Nsp1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP53a

Species:

Leishmania braziliensis

UniProt:

A4HKM6_LEIBR

TriTrypDb:

LbrM.32.2580 , LBRM2903_320033100

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0044613	nuclear pore central transport channel	3	1

Expansion

Sequence features

A4HKM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0006405	RNA export from nucleus	5	1
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051236	establishment of RNA localization	3	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6
GO:0017056	structural constituent of nuclear pore	2	6
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.537
CLV_NRD_NRD_1	403	405	PF00675	0.437
CLV_PCSK_SKI1_1	436	440	PF00082	0.361
CLV_PCSK_SKI1_1	446	450	PF00082	0.396
CLV_PCSK_SKI1_1	505	509	PF00082	0.556
DEG_APCC_DBOX_1	536	544	PF00400	0.609
DEG_SCF_FBW7_1	107	113	PF00400	0.536
DEG_SPOP_SBC_1	235	239	PF00917	0.542
DOC_CKS1_1	107	112	PF01111	0.534
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.691
DOC_MAPK_gen_1	404	412	PF00069	0.437
DOC_MAPK_MEF2A_6	404	412	PF00069	0.437
DOC_PP2B_LxvP_1	101	104	PF13499	0.527
DOC_PP2B_LxvP_1	144	147	PF13499	0.521
DOC_PP2B_LxvP_1	177	180	PF13499	0.687
DOC_USP7_MATH_1	120	124	PF00917	0.683
DOC_USP7_MATH_1	132	136	PF00917	0.586
DOC_USP7_MATH_1	139	143	PF00917	0.510
DOC_USP7_MATH_1	205	209	PF00917	0.645
DOC_USP7_MATH_1	228	232	PF00917	0.540
DOC_USP7_MATH_1	235	239	PF00917	0.503
DOC_USP7_MATH_1	341	345	PF00917	0.640
DOC_USP7_MATH_1	367	371	PF00917	0.648
DOC_USP7_MATH_1	388	392	PF00917	0.531
DOC_USP7_MATH_1	451	455	PF00917	0.437
DOC_USP7_MATH_1	5	9	PF00917	0.671
DOC_USP7_MATH_1	565	569	PF00917	0.517
DOC_USP7_MATH_1	59	63	PF00917	0.599
DOC_USP7_MATH_1	87	91	PF00917	0.572
DOC_USP7_MATH_1	92	96	PF00917	0.668
DOC_WW_Pin1_4	106	111	PF00397	0.698
DOC_WW_Pin1_4	133	138	PF00397	0.704
DOC_WW_Pin1_4	16	21	PF00397	0.705
DOC_WW_Pin1_4	181	186	PF00397	0.533
DOC_WW_Pin1_4	226	231	PF00397	0.654
DOC_WW_Pin1_4	347	352	PF00397	0.725
DOC_WW_Pin1_4	386	391	PF00397	0.666
DOC_WW_Pin1_4	85	90	PF00397	0.537
LIG_14-3-3_CanoR_1	505	510	PF00244	0.554
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_2	182	186	PF00653	0.531
LIG_BRCT_BRCA1_1	134	138	PF00533	0.702
LIG_BRCT_BRCA1_1	195	199	PF00533	0.597
LIG_BRCT_BRCA1_1	239	243	PF00533	0.540
LIG_BRCT_BRCA1_1	358	362	PF00533	0.544
LIG_BRCT_BRCA1_1	390	394	PF00533	0.437
LIG_FHA_1	262	268	PF00498	0.683
LIG_FHA_1	547	553	PF00498	0.474
LIG_FHA_1	73	79	PF00498	0.540
LIG_FHA_2	256	262	PF00498	0.535
LIG_FHA_2	324	330	PF00498	0.537
LIG_FHA_2	366	372	PF00498	0.540
LIG_FHA_2	456	462	PF00498	0.437
LIG_GBD_Chelix_1	566	574	PF00786	0.528
LIG_LIR_Gen_1	508	516	PF02991	0.558
LIG_LIR_Nem_3	508	512	PF02991	0.564
LIG_NRBOX	573	579	PF00104	0.549
LIG_PCNA_PIPBox_1	466	475	PF02747	0.437
LIG_PCNA_yPIPBox_3	463	473	PF02747	0.437
LIG_SH2_CRK	509	513	PF00017	0.476
LIG_SH2_GRB2like	509	512	PF00017	0.547
LIG_SH2_SRC	509	512	PF00017	0.547
LIG_SH2_STAP1	509	513	PF00017	0.546
LIG_SH2_STAT3	483	486	PF00017	0.437
LIG_SH2_STAT5	472	475	PF00017	0.437
LIG_SH3_3	101	107	PF00018	0.618
LIG_SH3_3	86	92	PF00018	0.594
LIG_SUMO_SIM_par_1	510	518	PF11976	0.362
LIG_TRAF2_1	390	393	PF00917	0.496
LIG_TYR_ITIM	507	512	PF00017	0.449
MOD_CK1_1	167	173	PF00069	0.534
MOD_CK1_1	208	214	PF00069	0.600
MOD_CK1_1	226	232	PF00069	0.491
MOD_CK1_1	31	37	PF00069	0.532
MOD_CK1_1	345	351	PF00069	0.659
MOD_CK1_1	369	375	PF00069	0.566
MOD_CK1_1	64	70	PF00069	0.606
MOD_CK1_1	8	14	PF00069	0.511
MOD_CK1_1	90	96	PF00069	0.679
MOD_CK2_1	323	329	PF00069	0.535
MOD_CK2_1	365	371	PF00069	0.541
MOD_CK2_1	455	461	PF00069	0.437
MOD_CK2_1	533	539	PF00069	0.596
MOD_CK2_1	541	547	PF00069	0.518
MOD_CK2_1	565	571	PF00069	0.521
MOD_GlcNHglycan	113	116	PF01048	0.501
MOD_GlcNHglycan	122	125	PF01048	0.611
MOD_GlcNHglycan	148	151	PF01048	0.718
MOD_GlcNHglycan	159	162	PF01048	0.585
MOD_GlcNHglycan	166	169	PF01048	0.507
MOD_GlcNHglycan	190	193	PF01048	0.653
MOD_GlcNHglycan	195	198	PF01048	0.610
MOD_GlcNHglycan	207	210	PF01048	0.545
MOD_GlcNHglycan	225	228	PF01048	0.517
MOD_GlcNHglycan	230	233	PF01048	0.625
MOD_GlcNHglycan	239	242	PF01048	0.598
MOD_GlcNHglycan	264	267	PF01048	0.548
MOD_GlcNHglycan	302	305	PF01048	0.594
MOD_GlcNHglycan	344	347	PF01048	0.733
MOD_GlcNHglycan	43	46	PF01048	0.677
MOD_GlcNHglycan	453	456	PF01048	0.437
MOD_GlcNHglycan	563	566	PF01048	0.524
MOD_GlcNHglycan	567	570	PF01048	0.468
MOD_GlcNHglycan	57	60	PF01048	0.585
MOD_GlcNHglycan	63	66	PF01048	0.528
MOD_GlcNHglycan	8	11	PF01048	0.503
MOD_GlcNHglycan	89	92	PF01048	0.651
MOD_GlcNHglycan	94	97	PF01048	0.661
MOD_GSK3_1	106	113	PF00069	0.528
MOD_GSK3_1	133	140	PF00069	0.565
MOD_GSK3_1	164	171	PF00069	0.648
MOD_GSK3_1	184	191	PF00069	0.652
MOD_GSK3_1	222	229	PF00069	0.545
MOD_GSK3_1	28	35	PF00069	0.554
MOD_GSK3_1	323	330	PF00069	0.730
MOD_GSK3_1	335	342	PF00069	0.569
MOD_GSK3_1	353	360	PF00069	0.600
MOD_GSK3_1	365	372	PF00069	0.566
MOD_GSK3_1	41	48	PF00069	0.636
MOD_GSK3_1	436	443	PF00069	0.352
MOD_GSK3_1	447	454	PF00069	0.391
MOD_GSK3_1	55	62	PF00069	0.582
MOD_GSK3_1	561	568	PF00069	0.522
MOD_GSK3_1	92	99	PF00069	0.706
MOD_N-GLC_1	533	538	PF02516	0.595
MOD_N-GLC_1	55	60	PF02516	0.521
MOD_NEK2_1	111	116	PF00069	0.732
MOD_NEK2_1	154	159	PF00069	0.653
MOD_NEK2_1	169	174	PF00069	0.520
MOD_NEK2_1	243	248	PF00069	0.528
MOD_NEK2_1	294	299	PF00069	0.700
MOD_NEK2_1	323	328	PF00069	0.716
MOD_NEK2_1	379	384	PF00069	0.523
MOD_NEK2_1	43	48	PF00069	0.534
MOD_NEK2_1	55	60	PF00069	0.488
MOD_NEK2_1	6	11	PF00069	0.680
MOD_NEK2_2	357	362	PF00069	0.545
MOD_PIKK_1	388	394	PF00454	0.437
MOD_PKB_1	434	442	PF00069	0.284
MOD_Plk_1	455	461	PF00069	0.437
MOD_Plk_4	357	363	PF00069	0.546
MOD_Plk_4	440	446	PF00069	0.437
MOD_ProDKin_1	106	112	PF00069	0.700
MOD_ProDKin_1	133	139	PF00069	0.704
MOD_ProDKin_1	16	22	PF00069	0.705
MOD_ProDKin_1	181	187	PF00069	0.535
MOD_ProDKin_1	226	232	PF00069	0.653
MOD_ProDKin_1	347	353	PF00069	0.725
MOD_ProDKin_1	386	392	PF00069	0.437
MOD_ProDKin_1	85	91	PF00069	0.537
MOD_SUMO_rev_2	471	480	PF00179	0.437
MOD_SUMO_rev_2	517	526	PF00179	0.548
TRG_DiLeu_BaEn_1	573	578	PF01217	0.547
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.615
TRG_DiLeu_LyEn_5	375	380	PF01217	0.532
TRG_DiLeu_LyEn_5	573	578	PF01217	0.547
TRG_ENDOCYTIC_2	509	512	PF00928	0.477
TRG_Pf-PMV_PEXEL_1	404	409	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5T9	Leishmania donovani	63%	99%
A4I861	Leishmania infantum	64%	99%
E9B314	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4Q540	Leishmania major	63%	98%