Leishmania braziliensis	26%	98%
A4HKM9	Leishmania braziliensis	38%	69%
A4I001	Leishmania infantum	36%	95%
A4I859	Leishmania infantum	80%	100%
A4IAF4	Leishmania infantum	40%	100%
A4L9J0	Oryctolagus cuniculus	30%	100%
A8W649	Sus scrofa	29%	100%
A9Y006	Sus scrofa	26%	96%
C8ZJM1	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	28%	85%
E9AVX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
E9B316	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B5H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
F9UUD2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	32%	100%
G5CTG1	Milnesium tardigradum	23%	80%
G5CTG2	Milnesium tardigradum	27%	100%
O22588	Arabidopsis thaliana	30%	100%
O26206	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O43315	Homo sapiens	27%	94%
O77750	Bos taurus	32%	86%
O82598	Arabidopsis thaliana	28%	100%
O94778	Homo sapiens	31%	100%
P06624	Bos taurus	28%	100%
P08995	Glycine max	29%	100%
P09011	Rattus norvegicus	28%	100%
P0CD89	Saccharomyces cerevisiae	27%	96%
P0CD92	Saccharomyces cerevisiae	28%	85%
P0DO53	Musa acuminata	28%	100%
P0DO54	Musa acuminata	28%	100%
P25794	Pisum sativum	27%	96%
P25818	Arabidopsis thaliana	29%	100%
P26587	Arabidopsis thaliana	27%	100%
P29972	Homo sapiens	27%	100%
P29975	Rattus norvegicus	28%	100%
P30301	Homo sapiens	31%	100%
P30302	Arabidopsis thaliana	28%	98%
P33560	Antirrhinum majus	27%	100%
P42067	Medicago sativa	27%	100%
P43286	Arabidopsis thaliana	28%	97%
P43287	Arabidopsis thaliana	25%	98%
P47862	Rattus norvegicus	25%	95%
P47863	Rattus norvegicus	33%	86%
P47864	Rattus norvegicus	26%	100%
P47865	Bos taurus	29%	100%
P49173	Nicotiana alata	27%	100%
P51180	Mus musculus	28%	100%
P55064	Homo sapiens	28%	100%
P55088	Mus musculus	32%	86%
P56401	Ovis aries	27%	100%
P60925	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	25%	100%
P61837	Arabidopsis thaliana	27%	97%
P61838	Vicia faba	27%	97%
P73809	Synechocystis sp. (strain PCC 6803 / Kazusa)	28%	100%
Q02013	Mus musculus	26%	100%
Q06019	Lithobates pipiens	29%	100%
Q06611	Arabidopsis thaliana	27%	97%
Q08451	Solanum lycopersicum	26%	97%
Q08733	Arabidopsis thaliana	27%	97%
Q08DE6	Bos taurus	26%	95%
Q0DK16	Oryza sativa subsp. japonica	27%	97%
Q0IWF3	Oryza sativa subsp. japonica	30%	89%
Q0JPT5	Oryza sativa subsp. japonica	31%	92%
Q19KC1	Zea mays	26%	94%
Q23808	Cicadella viridis	28%	100%
Q25074	Haematobia irritans exigua	30%	100%
Q39196	Arabidopsis thaliana	27%	97%
Q40746	Oryza sativa subsp. japonica	27%	98%
Q41870	Zea mays	27%	97%
Q41951	Arabidopsis thaliana	29%	100%
Q41963	Arabidopsis thaliana	29%	100%
Q4Q2F7	Leishmania major	40%	95%
Q4Q538	Leishmania major	79%	100%
Q4QBK5	Leishmania major	35%	100%
Q54V53	Dictyostelium discoideum	28%	100%
Q54WT8	Dictyostelium discoideum	31%	95%
Q5R819	Pongo abelii	27%	100%
Q67WJ8	Oryza sativa subsp. japonica	30%	93%
Q6EU94	Oryza sativa subsp. japonica	25%	96%
Q6J8I9	Ovis aries	28%	100%
Q6PQZ1	Sus scrofa	28%	100%
Q6RZ07	Cavia porcellus	27%	100%
Q6Z2T3	Oryza sativa subsp. japonica	28%	93%
Q7EYH7	Oryza sativa subsp. japonica	26%	91%
Q7MIV9	Vibrio vulnificus (strain YJ016)	27%	100%
Q7N5C1	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	25%	100%
Q7NNP3	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	27%	100%
Q7PWV1	Anopheles gambiae	31%	100%
Q7W917	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	29%	100%
Q7WKG2	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	29%	100%
Q7XLR1	Oryza sativa subsp. japonica	31%	99%
Q7XSQ9	Oryza sativa subsp. japonica	27%	97%
Q7XU31	Oryza sativa subsp. japonica	26%	100%
Q84RL6	Zea mays	29%	100%
Q866S3	Ovis aries	27%	100%
Q87MQ5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	27%	100%
Q89EG9	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	26%	100%
Q8DB17	Vibrio vulnificus (strain CMCP6)	28%	100%
Q8EHC1	Shewanella oneidensis (strain MR-1)	32%	100%
Q8GRI8	Oryza sativa subsp. japonica	30%	98%
Q8GRT8	Oryza sativa subsp. japonica	27%	97%
Q8LAA6	Arabidopsis thaliana	28%	97%
Q8LAI1	Arabidopsis thaliana	27%	100%
Q8LFP7	Arabidopsis thaliana	28%	95%
Q8R2N1	Mus musculus	24%	95%
Q8VZW1	Arabidopsis thaliana	24%	94%
Q8W036	Arabidopsis thaliana	24%	98%
Q8W037	Arabidopsis thaliana	25%	97%
Q923J4	Dipodomys merriami	33%	86%
Q92482	Homo sapiens	25%	95%
Q92NM3	Rhizobium meliloti (strain 1021)	28%	100%
Q9AQU5	Zea mays	27%	95%
Q9AR14	Zea mays	26%	97%
Q9ASI1	Oryza sativa subsp. japonica	28%	97%
Q9AT74	Zea mays	29%	92%
Q9AT75	Zea mays	26%	100%
Q9ATL2	Zea mays	30%	100%
Q9ATL8	Zea mays	28%	100%
Q9ATM4	Zea mays	28%	97%
Q9ATM5	Zea mays	28%	97%
Q9ATN0	Zea mays	27%	94%
Q9ATN1	Zea mays	29%	92%
Q9ATN2	Zea mays	29%	95%
Q9ATN4	Zea mays	28%	99%
Q9C4Z5	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	28%	100%
Q9C6T0	Arabidopsis thaliana	25%	86%
Q9FF53	Arabidopsis thaliana	28%	96%
Q9FGL2	Arabidopsis thaliana	26%	100%
Q9FIZ9	Arabidopsis thaliana	24%	98%
Q9FY14	Medicago truncatula	28%	100%
Q9HWZ3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	100%
Q9N2J4	Canis lupus familiaris	27%	100%
Q9NHW7	Aedes aegypti	30%	100%
Q9SAI4	Arabidopsis thaliana	25%	91%
Q9STX9	Arabidopsis thaliana	29%	100%
Q9SV84	Arabidopsis thaliana	27%	91%
Q9SXF8	Oryza sativa subsp. japonica	28%	97%
Q9U8P7	Dictyostelium discoideum	30%	100%
Q9V5Z7	Drosophila melanogaster	27%	100%
Q9WTY4	Mus musculus	28%	100%
Q9XF58	Zea mays	27%	98%
Q9XF59	Zea mays	26%	96%
Q9ZV07	Arabidopsis thaliana	27%	96%
S5ZH89	Musa acuminata	27%	97%
V5ANF5	Trypanosoma cruzi	63%	100%
V5B469	Trypanosoma cruzi	37%	100%
V5BW46	Trypanosoma cruzi	36%	100%