Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HKL6_LEIBR

TriTrypDb:

LbrM.32.2480 , LBRM2903_320031600

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.675
CLV_C14_Caspase3-7	6	10	PF00656	0.551
CLV_NRD_NRD_1	216	218	PF00675	0.560
CLV_PCSK_KEX2_1	215	217	PF00082	0.571
CLV_PCSK_KEX2_1	286	288	PF00082	0.590
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.488
CLV_PCSK_PC7_1	211	217	PF00082	0.597
CLV_PCSK_SKI1_1	286	290	PF00082	0.578
CLV_PCSK_SKI1_1	83	87	PF00082	0.471
DEG_SPOP_SBC_1	10	14	PF00917	0.539
DEG_SPOP_SBC_1	167	171	PF00917	0.686
DOC_CYCLIN_RxL_1	280	293	PF00134	0.507
DOC_CYCLIN_yClb1_LxF_4	120	125	PF00134	0.324
DOC_MAPK_FxFP_2	125	128	PF00069	0.459
DOC_MAPK_gen_1	215	224	PF00069	0.551
DOC_MAPK_MEF2A_6	215	223	PF00069	0.454
DOC_PP1_RVXF_1	120	126	PF00149	0.330
DOC_PP2B_LxvP_1	162	165	PF13499	0.521
DOC_PP4_FxxP_1	125	128	PF00568	0.459
DOC_USP7_MATH_1	10	14	PF00917	0.576
DOC_USP7_MATH_1	261	265	PF00917	0.511
DOC_WW_Pin1_4	256	261	PF00397	0.569
DOC_WW_Pin1_4	274	279	PF00397	0.433
DOC_WW_Pin1_4	33	38	PF00397	0.644
LIG_14-3-3_CanoR_1	122	126	PF00244	0.476
LIG_14-3-3_CanoR_1	150	154	PF00244	0.683
LIG_14-3-3_CanoR_1	196	205	PF00244	0.641
LIG_14-3-3_CanoR_1	251	257	PF00244	0.412
LIG_14-3-3_CanoR_1	50	55	PF00244	0.546
LIG_BRCT_BRCA1_1	224	228	PF00533	0.346
LIG_FHA_1	108	114	PF00498	0.499
LIG_FHA_1	157	163	PF00498	0.717
LIG_FHA_1	2	8	PF00498	0.581
LIG_FHA_1	200	206	PF00498	0.616
LIG_FHA_1	234	240	PF00498	0.492
LIG_FHA_1	260	266	PF00498	0.490
LIG_FHA_1	293	299	PF00498	0.609
LIG_FHA_1	34	40	PF00498	0.556
LIG_FHA_2	131	137	PF00498	0.539
LIG_FHA_2	169	175	PF00498	0.737
LIG_FHA_2	88	94	PF00498	0.480
LIG_IRF3_LxIS_1	218	225	PF10401	0.289
LIG_LIR_Apic_2	124	128	PF02991	0.463
LIG_LIR_Gen_1	179	186	PF02991	0.548
LIG_LIR_Gen_1	291	298	PF02991	0.350
LIG_LIR_Nem_3	179	184	PF02991	0.551
LIG_LIR_Nem_3	291	297	PF02991	0.355
LIG_RPA_C_Fungi	72	84	PF08784	0.328
LIG_SH2_CRK	294	298	PF00017	0.350
LIG_SH2_GRB2like	102	105	PF00017	0.584
LIG_SH2_NCK_1	181	185	PF00017	0.545
LIG_SH2_SRC	181	184	PF00017	0.548
LIG_SH2_STAP1	115	119	PF00017	0.522
LIG_SH2_STAP1	294	298	PF00017	0.350
LIG_SH2_STAT5	102	105	PF00017	0.506
LIG_SH2_STAT5	294	297	PF00017	0.466
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.407
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.556
LIG_SUMO_SIM_par_1	220	225	PF11976	0.317
LIG_SUMO_SIM_par_1	261	267	PF11976	0.581
LIG_SUMO_SIM_par_1	293	299	PF11976	0.356
LIG_TYR_ITIM	292	297	PF00017	0.354
LIG_UBA3_1	221	227	PF00899	0.456
MOD_CK1_1	14	20	PF00069	0.650
MOD_CK1_1	152	158	PF00069	0.689
MOD_CK1_1	160	166	PF00069	0.650
MOD_CK1_1	169	175	PF00069	0.611
MOD_CK1_1	199	205	PF00069	0.746
MOD_CK1_1	259	265	PF00069	0.570
MOD_CK1_1	267	273	PF00069	0.543
MOD_CK1_1	49	55	PF00069	0.508
MOD_CK2_1	10	16	PF00069	0.655
MOD_CK2_1	130	136	PF00069	0.476
MOD_CK2_1	140	146	PF00069	0.548
MOD_CK2_1	296	302	PF00069	0.403
MOD_CK2_1	87	93	PF00069	0.592
MOD_GlcNHglycan	140	145	PF01048	0.767
MOD_GlcNHglycan	19	22	PF01048	0.727
MOD_GlcNHglycan	198	201	PF01048	0.518
MOD_GlcNHglycan	224	227	PF01048	0.296
MOD_GlcNHglycan	67	70	PF01048	0.531
MOD_GSK3_1	10	17	PF00069	0.723
MOD_GSK3_1	126	133	PF00069	0.625
MOD_GSK3_1	149	156	PF00069	0.738
MOD_GSK3_1	166	173	PF00069	0.724
MOD_GSK3_1	186	193	PF00069	0.526
MOD_GSK3_1	252	259	PF00069	0.681
MOD_GSK3_1	29	36	PF00069	0.668
MOD_GSK3_1	292	299	PF00069	0.349
MOD_GSK3_1	46	53	PF00069	0.708
MOD_N-GLC_1	14	19	PF02516	0.773
MOD_N-GLC_1	59	64	PF02516	0.416
MOD_NEK2_1	113	118	PF00069	0.282
MOD_NEK2_1	153	158	PF00069	0.521
MOD_NEK2_1	186	191	PF00069	0.541
MOD_NEK2_1	198	203	PF00069	0.520
MOD_NEK2_1	222	227	PF00069	0.411
MOD_NEK2_1	292	297	PF00069	0.504
MOD_NEK2_2	261	266	PF00069	0.487
MOD_PKA_2	121	127	PF00069	0.457
MOD_PKA_2	149	155	PF00069	0.682
MOD_PKA_2	49	55	PF00069	0.538
MOD_Plk_1	14	20	PF00069	0.793
MOD_Plk_1	290	296	PF00069	0.353
MOD_Plk_1	59	65	PF00069	0.456
MOD_Plk_4	186	192	PF00069	0.539
MOD_Plk_4	292	298	PF00069	0.499
MOD_ProDKin_1	256	262	PF00069	0.575
MOD_ProDKin_1	274	280	PF00069	0.433
MOD_ProDKin_1	33	39	PF00069	0.644
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.461
TRG_ENDOCYTIC_2	181	184	PF00928	0.548
TRG_ENDOCYTIC_2	294	297	PF00928	0.446
TRG_ER_diArg_1	215	217	PF00400	0.571
TRG_ER_diArg_1	74	77	PF00400	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y8	Leptomonas seymouri	47%	89%
A0A3S7X5S5	Leishmania donovani	67%	90%
A4I848	Leishmania infantum	67%	90%
E9B306	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	91%
Q4Q550	Leishmania major	64%	100%