Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKM7_LEIBR

TriTrypDb:

LbrM.32.2590 , LBRM2903_320033200

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	663	667	PF00656	0.408
CLV_NRD_NRD_1	127	129	PF00675	0.453
CLV_NRD_NRD_1	214	216	PF00675	0.348
CLV_NRD_NRD_1	255	257	PF00675	0.465
CLV_NRD_NRD_1	295	297	PF00675	0.424
CLV_NRD_NRD_1	584	586	PF00675	0.514
CLV_NRD_NRD_1	632	634	PF00675	0.489
CLV_NRD_NRD_1	823	825	PF00675	0.346
CLV_PCSK_KEX2_1	127	129	PF00082	0.453
CLV_PCSK_KEX2_1	255	257	PF00082	0.465
CLV_PCSK_KEX2_1	294	296	PF00082	0.456
CLV_PCSK_KEX2_1	397	399	PF00082	0.503
CLV_PCSK_KEX2_1	576	578	PF00082	0.648
CLV_PCSK_KEX2_1	584	586	PF00082	0.446
CLV_PCSK_KEX2_1	632	634	PF00082	0.489
CLV_PCSK_KEX2_1	804	806	PF00082	0.429
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.447
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.648
CLV_PCSK_PC1ET2_1	804	806	PF00082	0.429
CLV_PCSK_SKI1_1	123	127	PF00082	0.394
CLV_PCSK_SKI1_1	161	165	PF00082	0.487
CLV_PCSK_SKI1_1	202	206	PF00082	0.482
CLV_PCSK_SKI1_1	216	220	PF00082	0.480
CLV_PCSK_SKI1_1	532	536	PF00082	0.445
CLV_PCSK_SKI1_1	576	580	PF00082	0.601
DEG_MDM2_SWIB_1	483	491	PF02201	0.298
DEG_SCF_FBW7_1	240	247	PF00400	0.442
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.576
DOC_MAPK_gen_1	481	491	PF00069	0.432
DOC_MAPK_gen_1	584	595	PF00069	0.448
DOC_MAPK_gen_1	632	640	PF00069	0.532
DOC_MAPK_HePTP_8	630	642	PF00069	0.488
DOC_MAPK_MEF2A_6	584	593	PF00069	0.459
DOC_MAPK_MEF2A_6	633	642	PF00069	0.487
DOC_PP4_FxxP_1	432	435	PF00568	0.500
DOC_PP4_FxxP_1	678	681	PF00568	0.566
DOC_PP4_FxxP_1	92	95	PF00568	0.542
DOC_USP7_MATH_1	244	248	PF00917	0.452
DOC_USP7_MATH_1	413	417	PF00917	0.666
DOC_USP7_MATH_1	48	52	PF00917	0.630
DOC_USP7_MATH_1	65	69	PF00917	0.530
DOC_USP7_MATH_1	773	777	PF00917	0.473
DOC_USP7_MATH_1	96	100	PF00917	0.658
DOC_WW_Pin1_4	112	117	PF00397	0.595
DOC_WW_Pin1_4	141	146	PF00397	0.475
DOC_WW_Pin1_4	177	182	PF00397	0.633
DOC_WW_Pin1_4	240	245	PF00397	0.413
DOC_WW_Pin1_4	302	307	PF00397	0.481
DOC_WW_Pin1_4	318	323	PF00397	0.449
DOC_WW_Pin1_4	458	463	PF00397	0.575
DOC_WW_Pin1_4	677	682	PF00397	0.605
DOC_WW_Pin1_4	769	774	PF00397	0.646
DOC_WW_Pin1_4	91	96	PF00397	0.806
LIG_14-3-3_CanoR_1	184	188	PF00244	0.586
LIG_14-3-3_CanoR_1	202	211	PF00244	0.457
LIG_14-3-3_CanoR_1	25	35	PF00244	0.465
LIG_14-3-3_CanoR_1	255	262	PF00244	0.516
LIG_14-3-3_CanoR_1	331	339	PF00244	0.287
LIG_14-3-3_CanoR_1	350	357	PF00244	0.406
LIG_14-3-3_CanoR_1	532	541	PF00244	0.528
LIG_14-3-3_CanoR_1	577	587	PF00244	0.462
LIG_14-3-3_CanoR_1	632	642	PF00244	0.514
LIG_14-3-3_CanoR_1	748	754	PF00244	0.484
LIG_14-3-3_CanoR_1	81	86	PF00244	0.602
LIG_14-3-3_CanoR_1	91	95	PF00244	0.596
LIG_Actin_WH2_2	336	352	PF00022	0.455
LIG_APCC_ABBA_1	781	786	PF00400	0.433
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BRCT_BRCA1_1	353	357	PF00533	0.545
LIG_Clathr_ClatBox_1	139	143	PF01394	0.476
LIG_Clathr_ClatBox_1	712	716	PF01394	0.336
LIG_FHA_1	184	190	PF00498	0.528
LIG_FHA_1	206	212	PF00498	0.364
LIG_FHA_1	244	250	PF00498	0.455
LIG_FHA_1	324	330	PF00498	0.335
LIG_FHA_1	343	349	PF00498	0.386
LIG_FHA_1	358	364	PF00498	0.355
LIG_FHA_1	477	483	PF00498	0.369
LIG_FHA_1	502	508	PF00498	0.513
LIG_FHA_1	512	518	PF00498	0.310
LIG_FHA_1	623	629	PF00498	0.669
LIG_FHA_1	635	641	PF00498	0.493
LIG_FHA_1	646	652	PF00498	0.637
LIG_FHA_1	715	721	PF00498	0.434
LIG_FHA_1	754	760	PF00498	0.449
LIG_FHA_2	276	282	PF00498	0.363
LIG_FHA_2	354	360	PF00498	0.534
LIG_FHA_2	419	425	PF00498	0.672
LIG_FHA_2	434	440	PF00498	0.503
LIG_LIR_Apic_2	429	435	PF02991	0.505
LIG_LIR_Apic_2	90	95	PF02991	0.546
LIG_LIR_Gen_1	590	599	PF02991	0.428
LIG_LIR_Gen_1	652	662	PF02991	0.447
LIG_LIR_Nem_3	162	168	PF02991	0.538
LIG_LIR_Nem_3	29	35	PF02991	0.469
LIG_LIR_Nem_3	590	595	PF02991	0.437
LIG_LIR_Nem_3	605	610	PF02991	0.434
LIG_LIR_Nem_3	652	658	PF02991	0.454
LIG_NRBOX	377	383	PF00104	0.426
LIG_NRBOX	594	600	PF00104	0.376
LIG_PAM2_1	724	736	PF00658	0.431
LIG_Pex14_2	483	487	PF04695	0.315
LIG_PTB_Apo_2	163	170	PF02174	0.559
LIG_PTB_Phospho_1	163	169	PF10480	0.552
LIG_RPA_C_Fungi	326	338	PF08784	0.442
LIG_RPA_C_Fungi	601	613	PF08784	0.384
LIG_SH2_CRK	610	614	PF00017	0.446
LIG_SH2_CRK	655	659	PF00017	0.435
LIG_SH2_GRB2like	10	13	PF00017	0.408
LIG_SH2_PTP2	493	496	PF00017	0.415
LIG_SH2_STAT3	454	457	PF00017	0.517
LIG_SH2_STAT5	10	13	PF00017	0.528
LIG_SH2_STAT5	493	496	PF00017	0.379
LIG_SH2_STAT5	725	728	PF00017	0.377
LIG_SH2_STAT5	820	823	PF00017	0.311
LIG_SH3_3	108	114	PF00018	0.655
LIG_SH3_3	139	145	PF00018	0.483
LIG_SH3_3	42	48	PF00018	0.583
LIG_SH3_CIN85_PxpxPR_1	114	119	PF14604	0.476
LIG_Sin3_3	102	109	PF02671	0.515
LIG_SxIP_EBH_1	110	123	PF03271	0.465
LIG_TYR_ITIM	491	496	PF00017	0.360
LIG_TYR_ITIM	818	823	PF00017	0.305
MOD_CDC14_SPxK_1	680	683	PF00782	0.474
MOD_CDK_SPxK_1	677	683	PF00069	0.442
MOD_CDK_SPxxK_3	112	119	PF00069	0.482
MOD_CDK_SPxxK_3	177	184	PF00069	0.488
MOD_CK1_1	300	306	PF00069	0.533
MOD_CK1_1	321	327	PF00069	0.450
MOD_CK1_1	352	358	PF00069	0.433
MOD_CK1_1	437	443	PF00069	0.647
MOD_CK1_1	461	467	PF00069	0.572
MOD_CK1_1	50	56	PF00069	0.498
MOD_CK1_1	508	514	PF00069	0.371
MOD_CK1_1	687	693	PF00069	0.511
MOD_CK1_1	72	78	PF00069	0.518
MOD_CK1_1	795	801	PF00069	0.436
MOD_CK2_1	143	149	PF00069	0.464
MOD_CK2_1	244	250	PF00069	0.447
MOD_CK2_1	418	424	PF00069	0.745
MOD_CK2_1	433	439	PF00069	0.504
MOD_CK2_1	441	447	PF00069	0.543
MOD_Cter_Amidation	292	295	PF01082	0.428
MOD_DYRK1A_RPxSP_1	458	462	PF00069	0.620
MOD_GlcNHglycan	246	249	PF01048	0.467
MOD_GlcNHglycan	290	293	PF01048	0.550
MOD_GlcNHglycan	52	55	PF01048	0.626
MOD_GlcNHglycan	618	621	PF01048	0.531
MOD_GlcNHglycan	67	70	PF01048	0.528
MOD_GlcNHglycan	726	729	PF01048	0.419
MOD_GlcNHglycan	800	803	PF01048	0.452
MOD_GlcNHglycan	807	810	PF01048	0.540
MOD_GSK3_1	240	247	PF00069	0.464
MOD_GSK3_1	298	305	PF00069	0.540
MOD_GSK3_1	317	324	PF00069	0.489
MOD_GSK3_1	349	356	PF00069	0.578
MOD_GSK3_1	433	440	PF00069	0.644
MOD_GSK3_1	472	479	PF00069	0.554
MOD_GSK3_1	501	508	PF00069	0.341
MOD_GSK3_1	594	601	PF00069	0.351
MOD_GSK3_1	645	652	PF00069	0.594
MOD_GSK3_1	65	72	PF00069	0.557
MOD_GSK3_1	683	690	PF00069	0.531
MOD_GSK3_1	749	756	PF00069	0.496
MOD_GSK3_1	769	776	PF00069	0.459
MOD_GSK3_1	87	94	PF00069	0.600
MOD_N-GLC_1	357	362	PF02516	0.397
MOD_N-GLC_1	505	510	PF02516	0.342
MOD_N-GLC_1	633	638	PF02516	0.594
MOD_N-GLC_1	65	70	PF02516	0.510
MOD_N-GLC_1	96	101	PF02516	0.507
MOD_NEK2_1	154	159	PF00069	0.453
MOD_NEK2_1	205	210	PF00069	0.437
MOD_NEK2_1	27	32	PF00069	0.473
MOD_NEK2_1	349	354	PF00069	0.462
MOD_NEK2_1	357	362	PF00069	0.397
MOD_NEK2_1	381	386	PF00069	0.345
MOD_NEK2_1	501	506	PF00069	0.369
MOD_NEK2_1	598	603	PF00069	0.436
MOD_NEK2_1	640	645	PF00069	0.593
MOD_NEK2_1	80	85	PF00069	0.658
MOD_NEK2_2	323	328	PF00069	0.355
MOD_NEK2_2	749	754	PF00069	0.483
MOD_PIKK_1	441	447	PF00454	0.508
MOD_PIKK_1	452	458	PF00454	0.494
MOD_PIKK_1	578	584	PF00454	0.474
MOD_PIKK_1	687	693	PF00454	0.511
MOD_PKA_1	576	582	PF00069	0.515
MOD_PKA_1	632	638	PF00069	0.493
MOD_PKA_2	183	189	PF00069	0.586
MOD_PKA_2	254	260	PF00069	0.454
MOD_PKA_2	330	336	PF00069	0.303
MOD_PKA_2	349	355	PF00069	0.422
MOD_PKA_2	576	582	PF00069	0.515
MOD_PKA_2	632	638	PF00069	0.576
MOD_PKA_2	640	646	PF00069	0.697
MOD_PKA_2	749	755	PF00069	0.478
MOD_PKA_2	80	86	PF00069	0.624
MOD_PKA_2	90	96	PF00069	0.604
MOD_Plk_1	149	155	PF00069	0.384
MOD_Plk_1	298	304	PF00069	0.438
MOD_Plk_1	357	363	PF00069	0.398
MOD_Plk_1	428	434	PF00069	0.509
MOD_Plk_1	446	452	PF00069	0.472
MOD_Plk_1	633	639	PF00069	0.541
MOD_Plk_1	795	801	PF00069	0.550
MOD_Plk_2-3	143	149	PF00069	0.470
MOD_Plk_2-3	310	316	PF00069	0.526
MOD_Plk_4	27	33	PF00069	0.429
MOD_Plk_4	323	329	PF00069	0.566
MOD_Plk_4	428	434	PF00069	0.615
MOD_Plk_4	461	467	PF00069	0.408
MOD_Plk_4	594	600	PF00069	0.491
MOD_Plk_4	684	690	PF00069	0.702
MOD_Plk_4	749	755	PF00069	0.473
MOD_ProDKin_1	112	118	PF00069	0.591
MOD_ProDKin_1	141	147	PF00069	0.469
MOD_ProDKin_1	177	183	PF00069	0.629
MOD_ProDKin_1	240	246	PF00069	0.405
MOD_ProDKin_1	302	308	PF00069	0.483
MOD_ProDKin_1	318	324	PF00069	0.436
MOD_ProDKin_1	458	464	PF00069	0.558
MOD_ProDKin_1	677	683	PF00069	0.615
MOD_ProDKin_1	769	775	PF00069	0.636
MOD_ProDKin_1	91	97	PF00069	0.804
MOD_SUMO_rev_2	212	220	PF00179	0.329
MOD_SUMO_rev_2	437	443	PF00179	0.525
MOD_SUMO_rev_2	686	695	PF00179	0.626
TRG_DiLeu_BaEn_1	19	24	PF01217	0.472
TRG_DiLeu_BaEn_4	149	155	PF01217	0.444
TRG_ENDOCYTIC_2	493	496	PF00928	0.379
TRG_ENDOCYTIC_2	610	613	PF00928	0.438
TRG_ENDOCYTIC_2	655	658	PF00928	0.438
TRG_ENDOCYTIC_2	820	823	PF00928	0.311
TRG_ER_diArg_1	118	121	PF00400	0.541
TRG_ER_diArg_1	126	128	PF00400	0.377
TRG_ER_diArg_1	254	256	PF00400	0.462
TRG_ER_diArg_1	294	296	PF00400	0.371
TRG_ER_diArg_1	483	486	PF00400	0.458
TRG_NES_CRM1_1	495	510	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	703	707	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT3	Leptomonas seymouri	45%	100%
A0A3Q8IGW2	Leishmania donovani	72%	100%
A4I860	Leishmania infantum	72%	100%
D0AAC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B315	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	97%
Q4Q539	Leishmania major	70%	98%