Receptor-type adenylate cyclase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HKL5_LEIBR

TriTrypDb:

LbrM.32.2470 , LBRM2903_280009200

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031510	SUMO activating enzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HKL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	6
GO:0016874	ligase activity	2	6
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	6
GO:0019948	SUMO activating enzyme activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0140657	ATP-dependent activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	41	43	PF00675	0.459
CLV_PCSK_KEX2_1	41	43	PF00082	0.536
CLV_PCSK_SKI1_1	71	75	PF00082	0.401
DEG_APCC_DBOX_1	99	107	PF00400	0.399
DOC_MAPK_gen_1	65	74	PF00069	0.342
DOC_MAPK_MEF2A_6	67	76	PF00069	0.392
DOC_MAPK_MEF2A_6	79	87	PF00069	0.432
DOC_MAPK_NFAT4_5	71	79	PF00069	0.382
DOC_PP2B_LxvP_1	173	176	PF13499	0.417
DOC_USP7_MATH_1	44	48	PF00917	0.475
DOC_USP7_MATH_1	57	61	PF00917	0.499
LIG_BIR_II_1	1	5	PF00653	0.460
LIG_BIR_III_2	9	13	PF00653	0.650
LIG_BRCT_BRCA1_1	83	87	PF00533	0.560
LIG_FHA_1	78	84	PF00498	0.455
LIG_FHA_2	105	111	PF00498	0.475
LIG_FHA_2	193	199	PF00498	0.451
LIG_GBD_Chelix_1	35	43	PF00786	0.422
LIG_LIR_Nem_3	186	192	PF02991	0.505
LIG_LIR_Nem_3	50	55	PF02991	0.413
LIG_NRBOX	169	175	PF00104	0.418
LIG_NRP_CendR_1	199	201	PF00754	0.453
LIG_Pex14_2	162	166	PF04695	0.470
LIG_PTB_Apo_2	165	172	PF02174	0.417
LIG_REV1ctd_RIR_1	188	198	PF16727	0.449
LIG_SH2_CRK	40	44	PF00017	0.458
LIG_SH2_CRK	69	73	PF00017	0.299
LIG_SH2_NCK_1	95	99	PF00017	0.465
LIG_SH2_STAP1	180	184	PF00017	0.435
LIG_SH2_STAT3	180	183	PF00017	0.438
LIG_SH3_3	182	188	PF00018	0.515
LIG_SH3_3	53	59	PF00018	0.423
MOD_CK2_1	192	198	PF00069	0.451
MOD_CK2_1	44	50	PF00069	0.552
MOD_GlcNHglycan	123	126	PF01048	0.552
MOD_GlcNHglycan	145	148	PF01048	0.460
MOD_GSK3_1	26	33	PF00069	0.468
MOD_GSK3_1	77	84	PF00069	0.513
MOD_NEK2_1	148	153	PF00069	0.449
MOD_NEK2_1	169	174	PF00069	0.422
MOD_NEK2_1	192	197	PF00069	0.450
MOD_NEK2_1	26	31	PF00069	0.447
MOD_Plk_1	192	198	PF00069	0.451
MOD_Plk_4	30	36	PF00069	0.461
MOD_Plk_4	57	63	PF00069	0.550
TRG_ENDOCYTIC_2	40	43	PF00928	0.447
TRG_ENDOCYTIC_2	69	72	PF00928	0.302
TRG_ENDOCYTIC_2	95	98	PF00928	0.374
TRG_ER_diArg_1	40	42	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G3	Leptomonas seymouri	54%	70%
A0A3S7X162	Leishmania donovani	87%	70%
A4HG77	Leishmania braziliensis	100%	70%
A4I3A8	Leishmania infantum	87%	70%
E9AZJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	70%
Q4Q8N4	Leishmania major	85%	70%