Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HKM1_LEIBR

TriTrypDb:

LbrM.32.2530 , LBRM2903_320032500

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.526
CLV_C14_Caspase3-7	251	255	PF00656	0.725
CLV_NRD_NRD_1	210	212	PF00675	0.587
CLV_NRD_NRD_1	34	36	PF00675	0.654
CLV_NRD_NRD_1	439	441	PF00675	0.663
CLV_NRD_NRD_1	71	73	PF00675	0.463
CLV_NRD_NRD_1	96	98	PF00675	0.661
CLV_PCSK_KEX2_1	210	212	PF00082	0.587
CLV_PCSK_KEX2_1	263	265	PF00082	0.823
CLV_PCSK_KEX2_1	34	36	PF00082	0.654
CLV_PCSK_KEX2_1	362	364	PF00082	0.797
CLV_PCSK_KEX2_1	439	441	PF00082	0.663
CLV_PCSK_KEX2_1	71	73	PF00082	0.489
CLV_PCSK_KEX2_1	96	98	PF00082	0.661
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.823
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.797
CLV_PCSK_PC7_1	30	36	PF00082	0.648
CLV_PCSK_SKI1_1	172	176	PF00082	0.427
CLV_PCSK_SKI1_1	348	352	PF00082	0.773
CLV_PCSK_SKI1_1	96	100	PF00082	0.647
DEG_APCC_DBOX_1	118	126	PF00400	0.515
DEG_ODPH_VHL_1	186	197	PF01847	0.528
DOC_MAPK_gen_1	117	124	PF00069	0.517
DOC_MAPK_gen_1	172	180	PF00069	0.675
DOC_MAPK_gen_1	412	421	PF00069	0.824
DOC_MAPK_MEF2A_6	414	423	PF00069	0.558
DOC_PP1_RVXF_1	261	268	PF00149	0.822
DOC_PP2B_LxvP_1	189	192	PF13499	0.519
DOC_PP4_FxxP_1	123	126	PF00568	0.515
DOC_USP7_MATH_1	346	350	PF00917	0.782
DOC_USP7_MATH_1	82	86	PF00917	0.533
DOC_WW_Pin1_4	255	260	PF00397	0.838
DOC_WW_Pin1_4	294	299	PF00397	0.588
DOC_WW_Pin1_4	373	378	PF00397	0.840
LIG_14-3-3_CanoR_1	230	239	PF00244	0.571
LIG_14-3-3_CanoR_1	275	280	PF00244	0.547
LIG_14-3-3_CanoR_1	286	294	PF00244	0.700
LIG_14-3-3_CanoR_1	348	353	PF00244	0.773
LIG_14-3-3_CanoR_1	363	372	PF00244	0.558
LIG_14-3-3_CanoR_1	414	420	PF00244	0.556
LIG_14-3-3_CanoR_1	439	443	PF00244	0.728
LIG_14-3-3_CanoR_1	447	452	PF00244	0.606
LIG_Actin_WH2_1	412	427	PF00022	0.560
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BRCT_BRCA1_1	140	144	PF00533	0.552
LIG_BRCT_BRCA1_1	337	341	PF00533	0.723
LIG_FHA_1	144	150	PF00498	0.534
LIG_FHA_1	173	179	PF00498	0.574
LIG_FHA_1	181	187	PF00498	0.499
LIG_FHA_1	192	198	PF00498	0.535
LIG_FHA_1	217	223	PF00498	0.532
LIG_FHA_1	34	40	PF00498	0.654
LIG_FHA_1	340	346	PF00498	0.830
LIG_FHA_1	389	395	PF00498	0.541
LIG_FHA_1	399	405	PF00498	0.516
LIG_FHA_2	132	138	PF00498	0.524
LIG_FHA_2	196	202	PF00498	0.583
LIG_FHA_2	23	29	PF00498	0.641
LIG_LIR_Apic_2	121	126	PF02991	0.518
LIG_LIR_Gen_1	271	281	PF02991	0.643
LIG_LIR_Gen_1	9	18	PF02991	0.416
LIG_LIR_Nem_3	271	276	PF02991	0.789
LIG_LIR_Nem_3	9	15	PF02991	0.653
LIG_SH2_GRB2like	408	411	PF00017	0.719
LIG_SH2_STAT5	106	109	PF00017	0.421
LIG_SH2_STAT5	408	411	PF00017	0.698
LIG_SH3_3	182	188	PF00018	0.623
LIG_SH3_3	233	239	PF00018	0.708
LIG_SH3_3	303	309	PF00018	0.709
LIG_SH3_3	416	422	PF00018	0.564
LIG_SUMO_SIM_par_1	166	171	PF11976	0.471
LIG_SUMO_SIM_par_1	193	201	PF11976	0.778
LIG_TRAF2_1	198	201	PF00917	0.585
LIG_TRAF2_1	55	58	PF00917	0.386
LIG_TRAF2_1	7	10	PF00917	0.653
LIG_TRAF2_1	88	91	PF00917	0.644
LIG_UBA3_1	122	128	PF00899	0.517
LIG_UBA3_1	166	173	PF00899	0.667
MOD_CDC14_SPxK_1	376	379	PF00782	0.848
MOD_CDK_SPxK_1	373	379	PF00069	0.842
MOD_CDK_SPxxK_3	255	262	PF00069	0.737
MOD_CK1_1	127	133	PF00069	0.659
MOD_CK1_1	193	199	PF00069	0.605
MOD_CK1_1	218	224	PF00069	0.673
MOD_CK1_1	297	303	PF00069	0.570
MOD_CK1_1	390	396	PF00069	0.580
MOD_CK1_1	426	432	PF00069	0.785
MOD_CK1_1	435	441	PF00069	0.540
MOD_CK2_1	195	201	PF00069	0.707
MOD_CK2_1	255	261	PF00069	0.739
MOD_CK2_1	268	274	PF00069	0.545
MOD_CK2_1	3	9	PF00069	0.674
MOD_GlcNHglycan	140	143	PF01048	0.699
MOD_GlcNHglycan	212	215	PF01048	0.564
MOD_GlcNHglycan	240	243	PF01048	0.589
MOD_GlcNHglycan	250	253	PF01048	0.554
MOD_GlcNHglycan	309	312	PF01048	0.710
MOD_GlcNHglycan	327	330	PF01048	0.549
MOD_GlcNHglycan	337	340	PF01048	0.734
MOD_GlcNHglycan	348	351	PF01048	0.647
MOD_GlcNHglycan	425	428	PF01048	0.845
MOD_GlcNHglycan	6	9	PF01048	0.665
MOD_GlcNHglycan	84	87	PF01048	0.528
MOD_GSK3_1	127	134	PF00069	0.782
MOD_GSK3_1	136	143	PF00069	0.643
MOD_GSK3_1	168	175	PF00069	0.440
MOD_GSK3_1	191	198	PF00069	0.708
MOD_GSK3_1	218	225	PF00069	0.717
MOD_GSK3_1	327	334	PF00069	0.695
MOD_GSK3_1	335	342	PF00069	0.712
MOD_GSK3_1	344	351	PF00069	0.529
MOD_GSK3_1	434	441	PF00069	0.727
MOD_GSK3_1	443	450	PF00069	0.608
MOD_N-GLC_1	398	403	PF02516	0.544
MOD_NEK2_1	166	171	PF00069	0.447
MOD_NEK2_2	339	344	PF00069	0.833
MOD_OFUCOSY	325	331	PF10250	0.568
MOD_PIKK_1	286	292	PF00454	0.596
MOD_PIKK_1	331	337	PF00454	0.789
MOD_PIKK_1	370	376	PF00454	0.727
MOD_PIKK_1	426	432	PF00454	0.579
MOD_PIKK_1	62	68	PF00454	0.543
MOD_PKA_1	172	178	PF00069	0.418
MOD_PKA_1	210	216	PF00069	0.571
MOD_PKA_2	210	216	PF00069	0.839
MOD_PKA_2	229	235	PF00069	0.517
MOD_PKA_2	237	243	PF00069	0.562
MOD_PKA_2	274	280	PF00069	0.814
MOD_PKA_2	285	291	PF00069	0.861
MOD_PKA_2	33	39	PF00069	0.652
MOD_PKA_2	335	341	PF00069	0.682
MOD_PKA_2	364	370	PF00069	0.799
MOD_PKA_2	435	441	PF00069	0.748
MOD_PKA_2	446	452	PF00069	0.604
MOD_PKA_2	82	88	PF00069	0.651
MOD_Plk_1	153	159	PF00069	0.686
MOD_Plk_4	127	133	PF00069	0.514
MOD_Plk_4	153	159	PF00069	0.761
MOD_Plk_4	218	224	PF00069	0.740
MOD_Plk_4	348	354	PF00069	0.771
MOD_ProDKin_1	255	261	PF00069	0.837
MOD_ProDKin_1	294	300	PF00069	0.587
MOD_ProDKin_1	373	379	PF00069	0.842
MOD_SUMO_rev_2	258	265	PF00179	0.805
TRG_DiLeu_BaEn_1	10	15	PF01217	0.651
TRG_DiLeu_BaEn_2	94	100	PF01217	0.380
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.564
TRG_ENDOCYTIC_2	12	15	PF00928	0.653
TRG_ER_diArg_1	117	120	PF00400	0.738
TRG_ER_diArg_1	210	212	PF00400	0.587
TRG_ER_diArg_1	71	73	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITE5	Leishmania donovani	61%	100%
A4I853	Leishmania infantum	62%	100%
E9B310	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q545	Leishmania major	63%	100%