Putative methionyl-tRNA formyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methionyl-tRNA formyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKL4_LEIBR

TriTrypDb:

LbrM.32.2460 , LBRM2903_320031500

Length:

972

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019988	charged-tRNA amino acid modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071951	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	8	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0009058	biosynthetic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004479	methionyl-tRNA formyltransferase activity	5	6
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140101	catalytic activity, acting on a tRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.344
CLV_C14_Caspase3-7	17	21	PF00656	0.548
CLV_C14_Caspase3-7	261	265	PF00656	0.516
CLV_C14_Caspase3-7	52	56	PF00656	0.587
CLV_C14_Caspase3-7	561	565	PF00656	0.536
CLV_C14_Caspase3-7	791	795	PF00656	0.509
CLV_MEL_PAP_1	756	762	PF00089	0.515
CLV_NRD_NRD_1	645	647	PF00675	0.453
CLV_NRD_NRD_1	649	651	PF00675	0.435
CLV_NRD_NRD_1	770	772	PF00675	0.556
CLV_NRD_NRD_1	804	806	PF00675	0.604
CLV_NRD_NRD_1	952	954	PF00675	0.543
CLV_PCSK_FUR_1	802	806	PF00082	0.532
CLV_PCSK_KEX2_1	122	124	PF00082	0.517
CLV_PCSK_KEX2_1	645	647	PF00082	0.453
CLV_PCSK_KEX2_1	649	651	PF00082	0.435
CLV_PCSK_KEX2_1	770	772	PF00082	0.556
CLV_PCSK_KEX2_1	804	806	PF00082	0.604
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.517
CLV_PCSK_PC7_1	645	651	PF00082	0.468
CLV_PCSK_SKI1_1	110	114	PF00082	0.443
CLV_PCSK_SKI1_1	115	119	PF00082	0.411
CLV_PCSK_SKI1_1	207	211	PF00082	0.269
CLV_PCSK_SKI1_1	212	216	PF00082	0.269
CLV_PCSK_SKI1_1	645	649	PF00082	0.447
CLV_PCSK_SKI1_1	650	654	PF00082	0.427
CLV_PCSK_SKI1_1	785	789	PF00082	0.586
DEG_APCC_DBOX_1	486	494	PF00400	0.481
DEG_APCC_DBOX_1	644	652	PF00400	0.432
DEG_COP1_1	886	896	PF00400	0.628
DEG_Nend_UBRbox_1	1	4	PF02207	0.480
DEG_SPOP_SBC_1	150	154	PF00917	0.519
DOC_ANK_TNKS_1	243	250	PF00023	0.414
DOC_CKS1_1	724	729	PF01111	0.400
DOC_CYCLIN_RxL_1	782	791	PF00134	0.583
DOC_MAPK_gen_1	487	495	PF00069	0.515
DOC_MAPK_gen_1	508	518	PF00069	0.521
DOC_MAPK_gen_1	528	535	PF00069	0.483
DOC_MAPK_gen_1	645	653	PF00069	0.356
DOC_MAPK_gen_1	770	776	PF00069	0.516
DOC_MAPK_HePTP_8	950	967	PF00069	0.537
DOC_MAPK_MEF2A_6	528	535	PF00069	0.483
DOC_MAPK_MEF2A_6	804	812	PF00069	0.517
DOC_MAPK_MEF2A_6	945	952	PF00069	0.534
DOC_MAPK_MEF2A_6	959	967	PF00069	0.542
DOC_MAPK_NFAT4_5	528	536	PF00069	0.476
DOC_PP1_RVXF_1	281	287	PF00149	0.421
DOC_PP1_RVXF_1	771	777	PF00149	0.595
DOC_PP2B_LxvP_1	216	219	PF13499	0.414
DOC_PP2B_LxvP_1	493	496	PF13499	0.502
DOC_PP2B_LxvP_1	907	910	PF13499	0.499
DOC_SPAK_OSR1_1	759	763	PF12202	0.527
DOC_USP7_MATH_1	128	132	PF00917	0.588
DOC_USP7_MATH_1	151	155	PF00917	0.603
DOC_USP7_MATH_1	171	175	PF00917	0.548
DOC_USP7_MATH_1	262	266	PF00917	0.469
DOC_USP7_MATH_1	31	35	PF00917	0.570
DOC_USP7_MATH_1	316	320	PF00917	0.510
DOC_USP7_MATH_1	324	328	PF00917	0.640
DOC_USP7_MATH_1	330	334	PF00917	0.563
DOC_USP7_MATH_1	457	461	PF00917	0.653
DOC_USP7_MATH_1	626	630	PF00917	0.510
DOC_USP7_MATH_1	792	796	PF00917	0.507
DOC_USP7_MATH_1	823	827	PF00917	0.535
DOC_USP7_MATH_1	879	883	PF00917	0.556
DOC_USP7_UBL2_3	168	172	PF12436	0.650
DOC_USP7_UBL2_3	941	945	PF12436	0.549
DOC_WW_Pin1_4	161	166	PF00397	0.593
DOC_WW_Pin1_4	181	186	PF00397	0.548
DOC_WW_Pin1_4	233	238	PF00397	0.469
DOC_WW_Pin1_4	320	325	PF00397	0.558
DOC_WW_Pin1_4	362	367	PF00397	0.586
DOC_WW_Pin1_4	473	478	PF00397	0.595
DOC_WW_Pin1_4	497	502	PF00397	0.653
DOC_WW_Pin1_4	554	559	PF00397	0.550
DOC_WW_Pin1_4	634	639	PF00397	0.488
DOC_WW_Pin1_4	723	728	PF00397	0.421
LIG_14-3-3_CanoR_1	489	494	PF00244	0.714
LIG_14-3-3_CanoR_1	602	607	PF00244	0.497
LIG_14-3-3_CanoR_1	655	662	PF00244	0.471
LIG_14-3-3_CanoR_1	725	731	PF00244	0.484
LIG_14-3-3_CanoR_1	849	854	PF00244	0.665
LIG_APCC_ABBA_1	556	561	PF00400	0.548
LIG_APCC_ABBA_1	965	970	PF00400	0.537
LIG_BIR_III_4	20	24	PF00653	0.522
LIG_BRCT_BRCA1_1	177	181	PF00533	0.502
LIG_BRCT_BRCA1_1	235	239	PF00533	0.469
LIG_deltaCOP1_diTrp_1	561	566	PF00928	0.534
LIG_deltaCOP1_diTrp_1	769	776	PF00928	0.513
LIG_deltaCOP1_diTrp_1	930	935	PF00928	0.514
LIG_EVH1_2	780	784	PF00568	0.483
LIG_FHA_1	199	205	PF00498	0.519
LIG_FHA_1	313	319	PF00498	0.585
LIG_FHA_1	490	496	PF00498	0.494
LIG_FHA_1	66	72	PF00498	0.373
LIG_FHA_1	729	735	PF00498	0.473
LIG_FHA_1	958	964	PF00498	0.609
LIG_FHA_2	259	265	PF00498	0.516
LIG_FHA_2	43	49	PF00498	0.513
LIG_FHA_2	541	547	PF00498	0.477
LIG_FHA_2	686	692	PF00498	0.476
LIG_FHA_2	716	722	PF00498	0.516
LIG_LIR_Apic_2	205	211	PF02991	0.469
LIG_LIR_Apic_2	586	592	PF02991	0.488
LIG_LIR_Apic_2	622	626	PF02991	0.503
LIG_LIR_Gen_1	236	247	PF02991	0.474
LIG_LIR_Gen_1	580	589	PF02991	0.503
LIG_LIR_Gen_1	729	738	PF02991	0.500
LIG_LIR_Nem_3	205	209	PF02991	0.469
LIG_LIR_Nem_3	236	242	PF02991	0.474
LIG_LIR_Nem_3	365	371	PF02991	0.613
LIG_LIR_Nem_3	577	581	PF02991	0.619
LIG_LIR_Nem_3	729	733	PF02991	0.525
LIG_LIR_Nem_3	920	926	PF02991	0.495
LIG_MYND_1	226	230	PF01753	0.469
LIG_MYND_1	736	740	PF01753	0.495
LIG_NRBOX	647	653	PF00104	0.346
LIG_PCNA_yPIPBox_3	625	634	PF02747	0.399
LIG_PDZ_Class_3	967	972	PF00595	0.464
LIG_Pex14_1	562	566	PF04695	0.580
LIG_Pex14_1	772	776	PF04695	0.518
LIG_Pex14_2	566	570	PF04695	0.527
LIG_Rb_LxCxE_1	543	561	PF01857	0.478
LIG_Rb_LxCxE_1	921	937	PF01857	0.497
LIG_SH2_CRK	589	593	PF00017	0.515
LIG_SH2_CRK	777	781	PF00017	0.572
LIG_SH2_CRK	923	927	PF00017	0.479
LIG_SH2_PTP2	964	967	PF00017	0.540
LIG_SH2_STAP1	198	202	PF00017	0.469
LIG_SH2_STAP1	568	572	PF00017	0.535
LIG_SH2_STAT3	915	918	PF00017	0.605
LIG_SH2_STAT5	208	211	PF00017	0.469
LIG_SH2_STAT5	285	288	PF00017	0.400
LIG_SH2_STAT5	623	626	PF00017	0.501
LIG_SH2_STAT5	892	895	PF00017	0.626
LIG_SH2_STAT5	91	94	PF00017	0.408
LIG_SH2_STAT5	915	918	PF00017	0.558
LIG_SH2_STAT5	964	967	PF00017	0.540
LIG_SH3_1	589	595	PF00018	0.525
LIG_SH3_3	271	277	PF00018	0.472
LIG_SH3_3	305	311	PF00018	0.520
LIG_SH3_3	315	321	PF00018	0.747
LIG_SH3_3	461	467	PF00018	0.601
LIG_SH3_3	552	558	PF00018	0.594
LIG_SH3_3	589	595	PF00018	0.461
LIG_SH3_3	61	67	PF00018	0.418
LIG_SH3_3	730	736	PF00018	0.532
LIG_SH3_3	95	101	PF00018	0.404
LIG_SH3_5	194	198	PF00018	0.318
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.496
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.416
LIG_SUMO_SIM_anti_2	705	710	PF11976	0.387
LIG_SUMO_SIM_par_1	199	205	PF11976	0.516
LIG_TRAF2_1	447	450	PF00917	0.584
LIG_TYR_ITIM	962	967	PF00017	0.539
LIG_UBA3_1	113	122	PF00899	0.502
LIG_UBA3_1	253	257	PF00899	0.411
LIG_WRC_WIRS_1	203	208	PF05994	0.469
LIG_WW_3	756	760	PF00397	0.511
MOD_CDK_SPxK_1	634	640	PF00069	0.488
MOD_CDK_SPxxK_3	161	168	PF00069	0.517
MOD_CK1_1	174	180	PF00069	0.684
MOD_CK1_1	312	318	PF00069	0.578
MOD_CK1_1	323	329	PF00069	0.543
MOD_CK1_1	331	337	PF00069	0.590
MOD_CK1_1	359	365	PF00069	0.650
MOD_CK1_1	392	398	PF00069	0.681
MOD_CK1_1	442	448	PF00069	0.682
MOD_CK1_1	554	560	PF00069	0.552
MOD_CK1_1	670	676	PF00069	0.573
MOD_CK1_1	761	767	PF00069	0.516
MOD_CK1_1	843	849	PF00069	0.660
MOD_CK1_1	919	925	PF00069	0.433
MOD_CK2_1	444	450	PF00069	0.641
MOD_CK2_1	540	546	PF00069	0.477
MOD_CK2_1	715	721	PF00069	0.517
MOD_CMANNOS	932	935	PF00535	0.504
MOD_Cter_Amidation	120	123	PF01082	0.418
MOD_DYRK1A_RPxSP_1	473	477	PF00069	0.515
MOD_GlcNHglycan	110	113	PF01048	0.610
MOD_GlcNHglycan	119	122	PF01048	0.501
MOD_GlcNHglycan	126	129	PF01048	0.481
MOD_GlcNHglycan	178	181	PF01048	0.653
MOD_GlcNHglycan	239	242	PF01048	0.211
MOD_GlcNHglycan	264	267	PF01048	0.304
MOD_GlcNHglycan	330	333	PF01048	0.584
MOD_GlcNHglycan	358	361	PF01048	0.525
MOD_GlcNHglycan	501	504	PF01048	0.522
MOD_GlcNHglycan	6	9	PF01048	0.454
MOD_GlcNHglycan	628	631	PF01048	0.403
MOD_GlcNHglycan	751	755	PF01048	0.656
MOD_GlcNHglycan	790	793	PF01048	0.609
MOD_GlcNHglycan	794	797	PF01048	0.622
MOD_GlcNHglycan	868	871	PF01048	0.536
MOD_GlcNHglycan	880	884	PF01048	0.544
MOD_GSK3_1	104	111	PF00069	0.447
MOD_GSK3_1	124	131	PF00069	0.462
MOD_GSK3_1	145	152	PF00069	0.674
MOD_GSK3_1	157	164	PF00069	0.734
MOD_GSK3_1	171	178	PF00069	0.621
MOD_GSK3_1	198	205	PF00069	0.494
MOD_GSK3_1	233	240	PF00069	0.469
MOD_GSK3_1	258	265	PF00069	0.516
MOD_GSK3_1	27	34	PF00069	0.571
MOD_GSK3_1	312	319	PF00069	0.566
MOD_GSK3_1	320	327	PF00069	0.648
MOD_GSK3_1	331	338	PF00069	0.618
MOD_GSK3_1	388	395	PF00069	0.773
MOD_GSK3_1	413	420	PF00069	0.592
MOD_GSK3_1	562	569	PF00069	0.582
MOD_GSK3_1	715	722	PF00069	0.427
MOD_GSK3_1	788	795	PF00069	0.570
MOD_GSK3_1	840	847	PF00069	0.630
MOD_GSK3_1	9	16	PF00069	0.452
MOD_N-GLC_1	14	19	PF02516	0.534
MOD_N-GLC_1	442	447	PF02516	0.547
MOD_N-GLC_1	792	797	PF02516	0.563
MOD_NEK2_1	108	113	PF00069	0.433
MOD_NEK2_1	117	122	PF00069	0.446
MOD_NEK2_1	124	129	PF00069	0.557
MOD_NEK2_1	176	181	PF00069	0.503
MOD_NEK2_1	335	340	PF00069	0.527
MOD_NEK2_1	413	418	PF00069	0.702
MOD_NEK2_1	439	444	PF00069	0.644
MOD_NEK2_1	516	521	PF00069	0.558
MOD_NEK2_1	566	571	PF00069	0.529
MOD_NEK2_1	632	637	PF00069	0.389
MOD_NEK2_1	788	793	PF00069	0.584
MOD_NEK2_1	9	14	PF00069	0.482
MOD_NEK2_2	720	725	PF00069	0.523
MOD_PIKK_1	287	293	PF00454	0.389
MOD_PIKK_1	437	443	PF00454	0.528
MOD_PIKK_1	728	734	PF00454	0.476
MOD_PIKK_1	761	767	PF00454	0.606
MOD_PIKK_1	794	800	PF00454	0.537
MOD_PIKK_1	900	906	PF00454	0.677
MOD_PKA_2	309	315	PF00069	0.619
MOD_PKA_2	328	334	PF00069	0.748
MOD_PKA_2	601	607	PF00069	0.492
MOD_PKA_2	758	764	PF00069	0.604
MOD_PKA_2	9	15	PF00069	0.491
MOD_PKB_1	487	495	PF00069	0.485
MOD_Plk_1	198	204	PF00069	0.516
MOD_Plk_1	316	322	PF00069	0.604
MOD_Plk_1	720	726	PF00069	0.523
MOD_Plk_1	919	925	PF00069	0.515
MOD_Plk_4	184	190	PF00069	0.514
MOD_Plk_4	198	204	PF00069	0.434
MOD_Plk_4	210	216	PF00069	0.495
MOD_Plk_4	224	230	PF00069	0.470
MOD_Plk_4	249	255	PF00069	0.411
MOD_Plk_4	364	370	PF00069	0.605
MOD_Plk_4	389	395	PF00069	0.789
MOD_Plk_4	551	557	PF00069	0.589
MOD_Plk_4	562	568	PF00069	0.608
MOD_ProDKin_1	161	167	PF00069	0.594
MOD_ProDKin_1	181	187	PF00069	0.534
MOD_ProDKin_1	233	239	PF00069	0.469
MOD_ProDKin_1	320	326	PF00069	0.558
MOD_ProDKin_1	362	368	PF00069	0.584
MOD_ProDKin_1	473	479	PF00069	0.591
MOD_ProDKin_1	497	503	PF00069	0.653
MOD_ProDKin_1	554	560	PF00069	0.551
MOD_ProDKin_1	634	640	PF00069	0.488
MOD_ProDKin_1	723	729	PF00069	0.424
MOD_SUMO_rev_2	103	108	PF00179	0.514
MOD_SUMO_rev_2	831	841	PF00179	0.536
TRG_DiLeu_BaEn_2	45	51	PF01217	0.519
TRG_DiLeu_BaEn_3	52	58	PF01217	0.359
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.542
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.451
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.339
TRG_ENDOCYTIC_2	285	288	PF00928	0.400
TRG_ENDOCYTIC_2	581	584	PF00928	0.566
TRG_ENDOCYTIC_2	923	926	PF00928	0.468
TRG_ENDOCYTIC_2	964	967	PF00928	0.540
TRG_ER_diArg_1	371	374	PF00400	0.572
TRG_ER_diArg_1	644	646	PF00400	0.457
TRG_ER_diArg_1	648	650	PF00400	0.437
TRG_ER_diArg_1	770	772	PF00400	0.556
TRG_ER_diArg_1	773	776	PF00400	0.557
TRG_ER_diArg_1	803	805	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	649	654	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE1	Leptomonas seymouri	48%	83%
A0A3Q8IG07	Leishmania donovani	69%	99%
A4I847	Leishmania infantum	69%	99%
E9B305	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q551	Leishmania major	68%	99%