CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein Hsp20, putative

Species:

Leishmania braziliensis

UniProt:

A4HKL7_LEIBR

TriTrypDb:

LbrM.32.2490 , LBRM2903_320031700

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0015631	tubulin binding	4	5
GO:0019899	enzyme binding	3	5
GO:0031625	ubiquitin protein ligase binding	5	5
GO:0044389	ubiquitin-like protein ligase binding	4	5
GO:0044548	S100 protein binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.588
CLV_C14_Caspase3-7	54	58	PF00656	0.437
CLV_PCSK_KEX2_1	135	137	PF00082	0.478
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.538
CLV_PCSK_SKI1_1	156	160	PF00082	0.334
DOC_CKS1_1	47	52	PF01111	0.560
DOC_MAPK_gen_1	147	155	PF00069	0.483
DOC_MAPK_gen_1	156	166	PF00069	0.518
DOC_MAPK_MEF2A_6	149	157	PF00069	0.533
DOC_MAPK_MEF2A_6	159	168	PF00069	0.537
DOC_PP1_RVXF_1	110	116	PF00149	0.469
DOC_USP7_MATH_1	67	71	PF00917	0.496
DOC_USP7_UBL2_3	135	139	PF12436	0.507
DOC_USP7_UBL2_3	145	149	PF12436	0.462
DOC_USP7_UBL2_3	18	22	PF12436	0.620
DOC_USP7_UBL2_3	36	40	PF12436	0.480
DOC_WW_Pin1_4	46	51	PF00397	0.528
LIG_14-3-3_CanoR_1	141	148	PF00244	0.498
LIG_14-3-3_CanoR_1	81	86	PF00244	0.363
LIG_APCC_ABBA_1	83	88	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_FHA_1	148	154	PF00498	0.485
LIG_FHA_1	47	53	PF00498	0.558
LIG_FHA_1	66	72	PF00498	0.348
LIG_FHA_1	87	93	PF00498	0.333
LIG_FHA_2	114	120	PF00498	0.505
LIG_FHA_2	94	100	PF00498	0.475
LIG_LIR_Gen_1	162	172	PF02991	0.398
LIG_LIR_Gen_1	80	90	PF02991	0.446
LIG_LIR_Nem_3	162	168	PF02991	0.375
LIG_LIR_Nem_3	80	85	PF02991	0.435
LIG_Pex14_2	111	115	PF04695	0.493
LIG_SH2_STAT5	86	89	PF00017	0.335
LIG_SH3_3	58	64	PF00018	0.650
LIG_SH3_4	147	154	PF00018	0.537
LIG_SUMO_SIM_par_1	67	72	PF11976	0.570
LIG_SUMO_SIM_par_1	88	93	PF11976	0.328
LIG_TRAF2_1	179	182	PF00917	0.668
LIG_UBA3_1	153	160	PF00899	0.495
MOD_CK1_1	72	78	PF00069	0.474
MOD_CK2_1	114	120	PF00069	0.524
MOD_CK2_1	181	187	PF00069	0.717
MOD_CK2_1	93	99	PF00069	0.491
MOD_GlcNHglycan	142	145	PF01048	0.355
MOD_GlcNHglycan	176	179	PF01048	0.630
MOD_GSK3_1	107	114	PF00069	0.445
MOD_GSK3_1	127	134	PF00069	0.486
MOD_GSK3_1	170	177	PF00069	0.492
MOD_GSK3_1	51	58	PF00069	0.580
MOD_GSK3_1	65	72	PF00069	0.448
MOD_GSK3_1	93	100	PF00069	0.617
MOD_LATS_1	125	131	PF00433	0.294
MOD_N-GLC_1	170	175	PF02516	0.436
MOD_N-GLC_1	55	60	PF02516	0.558
MOD_NEK2_1	111	116	PF00069	0.337
MOD_NEK2_1	9	14	PF00069	0.494
MOD_NEK2_1	97	102	PF00069	0.554
MOD_NEK2_2	17	22	PF00069	0.481
MOD_PIKK_1	147	153	PF00454	0.544
MOD_PK_1	127	133	PF00069	0.444
MOD_PK_1	160	166	PF00069	0.518
MOD_PK_1	81	87	PF00069	0.465
MOD_PKA_2	140	146	PF00069	0.518
MOD_PKA_2	174	180	PF00069	0.555
MOD_Plk_1	56	62	PF00069	0.482
MOD_Plk_1	97	103	PF00069	0.561
MOD_Plk_2-3	181	187	PF00069	0.682
MOD_Plk_2-3	93	99	PF00069	0.575
MOD_Plk_4	160	166	PF00069	0.393
MOD_Plk_4	24	30	PF00069	0.531
MOD_Plk_4	57	63	PF00069	0.506
MOD_Plk_4	81	87	PF00069	0.323
MOD_ProDKin_1	46	52	PF00069	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H6	Leptomonas seymouri	70%	85%
A0A0S4KMW7	Bodo saltans	40%	100%
A0A1X0NU46	Trypanosomatidae	42%	88%
A0A3G1S267	Trypanosoma rangeli	38%	91%
A0A3S7X5U5	Leishmania donovani	86%	100%
A4I849	Leishmania infantum	86%	100%
D0AAB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	90%
E9B307	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q549	Leishmania major	83%	100%
V5DCC8	Trypanosoma cruzi	42%	90%