Putative sphingosine-1-phosphate phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine-1-phosphate phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKM0_LEIBR

TriTrypDb:

LbrM.32.2520 , LBRM2903_320032400

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HKM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKM0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0030258	lipid modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.578
CLV_C14_Caspase3-7	563	567	PF00656	0.695
CLV_PCSK_KEX2_1	277	279	PF00082	0.464
CLV_PCSK_KEX2_1	590	592	PF00082	0.275
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.507
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.275
CLV_PCSK_SKI1_1	259	263	PF00082	0.591
CLV_PCSK_SKI1_1	475	479	PF00082	0.322
CLV_PCSK_SKI1_1	542	546	PF00082	0.414
CLV_PCSK_SKI1_1	629	633	PF00082	0.576
DEG_APCC_DBOX_1	169	177	PF00400	0.484
DEG_MDM2_SWIB_1	360	368	PF02201	0.315
DEG_MDM2_SWIB_1	448	456	PF02201	0.203
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SCF_FBW7_1	19	26	PF00400	0.627
DOC_CKS1_1	235	240	PF01111	0.217
DOC_CYCLIN_RxL_1	623	636	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.515
DOC_MAPK_DCC_7	109	119	PF00069	0.608
DOC_MAPK_DCC_7	170	178	PF00069	0.480
DOC_MAPK_gen_1	550	559	PF00069	0.589
DOC_MAPK_MEF2A_6	266	274	PF00069	0.240
DOC_MAPK_MEF2A_6	491	500	PF00069	0.568
DOC_MAPK_MEF2A_6	513	521	PF00069	0.651
DOC_MAPK_MEF2A_6	550	559	PF00069	0.589
DOC_PP1_RVXF_1	172	179	PF00149	0.581
DOC_PP1_RVXF_1	473	479	PF00149	0.465
DOC_PP2B_LxvP_1	227	230	PF13499	0.277
DOC_PP2B_PxIxI_1	554	560	PF00149	0.591
DOC_PP4_FxxP_1	12	15	PF00568	0.714
DOC_PP4_FxxP_1	262	265	PF00568	0.282
DOC_USP7_MATH_1	326	330	PF00917	0.367
DOC_USP7_MATH_1	523	527	PF00917	0.655
DOC_USP7_MATH_1	67	71	PF00917	0.626
DOC_USP7_UBL2_3	475	479	PF12436	0.576
DOC_WW_Pin1_4	19	24	PF00397	0.783
DOC_WW_Pin1_4	234	239	PF00397	0.214
DOC_WW_Pin1_4	371	376	PF00397	0.361
DOC_WW_Pin1_4	392	397	PF00397	0.558
DOC_WW_Pin1_4	551	556	PF00397	0.687
DOC_WW_Pin1_4	631	636	PF00397	0.508
DOC_WW_Pin1_4	75	80	PF00397	0.723
DOC_WW_Pin1_4	93	98	PF00397	0.598
LIG_14-3-3_CanoR_1	36	44	PF00244	0.769
LIG_14-3-3_CanoR_1	528	534	PF00244	0.600
LIG_14-3-3_CanoR_1	591	596	PF00244	0.442
LIG_Actin_WH2_2	159	176	PF00022	0.502
LIG_Actin_WH2_2	461	477	PF00022	0.402
LIG_Actin_WH2_2	598	613	PF00022	0.332
LIG_APCC_ABBA_1	300	305	PF00400	0.222
LIG_BRCT_BRCA1_1	294	298	PF00533	0.240
LIG_BRCT_BRCA1_1	405	409	PF00533	0.440
LIG_BRCT_BRCA1_1	444	448	PF00533	0.273
LIG_BRCT_BRCA1_1	461	465	PF00533	0.339
LIG_BRCT_BRCA1_1	8	12	PF00533	0.618
LIG_eIF4E_1	383	389	PF01652	0.385
LIG_FHA_1	2	8	PF00498	0.777
LIG_FHA_1	224	230	PF00498	0.302
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_1	408	414	PF00498	0.332
LIG_FHA_1	455	461	PF00498	0.264
LIG_FHA_1	596	602	PF00498	0.252
LIG_FHA_2	159	165	PF00498	0.637
LIG_FHA_2	255	261	PF00498	0.234
LIG_FHA_2	37	43	PF00498	0.692
LIG_FHA_2	393	399	PF00498	0.558
LIG_LIR_Apic_2	260	265	PF02991	0.282
LIG_LIR_Apic_2	282	288	PF02991	0.240
LIG_LIR_Apic_2	305	311	PF02991	0.190
LIG_LIR_Apic_2	624	630	PF02991	0.364
LIG_LIR_Apic_2	9	15	PF02991	0.793
LIG_LIR_Gen_1	223	233	PF02991	0.275
LIG_LIR_Gen_1	295	306	PF02991	0.254
LIG_LIR_Gen_1	329	337	PF02991	0.367
LIG_LIR_Gen_1	374	384	PF02991	0.310
LIG_LIR_Gen_1	437	448	PF02991	0.244
LIG_LIR_Gen_1	462	473	PF02991	0.473
LIG_LIR_Gen_1	495	504	PF02991	0.480
LIG_LIR_Nem_3	20	24	PF02991	0.721
LIG_LIR_Nem_3	221	227	PF02991	0.340
LIG_LIR_Nem_3	295	301	PF02991	0.254
LIG_LIR_Nem_3	329	333	PF02991	0.367
LIG_LIR_Nem_3	362	367	PF02991	0.394
LIG_LIR_Nem_3	373	379	PF02991	0.303
LIG_LIR_Nem_3	417	423	PF02991	0.213
LIG_LIR_Nem_3	425	430	PF02991	0.251
LIG_LIR_Nem_3	437	443	PF02991	0.297
LIG_LIR_Nem_3	445	449	PF02991	0.263
LIG_LIR_Nem_3	462	468	PF02991	0.431
LIG_LYPXL_SIV_4	378	386	PF13949	0.203
LIG_PCNA_PIPBox_1	206	215	PF02747	0.436
LIG_Pex14_2	356	360	PF04695	0.272
LIG_Pex14_2	440	444	PF04695	0.248
LIG_Pex14_2	448	452	PF04695	0.262
LIG_Pex14_2	600	604	PF04695	0.316
LIG_PTB_Apo_2	309	316	PF02174	0.310
LIG_PTB_Apo_2	324	331	PF02174	0.188
LIG_SH2_CRK	225	229	PF00017	0.264
LIG_SH2_CRK	285	289	PF00017	0.240
LIG_SH2_CRK	427	431	PF00017	0.329
LIG_SH2_GRB2like	568	571	PF00017	0.671
LIG_SH2_PTP2	308	311	PF00017	0.190
LIG_SH2_PTP2	379	382	PF00017	0.306
LIG_SH2_PTP2	383	386	PF00017	0.322
LIG_SH2_SRC	403	406	PF00017	0.491
LIG_SH2_SRC	568	571	PF00017	0.596
LIG_SH2_STAP1	225	229	PF00017	0.198
LIG_SH2_STAP1	485	489	PF00017	0.476
LIG_SH2_STAT5	182	185	PF00017	0.508
LIG_SH2_STAT5	186	189	PF00017	0.499
LIG_SH2_STAT5	212	215	PF00017	0.284
LIG_SH2_STAT5	225	228	PF00017	0.297
LIG_SH2_STAT5	253	256	PF00017	0.248
LIG_SH2_STAT5	303	306	PF00017	0.316
LIG_SH2_STAT5	308	311	PF00017	0.320
LIG_SH2_STAT5	324	327	PF00017	0.402
LIG_SH2_STAT5	334	337	PF00017	0.464
LIG_SH2_STAT5	367	370	PF00017	0.368
LIG_SH2_STAT5	379	382	PF00017	0.300
LIG_SH2_STAT5	383	386	PF00017	0.278
LIG_SH2_STAT5	403	406	PF00017	0.384
LIG_SH2_STAT5	497	500	PF00017	0.567
LIG_SH2_STAT5	568	571	PF00017	0.671
LIG_SH2_STAT5	595	598	PF00017	0.198
LIG_SH2_STAT5	627	630	PF00017	0.374
LIG_SH3_1	627	633	PF00018	0.374
LIG_SH3_3	169	175	PF00018	0.522
LIG_SH3_3	21	27	PF00018	0.827
LIG_SH3_3	262	268	PF00018	0.243
LIG_SH3_3	393	399	PF00018	0.558
LIG_SH3_3	514	520	PF00018	0.588
LIG_SH3_3	627	633	PF00018	0.457
LIG_SUMO_SIM_par_1	115	123	PF11976	0.613
LIG_SUMO_SIM_par_1	155	161	PF11976	0.625
LIG_SUMO_SIM_par_1	225	231	PF11976	0.203
LIG_SUMO_SIM_par_1	456	462	PF11976	0.203
LIG_TRAF2_1	492	495	PF00917	0.478
LIG_TYR_ITIM	210	215	PF00017	0.507
LIG_TYR_ITIM	381	386	PF00017	0.332
LIG_WRC_WIRS_1	297	302	PF05994	0.339
LIG_WRC_WIRS_1	420	425	PF05994	0.269
LIG_WRC_WIRS_1	443	448	PF05994	0.262
LIG_WRC_WIRS_1	601	606	PF05994	0.367
LIG_WW_2	27	30	PF00397	0.625
MOD_CDK_SPK_2	75	80	PF00069	0.623
MOD_CDK_SPK_2	93	98	PF00069	0.589
MOD_CK1_1	120	126	PF00069	0.761
MOD_CK1_1	137	143	PF00069	0.667
MOD_CK1_1	289	295	PF00069	0.241
MOD_CK1_1	422	428	PF00069	0.271
MOD_CK1_1	466	472	PF00069	0.473
MOD_CK1_1	576	582	PF00069	0.577
MOD_CK1_1	6	12	PF00069	0.724
MOD_CK1_1	70	76	PF00069	0.628
MOD_CK1_1	92	98	PF00069	0.713
MOD_CK2_1	158	164	PF00069	0.643
MOD_CK2_1	36	42	PF00069	0.661
MOD_CMANNOS	583	586	PF00535	0.311
MOD_Cter_Amidation	275	278	PF01082	0.464
MOD_GlcNHglycan	136	139	PF01048	0.466
MOD_GlcNHglycan	16	19	PF01048	0.591
MOD_GlcNHglycan	239	242	PF01048	0.472
MOD_GlcNHglycan	294	297	PF01048	0.507
MOD_GlcNHglycan	44	47	PF01048	0.600
MOD_GlcNHglycan	469	472	PF01048	0.327
MOD_GlcNHglycan	481	484	PF01048	0.440
MOD_GlcNHglycan	64	67	PF01048	0.585
MOD_GlcNHglycan	72	75	PF01048	0.559
MOD_GlcNHglycan	91	94	PF01048	0.403
MOD_GSK3_1	137	144	PF00069	0.701
MOD_GSK3_1	158	165	PF00069	0.571
MOD_GSK3_1	19	26	PF00069	0.764
MOD_GSK3_1	2	9	PF00069	0.749
MOD_GSK3_1	292	299	PF00069	0.261
MOD_GSK3_1	31	38	PF00069	0.812
MOD_GSK3_1	403	410	PF00069	0.530
MOD_GSK3_1	422	429	PF00069	0.245
MOD_GSK3_1	44	51	PF00069	0.686
MOD_GSK3_1	459	466	PF00069	0.387
MOD_GSK3_1	519	526	PF00069	0.707
MOD_GSK3_1	591	598	PF00069	0.433
MOD_GSK3_1	83	90	PF00069	0.742
MOD_LATS_1	275	281	PF00433	0.257
MOD_LATS_1	589	595	PF00433	0.551
MOD_N-GLC_1	326	331	PF02516	0.198
MOD_NEK2_1	1	6	PF00069	0.768
MOD_NEK2_1	35	40	PF00069	0.822
MOD_NEK2_1	407	412	PF00069	0.351
MOD_NEK2_1	600	605	PF00069	0.347
MOD_NEK2_2	131	136	PF00069	0.606
MOD_NEK2_2	158	163	PF00069	0.531
MOD_NEK2_2	181	186	PF00069	0.529
MOD_NEK2_2	296	301	PF00069	0.240
MOD_NEK2_2	403	408	PF00069	0.467
MOD_NEK2_2	419	424	PF00069	0.273
MOD_NEK2_2	523	528	PF00069	0.630
MOD_PIKK_1	126	132	PF00454	0.615
MOD_PIKK_1	512	518	PF00454	0.580
MOD_PIKK_1	568	574	PF00454	0.733
MOD_PK_1	98	104	PF00069	0.614
MOD_PKA_1	277	283	PF00069	0.293
MOD_PKA_2	162	168	PF00069	0.508
MOD_PKA_2	277	283	PF00069	0.307
MOD_PKA_2	35	41	PF00069	0.770
MOD_PKA_2	407	413	PF00069	0.367
MOD_PKA_2	512	518	PF00069	0.672
MOD_PKA_2	70	76	PF00069	0.628
MOD_Plk_1	326	332	PF00069	0.198
MOD_Plk_1	463	469	PF00069	0.528
MOD_Plk_4	162	168	PF00069	0.580
MOD_Plk_4	223	229	PF00069	0.244
MOD_Plk_4	243	249	PF00069	0.274
MOD_Plk_4	350	356	PF00069	0.332
MOD_Plk_4	422	428	PF00069	0.314
MOD_Plk_4	591	597	PF00069	0.459
MOD_Plk_4	600	606	PF00069	0.323
MOD_Plk_4	98	104	PF00069	0.614
MOD_ProDKin_1	19	25	PF00069	0.783
MOD_ProDKin_1	234	240	PF00069	0.214
MOD_ProDKin_1	371	377	PF00069	0.362
MOD_ProDKin_1	392	398	PF00069	0.557
MOD_ProDKin_1	551	557	PF00069	0.687
MOD_ProDKin_1	75	81	PF00069	0.724
MOD_ProDKin_1	93	99	PF00069	0.598
MOD_SUMO_rev_2	105	115	PF00179	0.620
MOD_SUMO_rev_2	535	544	PF00179	0.629
TRG_DiLeu_BaEn_1	223	228	PF01217	0.203
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.517
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.375
TRG_ENDOCYTIC_2	212	215	PF00928	0.325
TRG_ENDOCYTIC_2	225	228	PF00928	0.325
TRG_ENDOCYTIC_2	303	306	PF00928	0.240
TRG_ENDOCYTIC_2	334	337	PF00928	0.507
TRG_ENDOCYTIC_2	379	382	PF00928	0.385
TRG_ENDOCYTIC_2	383	386	PF00928	0.347
TRG_ENDOCYTIC_2	427	430	PF00928	0.326
TRG_ENDOCYTIC_2	497	500	PF00928	0.586
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9L1	Leptomonas seymouri	54%	100%
A0A1X0NUR9	Trypanosomatidae	35%	100%
A0A3Q8IGA4	Leishmania donovani	65%	99%
A0A422MU49	Trypanosoma rangeli	40%	100%
A4I852	Leishmania infantum	66%	99%
Q4Q546	Leishmania major	64%	100%