Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKL9_LEIBR

TriTrypDb:

LbrM.32.2510 , LBRM2903_320032300

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL9

PDB structure(s): 7aih_Ao , 7ane_Ao

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.436
CLV_NRD_NRD_1	27	29	PF00675	0.610
CLV_NRD_NRD_1	96	98	PF00675	0.514
CLV_PCSK_KEX2_1	26	28	PF00082	0.606
CLV_PCSK_KEX2_1	96	98	PF00082	0.514
CLV_PCSK_SKI1_1	174	178	PF00082	0.526
CLV_PCSK_SKI1_1	220	224	PF00082	0.449
CLV_PCSK_SKI1_1	6	10	PF00082	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.695
DOC_CDC14_PxL_1	231	239	PF14671	0.429
DOC_CKS1_1	123	128	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	237	243	PF00134	0.463
DOC_MAPK_MEF2A_6	148	155	PF00069	0.295
DOC_MAPK_NFAT4_5	148	156	PF00069	0.298
DOC_PP1_SILK_1	220	225	PF00149	0.470
DOC_WW_Pin1_4	107	112	PF00397	0.490
DOC_WW_Pin1_4	122	127	PF00397	0.446
DOC_WW_Pin1_4	39	44	PF00397	0.502
LIG_14-3-3_CanoR_1	210	214	PF00244	0.525
LIG_14-3-3_CanoR_1	276	283	PF00244	0.375
LIG_14-3-3_CanoR_1	81	89	PF00244	0.448
LIG_14-3-3_CanoR_1	96	105	PF00244	0.445
LIG_Actin_WH2_2	151	167	PF00022	0.427
LIG_APCC_ABBA_1	151	156	PF00400	0.291
LIG_FHA_1	186	192	PF00498	0.457
LIG_FHA_1	3	9	PF00498	0.686
LIG_FHA_2	164	170	PF00498	0.561
LIG_LIR_Apic_2	132	136	PF02991	0.420
LIG_LIR_Apic_2	229	235	PF02991	0.437
LIG_LIR_Nem_3	110	116	PF02991	0.500
LIG_LIR_Nem_3	229	234	PF02991	0.439
LIG_PDZ_Class_2	279	284	PF00595	0.489
LIG_PTB_Apo_2	252	259	PF02174	0.367
LIG_PTB_Phospho_1	252	258	PF10480	0.365
LIG_SH2_CRK	133	137	PF00017	0.403
LIG_SH2_CRK	232	236	PF00017	0.439
LIG_SH2_GRB2like	16	19	PF00017	0.609
LIG_SH2_NCK_1	116	120	PF00017	0.415
LIG_SH2_NCK_1	123	127	PF00017	0.381
LIG_SH2_NCK_1	133	137	PF00017	0.356
LIG_SH2_NCK_1	232	236	PF00017	0.342
LIG_SH2_SRC	116	119	PF00017	0.412
LIG_SH2_STAP1	258	262	PF00017	0.392
LIG_SH2_STAP1	277	281	PF00017	0.369
LIG_SH2_STAT3	141	144	PF00017	0.497
LIG_SH2_STAT5	133	136	PF00017	0.394
LIG_SH2_STAT5	141	144	PF00017	0.349
LIG_SH2_STAT5	154	157	PF00017	0.389
LIG_SH2_STAT5	178	181	PF00017	0.516
LIG_SH2_STAT5	236	239	PF00017	0.346
LIG_SH2_STAT5	258	261	PF00017	0.389
LIG_SH2_STAT5	277	280	PF00017	0.376
LIG_SH2_STAT5	32	35	PF00017	0.640
LIG_SH3_3	237	243	PF00018	0.436
LIG_SH3_3	37	43	PF00018	0.587
LIG_TRAF2_2	269	274	PF00917	0.550
MOD_CK1_1	95	101	PF00069	0.551
MOD_CK2_1	169	175	PF00069	0.497
MOD_CK2_1	57	63	PF00069	0.547
MOD_CMANNOS	79	82	PF00535	0.453
MOD_GlcNHglycan	161	164	PF01048	0.526
MOD_GlcNHglycan	182	185	PF01048	0.495
MOD_GlcNHglycan	237	240	PF01048	0.460
MOD_GlcNHglycan	249	252	PF01048	0.485
MOD_GlcNHglycan	59	62	PF01048	0.521
MOD_GlcNHglycan	99	102	PF01048	0.549
MOD_GSK3_1	159	166	PF00069	0.462
MOD_GSK3_1	176	183	PF00069	0.379
MOD_GSK3_1	95	102	PF00069	0.544
MOD_NEK2_1	1	6	PF00069	0.663
MOD_NEK2_1	131	136	PF00069	0.487
MOD_NEK2_1	8	13	PF00069	0.634
MOD_PIKK_1	244	250	PF00454	0.469
MOD_PKA_2	209	215	PF00069	0.541
MOD_PKA_2	275	281	PF00069	0.378
MOD_PKA_2	80	86	PF00069	0.443
MOD_PKA_2	95	101	PF00069	0.435
MOD_Plk_2-3	169	175	PF00069	0.308
MOD_Plk_4	176	182	PF00069	0.503
MOD_Plk_4	256	262	PF00069	0.372
MOD_ProDKin_1	107	113	PF00069	0.490
MOD_ProDKin_1	122	128	PF00069	0.451
MOD_ProDKin_1	39	45	PF00069	0.492
TRG_ENDOCYTIC_2	116	119	PF00928	0.412
TRG_ENDOCYTIC_2	231	234	PF00928	0.425
TRG_ENDOCYTIC_2	258	261	PF00928	0.389
TRG_ER_diArg_1	223	226	PF00400	0.405
TRG_ER_diArg_1	26	28	PF00400	0.606
TRG_ER_diArg_1	68	71	PF00400	0.452
TRG_NLS_MonoExtN_4	26	32	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P338	Leptomonas seymouri	76%	100%
A0A1X0NU54	Trypanosomatidae	64%	100%
A0A3S7X5S2	Leishmania donovani	87%	100%
A0A422MUA3	Trypanosoma rangeli	60%	100%
A4I851	Leishmania infantum	87%	100%
D0AAB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0AAB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	73%
E9B309	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q547	Leishmania major	86%	100%
V5BKN6	Trypanosoma cruzi	59%	100%